| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Saha, A Adhikary, P Ray, S Saha, S Chakraborty, S Mohanty, K Das, S Mukherjee, M Mazumdar, L Lahiri, D M S Hossain, G Sa, T Da. Restoration of tumor suppressor p53 by differentially regulating pro- and anti-p53 networks in HPV-18-infected cervical cancer cells. Oncogene. vol 31. issue 2. 2012-02-29. PMID:21765464. |
here we report that differential regulation of pro- and anti-p53 setups not only upregulates p53 transcription but also stabilizes and activates p53 protein to ensure p53-induced apoptosis in hpv-18-infected cervical cancer. |
2012-02-29 |
2023-08-12 |
human |
| B Saha, A Adhikary, P Ray, S Saha, S Chakraborty, S Mohanty, K Das, S Mukherjee, M Mazumdar, L Lahiri, D M S Hossain, G Sa, T Da. Restoration of tumor suppressor p53 by differentially regulating pro- and anti-p53 networks in HPV-18-infected cervical cancer cells. Oncogene. vol 31. issue 2. 2012-02-29. PMID:21765464. |
that restored p53 is functional has been confirmed by its ability of transactivating bax and p53-upregulated modulator of apoptosis, which in turn switch on the apoptotic machinery in these cells. |
2012-02-29 |
2023-08-12 |
human |
| Sailendra Nath Sarma, Youn-Jung Kim, Jae-Chun Ry. Differential gene expression profiles of human leukemia cell lines exposed to benzene and its metabolites. Environmental toxicology and pharmacology. vol 32. issue 2. 2012-02-29. PMID:21843810. |
all genes that were identified were then functionally categorized as being involved in the cell cycle, the p53 signaling pathway, apoptosis, the mapk signaling pathway, or the t cell receptor signaling pathway. |
2012-02-29 |
2023-08-12 |
human |
| Gabriela Imreh, Helin Vakifahmetoglu Norberg, Stefan Imreh, Boris Zhivotovsk. Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis. Journal of cell science. vol 124. issue Pt 17. 2012-02-29. PMID:21878502. |
in addition to p53 deficiency, the depletion of atm (ataxia telangiectasia mutated), but not atr (ataxia telangiectasia and rad3-related protein), protected against apoptosis and shifted cell death towards necrosis. |
2012-02-29 |
2023-08-12 |
Not clear |
| Baltazar D Aguda, Yangjin Kim, Hong Sug Kim, Avner Friedman, Howard A Fin. Qualitative network modeling of the Myc-p53 control system of cell proliferation and differentiation. Biophysical journal. vol 101. issue 9. 2012-02-29. PMID:22067145. |
we propose that an essential role of p53 is to prevent the system from entering or staying too long in the cancer zone by downregulating myc or, when myc activity somehow becomes too high, by inducing apoptosis, cell cycle arrest, or differentiation. |
2012-02-29 |
2023-08-12 |
Not clear |
| Ji-Young Kim, Kyu-Sun Lee, Jin-Ee Seol, Kweon Yu, Debabrata Chakravarti, Sang-Beom Se. Inhibition of p53 acetylation by INHAT subunit SET/TAF-Iβ represses p53 activity. Nucleic acids research. vol 40. issue 1. 2012-02-27. PMID:21911363. |
using different apoptosis analyses, including facs, tunel and brdu incorporation assays, we also found that set/taf-iβ induced cellular proliferation via inhibition of p53 acetylation. |
2012-02-27 |
2023-08-12 |
drosophila_melanogaster |
| Linqiang Tian, Delong Yin, Ye Ren, Chen Gong, Anmin Chen, Feng-Jin Gu. Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. Molecular medicine reports. vol 5. issue 1. 2012-02-27. PMID:21993662. |
plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. |
2012-02-27 |
2023-08-12 |
human |
| Pani A Apostolidis, Donna S Woulfe, Massiel Chavez, William M Miller, Eleftherios T Papoutsaki. Role of tumor suppressor p53 in megakaryopoiesis and platelet function. Experimental hematology. vol 40. issue 2. 2012-02-27. PMID:22024107. |
this was due to 30% greater dna synthesis in p53(-/-) megakaryocytes and 31% greater apoptosis in p53(+/+) megakaryocytes by day 4 of culture. |
2012-02-27 |
2023-08-12 |
mouse |
| Hyunkyung Kim, Ji Min Lee, Gina Lee, Jinhyuk Bhin, Se Kyu Oh, Kyeongkyu Kim, Ki Eun Pyo, Jason S Lee, Hwa Young Yim, Keun Il Kim, Daehee Hwang, Jongkyeong Chung, Sung Hee Bae. DNA damage-induced RORα is crucial for p53 stabilization and increased apoptosis. Molecular cell. vol 44. issue 5. 2012-02-27. PMID:22152482. |
dna damage-induced rorα is crucial for p53 stabilization and increased apoptosis. |
2012-02-27 |
2023-08-12 |
drosophila_melanogaster |
| Hyunkyung Kim, Ji Min Lee, Gina Lee, Jinhyuk Bhin, Se Kyu Oh, Kyeongkyu Kim, Ki Eun Pyo, Jason S Lee, Hwa Young Yim, Keun Il Kim, Daehee Hwang, Jongkyeong Chung, Sung Hee Bae. DNA damage-induced RORα is crucial for p53 stabilization and increased apoptosis. Molecular cell. vol 44. issue 5. 2012-02-27. PMID:22152482. |
interestingly, microarray analysis revealed that rorα-mediated p53 stabilization leads to the activation of a subset of p53 target genes that are specifically involved in apoptosis. |
2012-02-27 |
2023-08-12 |
drosophila_melanogaster |
