| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong-Jun Shin, Brandon Hencey, Steven M Lipkin, Xiling She. Frequency domain analysis reveals external periodic fluctuations can generate sustained p53 oscillation. PloS one. vol 6. issue 7. 2011-12-06. PMID:21829536. |
p53 is a well-known tumor suppressor protein that regulates many pathways, such as ones involved in cell cycle and apoptosis. |
2011-12-06 |
2023-08-12 |
Not clear |
| Wataru Nakajima, Nobuyuki Tanak. Noxa induces apoptosis in oncogene-expressing cells through catch-and-release mechanism operating between Puma and Mcl-1. Biochemical and biophysical research communications. vol 413. issue 4. 2011-12-06. PMID:21945433. |
tumor suppressor p53 induces apoptosis by transcriptional induction of noxa and puma, which encode the proapoptotic bh3-only member of the bcl-2 family proteins. |
2011-12-06 |
2023-08-12 |
Not clear |
| Wataru Nakajima, Nobuyuki Tanak. Noxa induces apoptosis in oncogene-expressing cells through catch-and-release mechanism operating between Puma and Mcl-1. Biochemical and biophysical research communications. vol 413. issue 4. 2011-12-06. PMID:21945433. |
in the p53-mediated tumor surveillance system, p53 induces apoptosis or replicative senescence in oncogene-expressing cells, resulting in elimination of such cells. |
2011-12-06 |
2023-08-12 |
Not clear |
| Zhao Zhang, Yang Yang, Weijun Pang, Chao Sun, Gongshe Yan. [Effect and underlying mechanism of resveratol on porcine primary preadipocyte apoptosis]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 26. issue 8. 2011-12-05. PMID:21090107. |
we used optical microscope and fluorescence microscope to observe morphological changes during apoptosis after hoechst 33258 fluorescent dyes staining; and rt-pcr and western blotting to measure the expression of apoptosis-associated gene sirt1, caspase-3, bcl-2, bax, p53, nf-kappab. |
2011-12-05 |
2023-08-12 |
Not clear |
| D Filipović, J Zlatković, D Inta, I Bjelobaba, M Stojiljkovic, P Gas. Chronic isolation stress predisposes the frontal cortex but not the hippocampus to the potentially detrimental release of cytochrome c from mitochondria and the activation of caspase-3. Journal of neuroscience research. vol 89. issue 9. 2011-12-05. PMID:21656845. |
the tumor suppressor protein p53 can trigger apoptosis independently of its transcriptional activity, through subcellular translocation of cytochrome c and caspase activation. |
2011-12-05 |
2023-08-12 |
rat |
| D Filipović, J Zlatković, D Inta, I Bjelobaba, M Stojiljkovic, P Gas. Chronic isolation stress predisposes the frontal cortex but not the hippocampus to the potentially detrimental release of cytochrome c from mitochondria and the activation of caspase-3. Journal of neuroscience research. vol 89. issue 9. 2011-12-05. PMID:21656845. |
to define better the proapoptotic role of p53 under various stress conditions, we investigated the protein levels of p53 and cytochrome c in mitochondrial and cytosolic fractions, as well as caspase-3 activation and apoptosis, in the prefrontal cortex and hippocampus of male wistar rats subjected to acute, chronic, or combined stressors. |
2011-12-05 |
2023-08-12 |
rat |
| Hongbo Wang, Chunhong Ya. A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells. Neoplasia (New York, N.Y.). vol 13. issue 7. 2011-12-05. PMID:21750655. |
a small-molecule p53 activator induces apoptosis through inhibiting mdmx expression in breast cancer cells. |
2011-12-05 |
2023-08-12 |
Not clear |
| Hongbo Wang, Chunhong Ya. A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells. Neoplasia (New York, N.Y.). vol 13. issue 7. 2011-12-05. PMID:21750655. |
here, we report that xi-011 promoted breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. |
2011-12-05 |
2023-08-12 |
Not clear |
| Elin Hallan Naderi, Aart G Jochemsen, Heidi Kiil Blomhoff, Soheil Nader. Activation of cAMP signaling interferes with stress-induced p53 accumulation in ALL-derived cells by promoting the interaction between p53 and HDM2. Neoplasia (New York, N.Y.). vol 13. issue 7. 2011-12-05. PMID:21750659. |
the apoptosis inhibitory effect of camp is further shown to depend on this effect on p53 levels. |
2011-12-05 |
2023-08-12 |
Not clear |
| Azusa Ito, Akinori Morita, Soichiro Ohya, Shinichi Yamamoto, Atsushi Enomoto, Masahiko Ikekit. Cycloheximide suppresses radiation-induced apoptosis in MOLT-4 cells with Arg72 variant of p53 through translational inhibition of p53 accumulation. Journal of radiation research. vol 52. issue 3. 2011-11-29. PMID:21467739. |
cycloheximide suppresses radiation-induced apoptosis in molt-4 cells with arg72 variant of p53 through translational inhibition of p53 accumulation. |
2011-11-29 |
2023-08-12 |
human |
| Azusa Ito, Akinori Morita, Soichiro Ohya, Shinichi Yamamoto, Atsushi Enomoto, Masahiko Ikekit. Cycloheximide suppresses radiation-induced apoptosis in MOLT-4 cells with Arg72 variant of p53 through translational inhibition of p53 accumulation. Journal of radiation research. vol 52. issue 3. 2011-11-29. PMID:21467739. |
