| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shiekh Tanveer Ahmad, Wani Arjumand, Amlesh Seth, Sana Nafees, Summya Rashid, Nemat Ali, Sarwat Sultan. Preclinical renal cancer chemopreventive efficacy of geraniol by modulation of multiple molecular pathways. Toxicology. vol 290. issue 1. 2011-11-21. PMID:21907755. |
goh was able to down regulate expression of kim-1, nfκb, pcna, p53 along with induction of apoptosis. |
2011-11-21 |
2023-08-12 |
rat |
| Takayuki Fujita, Yoshihiro Ishikaw. Apoptosis in heart failure. -The role of the β-adrenergic receptor-mediated signaling pathway and p53-mediated signaling pathway in the apoptosis of cardiomyocytes-. Circulation journal : official journal of the Japanese Circulation Society. vol 75. issue 8. 2011-11-18. PMID:21747195. |
the present review highlights the apoptosis of cardiomyocytes, which is one of the important mechanisms that leads to hf and can be induced by both β-adrenergic signaling and p53. |
2011-11-18 |
2023-08-12 |
human |
| Alexander H Stegh, Ronald A DePinh. Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma. Cell cycle (Georgetown, Tex.). vol 10. issue 1. 2011-11-15. PMID:21200141. |
the prime importance of p53 signaling for gliomapathogenesis is further evidenced by epistatic genetic events targeting additional pathway components including deletion of p14 (arf) (cdkn2a) and amplification of the p53-degrading ubiquitin ligases mdm2 and mdm4. recent studies have identified and validated bcl2-like 12 (bcl2l12) as a potent glioma oncoprotein with multiple strategic points in apoptosis regulatory networks, i.e. |
2011-11-15 |
2023-08-12 |
Not clear |
| Chris Z Y Zhang, H T Zhang, George G Chen, Paul B S La. Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment. Apoptosis : an international journal on programmed cell death. vol 16. issue 7. 2011-11-15. PMID:21468663. |
in this study, we showed that etoposide treatment activated caspase-8 and caspase-3, leading to cleavages of p53, bid and parp, which subsequently induced apoptosis. |
2011-11-15 |
2023-08-12 |
Not clear |
| Chris Z Y Zhang, H T Zhang, George G Chen, Paul B S La. Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment. Apoptosis : an international journal on programmed cell death. vol 16. issue 7. 2011-11-15. PMID:21468663. |
moreover, the pretreatment with trichostatin a (tsa, a histone deacetylase inhibitor) or tsa in combination with etoposide significantly sensitized hcc cells to apoptosis by inhibiting erk phosphorylation, reactivating caspases and parp, and inducing translocation of p53 and bid to cytoplasm. |
2011-11-15 |
2023-08-12 |
Not clear |
| Saša Kenig, Robert Frangež, Anja Pucer, Tamara La. Inhibition of cathepsin L lowers the apoptotic threshold of glioblastoma cells by up-regulating p53 and transcription of caspases 3 and 7. Apoptosis : an international journal on programmed cell death. vol 16. issue 7. 2011-11-15. PMID:21484410. |
the importance of p53 in this process is highlighted by the fact that in u87 cells with inhibited p53 transcriptional activity or in p53-negative cells u251, cathepsin l inhibition did not influence caspase 7 expression and had minimal effect on the level of apoptosis. |
2011-11-15 |
2023-08-12 |
Not clear |
| Xènia Garrofé-Ochoa, Ana M Cosialls, Judit Ribas, Joan Gil, Jacint Boi. Transcriptional modulation of apoptosis regulators by roscovitine and related compounds. Apoptosis : an international journal on programmed cell death. vol 16. issue 7. 2011-11-15. PMID:21505869. |
however, the mrna of p53-upregulated modulator of apoptosis (puma) gene escaped from this transcription inhibition in neuroblastoma cells with a functional p53 protein. |
2011-11-15 |
2023-08-12 |
Not clear |
| Xènia Garrofé-Ochoa, Ana M Cosialls, Judit Ribas, Joan Gil, Jacint Boi. Transcriptional modulation of apoptosis regulators by roscovitine and related compounds. Apoptosis : an international journal on programmed cell death. vol 16. issue 7. 2011-11-15. PMID:21505869. |
the increase of puma mrna was not found in roscovitine-treated cell lines defective in p53, which underwent apoptosis like their p53 proficient counterparts. |
2011-11-15 |
2023-08-12 |
Not clear |
| Salma Abdelmoula-Souissi, Agnès Delahodde, Monique Bolotin-Fukuhara, Ali Gargouri, Raja Mokdad-Gargour. Cellular localization of human p53 expressed in the yeast Saccharomyces cerevisiae: effect of NLSI deletion. Apoptosis : an international journal on programmed cell death. vol 16. issue 7. 2011-11-15. PMID:21553245. |
the tumor suppressor p53 plays a central role in the regulation of cellular growth and apoptosis. |
2011-11-15 |
2023-08-12 |
human |
