| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nirojini Sivachandran, Christopher W Dawson, Lawrence S Young, Fei-Fei Liu, Jaap Middeldorp, Lori Frappie. Contributions of the Epstein-Barr virus EBNA1 protein to gastric carcinoma. Journal of virology. vol 86. issue 1. 2012-02-14. PMID:22013060. |
consistent with pml functions, ebna1 expression decreased p53 activation and apoptosis in response to dna damage and resulted in increased cell survival. |
2012-02-14 |
2023-08-12 |
Not clear |
| Alessandro Balbi, Maria Anzaldi, Chiara Macciò, Cinzia Aiello, Mauro Mazzei, Rosaria Gangemi, Patrizio Castagnola, Mariangela Miele, Camillo Rosano, Maurizio Vial. Synthesis and biological evaluation of novel pyrazole derivatives with anticancer activity. European journal of medicinal chemistry. vol 46. issue 11. 2012-02-13. PMID:21920636. |
the expression of p53 and p21(waf1), which induce apoptosis and cell cycle arrest, was evaluated by western blot analysis in cells treated with compound 12d. |
2012-02-13 |
2023-08-12 |
human |
| b' B Zegura, G Gajski, A Straser, V Garaj-Vrhovac, M Filipi\\xc4\\x8. Microcystin-LR induced DNA damage in human peripheral blood lymphocytes. Mutation research. vol 726. issue 2. 2012-02-13. PMID:22001196.' |
after 24h, dna damage-responsive genes (p53, mdm2, gadd45a, cdkn1a), a gene involved in apoptosis (bax) and oxidative stress-responsive genes (cat, gpx1, sod1, gsr, gclc) were up-regulated. |
2012-02-13 |
2023-08-12 |
human |
| María J Ruiz-Magaña, Jose M Rodríguez-Vargas, Jorge C Morales, Manuel A Saldivia, Klaus Schulze-Osthoff, Carmen Ruiz-Rui. The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells. International journal of cancer. vol 130. issue 5. 2012-02-10. PMID:21455989. |
the dna methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and dna damage in p53 mutant leukemic t cells. |
2012-02-10 |
2023-08-12 |
Not clear |
| María J Ruiz-Magaña, Jose M Rodríguez-Vargas, Jorge C Morales, Manuel A Saldivia, Klaus Schulze-Osthoff, Carmen Ruiz-Rui. The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells. International journal of cancer. vol 130. issue 5. 2012-02-10. PMID:21455989. |
both inhibitors induced caspase-dependent apoptosis in jurkat, cem-6 and molt-4 leukemia t cell lines, all with mutant p53, whereas resting and activated normal t lymphocytes were highly resistant to these demethylating agents. |
2012-02-10 |
2023-08-12 |
Not clear |
| Elisabeth Oya, Johan Ovrevik, Volker M Arlt, Eszter Nagy, David H Phillips, Jørn A Holm. DNA damage and DNA damage response in human bronchial epithelial BEAS-2B cells following exposure to 2-nitrobenzanthrone and 3-nitrobenzanthrone: role in apoptosis. Mutagenesis. vol 26. issue 6. 2012-02-10. PMID:21715570. |
the p53 inhibitor pifithrin-α inhibited 3-nba-induced apoptosis while small effects were seen using pifithrin-μ, suggesting that 3-nba-induced cell death is a result of transcriptional activation of p53. |
2012-02-10 |
2023-08-12 |
human |
| Ikuko Tsujimoto, Kei Moriya, Keiko Sakai, Gerhard Dickneite, Takao Saka. Critical role of factor XIII in the initial stages of carbon tetrachloride-induced adult liver remodeling. The American journal of pathology. vol 179. issue 6. 2012-02-09. PMID:22019897. |
furthermore, fxiiia deficiency caused significantly increased hepatocyte apoptosis and a delay in hepatocyte regeneration after injury, which were accompanied by a significantly high induction of p53 expression. |
2012-02-09 |
2023-08-12 |
Not clear |
| Patricia J Keel. Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion. Journal of mammary gland biology and neoplasia. vol 16. issue 3. 2012-02-07. PMID:21822945. |
signaling from fak moreover regulates p53 and mir-200 members, which control apoptosis and epithelial phenotype, such that a compliant matrix is predicted to promote normal mammary gland architecture and suppress tumor formation. |
2012-02-07 |
2023-08-12 |
Not clear |
| Vivek Bhakta Mathema, Young-Sang Ko. Inhibitor of growth-4 mediates chromatin modification and has a suppressive effect on tumorigenesis and innate immunity. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 1. 2012-02-06. PMID:21971889. |
its interaction with liprin α1 and p53 contribute to mitigate cell spreading and induce apoptosis of cancer cells. |
2012-02-06 |
2023-08-12 |
Not clear |