moreover, recent studies have shown that the codon 72 polymorphic variants of p53 show different sensitivities to apoptosis signals. |
2011-11-29 |
2023-08-12 |
human |
| Azusa Ito, Akinori Morita, Soichiro Ohya, Shinichi Yamamoto, Atsushi Enomoto, Masahiko Ikekit. Cycloheximide suppresses radiation-induced apoptosis in MOLT-4 cells with Arg72 variant of p53 through translational inhibition of p53 accumulation. Journal of radiation research. vol 52. issue 3. 2011-11-29. PMID:21467739. |
we next investigated the involvement of the transcription-independent function of p53 using an rna synthesis inhibitor, actinomycin d (actd), and a protein synthesis inhibitor, cycloheximide (chx), and found that the apoptosis was suppressed by chx but not by actd. |
2011-11-29 |
2023-08-12 |
human |
| Azusa Ito, Akinori Morita, Soichiro Ohya, Shinichi Yamamoto, Atsushi Enomoto, Masahiko Ikekit. Cycloheximide suppresses radiation-induced apoptosis in MOLT-4 cells with Arg72 variant of p53 through translational inhibition of p53 accumulation. Journal of radiation research. vol 52. issue 3. 2011-11-29. PMID:21467739. |
we also revealed that the suppressive effect of chx on apoptosis was specifically mediated by p53, using a p53-knockdown molt-4 transfectant. |
2011-11-29 |
2023-08-12 |
human |
| Azusa Ito, Akinori Morita, Soichiro Ohya, Shinichi Yamamoto, Atsushi Enomoto, Masahiko Ikekit. Cycloheximide suppresses radiation-induced apoptosis in MOLT-4 cells with Arg72 variant of p53 through translational inhibition of p53 accumulation. Journal of radiation research. vol 52. issue 3. 2011-11-29. PMID:21467739. |
furthermore, the suppressive effect of chx on apoptosis was highly correlated with the suppression of p53 protein accumulation, and less correlated with the suppression of p53 target genes expression. |
2011-11-29 |
2023-08-12 |
human |
| Azusa Ito, Akinori Morita, Soichiro Ohya, Shinichi Yamamoto, Atsushi Enomoto, Masahiko Ikekit. Cycloheximide suppresses radiation-induced apoptosis in MOLT-4 cells with Arg72 variant of p53 through translational inhibition of p53 accumulation. Journal of radiation research. vol 52. issue 3. 2011-11-29. PMID:21467739. |
these results indicated that p53 transactivation is not necessary to induce apoptosis, and that p53 protein accumulation itself is both necessary and sufficient to do so. |
2011-11-29 |
2023-08-12 |
human |
| Wei Qiu, Xinwei Wang, Brian Leibowitz, Wancai Yang, Lin Zhang, Jian Y. PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice. Hepatology (Baltimore, Md.). vol 54. issue 4. 2011-11-29. PMID:21725994. |
in this study, we investigated the role of p53 up-regulated modulator of apoptosis (puma), a bh3-only protein important for both p53-dependent and -independent apoptosis, in a diethylnitrosamine (den)-induced liver carcinogenesis model. |
2011-11-29 |
2023-08-12 |
mouse |
| Anja Rogler, Michael Rogenhofer, Albert Borchardt, Jens-Claudio Lunz, Antje Knoell, Ferdinand Hofstaedter, Andrea Tannapfel, Wolf Wieland, Arndt Hartmann, Robert Stoeh. P53 codon 72 (Arg72Pro) polymorphism and prostate cancer risk: association between disease onset and proline genotype. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 78. issue 4. 2011-11-29. PMID:21778786. |
however, disease onset might be modulated by the p53 pro72 allele, suggesting an important role of apoptosis regulation in prostate carcinogenesis. |
2011-11-29 |
2023-08-12 |
human |
| D Pan, L-Z Pan, R Hill, P Marcato, M Shmulevitz, L T Vassilev, P W K Le. Stabilisation of p53 enhances reovirus-induced apoptosis and virus spread through p53-dependent NF-κB activation. British journal of cancer. vol 105. issue 7. 2011-11-29. PMID:21863032. |
stabilisation of p53 enhances reovirus-induced apoptosis and virus spread through p53-dependent nf-κb activation. |
2011-11-29 |
2023-08-12 |
Not clear |
| Giovambattista Pani, Tommaso Galeott. Role of MnSOD and p66shc in mitochondrial response to p53. Antioxidants & redox signaling. vol 15. issue 6. 2011-11-28. PMID:20712406. |
mitochondria are central to redox homeostasis, produce energy, and trigger apoptosis and senescence: not surprisingly, many "old" and "new" functions of p53 appear to be based in mitochondria. |
2011-11-28 |
2023-08-12 |
Not clear |
| Wassim Chatoo, Mohamed Abdouh, Gilbert Bernie. p53 pro-oxidant activity in the central nervous system: implication in aging and neurodegenerative diseases. Antioxidants & redox signaling. vol 15. issue 6. 2011-11-28. PMID:20849375. |
after its activation, via dna damage, oxidative stress, or aberrant expression of oncogenes, p53 transduces its classical effect through several mechanisms comprising activation of the dna repair machinery, cell cycle arrest, and initiation of apoptosis or senescence. |
2011-11-28 |
2023-08-12 |
Not clear |