| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong Lin, Wei Xiong, Xiang Zhang, Bolin Liu, Wei Zhang, Yongqiang Zhang, Jinxiang Cheng, Huiyong Huan. Notch-1 activation-dependent p53 restoration contributes to resveratrol-induced apoptosis in glioblastoma cells. Oncology reports. vol 26. issue 4. 2012-01-23. PMID:21743969. |
we demonstrated that resveratrol strongly suppressed cell growth and induced apoptosis in a172 and t98g glioblastoma cells, which have low active notch-1 expression and a heterozygous p53 mutation. |
2012-01-23 |
2023-08-12 |
Not clear |
| Hong Lin, Wei Xiong, Xiang Zhang, Bolin Liu, Wei Zhang, Yongqiang Zhang, Jinxiang Cheng, Huiyong Huan. Notch-1 activation-dependent p53 restoration contributes to resveratrol-induced apoptosis in glioblastoma cells. Oncology reports. vol 26. issue 4. 2012-01-23. PMID:21743969. |
moreover, simultaneous treatment with resveratrol and a notch-1 inhibitor (mrk-003) partially attenuated the apoptosis and completely blocked the activation of notch-1 and the increase in wild-type p53. |
2012-01-23 |
2023-08-12 |
Not clear |
| Hong Lin, Wei Xiong, Xiang Zhang, Bolin Liu, Wei Zhang, Yongqiang Zhang, Jinxiang Cheng, Huiyong Huan. Notch-1 activation-dependent p53 restoration contributes to resveratrol-induced apoptosis in glioblastoma cells. Oncology reports. vol 26. issue 4. 2012-01-23. PMID:21743969. |
in addition, the de-phosphorylation of akt, increased expression of bax and cleavage of caspase-3 were not fully reversed by mrk-003 treatment, suggesting that p53 restoration is not the only mechanism underlying resveratrol-induced apoptosis. |
2012-01-23 |
2023-08-12 |
Not clear |
| Joanna Zawacka-Pankau, Vera V Grinkevich, Sabine Hünten, Fedor Nikulenkov, Angela Gluch, Hai Li, Martin Enge, Alexander Kel, Galina Selivanov. Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer. The Journal of biological chemistry. vol 286. issue 48. 2012-01-23. PMID:21862591. |
using different approaches, we demonstrated that glycolysis block contributes to the robust induction of apoptosis by p53 in cancer cells. |
2012-01-23 |
2023-08-12 |
Not clear |
| Amala Rajasundari, Laurent Pays, Patrick Mehlen, Ganesan Rames. Netrin-1 overexpression in kidney proximal tubular epithelium ameliorates cisplatin nephrotoxicity. Laboratory investigation; a journal of technical methods and pathology. vol 91. issue 12. 2012-01-23. PMID:21876536. |
interestingly, ischemia reperfusion induced a large increase in apoptosis in wt mice but not in netrin-1 transgenic mice (215 ± 40 vs 94 ± 20 cells/5 hpf ( × 400), p < 0.0001), which was associated with reduced caspase-3 and p53 activation in the transgenic kidney. |
2012-01-23 |
2023-08-12 |
mouse |
| Edi Gabellieri, Monica Bucciantini, Massimo Stefani, Patrizia Cion. Does azurin bind to the transactivation domain of p53? A Trp phosphorescence study. Biophysical chemistry. vol 159. issue 2-3. 2012-01-23. PMID:21885181. |
the bacterial redox protein azurin has been shown to be able to enter into cancer cells and induce apoptosis by stabilizing p53. |
2012-01-23 |
2023-08-12 |
Not clear |
| Akiko Shinagawa, Yoshio Yoshida, Tetsuji Kurokawa, Yuko Horiuchi, Hideaki Tsuyoshi, Makoto Orisaka, Yoko Sawamura, Hynda K Kleinman, Fumikazu Kotsuj. The potent peptide antagonist to angiogenesis, C16Y, and cisplatin act synergistically in the down-regulation of the Bcl-2/Bax ratio and the induction of apoptosis in human ovarian cancer cells. International journal of oncology. vol 39. issue 6. 2012-01-20. PMID:21935568. |
on the other hand, c16y did not activate any other signal transduction pathways that usually culminate in the activation of apoptosis, such as the p53, p21waf1, p73, erk1/2 or pi3-akt pathways. |
2012-01-20 |
2023-08-12 |
human |
| Xuan Zhang, Xiping Liu, Huifeng Shang, Yan Xu, Minzhang Qia. Monocyte chemoattractant protein-1 induces endothelial cell apoptosis in vitro through a p53-dependent mitochondrial pathway. Acta biochimica et biophysica Sinica. vol 43. issue 10. 2012-01-19. PMID:21859809. |
moreover, mcp-1 upregulated p53 expression of huvecs and the p53-specific inhibitor pifithrin-α (pftα) rescued the mcp-1-induced apoptosis of huvecs. |
2012-01-19 |
2023-08-12 |
human |
| Thomas J Kucharski, Isabelle Gamache, Ole Gjoerup, Jose G Teodor. DNA damage response signaling triggers nuclear localization of the chicken anemia virus protein Apoptin. Journal of virology. vol 85. issue 23. 2012-01-19. PMID:21937663. |
the chicken anemia virus (cav) protein apoptin is a small, 13.6-kda protein that has the intriguing activity of inducing g(2)/m arrest and apoptosis specifically in cancer cells by a mechanism that is independent of p53. |
2012-01-19 |
2023-08-12 |
chicken |
| Jing Zhao, Yixin Lu, Han-Ming She. Targeting p53 as a therapeutic strategy in sensitizing TRAIL-induced apoptosis in cancer cells. Cancer letters. vol 314. issue 1. 2012-01-18. PMID:22030255. |
