| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunhua Lu, Shan Lu, Wei Liang, Jing Li, Xiaowei Dou, Chunjing Bian, Dan Shi, Lianming Liao, Robert Chunhua Zha. TAp63α mediates chemotherapeutic agent-induced apoptosis in human bone marrow mesenchymal stem cells. Stem cells and development. vol 20. issue 8. 2012-01-27. PMID:21142794. |
in vitro experiments have demonstrated that apoptosis of mscs can be induced by hypoxia, serum deprivation, and chemotherapeutic agents, and the process is p53 independent. |
2012-01-27 |
2023-08-12 |
human |
| Chunhua Lu, Shan Lu, Wei Liang, Jing Li, Xiaowei Dou, Chunjing Bian, Dan Shi, Lianming Liao, Robert Chunhua Zha. TAp63α mediates chemotherapeutic agent-induced apoptosis in human bone marrow mesenchymal stem cells. Stem cells and development. vol 20. issue 8. 2012-01-27. PMID:21142794. |
in this study, we investigated the role of p63 (a member of p53 family) in the regulation of apoptosis of mscs. |
2012-01-27 |
2023-08-12 |
human |
| Chunhua Lu, Shan Lu, Wei Liang, Jing Li, Xiaowei Dou, Chunjing Bian, Dan Shi, Lianming Liao, Robert Chunhua Zha. TAp63α mediates chemotherapeutic agent-induced apoptosis in human bone marrow mesenchymal stem cells. Stem cells and development. vol 20. issue 8. 2012-01-27. PMID:21142794. |
tap63α, a subtype of p63, is highly similar to p53 and plays a crucial role in apoptosis. |
2012-01-27 |
2023-08-12 |
human |
| Josep Tabernero, Luc Dirix, Patrick Schöffski, Andrés Cervantes, Jose Antonio Lopez-Martin, Jaume Capdevila, Ludy van Beijsterveldt, Suso Platero, Brett Hall, Zhilong Yuan, Roland Knoblauch, Sen Hong Zhuan. A phase I first-in-human pharmacokinetic and pharmacodynamic study of serdemetan in patients with advanced solid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 17. issue 19. 2012-01-27. PMID:21831953. |
originally isolated on the basis of its ability to induce p53, serdemetan showed potent activity in various preclinical models, inducing s-phase arrest and apoptosis in tp53 wild-type and mutant tumors. |
2012-01-27 |
2023-08-12 |
Not clear |
| Chao Dai, Yi Tang, Sung Yun Jung, Jun Qin, Stuart A Aaronson, Wei G. Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 47. 2012-01-27. PMID:22084066. |
p53 functions as a central node for organizing whether the cell responds to stress with apoptosis or cell cycle arrest; however, the molecular events that lead to apoptotic responses are not completely understood. |
2012-01-27 |
2023-08-12 |
Not clear |
| Chao Dai, Yi Tang, Sung Yun Jung, Jun Qin, Stuart A Aaronson, Wei G. Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 47. 2012-01-27. PMID:22084066. |
p90 has no obvious effects on either the levels of p53 or p53-mediated cell cycle arrest but is specifically required for p53-mediated apoptosis upon dna damage. |
2012-01-27 |
2023-08-12 |
Not clear |
| Chao Dai, Yi Tang, Sung Yun Jung, Jun Qin, Stuart A Aaronson, Wei G. Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 47. 2012-01-27. PMID:22084066. |
these studies indicate that p90 is a critical cofactor for p53-mediated apoptosis through promoting tip60-mediated p53 acetylation. |
2012-01-27 |
2023-08-12 |
Not clear |
| Aisling E O'Connor, Margaret M Mc Gee, Yury Likar, Vladimir Ponomarev, John J Callanan, Donal F O'shea, Annette T Byrne, William M Gallaghe. Mechanism of cell death mediated by a BF2-chelated tetraaryl-azadipyrromethene photodynamic therapeutic: dissection of the apoptotic pathway in vitro and in vivo. International journal of cancer. vol 130. issue 3. 2012-01-26. PMID:21413012. |
pdt-induced apoptosis was also found to be independent of p53 tumor suppressor status. |
2012-01-26 |
2023-08-12 |
human |
| S Y Nam, K Sabapath. p53 promotes cellular survival in a context-dependent manner by directly inducing the expression of haeme-oxygenase-1. Oncogene. vol 30. issue 44. 2012-01-26. PMID:21552291. |
a variety of cellular insults activate the tumour suppressor p53, leading generally to cell-cycle arrest or apoptosis. |
2012-01-26 |
2023-08-12 |
mouse |
| E Rudolf, K Rudolf, M Cervink. Camptothecin induces p53-dependent and -independent apoptogenic signaling in melanoma cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 11. 2012-01-26. PMID:21809047. |
here we report that cpt induced in bowes melanoma cells apoptosis which is essentially p53 and mitochondria-dependent but with some involvement of caspase-2 and p73. |
2012-01-26 |
2023-08-12 |
Not clear |
| E Rudolf, K Rudolf, M Cervink. Camptothecin induces p53-dependent and -independent apoptogenic signaling in melanoma cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 11. 2012-01-26. PMID:21809047. |
conversely, in mutant p53 melanoma cells overall levels of cpt-induced apoptosis are significantly lower, with p73 and caspase-2 signaling playing important roles. |