| Hui-Zhen Zhang, Feng-Quan Zhang, Chao-Feng Li, Dan Yi, Xiao-Li Fu, Liu-Xin Cu. A cyanobacterial toxin, microcystin-LR, induces apoptosis of sertoli cells by changing the expression levels of apoptosis-related proteins. The Tohoku journal of experimental medicine. vol 224. issue 3. 2012-02-03. PMID:21701130. |
both p53 and bax function as promoters of apoptosis, while bcl-2 is an apoptotic suppressor. |
2012-02-03 |
2023-08-12 |
human |
| Firat Baytekin, Burcin Tuna, Ugur Mungan, Guven Aslan, Kutsal Yorukogl. Significance of P-glycoprotein, p53, and survivin expression in renal cell carcinoma. Urologic oncology. vol 29. issue 5. 2012-02-02. PMID:19945306. |
this study addresses the relationship between cell cycle control protein p53, apoptosis inhibitor gene survivin, and chemotherapy resistance protein p-glycoprotein (p-gp) expression, and their prognostic impact in renal cell carcinoma (rcc). |
2012-02-02 |
2023-08-12 |
Not clear |
| Tai Li, Zhao-Bo Cui, Xiao-Xue Ke, Juan Tan, Fang-Fang Li, Ting Li, Xiang-Wei Wang, Hong-Juan Cu. Essential role for p53 and caspase-9 in DNA damaging drug-induced apoptosis in neuroblastoma IMR32 cells. DNA and cell biology. vol 30. issue 12. 2012-02-02. PMID:21612408. |
essential role for p53 and caspase-9 in dna damaging drug-induced apoptosis in neuroblastoma imr32 cells. |
2012-02-02 |
2023-08-12 |
human |
| Tai Li, Zhao-Bo Cui, Xiao-Xue Ke, Juan Tan, Fang-Fang Li, Ting Li, Xiang-Wei Wang, Hong-Juan Cu. Essential role for p53 and caspase-9 in DNA damaging drug-induced apoptosis in neuroblastoma IMR32 cells. DNA and cell biology. vol 30. issue 12. 2012-02-02. PMID:21612408. |
in this study, we present evidence that p53 mediates dna damaging drug-induced apoptosis in imr32 cells through the caspase-9 pathway. |
2012-02-02 |
2023-08-12 |
human |
| C Spinnler, E Hedström, H Li, J de Lange, F Nikulenkov, A F A S Teunisse, M Verlaan-de Vries, V Grinkevich, A G Jochemsen, G Selivanov. Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX. Cell death and differentiation. vol 18. issue 11. 2012-02-01. PMID:21546907. |
abrogation of wip1 expression by rita-activated p53 potentiates apoptosis induction via activation of atm and inhibition of hdmx. |
2012-02-01 |
2023-08-12 |
Not clear |
| C Spinnler, E Hedström, H Li, J de Lange, F Nikulenkov, A F A S Teunisse, M Verlaan-de Vries, V Grinkevich, A G Jochemsen, G Selivanov. Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX. Cell death and differentiation. vol 18. issue 11. 2012-02-01. PMID:21546907. |
however, hdm2 inhibitors do not prevent inhibition of p53 by hdmx, which impedes p53-mediated apoptosis. |
2012-02-01 |
2023-08-12 |
Not clear |
| Yael Aylon, Moshe Ore. p53: guardian of ploidy. Molecular oncology. vol 5. issue 4. 2012-02-01. PMID:21852209. |
true to form, the tumor suppressor p53 obstructs propagation of these dangerous chromosomal events by either instigating irreversible cell cycle arrest or apoptosis. |
2012-02-01 |
2023-08-12 |
Not clear |
| Gang Song, Weiwei Wang, Tianhui H. p53 facilitates BH3-only BID nuclear export to induce apoptosis in the irrepairable DNA damage response. Medical hypotheses. vol 77. issue 5. 2012-02-01. PMID:21856084. |
p53 facilitates bh3-only bid nuclear export to induce apoptosis in the irrepairable dna damage response. |
2012-02-01 |
2023-08-12 |
Not clear |
| Gang Song, Weiwei Wang, Tianhui H. p53 facilitates BH3-only BID nuclear export to induce apoptosis in the irrepairable DNA damage response. Medical hypotheses. vol 77. issue 5. 2012-02-01. PMID:21856084. |
moreover, p53 can, through the interaction with bid in the mitochondria to induce apoptosis. |
2012-02-01 |
2023-08-12 |
Not clear |
| Gang Song, Weiwei Wang, Tianhui H. p53 facilitates BH3-only BID nuclear export to induce apoptosis in the irrepairable DNA damage response. Medical hypotheses. vol 77. issue 5. 2012-02-01. PMID:21856084. |
given the above background, we hypothesize that p53 facilitates bid nuclear export to induce apoptosis in response to irreparable dna damage. |
2012-02-01 |
2023-08-12 |
Not clear |
| Andreas K Hock, Arnaud M Vigneron, Stephanie Carter, Robert L Ludwig, Karen H Vousde. Regulation of p53 stability and function by the deubiquitinating enzyme USP42. The EMBO journal. vol 30. issue 24. 2012-01-30. PMID:22085928. |
the p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. |
2012-01-30 |
2023-08-12 |
Not clear |