| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathryn T Bieging, Laura D Attard. Deconstructing p53 transcriptional networks in tumor suppression. Trends in cell biology. vol 22. issue 2. 2012-03-25. PMID:22154076. |
p53 is a pivotal tumor suppressor that induces apoptosis, cell-cycle arrest and senescence in response to stress signals. |
2012-03-25 |
2023-08-12 |
mouse |
| Kyunghwan Kim, Kyu Heo, Jongkyu Choi, Sarah Jackson, Hyunjung Kim, Yue Xiong, Woojin A. Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail. Molecular and cellular biology. vol 32. issue 4. 2012-03-25. PMID:22184063. |
vprbp knockdown leads to activation of p53 target genes and causes an increase in dna damage-induced apoptosis. |
2012-03-25 |
2023-08-12 |
Not clear |
| Siti Nur Aisyah Jauharoh, Jun Saegusa, Takeshi Sugimoto, Bambang Ardianto, Shimpei Kasagi, Daisuke Sugiyama, Chiyo Kurimoto, Osamu Tokuno, Yuji Nakamachi, Shunichi Kumagai, Seiji Kawan. SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production. Biochemical and biophysical research communications. vol 417. issue 1. 2012-03-22. PMID:22178074. |
furthermore, ro52-mediated apoptosis was not influenced by p53 protein level in hela cells. |
2012-03-22 |
2023-08-12 |
Not clear |
| Susanne Knoll, Katharina Fürst, Saijo Thomas, Sergio Villanueva Baselga, Anja Stoll, Stephanie Schaefer, Brigitte M Pütze. Dissection of cell context-dependent interactions between HBx and p53 family members in regulation of apoptosis: a role for HBV-induced HCC. Cell cycle (Georgetown, Tex.). vol 10. issue 20. 2012-03-20. PMID:22030623. |
dissection of cell context-dependent interactions between hbx and p53 family members in regulation of apoptosis: a role for hbv-induced hcc. |
2012-03-20 |
2023-08-12 |
Not clear |
| Susanne Knoll, Katharina Fürst, Saijo Thomas, Sergio Villanueva Baselga, Anja Stoll, Stephanie Schaefer, Brigitte M Pütze. Dissection of cell context-dependent interactions between HBx and p53 family members in regulation of apoptosis: a role for HBV-induced HCC. Cell cycle (Georgetown, Tex.). vol 10. issue 20. 2012-03-20. PMID:22030623. |
our data suggest that prevention of apoptosis in normal cells by hbx through inhibition of pro-apoptotic p53 family members via direct interaction and coaction with anti-apoptotic Δtap73 seems to be the key element in the decision in favor of cell survival. |
2012-03-20 |
2023-08-12 |
Not clear |
| Susanne Knoll, Katharina Fürst, Saijo Thomas, Sergio Villanueva Baselga, Anja Stoll, Stephanie Schaefer, Brigitte M Pütze. Dissection of cell context-dependent interactions between HBx and p53 family members in regulation of apoptosis: a role for HBV-induced HCC. Cell cycle (Georgetown, Tex.). vol 10. issue 20. 2012-03-20. PMID:22030623. |
the complex cell context-dependent interactions between p53 family members and hbx in the regulation of apoptosis may be essential in hbv-induced hcc and anticancer therapy. |
2012-03-20 |
2023-08-12 |
Not clear |
| Ling Zhang, Jennifer J Hu, Feng Gon. MG132 inhibition of proteasome blocks apoptosis induced by severe DNA damage. Cell cycle (Georgetown, Tex.). vol 10. issue 20. 2012-03-20. PMID:22031102. |
blockage of apoptosis by mg132 correlates with p53 stabilization and upregulation of p21/waf1, a p53 transcriptional target. |
2012-03-20 |
2023-08-12 |
Not clear |
| Ling Zhang, Jennifer J Hu, Feng Gon. MG132 inhibition of proteasome blocks apoptosis induced by severe DNA damage. Cell cycle (Georgetown, Tex.). vol 10. issue 20. 2012-03-20. PMID:22031102. |
surprisingly, in the absence of mg132, robust apoptosis induced by a high dose of uv irradiation correlate with rapid p53 degradation. |
2012-03-20 |
2023-08-12 |
Not clear |
| Jie Yin, Hui Fang Tang, Qiong Xiang, Jia Yu, Xiao Yang Yang, Nan Hu, Xiao Yong Le. MiR-122 increases sensitivity of drug-resistant BEL-7402/5-FU cells to 5-fluorouracil via down-regulation of bcl-2 family proteins. Die Pharmazie. vol 66. issue 12. 2012-03-20. PMID:22312705. |
accordingly, p53 protein expression showed a significant up-regulation; mtt results showed that after incubation with 5-fu, mir-122 transfectants had higher cell inhibitory rates than negative mirna or untreated cells; flow cytometry results demonstrated that apoptosis rate increased in mir-122 transfected cells, compared with negative mirna or untreated cells. |
2012-03-20 |
2023-08-12 |
human |
| Jie Yin, Hui Fang Tang, Qiong Xiang, Jia Yu, Xiao Yang Yang, Nan Hu, Xiao Yong Le. MiR-122 increases sensitivity of drug-resistant BEL-7402/5-FU cells to 5-fluorouracil via down-regulation of bcl-2 family proteins. Die Pharmazie. vol 66. issue 12. 2012-03-20. PMID:22312705. |
mir-122 can specifically down-regulate the expression of bcl-2 and bcl-xl, and increase p53 activity in bel-7402/5-fu cells, which increased cells spontaneous apoptosis and sensitize cells to 5-fu. |
