| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaobo Yan, Jie Feng, Zhaoming Ye, Xudong Miao, Weixu Li, Disheng Yan. p53 siRNA inhibits apoptosis of U2OS cells treated with azurin. Molecular medicine reports. vol 4. issue 6. 2012-01-09. PMID:21822538. |
the decrease in p53 protein levels did not inhibit cell apoptosis rates, but rather increased these rates in u2os osteosarcoma cells 3 days after treatment with p53 sirna. |
2012-01-09 |
2023-08-12 |
human |
| Xiaobo Yan, Jie Feng, Zhaoming Ye, Xudong Miao, Weixu Li, Disheng Yan. p53 siRNA inhibits apoptosis of U2OS cells treated with azurin. Molecular medicine reports. vol 4. issue 6. 2012-01-09. PMID:21822538. |
treatment with azurin may transform the function of p53 from inhibiting to inducing apoptosis. |
2012-01-09 |
2023-08-12 |
human |
| Chow Wenn Yew, Pei Lee, Wai Keong Chan, Vania Kai Jun Lim, Sun Kuie Tay, Theresa M C Tan, Lih-Wen Den. A novel MLL5 isoform that is essential to activate E6 and E7 transcription in HPV16/18-associated cervical cancers. Cancer research. vol 71. issue 21. 2012-01-09. PMID:21908553. |
mll5β downregulation was sufficient to restore p53 protein levels and reduce rb phosphorylation, thereby reactivating apoptosis and cell-cycle checkpoints. |
2012-01-09 |
2023-08-12 |
human |
| Alice Grison, Fiamma Mantovani, Anna Comel, Elena Agostoni, Stefano Gustincich, Francesca Persichetti, Giannino Del Sa. Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 44. 2012-01-09. PMID:22011578. |
ser46 phosphorylation and prolyl-isomerase pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin. |
2012-01-09 |
2023-08-12 |
mouse |
| Alice Grison, Fiamma Mantovani, Anna Comel, Elena Agostoni, Stefano Gustincich, Francesca Persichetti, Giannino Del Sa. Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 44. 2012-01-09. PMID:22011578. |
we demonstrate that expression of mhtt causes increased phosphorylation of p53 on ser46, leading to its interaction with phosphorylation-dependent prolyl isomerase pin1 and consequent dissociation from the apoptosis inhibitor iaspp, thereby inducing the expression of apoptotic target genes. |
2012-01-09 |
2023-08-12 |
mouse |
| Jixia Li, Yeon-Yong Cho, Alyssa Langfald, Andria Carper, Ronald A Lubet, Clinton J Grubbs, Marna E Ericson, Ann M Bod. Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 8. 2012-01-05. PMID:21791570. |
these results combined with immunoreactivity data indicated that, in addition to egfr and her2, lapatinib treatment was associated with changes in a number of other signaling molecules, including igf-1r, akt, and downstream targets such as gsk3, p27, p53, and cyclin d1 presumably leading to impaired proliferation, apoptosis, or cell-cycle arrest. |
2012-01-05 |
2023-08-12 |
human |
| Nancy Mah, Ying Wang, Mei-Chih Liao, Alessandro Prigione, Justyna Jozefczuk, Björn Lichtner, Katharina Wolfrum, Manuela Haltmeier, Max Flöttmann, Martin Schaefer, Alexander Hahn, Ralf Mrowka, Edda Klipp, Miguel A Andrade-Navarro, James Adjay. Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network. PloS one. vol 6. issue 8. 2012-01-05. PMID:21909390. |
experiments confirmed that upon viral transduction, the immediate response is innate immunity, which induces free radical generation, oxidative dna damage, p53 activation, senescence, and apoptosis, ultimately leading to a reduction in the reprogramming efficiency. |
2012-01-05 |
2023-08-12 |
human |
| Jingbo Liu, Daiwen Chen, Xiangbing Mao, Bing Y. Effects of maternal folic acid supplementation on morphology and apoptosis-related gene expression in jejunum of newborn intrauterine growth retarded piglets. Archives of animal nutrition. vol 65. issue 5. 2012-01-05. PMID:22164959. |
the expression of genes encoding dna methyltransferase-1 (dnmt-1), genes related to cell apoptosis (p53, bcl-2 and bax) and genes involved in dna repair (mpg, apex1 and tdg, firstly cloned in the present study) were investigated by reverse transcription (rt)-pcr in the jejunal section of the intestine. |
2012-01-05 |
2023-08-12 |
Not clear |
| Aichi Msaki, Ana M Sánchez, Li Fang Koh, Benjamin Barré, Sonia Rocha, Neil D Perkins, Renée F Johnso. The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration. Molecular biology of the cell. vol 22. issue 17. 2011-12-30. PMID:21737676. |
we also define a new component of cisplatin-induced, rela t505-dependent apoptosis, involving induction of noxa gene expression, an effect explained at least in part through induction of the p53 homologue, p73. |
2011-12-30 |
2023-08-12 |
mouse |
| E Chernigovskaya, D Atochin, L Yamova, P Huang, M Glazov. Immunohistochemical expression of Bcl-2, p53 and caspase-9 in hypothalamus magnocellular centers of nNOS knockout mice following water deprivation. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 86. issue 5. 2011-12-29. PMID:20662604. |
