| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Risaku Fukumoto, Juliann G Kian. Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation. Radiation research. vol 176. issue 3. 2011-10-13. PMID:21663398. |
geldanamycin analog 17-dmag limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kda after exposure to ionizing radiation. |
2011-10-13 |
2023-08-12 |
mouse |
| Roland Houben, Sonja Hesbacher, Corinna P Schmid, Claudia S Kauczok, Ulrike Flohr, Sebastian Haferkamp, Cornelia S L Müller, David Schrama, Jörg Wischhusen, Jürgen C Becke. High-level expression of wild-type p53 in melanoma cells is frequently associated with inactivity in p53 reporter gene assays. PloS one. vol 6. issue 7. 2011-10-13. PMID:21760960. |
inactivation of the p53 pathway that controls cell cycle progression, apoptosis and senescence, has been proposed to occur in virtually all human tumors and p53 is the protein most frequently mutated in human cancer. |
2011-10-13 |
2023-08-12 |
human |
| Arunachal Chatterjee, Saiful A Mir, Dipanjan Dutta, Arkadeep Mitra, Kanchan Pathak, Sagartirtha Sarka. Analysis of p53 and NF-κB signaling in modulating the cardiomyocyte fate during hypertrophy. Journal of cellular physiology. vol 226. issue 10. 2011-10-13. PMID:21792911. |
inhibition of p53 resulted in downregulation of apoptosis, nf-κb activation, and nf-κb-p300 binding; however, nf-κb inhibition did not inhibit apoptosis or p53-p300 binding. |
2011-10-13 |
2023-08-12 |
rat |
| Mikiya Fujieda, Taku Morita, Keishi Naruse, Yoshihiro Hayashi, Masayuki Ishihara, Tadafumi Yokoyama, Tomoko Toma, Kazuhize Ohta, Hiroshi Wakiguch. Effect of pravastatin on cisplatin-induced nephrotoxicity in rats. Human & experimental toxicology. vol 30. issue 7. 2011-10-11. PMID:20650967. |
histology was evaluated by light microscopy with immunohistochemistry for p53, p53-upregulated modulation of apoptosis (puma), and terminal deoxynucleotide transferase dutp nick end-labeling (tunel) staining. |
2011-10-11 |
2023-08-12 |
rat |
| Mikiya Fujieda, Taku Morita, Keishi Naruse, Yoshihiro Hayashi, Masayuki Ishihara, Tadafumi Yokoyama, Tomoko Toma, Kazuhize Ohta, Hiroshi Wakiguch. Effect of pravastatin on cisplatin-induced nephrotoxicity in rats. Human & experimental toxicology. vol 30. issue 7. 2011-10-11. PMID:20650967. |
pravastatin partially ameliorated cp-induced renal injury, based on suppression of the renal mda and tg levels, decreased p53 expression, and apoptosis in cp-treated rats. |
2011-10-11 |
2023-08-12 |
rat |
| Gloria M Palomo, Toñi Cerrato, Ricardo Gargini, Javier Diaz-Nid. Silencing of frataxin gene expression triggers p53-dependent apoptosis in human neuron-like cells. Human molecular genetics. vol 20. issue 14. 2011-10-11. PMID:21531789. |
frataxin-deficient neuron-like cells appear to die through apoptosis that is accompanied by up-regulation of p53, puma and bax and activation of caspase-3. |
2011-10-11 |
2023-08-12 |
human |
| Kenzui Taniue, Takeaki Oda, Tomoatsu Hayashi, Masumi Okuno, Tetsu Akiyam. A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis. EMBO reports. vol 12. issue 7. 2011-10-11. PMID:21617703. |
ruvbl1 blocks p53-mediated apoptosis by repressing the expression of p53 and its target genes. |
2011-10-11 |
2023-08-12 |
Not clear |
