| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teng Ma, Shumpei Yamada, Solachuddin J A Ichwan, Sachiko Iseki, Kiyoshi Ohtani, Megumi Otsu, Masa-Aki Iked. Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation. Biochemical and biophysical research communications. vol 417. issue 3. 2012-03-30. PMID:22166212. |
we show that nutlin-3 did not rescue the apoptotic defect of a ser46 phosphorylation-defective p53 mutant in p53-sensitive tumor cells, and that rita neither restored p53ser46 phosphorylation nor induced apoptosis in p53ser46 phosphorylation-deficient cells retaining wt-p53. |
2012-03-30 |
2023-08-12 |
human |
| Teng Ma, Shumpei Yamada, Solachuddin J A Ichwan, Sachiko Iseki, Kiyoshi Ohtani, Megumi Otsu, Masa-Aki Iked. Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation. Biochemical and biophysical research communications. vol 417. issue 3. 2012-03-30. PMID:22166212. |
furthermore, treatment with nutlin-3 or rita together with adenoviral p53 gene transfer also failed to induce apoptosis in p53ser46 phosphorylation-deficient cells either expressing or lacking wt-p53. |
2012-03-30 |
2023-08-12 |
human |
| Qi-En Wang, Chunhua Han, Bo Zhang, Kanaga Sabapathy, Altaf A Wan. Nucleotide excision repair factor XPC enhances DNA damage-induced apoptosis by downregulating the antiapoptotic short isoform of caspase-2. Cancer research. vol 72. issue 3. 2012-03-30. PMID:22174370. |
xpc enhances apoptosis induced by dna damage in a p53 nullizygous background, acting downstream of mitochondrial permeabilization and upstream of caspase-9 activation in the dna damage-induced apoptosis cascade. |
2012-03-30 |
2023-08-12 |
Not clear |
| Amanda M Goh, Chin Yan Lim, Poh Cheang Chiam, Ling Li, Michael B Mann, Karen M Mann, Sergio Menendez, David P Lan. Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 5. 2012-03-30. PMID:22307631. |
the p53 transcription factor modulates gene expression programs that induce cell cycle arrest, senescence, or apoptosis, thereby preventing tumorigenesis. |
2012-03-30 |
2023-08-12 |
mouse |
| Amanda M Goh, Chin Yan Lim, Poh Cheang Chiam, Ling Li, Michael B Mann, Karen M Mann, Sergio Menendez, David P Lan. Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 5. 2012-03-30. PMID:22307631. |
we have generated targeted transgenic reporter mice in which egfp expression is driven by p53 transcriptional activity at a response element from either the p21 or puma promoter, which induces cell cycle arrest/senescence and apoptosis, respectively. |
2012-03-30 |
2023-08-12 |
mouse |
| Valery A Chavez-Perez, Mary Strasberg-Rieber, Manuel Riebe. Metabolic utilization of exogenous pyruvate by mutant p53 (R175H) human melanoma cells promotes survival under glucose depletion. Cancer biology & therapy. vol 12. issue 7. 2012-03-28. PMID:21832879. |
dpi-mediated apoptosis in mutant p53 cells was counteracted by 2.77 mm glucose or pyruvate, but not by lactate supplementation. |
2012-03-28 |
2023-08-12 |
human |
| Yan Yin, Wei Chen, Changyan Tang, Hanjing Ding, Jongchol Jang, Meizhi Weng, Yongjun Cai, Guolin Zo. NF-κB, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G₂/M cell cycle arrest. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 12. 2012-03-28. PMID:22005259. |
nf-κb, jnk and p53 pathways are involved in tubeimoside-1-induced apoptosis in hepg2 cells with oxidative stress and g₂/m cell cycle arrest. |
2012-03-28 |
2023-08-12 |
human |
| Yan Yin, Wei Chen, Changyan Tang, Hanjing Ding, Jongchol Jang, Meizhi Weng, Yongjun Cai, Guolin Zo. NF-κB, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G₂/M cell cycle arrest. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 12. 2012-03-28. PMID:22005259. |
moreover, tubeimoside-1 induced accumulation of reactive oxygen species and arrested cell cycle at the g(2)/m phase, thus contributing to apoptosis, through signaling regulation by tumor necrosis factor α, nuclear factor κb (nf-κb), jun n-terminal kinase (jnk) and p53. |
2012-03-28 |
2023-08-12 |
human |
| Iwona Driskell, Hisanobu Oda, Sandra Blanco, Elisabete Nascimento, Peter Humphreys, Michaela Fry. The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin. The EMBO journal. vol 31. issue 3. 2012-03-28. PMID:22117221. |
increased apoptosis may be explained by our discovery that p63, an essential transcription factor for epidermal commitment is lost, while p53 is gained upon removal of setd8. |
2012-03-28 |
2023-08-12 |
mouse |
| Iwona Driskell, Hisanobu Oda, Sandra Blanco, Elisabete Nascimento, Peter Humphreys, Michaela Fry. The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin. The EMBO journal. vol 31. issue 3. 2012-03-28. PMID:22117221. |
