| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yashodhar P Bhandary, Shwetha K Shetty, Amarnath S Marudamuthu, Margaret R Gyetko, Steven Idell, Mehrnaz Gharaee-Kermani, Rashmi S Shetty, Barry C Starcher, Sreerama Shett. Regulation of alveolar epithelial cell apoptosis and pulmonary fibrosis by coordinate expression of components of the fibrinolytic system. American journal of physiology. Lung cellular and molecular physiology. vol 302. issue 5. 2012-04-16. PMID:22140072. |
we show that csp, an intervention targeting this pathway, protects the lung epithelium from apoptosis and prevents pf in blm-induced lung injury via upa-mediated inhibition of p53 and pai-1. |
2012-04-16 |
2023-08-12 |
mouse |
| Dan Hanson, Philip G Murray, Graeme C M Black, Peter E Clayto. The genetics of 3-M syndrome: unravelling a potential new regulatory growth pathway. Hormone research in paediatrics. vol 76. issue 6. 2012-04-16. PMID:22156540. |
cul7 also binds to p53 and may be involved in the control of p53-dependent apoptosis. |
2012-04-16 |
2023-08-12 |
Not clear |
| Takahiro Yaguchi, Takashi Nakano, Akinobu Gotoh, Tomoyuki Nishizak. Adenosine promotes GATA-2-regulated p53 gene transcription to induce HepG2 cell apoptosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 28. issue 4. 2012-04-16. PMID:22178888. |
adenosine promotes gata-2-regulated p53 gene transcription to induce hepg2 cell apoptosis. |
2012-04-16 |
2023-08-12 |
human |
| Kyle Meyer, Pavan Rajanahalli, Maqusood Ahamed, John J Rowe, Yiling Hon. ZnO nanoparticles induce apoptosis in human dermal fibroblasts via p53 and p38 pathways. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 8. 2012-04-13. PMID:21903158. |
zno nanoparticles induce apoptosis in human dermal fibroblasts via p53 and p38 pathways. |
2012-04-13 |
2023-08-12 |
human |
| Kyle Meyer, Pavan Rajanahalli, Maqusood Ahamed, John J Rowe, Yiling Hon. ZnO nanoparticles induce apoptosis in human dermal fibroblasts via p53 and p38 pathways. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 8. 2012-04-13. PMID:21903158. |
this study was designed to investigate the apoptosis induction by zno nps via mitogen-activated protein kinase p38 and cell cycle checkpoint protein p53 pathways in human dermal fibroblasts. |
2012-04-13 |
2023-08-12 |
human |
| Kyle Meyer, Pavan Rajanahalli, Maqusood Ahamed, John J Rowe, Yiling Hon. ZnO nanoparticles induce apoptosis in human dermal fibroblasts via p53 and p38 pathways. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 8. 2012-04-13. PMID:21903158. |
apoptosis induction was confirmed by the annexin v assay and western blot analysis showed the up-regulation of p53 and phospho-p38 proteins. |
2012-04-13 |
2023-08-12 |
human |
| Bernhard Biersack, Andrea Dietrich, Miroslava Zoldakova, Bernd Kalinowski, Reinhard Paschke, Rainer Schobert, Thomas Muelle. Lipophilic Pt(II) complexes with selective efficacy against cisplatin-resistant testicular cancer cells. Journal of inorganic biochemistry. vol 105. issue 12. 2012-04-13. PMID:22071088. |
their mechanism of apoptosis induction differed from that of cisplatin by being independent of p53 and of caspase-3 activation and by an early loss of the mitochondrial membrane potential. |
2012-04-13 |
2023-08-12 |
Not clear |
| Xiantao Zhang, Ming Zhao, Lvyi Chen, Haoyan Jiao, Hongxia Liu, Liyan Wang, Shuwei M. A triterpenoid from Thalictrum fortunei induces apoptosis in BEL-7402 cells through the P53-induced apoptosis pathway. Molecules (Basel, Switzerland). vol 16. issue 11. 2012-04-13. PMID:22086402. |
these findings indicate that compound 1 inhibits the growth activity of tumor cells, probably through the p53 protein-induced apoptosis pathway. |
2012-04-13 |
2023-08-12 |
human |
| Sayantan Jana, Sumit Paul, Snehasikta Swarnaka. Curcumin as anti-endometriotic agent: implication of MMP-3 and intrinsic apoptotic pathway. Biochemical pharmacology. vol 83. issue 6. 2012-04-13. PMID:22227273. |
these results were also supported by our therapeutic study, where curcumin induced apoptosis both by p53 dependent and independent manner, while celecoxib followed only p53 independent pathway. |
2012-04-13 |
2023-08-12 |
mouse |
| Tzu-Ching Kuo, Pu-Yuan Chang, Shiu-Feng Huang, Chen-Kung Chou, Chuck C-K Cha. Knockdown of HURP inhibits the proliferation of hepacellular carcinoma cells via downregulation of gankyrin and accumulation of p53. Biochemical pharmacology. vol 83. issue 6. 2012-04-13. PMID:22230478. |
on the other hand, the expression of exogenous p53 in h1299 and hep3b cells was decreased following overexpression of hurp, and these cells showed decreased sensitivity to cisplatin-induced apoptosis. |
2012-04-13 |
2023-08-12 |