| Sridhar Radhakrishnan, Lavanya Reddivari, Robert Sclafani, Undurti N Das, Jairam Vanamal. Resveratrol potentiates grape seed extract induced human colon cancer cell apoptosis. Frontiers in bioscience (Elite edition). vol 3. 2011-10-10. PMID:21622155. |
in this study, we showed that rsv (~25 micromolar) potentiated gse (≤ 35 microg/ml) induced colon cancer cell apoptosis via activation of p53 dependent pathways. |
2011-10-10 |
2023-08-12 |
human |
| Sridhar Radhakrishnan, Lavanya Reddivari, Robert Sclafani, Undurti N Das, Jairam Vanamal. Resveratrol potentiates grape seed extract induced human colon cancer cell apoptosis. Frontiers in bioscience (Elite edition). vol 3. 2011-10-10. PMID:21622155. |
elevation of apoptosis was much more pronounced in p53 +/+ cells compared to p53 -/- cells. |
2011-10-10 |
2023-08-12 |
human |
| Xinbing Sui, Lijun Jin, Xuefeng Huang, Shumin Geng, Chao He, Xiaotong H. p53 signaling and autophagy in cancer: a revolutionary strategy could be developed for cancer treatment. Autophagy. vol 7. issue 6. 2011-10-07. PMID:21099252. |
p53 as a tumor suppressor protein has been implicated in multiple aspects of biological processes, including apoptosis, cell cycle arrest, senescence, metabolism, differentiation and angiogenesis. |
2011-10-07 |
2023-08-12 |
Not clear |
| Seong-Taeck Kim, Jae-Woong Ko. Mechanisms of apoptosis on human lens epithelium after ultraviolet light exposure. Korean journal of ophthalmology : KJO. vol 25. issue 3. 2011-10-04. PMID:21655046. |
we intended to confirm the presence of cellular toxicity and apoptosis and to reveal the roles of p53, caspase 3 and noxa in these processes. |
2011-10-04 |
2023-08-12 |
human |
| Duk Hoon Kim, Yu Jin Jung, Jung Eun Lee, Ae Sin Lee, Kyung Pyo Kang, Sik Lee, Sung Kwang Park, Myung Kwan Han, Sang Yong Lee, Kunga Mohan Ramkumar, Mi Jeong Sung, Won Ki. SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53. American journal of physiology. Renal physiology. vol 301. issue 2. 2011-10-03. PMID:21593185. |
the nicotinamide adenine dinucleotide-dependent protein deacetylase sirt1 decreases apoptosis through deacetylating of p53, and resveratrol is known as an activator of sirt1. |
2011-10-03 |
2023-08-12 |
mouse |
| Duk Hoon Kim, Yu Jin Jung, Jung Eun Lee, Ae Sin Lee, Kyung Pyo Kang, Sik Lee, Sung Kwang Park, Myung Kwan Han, Sang Yong Lee, Kunga Mohan Ramkumar, Mi Jeong Sung, Won Ki. SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53. American journal of physiology. Renal physiology. vol 301. issue 2. 2011-10-03. PMID:21593185. |
resveratrol, a sirt1 activator, ameliorated cisplatin-induced acetylation of p53, apoptosis, and cytotoxicity in mpt cells. |
2011-10-03 |
2023-08-12 |
mouse |
| Poyil Pratheeshkumar, Girija Kutta. Vernolide-A, a sesquiterpene lactone from Vernonia cinerea, induces apoptosis in B16F-10 melanoma cells by modulating p53 and caspase-3 gene expressions and regulating NF-κB-mediated bcl-2 activation. Drug and chemical toxicology. vol 34. issue 3. 2011-10-03. PMID:21649480. |
vernolide-a, a sesquiterpene lactone from vernonia cinerea, induces apoptosis in b16f-10 melanoma cells by modulating p53 and caspase-3 gene expressions and regulating nf-κb-mediated bcl-2 activation. |
2011-10-03 |
2023-08-12 |
Not clear |
| Thayele Purayil Hamsa, Punathil Thejass, Girija Kutta. Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells. Drug and chemical toxicology. vol 34. issue 3. 2011-10-03. PMID:21649489. |
