| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ade Kallas, Martin Pook, Martti Maimets, Külli Zimmermann, Toivo Maimet. Nocodazole treatment decreases expression of pluripotency markers Nanog and Oct4 in human embryonic stem cells. PloS one. vol 6. issue 4. 2011-11-28. PMID:21559451. |
nocodazole-mediated cell-cycle arrest was accompanied by higher rate of apoptosis and upregulation of p53. |
2011-11-28 |
2023-08-12 |
human |
| Ade Kallas, Martin Pook, Martti Maimets, Külli Zimmermann, Toivo Maimet. Nocodazole treatment decreases expression of pluripotency markers Nanog and Oct4 in human embryonic stem cells. PloS one. vol 6. issue 4. 2011-11-28. PMID:21559451. |
in addition, the presence of rock-2 inhibitor y-27632 in the medium had no effect on increasing the expression of pluripotency markers nanog and oct4 or decreasing apoptosis or the level of p53. |
2011-11-28 |
2023-08-12 |
human |
| T Kaur, D Mukherjea, K Sheehan, S Jajoo, L P Rybak, V Ramkuma. Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation. Cell death & disease. vol 2. 2011-11-28. PMID:21776018. |
moreover, stat1 sirna protected against activation of p53, reduced apoptosis, reduced damage to ohcs and preserved hearing in rats. |
2011-11-28 |
2023-08-12 |
rat |
| Shai Grinberg, Gabriel Teiblum, Galia Rahav, Mary Bakhanashvil. p53 in cytoplasm exerts 3'→5' exonuclease activity with dsRNA. Cell cycle (Georgetown, Tex.). vol 9. issue 12. 2011-11-23. PMID:20519945. |
the possible roles of p53 dsrnase activity in cytoplasm in the inhibition of translation and induction of cell apoptosis, is discussed. |
2011-11-23 |
2023-08-12 |
Not clear |
| Ramanarao Dirisina, Rebecca B Katzman, Tatiana Goretsky, Elizabeth Managlia, Navdha Mittal, David B Williams, Wei Qiu, Jian Yu, Navdeep S Chandel, Lin Zhang, Terrence A Barret. p53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis. Gastroenterology. vol 141. issue 3. 2011-11-23. PMID:21699775. |
p53 and puma independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis. |
2011-11-23 |
2023-08-12 |
mouse |
| Ramanarao Dirisina, Rebecca B Katzman, Tatiana Goretsky, Elizabeth Managlia, Navdha Mittal, David B Williams, Wei Qiu, Jian Yu, Navdeep S Chandel, Lin Zhang, Terrence A Barret. p53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis. Gastroenterology. vol 141. issue 3. 2011-11-23. PMID:21699775. |
we investigated the role of p53 and its target, p53-upregulated modulator of apoptosis (puma), in inflammation-induced apoptosis of iecs. |
2011-11-23 |
2023-08-12 |
mouse |
| Hiroshi Katayama, Subrata Se. Functional significance of Aurora kinase A regulatory interactions with p53-ERα complex in human breast cancer cells. Hormones & cancer. vol 2. issue 2. 2011-11-23. PMID:21761334. |
we describe in this report functional consequences of aurora-a phosphorylation of p53 tumor suppressor protein on its subcellular distribution and binding with erα that may be important in downregulating the transcription of p53-responsive growth inhibitory genes and development of resistance to dna damage-induced apoptosis in aurora-a overexpressing human breast cancer cells. |
2011-11-23 |
2023-08-12 |
human |
| Ragu Kanagasabai, Karthikeyan Krishnamurthy, Lawrence J Druhan, Govindasamy Ilangova. Forced expression of heat shock protein 27 (Hsp27) reverses P-glycoprotein (ABCB1)-mediated drug efflux and MDR1 gene expression in Adriamycin-resistant human breast cancer cells. The Journal of biological chemistry. vol 286. issue 38. 2011-11-23. PMID:21784846. |
ectopic expression of hsp27, however, significantly depleted both mutant p53 and nf-κb (p65), reversed the drug resistance by inhibiting mdr1/p-gp expression in mcf-7/adr cells, and induced cell death by increased g(2)/m population and apoptosis. |
2011-11-23 |
2023-08-12 |
human |
| Uma Kant Misra, Yvonne Mowery, Steven Kaczowka, Salvatore Vincent Pizz. Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis. Molecular cancer therapeutics. vol 8. issue 5. 2011-11-22. PMID:19417154. |
ligation of cancer cell surface grp78 with antibodies directed against its cooh-terminal domain up-regulates p53 activity and promotes apoptosis. |
2011-11-22 |
2023-08-12 |
human |
| Jürgen Sonnemann, Chithra D Palani, Susan Wittig, Sabine Becker, Friederike Eichhorn, Astrid Voigt, James F Bec. Anticancer effects of the p53 activator nutlin-3 in Ewing's sarcoma cells. European journal of cancer (Oxford, England : 1990). vol 47. issue 9. 2011-11-22. PMID:21334198. |
the recently developed small-molecule mdm2 inhibitor nutlin-3 restores wild-type p53 function, resulting in the inhibition of cancer cell growth and the induction of apoptosis. |
2011-11-22 |
2023-08-12 |
Not clear |
| Jürgen Sonnemann, Chithra D Palani, Susan Wittig, Sabine Becker, Friederike Eichhorn, Astrid Voigt, James F Bec. Anticancer effects of the p53 activator nutlin-3 in Ewing's sarcoma cells. European journal of cancer (Oxford, England : 1990). vol 47. issue 9. 2011-11-22. PMID:21334198. |