2012-01-26 |
2023-08-12 |
Not clear |
| Minh T N Le, Ng Shyh-Chang, Swea Ling Khaw, Lingzi Chin, Cathleen Teh, Junliang Tay, Elizabeth O'Day, Vladimir Korzh, Henry Yang, Ashish Lal, Judy Lieberman, Harvey F Lodish, Bing Li. Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS genetics. vol 7. issue 9. 2012-01-26. PMID:21935352. |
because the p53 network is a central regulator of both apoptosis and proliferation, the dual roles of mir-125b raise the question of what genes in the p53 network might be regulated by mir-125b. |
2012-01-26 |
2023-08-12 |
mouse |
| Minh T N Le, Ng Shyh-Chang, Swea Ling Khaw, Lingzi Chin, Cathleen Teh, Junliang Tay, Elizabeth O'Day, Vladimir Korzh, Henry Yang, Ashish Lal, Judy Lieberman, Harvey F Lodish, Bing Li. Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS genetics. vol 7. issue 9. 2012-01-26. PMID:21935352. |
these targets include both apoptosis regulators like bak1, igfbp3, itch, puma, prkra, tp53inp1, tp53, zac1, and also cell-cycle regulators like cyclin c, cdc25c, cdkn2c, edn1, ppp1ca, sel1l, in the p53 network. |
2012-01-26 |
2023-08-12 |
mouse |
| Ali Cansu, Ozgür Ekinci, Ozalp Ekinci, Ayse Serdaroglu, Deniz Erdogan, Zafer Kutay Coskun, Seren Gulsen Gürge. Methylphenidate has dose-dependent negative effects on rat spermatogenesis: decreased round spermatids and testicular weight and increased p53 expression and apoptosis. Human & experimental toxicology. vol 30. issue 10. 2012-01-25. PMID:21183565. |
methylphenidate has dose-dependent negative effects on rat spermatogenesis: decreased round spermatids and testicular weight and increased p53 expression and apoptosis. |
2012-01-25 |
2023-08-12 |
rat |
| B Žegura, G Gajski, A Štraser, V Garaj-Vrhova. Cylindrospermopsin induced DNA damage and alteration in the expression of genes involved in the response to DNA damage, apoptosis and oxidative stress. Toxicon : official journal of the International Society on Toxinology. vol 58. issue 6-7. 2012-01-24. PMID:21867723. |
cyn induced changes in the mrna expression of p53 and its downstream regulated dna damage responsive genes mdm2, gadd45α and apoptosis genes, bcl-2 and bax, as well as oxidative stress responsive genes (gpx1, sod1, gsr, gclc), while no changes in the expression of genes cdkn1a and cat were observed. |
2012-01-24 |
2023-08-12 |
human |
| Harald Ehrhardt, David Schrembs, Christian Moritz, Franziska Wachter, Subrata Haldar, Ulrike Graubner, Michaela Nathrath, Irmela Jeremia. Optimized anti-tumor effects of anthracyclines plus Vinca alkaloids using a novel, mechanism-based application schedule. Blood. vol 118. issue 23. 2012-01-24. PMID:21926351. |
as underlying mechanism, doxorubicin activated p53, p53 induced cell-cycle arrest, and cell-cycle arrest disabled inactivation of antiapoptotic bcl-2 family members by vincristine; therefore, vincristine was unable to activate downstream apoptosis signaling. |
2012-01-24 |
2023-08-12 |
mouse |
| Harald Ehrhardt, David Schrembs, Christian Moritz, Franziska Wachter, Subrata Haldar, Ulrike Graubner, Michaela Nathrath, Irmela Jeremia. Optimized anti-tumor effects of anthracyclines plus Vinca alkaloids using a novel, mechanism-based application schedule. Blood. vol 118. issue 23. 2012-01-24. PMID:21926351. |
as molecular proof, antagonism was rescued by knockdown of p53, whereas knockdown of cyclin a inhibited vincristine-induced apoptosis. |
2012-01-24 |
2023-08-12 |
mouse |
| Raquel C Maia, Flavia C Vasconcelos, Thiago de Sá Bacelar, Eduardo J Salustiano, Luis Felipe R da Silva, Débora L Pereira, Arthur Moellman-Coelho, Chaquip D Netto, Alcides J da Silva, Vivian M Rumjanek, Paulo R R Cost. LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells. Investigational new drugs. vol 29. issue 6. 2012-01-23. PMID:20499132. |
moreover, this effect was not restricted to cell lines as lqb-118 produced significant apoptosis rate in cells from cml patients exhibiting multifactorial drug resistance phenotype such as p-glycoprotein, mrp1 and p53 overexpression. |
2012-01-23 |
2023-08-12 |
Not clear |
| Sachiko Murase, Steve W Poser, Joby Joseph, Ronald D McKa. p53 controls neuronal death in the CA3 region of the newborn mouse hippocampus. The European journal of neuroscience. vol 34. issue 3. 2012-01-23. PMID:21714817. |
here, we focus on the ca3 region to show that neuronal apoptosis requires p53. |
2012-01-23 |
2023-08-12 |
mouse |
| Hong Lin, Wei Xiong, Xiang Zhang, Bolin Liu, Wei Zhang, Yongqiang Zhang, Jinxiang Cheng, Huiyong Huan. Notch-1 activation-dependent p53 restoration contributes to resveratrol-induced apoptosis in glioblastoma cells. Oncology reports. vol 26. issue 4. 2012-01-23. PMID:21743969. |
notch-1 activation-dependent p53 restoration contributes to resveratrol-induced apoptosis in glioblastoma cells. |
2012-01-23 |
2023-08-12 |
Not clear |