sfn-induced apoptosis was associated with the activation of caspases 3 and 9, bax, and p53 and the downregulation of bcl-2, caspase-8, bid, and nf-kb. |
2011-10-03 |
2023-08-12 |
Not clear |
| Jin Hyup Lee, Aziz Sanca. Regulation of apoptosis by the circadian clock through NF-kappaB signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 29. 2011-10-03. PMID:21690409. |
here we show that cry mutation sensitizes p53 mutant and oncogenically transformed cells to tumor necrosis factor α (tnfα)-initiated apoptosis by interfacing with the nf-κb signaling pathway through the gsk3β kinase and alleviating prosurvival nf-κb signaling. |
2011-10-03 |
2023-08-12 |
mouse |
| Yeon-Hee Kook, Minhan Ka, Moonkyoung U. Neuroprotective cytokines repress PUMA induction in the 1-methyl-4-phenylpyridinium (MPP(+)) model of Parkinson's disease. Biochemical and biophysical research communications. vol 411. issue 2. 2011-10-03. PMID:21741364. |
here, we show that in rat pheochromocytoma pc12 cells, epo and g-csf efficiently repressed the 1-methyl-4-phenylpyridinium (mpp(+))-induced expression of the proapoptotic protein puma (p53 up-regulated modulator of apoptosis). |
2011-10-03 |
2023-08-12 |
rat |
| Sheng-Yow Ho, Wei-Jr Wu, Hui-Wen Chiu, Yi-An Chen, Yuan-Soon Ho, How-Ran Guo, Ying-Jan Wan. Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways. Chemico-biological interactions. vol 193. issue 2. 2011-10-03. PMID:21741957. |
the present study aimed to investigate the enhanced effects and mechanisms in apoptosis and the cycle distribution of hl-60 cells, a human leukemia cell line lacking a functional p53 protein, after combination treatment with arsenic trioxide (ato) and irradiation (ir). |
2011-10-03 |
2023-08-12 |
human |
| Takahiro Kodama, Tetsuo Takehara, Hayato Hikita, Satoshi Shimizu, Minoru Shigekawa, Hinako Tsunematsu, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Tatsuya Kanto, Naoki Hiramatsu, Satoshi Kubota, Masaharu Takigawa, Yoshito Tomimaru, Akira Tomokuni, Hiroaki Nagano, Yuichiro Doki, Masaki Mori, Norio Hayash. Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice. The Journal of clinical investigation. vol 121. issue 8. 2011-10-03. PMID:21747166. |
hepatocyte-specific deletion in mice of the gene encoding mdm2, a protein that promotes p53 degradation, led to hepatocyte synthesis of connective tissue growth factor (ctgf; the hepatic fibrogenic master switch), increased hepatocyte apoptosis, and spontaneous liver fibrosis; concurrent removal of p53 completely abolished this phenotype. |
2011-10-03 |
2023-08-12 |
mouse |
| Takahiro Kodama, Tetsuo Takehara, Hayato Hikita, Satoshi Shimizu, Minoru Shigekawa, Hinako Tsunematsu, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Tatsuya Kanto, Naoki Hiramatsu, Satoshi Kubota, Masaharu Takigawa, Yoshito Tomimaru, Akira Tomokuni, Hiroaki Nagano, Yuichiro Doki, Masaki Mori, Norio Hayash. Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice. The Journal of clinical investigation. vol 121. issue 8. 2011-10-03. PMID:21747166. |
compared with wild-type controls, mice with hepatocyte-specific p53 deletion exhibited similar levels of hepatocyte apoptosis but decreased liver fibrosis and hepatic ctgf expression in two models of liver fibrosis. |
2011-10-03 |
2023-08-12 |
mouse |