mouse |
| H Christian Reinhardt, Björn Schumache. The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends in genetics : TIG. vol 28. issue 3. 2012-04-13. PMID:22265392. |
dna damage response (ddr) pathways that are mediated through the tumor suppressor p53 play an important role in the cell-intrinsic responses to genome instability, including a transient cell cycle arrest, senescence and apoptosis. |
2012-04-13 |
2023-08-12 |
Not clear |
| Frank Essmann, Klaus Schulze-Osthof. Translational approaches targeting the p53 pathway for anti-cancer therapy. British journal of pharmacology. vol 165. issue 2. 2012-04-10. PMID:21718309. |
the p53 tumour suppressor blocks cancer development by triggering apoptosis or cellular senescence in response to oncogenic stress or dna damage. |
2012-04-10 |
2023-08-12 |
human |
| Anton Stangelberger, Andrew V Schally, Ferenc G Rick, Jozsef L Varga, Benjamin Baker, Marta Zarandi, Gabor Halmo. Inhibitory effects of antagonists of growth hormone releasing hormone on experimental prostate cancers are associated with upregulation of wild-type p53 and decrease in p21 and mutant p53 proteins. The Prostate. vol 72. issue 5. 2012-04-10. PMID:21796649. |
the tumor suppressor gene p53 is implicated in cell cycle control and apoptosis. |
2012-04-10 |
2023-08-12 |
human |
| Thao P Dan. Notch, apoptosis and cancer. Advances in experimental medicine and biology. vol 727. 2012-04-10. PMID:22399349. |
thus, we will also examine how apoptosis is modulated by the crosstalk between notch and other signaling pathways such as p53, nf-κb and pi3k-akt pathways. |
2012-04-10 |
2023-08-12 |
human |
| Klaus Roeme. Notch and the p53 clan of transcription factors. Advances in experimental medicine and biology. vol 727. 2012-04-10. PMID:22399351. |
with regard to cancer, it seems that notch acts as a tumour suppressor in cellular contexts where notch signalling supports p53 activation and both together can bring on its way an anti-proliferative programme of differentiation, senescence or apoptosis. |
2012-04-10 |
2023-08-12 |
Not clear |
| Nayden G Naydenov, Gianni Harris, Bryan Brown, Katherine L Schaefer, Swadesh K Das, Paul B Fisher, Andrei I Ivano. Loss of soluble N-ethylmaleimide-sensitive factor attachment protein α (αSNAP) induces epithelial cell apoptosis via down-regulation of Bcl-2 expression and disruption of the Golgi. The Journal of biological chemistry. vol 287. issue 8. 2012-04-09. PMID:22194596. |
apoptosis was not caused by activation of the major prodeath regulators bax and p53 and was independent of a key αsnap binding partner, nsf. |
2012-04-09 |
2023-08-12 |
Not clear |
| Ronak S Patel, Mahesh Rachamalla, Namoju R Chary, Firdos Y Shera, Kulbhushan Tikoo, Gopabandhu Jen. Cytarabine induced cerebellar neuronal damage in juvenile rat: correlating neurobehavioral performance with cellular and genetic alterations. Toxicology. vol 293. issue 1-3. 2012-04-09. PMID:22212197. |
endpoints of the evaluation included food and water intake, body and organ weight, behavioral parameters, histopathology, oxidative stress, dna damage, apoptosis, expression of p53, caspase-3 and calbindin d-28k (calbindin) as well as histone acetylation and methylation. |
2012-04-09 |
2023-08-12 |
rat |
| Ronak S Patel, Mahesh Rachamalla, Namoju R Chary, Firdos Y Shera, Kulbhushan Tikoo, Gopabandhu Jen. Cytarabine induced cerebellar neuronal damage in juvenile rat: correlating neurobehavioral performance with cellular and genetic alterations. Toxicology. vol 293. issue 1-3. 2012-04-09. PMID:22212197. |
present results indicated that ara-c, by inducing oxidative stress mediated dna damage, executes neuronal apoptosis which is accompanied by an increase in the p53 and caspase-3, but decrease in the calbindin expression. |
2012-04-09 |
2023-08-12 |
rat |
| Jing Xu, Mansoor Amij. Therapeutic gene delivery and transfection in human pancreatic cancer cells using epidermal growth factor receptor-targeted gelatin nanoparticles. Journal of visualized experiments : JoVE. issue 59. 2012-04-09. PMID:22231028. |
the p53 mechanism functions as a critical signaling pathway in cell growth, which regulates apoptosis, cell cycle arrest, metabolism and other processes (10). |
2012-04-09 |
2023-08-12 |
human |
| John Fuesler, Yasunori Nagahama, Joseph Szulewski, Joshua Mundorff, Stephanie Bireley, Jonathon S Core. An arrayed human genomic library constructed in the PAC shuttle vector pJCPAC-Mam2 for genome-wide association studies and gene therapy. Gene. vol 496. issue 2. 2012-04-09. PMID:22285925. |
additionally, expression of the p53 protein triggered apoptosis in a subset of the saos-2 cells. |
2012-04-09 |
2023-08-12 |
human |