| Hyunkyung Kim, Ji Min Lee, Gina Lee, Jinhyuk Bhin, Se Kyu Oh, Kyeongkyu Kim, Ki Eun Pyo, Jason S Lee, Hwa Young Yim, Keun Il Kim, Daehee Hwang, Jongkyeong Chung, Sung Hee Bae. DNA damage-induced RORα is crucial for p53 stabilization and increased apoptosis. Molecular cell. vol 44. issue 5. 2012-02-27. PMID:22152482. |
together, we determined that rorα is a p53 regulator that exerts its role in increased apoptosis via p53. |
2012-02-27 |
2023-08-12 |
drosophila_melanogaster |
| Jian Li, Yangde Zhang, Jingfeng Zhao, Fangren Kong, Yuxiang Che. Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells. Molecular and cellular biochemistry. vol 357. issue 1-2. 2012-02-24. PMID:21594648. |
to explore whether mir-22 is an important player in the development of chemoresistance in colon cancer, we overexpressed mir-22 and subsequently tested its role in cell proliferation, apoptosis, survival, and associated signaling in p53-mutated ht-29 and hct-15 cells, and p53 wild-type hct-116 cells. |
2012-02-24 |
2023-08-12 |
Not clear |
| Jian Li, Yangde Zhang, Jingfeng Zhao, Fangren Kong, Yuxiang Che. Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells. Molecular and cellular biochemistry. vol 357. issue 1-2. 2012-02-24. PMID:21594648. |
overexpression of mir-22 significantly decreased cell proliferation and survival, and induced cell apoptosis in the p53-mutated colon cancer cells, but played no role in the p53 wild-type cells. |
2012-02-24 |
2023-08-12 |
Not clear |
| María Angel García, Esther Carrasco, Margarita Aguilera, Pablo Alvarez, Carmen Rivas, Joaquin María Campos, Jose Carlos Prados, Miguel Angel Calleja, Mariano Esteban, Juan Antonio Marchal, Antonia Aráneg. The chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53-independent manner in colon and breast cancer cells. PloS one. vol 6. issue 8. 2012-02-24. PMID:21887339. |
pkr distribution and activation, apoptosis induction and cytotoxic effects were analyzed during 5-fu and 5-fu/ifnα treatment in several colon and breast cancer cell lines with different p53 status. |
2012-02-24 |
2023-08-12 |
human |
| Nidhi Bansal, Rama Kadamb, Shilpi Mittal, Leena Vig, Raisha Sharma, Bilikere S Dwarakanath, Daman Saluj. Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress. PloS one. vol 6. issue 10. 2012-02-24. PMID:22028823. |
depending on the cell type and severity of dna damage, p53 protein mediates cell cycle arrest or apoptosis, besides activating dna repair, which is apparently achieved by regulation of its target genes, as well as direct interaction with other proteins. |
2012-02-24 |
2023-08-12 |
human |
| Nidhi Bansal, Rama Kadamb, Shilpi Mittal, Leena Vig, Raisha Sharma, Bilikere S Dwarakanath, Daman Saluj. Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress. PloS one. vol 6. issue 10. 2012-02-24. PMID:22028823. |
the present study highlights for the first time the essential role of sin3b as an important associate of p53 in mediating the cellular responses to stress and in the transcriptional repression of genes encoding for heat shock proteins or proteins involved in regulation of cell cycle and apoptosis. |
2012-02-24 |
2023-08-12 |
human |
| Peng Longxi, Fang Buwu, Wang Yuan, Gao Sina. Expression of p53 in the effects of artesunate on induction of apoptosis and inhibition of proliferation in rat primary hepatic stellate cells. PloS one. vol 6. issue 10. 2012-02-24. PMID:22053192. |
expression of p53 in the effects of artesunate on induction of apoptosis and inhibition of proliferation in rat primary hepatic stellate cells. |
2012-02-24 |
2023-08-12 |
rat |
| Peng Longxi, Fang Buwu, Wang Yuan, Gao Sina. Expression of p53 in the effects of artesunate on induction of apoptosis and inhibition of proliferation in rat primary hepatic stellate cells. PloS one. vol 6. issue 10. 2012-02-24. PMID:22053192. |
thereby, p53 serves as a tumor suppressor by inducing cell cycle arrest, apoptosis, senescence and dna repair. |
2012-02-24 |
2023-08-12 |
rat |
| Peng Longxi, Fang Buwu, Wang Yuan, Gao Sina. Expression of p53 in the effects of artesunate on induction of apoptosis and inhibition of proliferation in rat primary hepatic stellate cells. PloS one. vol 6. issue 10. 2012-02-24. PMID:22053192. |
however, little is known about the expression of p53 in the effects of artesunate on induction of apoptosis and inhibition of proliferation in rat hscs. |
2012-02-24 |
2023-08-12 |
rat |
| David Matallanas, David Romano, Fahd Al-Mulla, Eric O'Neill, Waleed Al-Ali, Piero Crespo, Brendan Doyle, Colin Nixon, Owen Sansom, Matthias Drosten, Mariano Barbacid, Walter Kolc. Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Molecular cell. vol 44. issue 6. 2012-02-24. PMID:22195963. |
in this pathway lats1 binds to and sequesters the ubiquitin ligase mdm2 causing stabilization of the tumor suppressor p53 and apoptosis. |
2012-02-24 |
2023-08-12 |
mouse |