| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pang-Kuo Lo, Ji Shin Lee, Saraswati Sukuma. The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function. Cellular signalling. vol 24. issue 1. 2012-02-23. PMID:21964066. |
cosilencing of p53 by sirna synergistically enhanced the effect of foxf1 depletion on the stimulation of dna rereplication and apoptosis in wild-type hct116. |
2012-02-23 |
2023-08-12 |
Not clear |
| Rozenn Josse, Julie Dumont, Alain Fautrel, Marie-Anne Robin, André Guillouz. Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds. Toxicology and applied pharmacology. vol 258. issue 2. 2012-02-23. PMID:22100608. |
the main altered signaling pathway was the p53 pathway and related functions such as cell cycle, apoptosis and dna repair. |
2012-02-23 |
2023-08-12 |
human |
| Li-Wen Huang, Bau-Shan Hsieh, Hsiao-Ling Cheng, Yu-Chen Hu, Wen-Tsan Chang, Kee-Lung Chan. Arecoline decreases interleukin-6 production and induces apoptosis and cell cycle arrest in human basal cell carcinoma cells. Toxicology and applied pharmacology. vol 258. issue 2. 2012-02-23. PMID:22108589. |
this study demonstrates that arecoline has potential for preventing bcc tumorigenesis by reducing levels of the tumor cell survival factor il-6, increasing levels of the tumor suppressor factor p53, and eliciting cell cycle arrest, followed by apoptosis. |
2012-02-23 |
2023-08-12 |
mouse |
| Kaipeng Jing, Kyoung-Sub Song, Soyeon Shin, Nayeong Kim, Soyeon Jeong, Hye-Rim Oh, Ji-Hoon Park, Kang-Sik Seo, Jun-Young Heo, Jeongsu Han, Jong-Il Park, Chang Han, Tong Wu, Gi-Ryang Kweon, Seung-Kiel Park, Wan-Hee Yoon, Byung-Doo Hwang, Kyu Li. Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53. Autophagy. vol 7. issue 11. 2012-02-22. PMID:21811093. |
docosahexaenoic acid induces autophagy through p53/ampk/mtor signaling and promotes apoptosis in human cancer cells harboring wild-type p53. |
2012-02-22 |
2023-08-12 |
human |
| Su Chen, Da-Liang Wang, Yan Liu, Lei Zhao, Fang-Lin Su. RAD6 regulates the dosage of p53 by a combination of transcriptional and posttranscriptional mechanisms. Molecular and cellular biology. vol 32. issue 2. 2012-02-21. PMID:22083959. |
further studies showed that stress-induced p53 transcriptional activation, cell apoptosis, and disrupted cell cycle progression are all rad6 dependent. |
2012-02-21 |
2023-08-12 |
human |
| Can Tan, Li-Yang Zhang, Hong Chen, Ling Xiao, Xian-Peng Liu, Jian-Xiang Zhan. Overexpression of the human ubiquitin E3 ligase CUL4A alleviates hypoxia-reoxygenation injury in pheochromocytoma (PC12) cells. Biochemical and biophysical research communications. vol 416. issue 3-4. 2012-02-21. PMID:22120631. |
in pc12 cells subjected to hypoxia and reoxygenation, we found that hcul4a suppresses apoptosis and dna damage by regulating apoptosis-related proteins and cell cycle regulators (bcl-2, caspase-3, p53 and p27); consequently, hcul4a promotes cell survival. |
2012-02-21 |
2023-08-12 |
human |
| Wenjuan Li, Li Zhao, Wen Zang, Zhifang Liu, Long Chen, Tiantian Liu, Dawei Xu, Jihui Ji. Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer. Biochemical and biophysical research communications. vol 416. issue 3-4. 2012-02-21. PMID:22133676. |
knocking down jmjd2b expression by small interfering rna (sirna) in gastric and other cancer cells inhibited cell proliferation and/or induced apoptosis and elevated the expression of p53 and p21(cip1) proteins. |