targeting p53 as a therapeutic strategy in sensitizing trail-induced apoptosis in cancer cells. |
2012-01-18 |
2023-08-12 |
human |
| Jing Zhao, Yixin Lu, Han-Ming She. Targeting p53 as a therapeutic strategy in sensitizing TRAIL-induced apoptosis in cancer cells. Cancer letters. vol 314. issue 1. 2012-01-18. PMID:22030255. |
in this mini-review, we aim to provide an overview of the intricate relationship between p53 and the trail-mediated apoptosis pathway, and to summarize the current approaches of targeting p53 as a therapeutic strategy to sensitize trail-induced apoptosis in human cancer cells. |
2012-01-18 |
2023-08-12 |
human |
| Ke-Sheng Wang, Gang Chen, Hai-Lian Shen, Ting-Ting Li, Fei Chen, Qin-Wan Wang, Zhi-Qin Wang, Ze-Guang Han, Xin Zhan. Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination. PloS one. vol 6. issue 8. 2012-01-17. PMID:21887275. |
the tumor suppressor p53 controls multiple cellular functions including dna repair, cell cycle arrest and apoptosis. |
2012-01-17 |
2023-08-12 |
Not clear |
| Ricardo Aramayo, Michael B Sherman, Kathryne Brownless, Rudi Lurz, Andrei L Okorokov, Elena V Orlov. Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominance. Nucleic acids research. vol 39. issue 20. 2012-01-16. PMID:21764777. |
p53 can initiate cell cycle arrest, senescence and/or apoptosis via transactivation of p53 target genes, thus preventing cancer onset. |
2012-01-16 |
2023-08-12 |
Not clear |
| An-Chin Cheng, Mei-Ling Tsai, Chi-Mei Liu, Ming-Fen Lee, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pa. Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis. Food & function. vol 1. issue 3. 2012-01-16. PMID:21776480. |
this study investigated the effect of garcinol on hep3b cells, a human hepatocellular cancer cell line lacking functional p53, with the goal of elucidating the molecular mechanisms of p53-independent apoptosis in hepatocellular cancer. |
2012-01-16 |
2023-08-12 |
human |
| Zchong-Zcho Wu, Nian-Kang Sun, Kun-Yi Chien, Chuck C-K Cha. Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation. Biochemical pharmacology. vol 82. issue 11. 2012-01-16. PMID:21903092. |
expression of exogenous p53 in h1299 cells was increased following knockdown of napa and these cells showed increased sensitivity to cisplatin-induced apoptosis. |
2012-01-16 |
2023-08-12 |
Not clear |
| Zchong-Zcho Wu, Nian-Kang Sun, Kun-Yi Chien, Chuck C-K Cha. Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation. Biochemical pharmacology. vol 82. issue 11. 2012-01-16. PMID:21903092. |
these results indicate that napa promotes resistance to cisplatin through synoviolin and the erad complex which together induce the degradation of p53 and thus prevent apoptosis. |
2012-01-16 |
2023-08-12 |
Not clear |
| Jacky Chung, R Ian Grant, David R Kaplan, Meredith S Irwi. Special AT-rich binding protein-2 (SATB2) differentially affects disease-causing p63 mutant proteins. The Journal of biological chemistry. vol 286. issue 47. 2012-01-16. PMID:21965674. |
satb2 attenuates p63-mediated gene expression of perp (p53 apoptosis effector related to pmp-22), a critical downstream target gene during development, and specifically decreases p63 perp promoter binding. |
2012-01-16 |
2023-08-12 |
mouse |
| Nirmalya Sen, Yatendra Kumar Satija, Sanjeev Da. PGC-1α, a key modulator of p53, promotes cell survival upon metabolic stress. Molecular cell. vol 44. issue 4. 2012-01-16. PMID:22099309. |
metabolic stress results in p53 activation, which can trigger cell-cycle arrest, ros clearance, or apoptosis. |
2012-01-16 |
2023-08-12 |
mouse |
| Yesol Bak, Heejong Kim, Jeong-Woo Kang, Dong Hun Lee, Man Sub Kim, Yun Sun Park, Jung-Hee Kim, Kang-Yeoun Jung, Yoongho Lim, Jintae Hong, Do-Young Yoo. A synthetic naringenin derivative, 5-hydroxy-7,4'-diacetyloxyflavanone-N-phenyl hydrazone (N101-43), induces apoptosis through up-regulation of Fas/FasL expression and inhibition of PI3K/Akt signaling pathways in non-small-cell lung cancer cells. Journal of agricultural and food chemistry. vol 59. issue 18. 2012-01-13. PMID:21877710. |
expression of apoptosis and cell-cycle regulatory factors is altered: cyclins a and d1 and phospho-prb are down-regulated, but expression of cdk inhibitors such as p21, p27, and p53 is enhanced by n101-43 treatment; n101-43 also increases expression levels of the extrinsic death receptor fas and its binding partner fasl. |
2012-01-13 |
2023-08-12 |
human |
| Adriana Rodríguez-Marí, John H Postlethwai. The role of Fanconi anemia/BRCA genes in zebrafish sex determination. Methods in cell biology. vol 105. 2012-01-13. PMID:21951543. |
the sex reversal phenotype requires the action of tp53 (p53), an activator of apoptosis. |
2012-01-13 |
2023-08-12 |
human |