both overexpression of p63 and deletion of p53 rescue setd8-induced apoptosis. |
2012-03-28 |
2023-08-12 |
mouse |
| Xiao-Xin Sun, Kishore B Challagundla, Mu-Shui Da. Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. The EMBO journal. vol 31. issue 3. 2012-03-28. PMID:22124327. |
overexpression of otub1 drastically stabilizes and activates p53, leading to apoptosis and marked inhibition of cell proliferation in a p53-dependent manner. |
2012-03-28 |
2023-08-12 |
Not clear |
| S Vasseur, S Afzal, R Tomasini, F Guillaumond, J Tardivel-Lacombe, T W Mak, J L Iovann. Consequences of DJ-1 upregulation following p53 loss and cell transformation. Oncogene. vol 31. issue 5. 2012-03-27. PMID:21725356. |
p53 is a tumor suppressor that responds to various stress signals by initiating cell-cycle arrest, senescence and apoptosis. |
2012-03-27 |
2023-08-12 |
human |
| Acong Yang, Guilai Shi, Chenlin Zhou, Rui Lu, Hui Li, Lei Sun, Ying Ji. Nucleolin maintains embryonic stem cell self-renewal by suppression of p53 protein-dependent pathway. The Journal of biological chemistry. vol 286. issue 50. 2012-03-27. PMID:22013067. |
silencing of p53 rescues g(1) phase accumulation and apoptosis caused by nucleolin deficiency entirely, although it partially blocks abnormal differentiation in nucleolin-depleted escs. |
2012-03-27 |
2023-08-12 |
Not clear |
| Saeid Ghavami, Mark M Mutawe, Dedmer Schaafsma, Behzad Yeganeh, Helmut Unruh, Thomas Klonisch, Andrew J Halayk. Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle. American journal of physiology. Lung cellular and molecular physiology. vol 302. issue 4. 2012-03-27. PMID:22160308. |
notably, ggt1 inhibition induced expression of p53-dependent proteins, p53 upregulated modulator of apoptosis (noxa), and damage-regulated autophagy modulator (dram), this was inhibited by the p53 transcriptional activation inhibitor cyclic-pifithrin-α. |
2012-03-27 |
2023-08-12 |
human |
| Yujiro Tanaka, Aya Nakamura, Masaki Suimye Morioka, Shoko Inoue, Mimi Tamamori-Adachi, Kazuhiko Yamada, Kenji Taketani, Junya Kawauchi, Miki Tanaka-Okamoto, Jun Miyoshi, Hiroshi Tanaka, Shigetaka Kitajim. Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046379. |
further analysis of effects of atf3 knockdown on these targets revealed that stress-induced atf3 regulates genes in metabolic pathways, cell cycle, apoptosis, cell adhesion, and signalling including insulin, p53, wnt, and vegf pathways. |
2012-03-26 |
2023-08-12 |
human |
| Dorothea Muschik, Ilona Braspenning-Wesch, Eggert Stockfleth, Frank Rösl, Thomas G Hofmann, Ingo Nind. Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2. PloS one. vol 6. issue 11. 2012-03-26. PMID:22110707. |
hipk2 is an important regulator of apoptosis, which forms a complex with the tumor suppressor p53, mediating p53 phosphorylation at ser 46 and thus promoting pro-apoptotic gene expression. |
2012-03-26 |
2023-08-12 |
human |
| Dorothea Muschik, Ilona Braspenning-Wesch, Eggert Stockfleth, Frank Rösl, Thomas G Hofmann, Ingo Nind. Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2. PloS one. vol 6. issue 11. 2012-03-26. PMID:22110707. |
thus, cutaneous hpv23 e6 prevents hipk2-mediated p53 ser 46 phosphorylation, which may favour survival of uv-damaged keratinocytes and skin carcinogenesis by apoptosis evasion. |
2012-03-26 |
2023-08-12 |
human |
| Yanzhen Zhu, Yanjun Zen. Electroacupuncture protected pyramidal cells in hippocampal CA1 region of vascular dementia rats by inhibiting the expression of p53 and Noxa. CNS neuroscience & therapeutics. vol 17. issue 6. 2012-03-25. PMID:20950325. |
the aim of this study was to determine whether ea protects pyramidal cells from apoptosis in hippocampus of a vd rat model by inhibiting the expression of p53 and noxa. |
2012-03-25 |
2023-08-12 |
rat |
| Michael G Woo, Kai Xue, Jiayin Liu, Heidi McBride, Benjamin K Tsan. Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking. The Journal of biological chemistry. vol 287. issue 6. 2012-03-25. PMID:22117079. |
here, we present evidence that cddp promotes calpain-mediated parc down-regulation, mitochondrial and nuclear p53 accumulation, and apoptosis in chemosensitive but not resistant ovca cells. |
2012-03-25 |
2023-08-12 |
human |
| Michael G Woo, Kai Xue, Jiayin Liu, Heidi McBride, Benjamin K Tsan. Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking. The Journal of biological chemistry. vol 287. issue 6. 2012-03-25. PMID:22117079. |
the data presented here implicate the regulation of p53 subcellular localization and apoptosis by parc as a contributing factor in cddp resistance in ovca cells and ca(2+)/calpain in parc post-translational processing and chemosensitivity. |
2012-03-25 |
2023-08-12 |
human |