2012-02-21 |
2023-08-12 |
mouse |
| Pierre C Dagher, Erik M Mai, Takashi Hato, So-Young Lee, Melissa D Anderson, Stephanie C Karozos, Henry E Mang, Nicole L Knipe, Zoya Plotkin, Timothy A Sutto. The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury. American journal of physiology. Renal physiology. vol 302. issue 2. 2012-02-17. PMID:22049400. |
inhibition of the tumor suppressor p53 diminishes tubular cell apoptosis and protects renal function in animal models of acute kidney injury (aki). |
2012-02-17 |
2023-08-12 |
rat |
| Keisuke Kakisaka, Sophie C Cazanave, Christian D Fingas, Maria E Guicciardi, Steven F Bronk, Nathan W Werneburg, Justin L Mott, Gregory J Gore. Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 1. 2012-02-16. PMID:21995961. |
pa-mediated hepatocyte lipoapoptosis is associated with endoplasmic reticulum (er) stress, c-jun nh(2)-terminal kinase (jnk) activation, and a jnk-dependent upregulation of the potent proapoptotic bh3-only protein puma (p53 upregulated modulator of apoptosis). |
2012-02-16 |
2023-08-12 |
human |
| Xi Zhang, Yao Liu, Ying-jian Si, Xing-hua Chen, Zhong-jun Li, Lei Gao, Li Gao, Cheng Zhan. Effect of Cx43 gene-modified leukemic bone marrow stromal cells on the regulation of Jurkat cell line in vitro. Leukemia research. vol 36. issue 2. 2012-02-16. PMID:22030334. |
furthermore, compared with leukemic cells alone, the proliferation and apoptosis of leukemic cells co-cultured with bmscs were inhibited, the percentage of g0-phase cells was higher; and expression of p53 increased and bax decreased. |
2012-02-16 |
2023-08-12 |
Not clear |
| Michael Wenzel, Michael Wunderlich, Robert Besch, Hendrik Poeck, Simone Willms, Astrid Schwantes, Melanie Kremer, Gerd Sutter, Stefan Endres, Andreas Schmidt, Simon Rothenfusse. Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 1. 2012-02-16. PMID:22140256. |
although it does not require the ifn pathway known to be triggered by infection with mva or transfected dna via polymerase iii and retinoid acid-induced gene i-like helicases, it shows a strong dependence on components of the dna damage signaling pathway: cytosolic delivery of dna or infection with mva leads to phosphorylation of p53 (serines 15 and 46) and autophosphorylation of ataxia telangiectasia mutated (atm); depleting p53 or atm with small interfering rna or inhibiting the atm/atm-related kinase family by caffeine strongly reduces apoptosis. |
2012-02-16 |
2023-08-12 |
mouse |
| A V Sirotkin, A Benčo, A Tandlmajerová, D Vašíče. Involvement of transcription factor p53 and leptin in control of porcine ovarian granulosa cell functions. Cell proliferation. vol 45. issue 1. 2012-02-16. PMID:22151798. |
the aim of our in vitro experiments was to examine the role of transcription factor p53 and the metabolic hormone leptin, in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells, as well as involvement of p53 in mediating or modulating actions of leptin, on ovarian cells. |
2012-02-16 |
2023-08-12 |
Not clear |
| A V Sirotkin, A Benčo, A Tandlmajerová, D Vašíče. Involvement of transcription factor p53 and leptin in control of porcine ovarian granulosa cell functions. Cell proliferation. vol 45. issue 1. 2012-02-16. PMID:22151798. |
these multiple effects of the p53 gene construct on granulosa cells, cultured with and without leptin, (i) demonstrate that leptin can be involved in control of porcine ovarian cell proliferation, apoptosis and expression of p53, but not on p4 release; and (ii) confirm involvement of p53 in promoting apoptosis and suppression of proliferation and p4 secretion in these cells. |