we studied the interactions between apoptosis regulator proteins (bcl-2, p53 and caspase-9) and neuronal nitric oxide in vasopressinergic magnocellular centers of the hypothalamus using neuronal nitric oxide synthase (nnos) gene knockout mice. |
2011-12-29 |
2023-08-12 |
mouse |
| Lesetja R Motadi, Kanti D Bhoola, Zodwa Dlamin. Expression and function of retinoblastoma binding protein 6 (RBBP6) in human lung cancer. Immunobiology. vol 216. issue 10. 2011-12-27. PMID:21676486. |
however it is not known whether rbbp6 is expressed in lung cancer, or interacts with p53 and prb to modulate the proliferation or apoptosis of lung cancer cells. |
2011-12-27 |
2023-08-12 |
human |
| Lesetja R Motadi, Kanti D Bhoola, Zodwa Dlamin. Expression and function of retinoblastoma binding protein 6 (RBBP6) in human lung cancer. Immunobiology. vol 216. issue 10. 2011-12-27. PMID:21676486. |
rbbp6 may be involved in the degradation of p53, thereby enhancing cell proliferation and inhibiting apoptosis in lung cancer. |
2011-12-27 |
2023-08-12 |
human |
| Chiung-Hui Liu, Chung-Yi Chen, A-Mei Huang, Jih-Heng L. Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1. Journal of ethnopharmacology. vol 137. issue 1. 2011-12-27. PMID:21708241. |
subamolide a, a component isolated from cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and erk1/2 pathways in human urothelial carcinoma cell line ntub1. |
2011-12-27 |
2023-08-12 |
human |
| Kee Woei Ng, Stella P K Khoo, Boon Chin Heng, Magdiel I Setyawati, Eng Chok Tan, Xinxin Zhao, Sijing Xiong, Wanru Fang, David T Leong, Joachim S C Lo. The role of the tumor suppressor p53 pathway in the cellular DNA damage response to zinc oxide nanoparticles. Biomaterials. vol 32. issue 32. 2011-12-27. PMID:21807406. |
in this paper, we explored how zno nanoparticles cross-interact with a critical tumor suppressive pathway centered around p53, which is one of the most important known tumor suppressors that protects cells from developing cancer phenotypes through its control over major pathways like apoptosis, senescence and cell cycle progression. |
2011-12-27 |
2023-08-12 |
Not clear |
| Kee Woei Ng, Stella P K Khoo, Boon Chin Heng, Magdiel I Setyawati, Eng Chok Tan, Xinxin Zhao, Sijing Xiong, Wanru Fang, David T Leong, Joachim S C Lo. The role of the tumor suppressor p53 pathway in the cellular DNA damage response to zinc oxide nanoparticles. Biomaterials. vol 32. issue 32. 2011-12-27. PMID:21807406. |
this suggests that cellular responses like apoptosis in the presence of zno nanoparticles require p53 as the molecular master switch towards programmed cell death. |
2011-12-27 |
2023-08-12 |
Not clear |
| Jenny Barthson, Carla M Germano, Fabrice Moore, Adriano Maida, Daniel J Drucker, Piero Marchetti, Conny Gysemans, Chantal Mathieu, Gabriel Nuñez, Andrea Jurisicova, Decio L Eizirik, Esteban N Gurzo. Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation. The Journal of biological chemistry. vol 286. issue 45. 2011-12-27. PMID:21937453. |
the combination of tnf-α + ifn-γ induced dp5, p53 up-regulated modulator of apoptosis (puma), and bim expression in human islets and rodent β-cells. |
2011-12-27 |
2023-08-12 |
mouse |
| Shyhmin Huang, Sergio Benavente, Eric A Armstrong, Chunrong Li, Deric L Wheeler, Paul M Harar. p53 modulates acquired resistance to EGFR inhibitors and radiation. Cancer research. vol 71. issue 22. 2011-12-27. PMID:22068033. |
further studies indicate that p53 may enhance sensitivity to egfr inhibitors and radiation via induction of cell-cycle arrest, apoptosis, and dna damage repair. |
2011-12-27 |
2023-08-12 |
human |
| Pu Huang, Qun Zheng, Li-Hong X. The apoptotic effect of oral administration of microcystin-RR on mice liver. Environmental toxicology. vol 26. issue 5. 2011-12-23. PMID:20196164. |
apoptotic cell death in liver was detected by tunel assay, and the expression levels of bcl-2, bax and p53, grp 78 and chop which have been reported to be related to apoptosis and er stress were determined via western-blot. |
2011-12-23 |
2023-08-12 |
mouse |
| K P Ng, Q Ebrahem, S Negrotto, R Z Mahfouz, K A Link, Z Hu, X Gu, A Advani, M Kalaycio, R Sobecks, M Sekeres, E Copelan, T Radivoyevitch, J Maciejewski, J C Mulloy, Y Saunthararaja. p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia. Leukemia. vol 25. issue 11. 2011-12-22. PMID:21701495. |
in vitro and in vivo regimens of the deoxycytidine analogue decitabine that deplete the chromatin-modifying enzyme dna methyl-transferase 1 without phosphorylating p53 or inducing early apoptosis were determined. |
2011-12-22 |
2023-08-12 |
Not clear |
| Radha Munagala, Hina Kausar, Charu Munjal, Ramesh C Gupt. Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells. Carcinogenesis. vol 32. issue 11. 2011-12-22. PMID:21859835. |
this is the first demonstration indicating that wa significantly downregulates expression of hpv e6/e7 oncogenes and restores the p53 pathway, resulting in apoptosis of cervical cancer cells. |
2011-12-22 |
2023-08-12 |
mouse |