| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jung-Chien Cheng, Hsun-Ming Chang, Peter C K Leun. Wild-type p53 attenuates cancer cell motility by inducing growth differentiation factor-15 expression. Endocrinology. vol 152. issue 8. 2011-09-21. PMID:21586550. |
a major function of the p53 tumor suppressor is the regulation of the cell cycle and apoptosis. |
2011-09-21 |
2023-08-12 |
human |
| Jin Hyup Lee, Aziz Sanca. Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 26. 2011-09-21. PMID:21628572. |
as a consequence, when tumors arising from oncogenic ras-transformed p53(-/-) and p53(-/-)cry1(-/-)cry2(-/-) cells are treated with the anticancer drug oxaliplatin, p53(-/-) tumors continue to grow whereas p53(-/-)cry1(-/-)cry2(-/-) tumors exhibit extensive apoptosis and stop growing. |
2011-09-21 |
2023-08-12 |
Not clear |
| Jin Hyup Lee, Aziz Sanca. Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 26. 2011-09-21. PMID:21628572. |
this finding provides a mechanistic foundation for overcoming the resistance of p53-deficient tumor cells to apoptosis induced by dna-damaging agents and suggests that disruption of cryptochrome function may increase the sensitivity of tumors with p53 mutation to chemotherapy. |
2011-09-21 |
2023-08-12 |
Not clear |
| Stefan Lüth, Jörg Schrader, Stefan Zander, Antonella Carambia, Juliane Buchkremer, Samuel Huber, Kurt Reifenberg, Ken-Ichi Yamamura, Peter Schirmacher, Ansgar W Lohse, Johannes Herke. Chronic inflammatory IFN-γ signaling suppresses hepatocarcinogenesis in mice by sensitizing hepatocytes for apoptosis. Cancer research. vol 71. issue 11. 2011-09-20. PMID:21512142. |
indeed, exposure to ifn-γ in vivo or in vitro was associated with accumulation of p53 in hepatocytes and the sensitization of hepatocytes to apoptosis induced by genotoxic stress. |
2011-09-20 |
2023-08-12 |
mouse |
| Stefan Lüth, Jörg Schrader, Stefan Zander, Antonella Carambia, Juliane Buchkremer, Samuel Huber, Kurt Reifenberg, Ken-Ichi Yamamura, Peter Schirmacher, Ansgar W Lohse, Johannes Herke. Chronic inflammatory IFN-γ signaling suppresses hepatocarcinogenesis in mice by sensitizing hepatocytes for apoptosis. Cancer research. vol 71. issue 11. 2011-09-20. PMID:21512142. |
the ifn-γ-induced increase in apoptosis of hepatocytes seemed to be p53 dependent. |
2011-09-20 |
2023-08-12 |
mouse |
| Giuseppe Filomeni, Simone Cardaci, Ana Maria Da Costa Ferreira, Giuseppe Rotilio, Maria Rosa Ciriol. Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment. The Biochemical journal. vol 437. issue 3. 2011-09-19. PMID:21548882. |
transfection of sh-sy5y cells with a dominant-negative mutant of ampk resulted in a decrease in apoptosis and a significant reduction in phospho-active p38(mapk) and p53. |
2011-09-19 |
2023-08-12 |
Not clear |
| Giuseppe Filomeni, Simone Cardaci, Ana Maria Da Costa Ferreira, Giuseppe Rotilio, Maria Rosa Ciriol. Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment. The Biochemical journal. vol 437. issue 3. 2011-09-19. PMID:21548882. |
similarly, reverse genetics of p38(mapk) yielded a reduction in p53 and a decrease in the extent of apoptosis, confirming an exclusive hierarchy of activation that proceeds via ampk/p38(mapk)/p53. |
2011-09-19 |
2023-08-12 |
Not clear |
| Xin Liang, Aibin Wu, Yufang Xu, Ke Xu, Jianwen Liu, Xuhong Qia. B1, a novel naphthalimide-based DNA intercalator, induces cell cycle arrest and apoptosis in HeLa cells via p53 activation. Investigational new drugs. vol 29. issue 4. 2011-09-16. PMID:20179988. |
b1, a novel naphthalimide-based dna intercalator, induces cell cycle arrest and apoptosis in hela cells via p53 activation. |
2011-09-16 |
2023-08-12 |
Not clear |
| Sam Z Grinter, Yayun Liang, Sheng-You Huang, Salman M Hyder, Xiaoqin Zo. An inverse docking approach for identifying new potential anti-cancer targets. Journal of molecular graphics & modelling. vol 29. issue 6. 2011-09-16. PMID:21315634. |
prima-1 is well known for its ability to restore mutant p53's tumor suppressor function, leading to apoptosis in several types of cancer cells. |
2011-09-16 |
2023-08-12 |
human |
| Kelly A Avery-Kiejda, Nikola A Bowden, Amanda J Croft, Lyndee L Scurr, Carla F Kairupan, Katie A Ashton, Bente A Talseth-Palmer, Helen Rizos, Xu D Zhang, Rodney J Scott, Peter Herse. P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation. BMC cancer. vol 11. 2011-09-16. PMID:21615965. |
p53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation. |
2011-09-16 |
2023-08-12 |
human |
| Yan Wan, Wei Wu, Zhihua Yin, Peng Guan, Baosen Zho. MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis. BMC cancer. vol 11. 2011-09-16. PMID:21619694. |