2012-02-16 |
2023-08-12 |
Not clear |
| A V Sirotkin, A Benčo, A Tandlmajerová, D Vašíče. Involvement of transcription factor p53 and leptin in control of porcine ovarian granulosa cell functions. Cell proliferation. vol 45. issue 1. 2012-02-16. PMID:22151798. |
(iii) the similarity of p53 and leptin's actions on bax and cyclin b1, and inability of p53 to further promote leptin action on this parameter suggest that p53 can be a mediator of leptin's action on ovarian cell apoptosis. |
2012-02-16 |
2023-08-12 |
Not clear |
| Noor Hasima Nagoor, Norliza Shah Jehan Muttiah, Chong Soon Lim, Lionel L A In, Khalit Mohamad, Khalit Mohammad, Khalijah Awan. Regulation of apoptotic effects by erythrocarpine E, a cytotoxic limonoid from Chisocheton erythrocarpus in HSC-4 human oral cancer cells. PloS one. vol 6. issue 8. 2012-02-15. PMID:21858194. |
western blotting results demonstrated that the induction of apoptosis by ceb4 appeared to be mediated through regulation of the p53 signalling pathway as there was an increase in p53 phosphorylation levels. |
2012-02-15 |
2023-08-12 |
human |
| Francesca Nicolau-Galmés, Aintzane Asumendi, Erika Alonso-Tejerina, Gorka Pérez-Yarza, Shawkat-Muhialdin Jangi, Jesús Gardeazabal, Yoana Arroyo-Berdugo, Jesús María Careaga, Jose Luís Díaz-Ramón, Aintzane Apraiz, María D Boyan. Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms. Apoptosis : an international journal on programmed cell death. vol 16. issue 12. 2012-02-15. PMID:21861192. |
ros inhibition prevented p73 and noxa expression but not p53 and p21 expression, suggesting a role for noxa in p53-independent apoptosis in melanoma cells. |
2012-02-15 |
2023-08-12 |
Not clear |
| Lili Jiang, Qin Huang, Jihong Chang, Enhua Wang, Xueshan Qi. MicroRNA HSA-miR-125a-5p induces apoptosis by activating p53 in lung cancer cells. Experimental lung research. vol 37. issue 7. 2012-02-14. PMID:21777146. |
microrna hsa-mir-125a-5p induces apoptosis by activating p53 in lung cancer cells. |
2012-02-14 |
2023-08-12 |
human |
| Lili Jiang, Qin Huang, Jihong Chang, Enhua Wang, Xueshan Qi. MicroRNA HSA-miR-125a-5p induces apoptosis by activating p53 in lung cancer cells. Experimental lung research. vol 37. issue 7. 2012-02-14. PMID:21777146. |
moreover, blocking wild-type p53 attenuated the effect of hsa-mir-125a-5p on apoptosis. |
2012-02-14 |
2023-08-12 |
human |
| Lili Jiang, Qin Huang, Jihong Chang, Enhua Wang, Xueshan Qi. MicroRNA HSA-miR-125a-5p induces apoptosis by activating p53 in lung cancer cells. Experimental lung research. vol 37. issue 7. 2012-02-14. PMID:21777146. |
the effect of hsa-mir-125a-5p inhibitor on apoptosis was also weakened by blocking wild-type p53. |
2012-02-14 |
2023-08-12 |
human |
| Nirojini Sivachandran, Christopher W Dawson, Lawrence S Young, Fei-Fei Liu, Jaap Middeldorp, Lori Frappie. Contributions of the Epstein-Barr virus EBNA1 protein to gastric carcinoma. Journal of virology. vol 86. issue 1. 2012-02-14. PMID:22013060. |
we have investigated the cellular effects of the only ebv nuclear protein expressed in gc, ebna1, focusing on promyelocytic leukemia (pml) nuclear bodies (nbs), which play important roles in apoptosis, p53 activation, and tumor suppression. |
2012-02-14 |
2023-08-12 |
Not clear |