| Dashayini Mahalingam, Ling L Tay, Wei H Tan, Juin H Chai, Xueying Wan. Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts. The FEBS journal. vol 278. issue 19. 2011-11-14. PMID:21824286. |
taken together, we have shown that mt-hters induce double-stranded dna break-like damages in telomerase positive imr90 wthtert cells after phosphorylation of atm and p53 via suppression of trf2, which may eventually lead to apoptosis via elevation of gadd45γ. |
2011-11-14 |
2023-08-12 |
human |
| T M Stoenescu, Luminiţa Dana Ivan, Nicoleta Stoenescu, Doina Azoică. [Assessment tumor markers by immunohistochemistry (Ki67, p53 and Bcl-2) on a cohort of patients with cervical cancer in various stages of evolution]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. vol 115. issue 2. 2011-11-14. PMID:21870745. |
in defining new potential prognostic factors in cervical cancer, p53 protein expression, ki67 or issues related to bcl-2 oncogene involved in cellular apoptosis process, have been the subject of numerous publications. |
2011-11-14 |
2023-08-12 |
human |
| Wayne Chris Hawkes, Zeynep Alka. Delayed cell cycle progression from SEPW1 depletion is p53- and p21-dependent in MCF-7 breast cancer cells. Biochemical and biophysical research communications. vol 413. issue 1. 2011-11-14. PMID:21875573. |
in response to genomic stresses, p53 causes cell cycle arrest to allow time for genomic damage to be repaired before cell division or induces apoptosis to eliminate irreparably damaged cells. |
2011-11-14 |
2023-08-12 |
human |
| Yongtao Jiang, Ying Zhang, Jinling Luan, Huiying Duan, Feng Zhang, Kazumi Yagasaki, Guoying Zhan. Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action. Cytotechnology. vol 62. issue 6. 2011-11-10. PMID:20963488. |
bufalin induced the apoptosis and cell cycle arrest by affecting the protein expressions of bcl-2/bax, cytochrome c, caspase-3, parp, p53, p21waf1, cyclind1, and cox-2 in a549 cells. |
2011-11-10 |
2023-08-12 |
human |
| Chieh-Shan Wu, Yun-Ju Chen, Jeremy J W Chen, Jeng-Jer Shieh, Chia-Hsin Huang, Pei-Shan Lin, Gee-Chen Chang, Jinghua-Tsai Chang, Chi-Chen Li. Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2011-11-10. PMID:21760828. |
diminution of p53 by rna interference induced necrosis instead of apoptosis in a549 cells following terpinen-4-ol treatment, indicating that terpinen-4-ol-elicited apoptosis is p53-dependent. |
2011-11-10 |
2023-08-12 |
human |
| Mohammad Reza Zali, Omeed Moaven, Hamid Asadzadeh Aghdaee, Kamran Ghafarzadegan, Khadijeh Jami Ahmadi, Mehdi Farzadnia, Azadeh Arabi, Mohammad Reza Abbaszadega. Clinicopathological significance of E-cadherin, β-catenin and p53 expression in gastric adenocarinoma. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. vol 14. issue 4. 2011-11-10. PMID:21772890. |
p53 is a tumor suppressor gene which also regulates apoptosis. |
2011-11-10 |
2023-08-12 |
Not clear |
| Susan M Mendrysa, Sara Ghassemifar, Reem Male. p53 in the CNS: Perspectives on Development, Stem Cells, and Cancer. Genes & cancer. vol 2. issue 4. 2011-11-10. PMID:21779511. |
the anti-proliferative properties of p53 are mediated, in part, through the induction of apoptosis, cell cycle arrest, and senescence. |
2011-11-10 |
2023-08-12 |
human |
| Zhaohui Feng, Meihua Lin, Rui W. The Regulation of Aging and Longevity: A New and Complex Role of p53. Genes & cancer. vol 2. issue 4. 2011-11-10. PMID:21779512. |
as a transcription factor, in response to stress signals, p53 regulates its target genes and initiates stress responses, including cell cycle arrest, apoptosis, and/or senescence, to exert its function in tumor suppression. |
2011-11-10 |
2023-08-12 |
mouse |
| Marie P Khoury, Jean-Christophe Bourdo. p53 Isoforms: An Intracellular Microprocessor? Genes & cancer. vol 2. issue 4. 2011-11-10. PMID:21779513. |
indeed, the cellular response to damages can be switched from cell cycle arrest to apoptosis by only manipulating p53 isoform expression. |
2011-11-10 |
2023-08-12 |
human |
| Kazufumi Suzuki, Hisahiro Matsubar. Recent advances in p53 research and cancer treatment. Journal of biomedicine & biotechnology. vol 2011. 2011-11-09. PMID:21765642. |
we herein review the recent advances in p53 research and focus on apoptosis, cell cycle arrest, and senescence in response to stress. |
2011-11-09 |
2023-08-12 |
human |
| Ying Zhou, Ying Wei, Jing Zhu, Qingyuan Wang, Liang Bao, Yang Ma, Yu Chen, Dingqing Feng, Aijin Zhang, Jie Sun, Shreeram C Nallar, Keng Shen, Dhananjaya V Kalvakolanu, Weihua Xiao, Bin Lin. GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers. PloS one. vol 6. issue 7. 2011-11-09. PMID:21765936. |
grim-19 disrupts e6/e6ap complex to rescue p53 and induce apoptosis in cervical cancers. |
2011-11-09 |
2023-08-12 |
human |