the tumor suppressor gene p53 is involved in multiple cellular pathways including apoptosis, transcriptional control, and cell cycle regulation. |
2011-09-16 |
2023-08-12 |
Not clear |
| Hege O Ohnstad, Erik B Paulsen, Paul Noordhuis, Marianne Berg, Ragnhild A Lothe, Lyubomir T Vassilev, Ola Myklebos. MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines. BMC cancer. vol 11. 2011-09-16. PMID:21624110. |
the small-molecule mdm2 antagonist nutlin-3a activates the p53 pathway and efficiently induces apoptosis in tumours with amplified mdm2 gene and overexpression of mdm2 protein. |
2011-09-16 |
2023-08-12 |
human |
| Victor Solodushko, Diego F Alvarez, Ryan Viator, Tiffany Messerall, Brian Fout. Heterogeneous activation of p19Arf in pulmonary artery smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. vol 300. issue 4. 2011-09-15. PMID:21216978. |
p19(arf) is a tumor suppressor that leads to cell cycle arrest or apoptosis by stabilizing p53. |
2011-09-15 |
2023-08-12 |
mouse |
| M Seux, S Peuget, M P Montero, C Siret, V Rigot, P Clerc, V Gigoux, E Pellegrino, L Pouyet, P N'Guessan, S Garcia, M Dufresne, J L Iovanna, A Carrier, F André, N J Dusett. TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression. Oncogene. vol 30. issue 27. 2011-09-15. PMID:21339733. |
tumor protein 53 induced nuclear protein 1 (tp53inp1) is a p53 target gene that induces cell growth arrest and apoptosis by modulating p53 transcriptional activity. |
2011-09-15 |
2023-08-12 |
mouse |
| Roza Zandi, Galina Selivanova, Camilla Laulund Christensen, Thomas Alexander Gerds, Berthe Marie Willumsen, Hans Skovgaard Poulse. PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 17. issue 9. 2011-09-15. PMID:21415220. |
prima-1met/apr-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53. |
2011-09-15 |
2023-08-12 |
Not clear |
| Roza Zandi, Galina Selivanova, Camilla Laulund Christensen, Thomas Alexander Gerds, Berthe Marie Willumsen, Hans Skovgaard Poulse. PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 17. issue 9. 2011-09-15. PMID:21415220. |
prima-1(met) (p53-dependent reactivation of massive apoptosis), also known as apr-246, is a small molecule, which restores tumor suppressor function to mutant p53 and induces cancer cell death in various cancer types. |
2011-09-15 |
2023-08-12 |
Not clear |
| Roza Zandi, Galina Selivanova, Camilla Laulund Christensen, Thomas Alexander Gerds, Berthe Marie Willumsen, Hans Skovgaard Poulse. PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 17. issue 9. 2011-09-15. PMID:21415220. |
since p53 is mutated in more than 90% of sclc, we investigated the ability of prima-1(met) to induce apoptosis and inhibit tumor growth in sclc with different p53 mutations. |
2011-09-15 |
2023-08-12 |
Not clear |
| Hope M Amm, Patsy G Oliver, Choo Hyung Lee, Yufeng Li, Donald J Buchsbau. Combined modality therapy with TRAIL or agonistic death receptor antibodies. Cancer biology & therapy. vol 11. issue 5. 2011-09-14. PMID:21263219. |
this review provides an overview of the mechanisms associated with chemotherapy enhancement of trail receptor-targeted therapies including modulation of the apoptotic (death receptor expression, flip, and bcl-2 or inhibitors of apoptosis (iap) families) as well as cell signaling (nfκb, akt, p53) pathways. |
2011-09-14 |
2023-08-12 |
human |
| Ragu Kanagasabai, Krishnamurthy Karthikeyan, Kaushik Vedam, Wang Qien, Qianzheng Zhu, Govindasamy Ilangova. Hsp27 protects adenocarcinoma cells from UV-induced apoptosis by Akt and p21-dependent pathways of survival. Molecular cancer research : MCR. vol 8. issue 10. 2011-09-13. PMID:20858736. |
transcriptional activation of p53 target genes, due to dna damage, causes either apoptosis or survival by cell cycle arrest and dna repair. |
2011-09-13 |
2023-08-12 |
human |
| C G Roberts, E K A Millar, S A O'Toole, C M McNeil, G M Lehrbach, M Pinese, P Tobelmann, R A McCloy, E A Musgrove, R L Sutherland, A J But. Identification of PUMA as an estrogen target gene that mediates the apoptotic response to tamoxifen in human breast cancer cells and predicts patient outcome and tamoxifen responsiveness in breast cancer. Oncogene. vol 30. issue 28. 2011-09-13. PMID:21383694. |
here, we have identified the bcl-2 homology 3 (bh3)-only, pro-apoptotic regulator, puma (p53 upregulated modulator of apoptosis) as an estrogen target gene that is acutely downregulated in response to estrogen in breast cancer cell lines, independently of their p53 status. |
2011-09-13 |
2023-08-12 |
human |