consistently, nutlin-3 elicited apoptosis only in wild-type p53 cells, as assessed by caspase-3 activity assay and flow cytometric analyses of mitochondrial depolarisation and dna fragmentation. |
2011-11-22 |
2023-08-12 |
Not clear |
| Junji Moriya, Rui Chen, Jun-ichi Yamakawa, Kenroh Sasaki, Yasuhito Ishigaki, Takashi Takahash. Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells. Biological & pharmaceutical bulletin. vol 34. issue 3. 2011-11-22. PMID:21372384. |
furthermore, resveratrol inhibited neuronal apoptosis and expression of hippocampal acetylated p53 in the fatigue mice. |
2011-11-22 |
2023-08-12 |
mouse |
| A Morinaka, Y Funato, K Uesugi, H Mik. Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis. Oncogene. vol 30. issue 40. 2011-11-22. PMID:21516123. |
oligomeric peroxiredoxin-i is an essential intermediate for p53 to activate mst1 kinase and apoptosis. |
2011-11-22 |
2023-08-12 |
mouse |
| Sun-Yong Kim, Ji-Hyun Lee, Jin Won Huh, Jai Youl Ro, Yeon-Mock Oh, Sang-Do Lee, Sungkwan An, Yun-Song Le. Cigarette smoke induces Akt protein degradation by the ubiquitin-proteasome system. The Journal of biological chemistry. vol 286. issue 37. 2011-11-22. PMID:21778238. |
consistent with cytotoxicity, cse induced a progressive decrease of phosphorylated human homolog of mouse double minute homolog 2 (p-hdm2) and phosphorylated apoptosis signal regulating kinase 1 (p-ask1) with concomitant elevation of p53, p21, and phosphorylated p38 mapk. |
2011-11-22 |
2023-08-12 |
mouse |
| Yanjie Chen, Takayuki Fujita, Di Zhang, Hung Doan, Decha Pinkaew, Zhihe Liu, Jiaxin Wu, Yuichi Koide, Andrew Chiu, Curtis Chen-Jen Lin, Jui-Yoa Chang, Ke-He Ruan, Ken Fujis. Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein. The Journal of biological chemistry. vol 286. issue 37. 2011-11-22. PMID:21795694. |
in addition, fortilin, but not a double point mutant of fortilin lacking p53 binding, inhibits p53-dependent apoptosis. |
2011-11-22 |
2023-08-12 |
mouse |
| Yanjie Chen, Takayuki Fujita, Di Zhang, Hung Doan, Decha Pinkaew, Zhihe Liu, Jiaxin Wu, Yuichi Koide, Andrew Chiu, Curtis Chen-Jen Lin, Jui-Yoa Chang, Ke-He Ruan, Ken Fujis. Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein. The Journal of biological chemistry. vol 286. issue 37. 2011-11-22. PMID:21795694. |
furthermore, cells with wild-type p53 and fortilin, but not cells with wild-type p53 and the double point mutant of fortilin lacking p53 binding, fail to induce bax gene and apoptosis, leading to the formation of large tumor in athymic mice. |
2011-11-22 |
2023-08-12 |
mouse |
| T Hamsa, Girija Kutta. Ipobscurine, an indole alkaloid from Ipomoea obscura, inhibits tumor cell invasion and experimental metastasis by inducing apoptosis. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 30. issue 2. 2011-11-22. PMID:21967460. |
ipobscurine may also promote apoptosis by up-regulating pro-apoptotic molecules such as caspase-3, p53, and bax and by down-regulating anti-apoptotic bcl-2. |
2011-11-22 |
2023-08-12 |
Not clear |
| Bi-xing Zhao, Hang-zi Chen, Xiao-dan Du, Jie Luo, Jian-ping He, Rong-hao Wang, Yuan Wang, Rong Wu, Ru-rong Hou, Ming Hong, Qiao W. Orphan receptor TR3 enhances p53 transactivation and represses DNA double-strand break repair in hepatoma cells under ionizing radiation. Molecular endocrinology (Baltimore, Md.). vol 25. issue 8. 2011-11-21. PMID:21659476. |
phosphorylated tr3, in turn, enhances dna-pk-induced phosphorylation and p53 transcription activity, thereby enhancing ir-induced apoptosis in hepatoma cells. |
2011-11-21 |
2023-08-12 |
Not clear |
| Franz Hagn, Stephan Lagleder, Marco Retzlaff, Julia Rohrberg, Oliver Demmer, Klaus Richter, Johannes Buchner, Horst Kessle. Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53. Nature structural & molecular biology. vol 18. issue 10. 2011-11-21. PMID:21892170. |
here we present a structural characterization of the complex between hsp90 and the tumor suppressor p53, a key mediator of apoptosis whose structural integrity is crucial for cell-cycle control. |
2011-11-21 |
2023-08-12 |
human |
| Shiekh Tanveer Ahmad, Wani Arjumand, Amlesh Seth, Sana Nafees, Summya Rashid, Nemat Ali, Sarwat Sultan. Preclinical renal cancer chemopreventive efficacy of geraniol by modulation of multiple molecular pathways. Toxicology. vol 290. issue 1. 2011-11-21. PMID:21907755. |
the chemopreventive efficacy of goh was studied in terms of xenobiotic metabolizing enzyme activities, lpo, redox status, serum toxicity markers and the expression of putative nephrotoxicity biomarker kim-1, tumor suppressor gene p53, inflammation, cell proliferation and apoptosis related genes in the kidney tissue. |
2011-11-21 |
2023-08-12 |
rat |