2012-03-20 |
2023-08-12 |
human |
| Hai Li, Tadepally Lakshmikanth, Cinzia Garofalo, Martin Enge, Clemens Spinnler, Andrea Anichini, Laszlo Szekely, Klas Kärre, Ennio Carbone, Galina Selivanov. Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2. Cell cycle (Georgetown, Tex.). vol 10. issue 19. 2012-03-19. PMID:21941086. |
p53, a key tumor suppressor, represses tumorigenesis by eliciting growth arrest, apoptosis or senescence in cancer cells. |
2012-03-19 |
2023-08-12 |
human |
| Chih-Hua Tseng, Cherng-Chyi Tzeng, Kuin-Yu Chung, Chai-Lin Kao, Chih-Yao Hsu, Chih-Mei Cheng, Keng-Shiang Huang, Yeh-Long Che. Synthesis and antiproliferative evaluation of 6-aryl-11-iminoindeno[1,2-c]quinoline derivatives. Bioorganic & medicinal chemistry. vol 19. issue 24. 2012-03-19. PMID:22079254. |
further investigations have shown that 23a induced cell cycle arrest at g2/m phase and induce apoptosis via activation of p53, bax, and caspase-8 which consequently cause cell death. |
2012-03-19 |
2023-08-12 |
Not clear |
| Kageaki Kuribayashi, Niklas Finnberg, John R Jeffers, Gerard P Zambetti, Wafik S El-Deir. The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo. Cell cycle (Georgetown, Tex.). vol 10. issue 14. 2012-03-16. PMID:21709442. |
furthermore, p53 must rely on mechanisms independent of dr5 and puma to initiate apoptosis following γ-radiation in the spleen and thymus in vivo. |
2012-03-16 |
2023-08-12 |
mouse |
| Gregory A Azzam, Amanda K Frank, Monica Hollstein, Maureen E Murph. Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model. Cell cycle (Georgetown, Tex.). vol 10. issue 9. 2012-03-15. PMID:21566457. |
we recently reported on a mouse model for the codon 72 polymorphism in p53, and found that this polymorphism regulates the ability to cooperate with nf-kb and induce apoptosis. |
2012-03-15 |
2023-08-12 |
mouse |
| Ki-Eun Bae, Young-Woong Choi, Sang-Tae Kim, Young-Kyoon Ki. Components of rhizome extract of Cnidium officinale Makino and their in vitro biological effects. Molecules (Basel, Switzerland). vol 16. issue 10. 2012-03-15. PMID:22019572. |
in addition, falcarindiol induced apoptosis through strongly increased mrna expression of bax and p53, and slightly reduced bcl-2 mrna levels in a dose dependent manner. |
2012-03-15 |
2023-08-12 |
human |
| Rajan Gogna, Esha Madan, Periannan Kuppusamy, Uttam Pat. Chaperoning of mutant p53 protein by wild-type p53 protein causes hypoxic tumor regression. The Journal of biological chemistry. vol 287. issue 4. 2012-03-15. PMID:22147694. |
the chaperone function of wt p53 is directly linked to the induction of apoptosis in both cancer cells and tumor xenografts. |
2012-03-15 |
2023-08-12 |
Not clear |
| Maqusood Ahamed, Mohd Javed Akhtar, Mohan Raja, Iqbal Ahmad, Mohammad Kaleem Javed Siddiqui, Mohamad S AlSalhi, Salman A Alrokaya. ZnO nanorod-induced apoptosis in human alveolar adenocarcinoma cells via p53, survivin and bax/bcl-2 pathways: role of oxidative stress. Nanomedicine : nanotechnology, biology, and medicine. vol 7. issue 6. 2012-03-13. PMID:21664489. |
zno nanorod-induced apoptosis in human alveolar adenocarcinoma cells via p53, survivin and bax/bcl-2 pathways: role of oxidative stress. |
2012-03-13 |
2023-08-12 |
human |
| Maqusood Ahamed, Mohd Javed Akhtar, Mohan Raja, Iqbal Ahmad, Mohammad Kaleem Javed Siddiqui, Mohamad S AlSalhi, Salman A Alrokaya. ZnO nanorod-induced apoptosis in human alveolar adenocarcinoma cells via p53, survivin and bax/bcl-2 pathways: role of oxidative stress. Nanomedicine : nanotechnology, biology, and medicine. vol 7. issue 6. 2012-03-13. PMID:21664489. |
in conclusion, our data demonstrates that zno nanorod induced apoptosis in a549 cells through ros and oxidative stress via p53, survivin, bax/bcl-2 and caspase pathways. |
2012-03-13 |
2023-08-12 |
human |
| Pankaj K Singh, Stephen Y Wise, Elizabeth J Ducey, Oluseyi O Fatanmi, Thomas B Elliott, Vijay K Sing. α-Tocopherol succinate protects mice against radiation-induced gastrointestinal injury. Radiation research. vol 177. issue 2. 2012-03-13. PMID:22013885. |
jejunum sections were analyzed for crypts and villi, puma (p53 upregulated modulator of apoptosis), and apoptosis (terminal deoxynucleotidyl transferase dutp nick end labeling - tunel). |
2012-03-13 |
2023-08-12 |
mouse |
| Anastasia R Goloudina, Kan Tanoue, Arlette Hammann, Eric Fourmaux, Xavier Le Guezennec, Dmitry V Bulavin, Sharlyn J Mazur, Ettore Appella, Carmen Garrido, Oleg N Demido. Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 2. 2012-03-12. PMID:22065775. |
the overexpression of wip1 in normal tissues provided protection from cisplatin-induced apoptosis through decreased strength of upstream signaling to p53. |
2012-03-12 |
2023-08-12 |
Not clear |