| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Carmela Epistolato, Vittoria Disciglio, Gabriella Livide, Paola Berchialla, Maria Antonietta Mencarelli, Annabella Marozza, Mariangela Amenduni, Theodora Hadjistilianou, Sonia De Francesco, Antonio Acquaviva, Paolo Toti, Francesco Cetta, Francesca Ariani, Mario De Marchi, Alessandra Renieri, Daniela Giachin. p53 Arg72Pro and MDM2 309 SNPs in hereditary retinoblastoma. Journal of human genetics. vol 56. issue 9. 2012-03-09. PMID:21814224. |
the tumor suppressor p53 and its negative regulator mdm2 have crucial roles in a variety of cellular functions such as the control of the cell cycle, senescence, genome stability and apoptosis, and are frequently deregulated in carcinogenesis. |
2012-03-09 |
2023-08-12 |
Not clear |
| Ye-Ming J Sun, Theresa Hoang, Judith A Neubauer, Arthur S Walter. Opioids protect against substantia nigra cell degeneration under conditions of iron deprivation: a mechanism of possible relevance to the Restless Legs Syndrome (RLS) and Parkinson's disease. Journal of the neurological sciences. vol 304. issue 1-2. 2012-03-06. PMID:21376342. |
our previous studies indicate that the dna-damage induced apoptosis family gene p53 is activated in this model and that pre-exposure to dadle prevents this activation. |
2012-03-06 |
2023-08-12 |
rat |
| J H Jung, S Bae, J Y Lee, S R Woo, H J Cha, Y Yoon, K-S Suh, S-J Lee, I-C Park, Y-W Jin, K-H Lee, S An, J H Le. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. Cell death and differentiation. vol 18. issue 12. 2012-03-06. PMID:21597459. |
following dna damage, p53 translocates to the cytoplasm and mitochondria, where it triggers transcription-independent apoptosis by binding to bcl-2 family proteins. |
2012-03-06 |
2023-08-12 |
Not clear |
| J R Matthews, O J Sansom, A R Clark. Absolute requirement for STAT3 function in small-intestine crypt stem cell survival. Cell death and differentiation. vol 18. issue 12. 2012-03-06. PMID:21637293. |
rapid clearance of recombined stat3(fl/-) cells involves apoptosis potentially induced by elevated c-myc in non-recombined cells and involves elevated p53 expression and caspase 3 activation. |
2012-03-06 |
2023-08-12 |
mouse |
| Guifen He, Qian Wang, Yuqi Zhou, Xiaohua Wu, Lan Wang, Nadire Duru, Xiangtao Kong, Pingzhao Zhang, Bo Wan, Long Sui, Qisang Guo, Jian-Jian Li, Long Y. YY1 is a novel potential therapeutic target for the treatment of HPV infection-induced cervical cancer by arsenic trioxide. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 21. issue 6. 2012-03-06. PMID:21792014. |
here we sought to determine whether yy1 is upregulated in the cervical cancer tissues and yy1 inhibition contributes to apoptosis of cervical cancer cells, which is at least partly p53 dependent. |
2012-03-06 |
2023-08-12 |
human |
| Kyu Yeoun Won, Sung-Jig Lim, Gou Young Kim, Youn Wha Kim, Sang-Ah Han, Jeong Yoon Song, Dong-Ki Le. Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer. Human pathology. vol 43. issue 2. 2012-03-06. PMID:21820150. |
the results of recent studies have indicated that p53, the most commonly mutated tumor suppressor gene, may have important functions in the regulation of energy-generating metabolic pathways that switch from oxidative phosphorylation to glycolysis via the synthesis of cytochrome c oxidase 2 (sco2), p53-transactivated tp53-induced glycolysis (tigar), and apoptosis regulator. |
2012-03-06 |
2023-08-12 |
human |
| Charles C Weige, Kimberly F Allred, Cameron M Armstrong, Clinton D Allre. P53 mediates estradiol induced activation of apoptosis and DNA repair in non-malignant colonocytes. The Journal of steroid biochemistry and molecular biology. vol 128. issue 3-5. 2012-03-06. PMID:22100717. |
p53 mediates estradiol induced activation of apoptosis and dna repair in non-malignant colonocytes. |
2012-03-06 |
2023-08-12 |
mouse |
| Charles C Weige, Kimberly F Allred, Cameron M Armstrong, Clinton D Allre. P53 mediates estradiol induced activation of apoptosis and DNA repair in non-malignant colonocytes. The Journal of steroid biochemistry and molecular biology. vol 128. issue 3-5. 2012-03-06. PMID:22100717. |
the p53 protein plays a crucial role in the cellular response to stress by inducing cell cycle arrest, dna repair mechanisms, and/or apoptosis. |
2012-03-06 |
2023-08-12 |
mouse |
| Charles C Weige, Kimberly F Allred, Cameron M Armstrong, Clinton D Allre. P53 mediates estradiol induced activation of apoptosis and DNA repair in non-malignant colonocytes. The Journal of steroid biochemistry and molecular biology. vol 128. issue 3-5. 2012-03-06. PMID:22100717. |
due to the observed induction of apoptosis in response to e₂, we are investigating the role of p53 in this chemo-protective mechanism. |
2012-03-06 |
2023-08-12 |
mouse |
| Charles C Weige, Kimberly F Allred, Cameron M Armstrong, Clinton D Allre. P53 mediates estradiol induced activation of apoptosis and DNA repair in non-malignant colonocytes. The Journal of steroid biochemistry and molecular biology. vol 128. issue 3-5. 2012-03-06. PMID:22100717. |
e₂ suppressed growth of young adult mouse colonocytes (yamcs) by inducing apoptosis and these physiological responses were completely lost in yamcs lacking a functional p53 protein. |
2012-03-06 |
2023-08-12 |
mouse |
| Rehan Khan, Abdul Quaiyoom Khan, Wajhul Qamar, Abdul Lateef, Mir Tahir, Muneeb U Rehman, Farrah Ali, Sarwat Sultan. Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. Toxicology and applied pharmacology. vol 258. issue 3. 2012-03-06. PMID:22155348. |
toxicity via amelioration of oxidative stress and apoptosis: probable role of p38mapk and p53. |
2012-03-06 |
2023-08-12 |
rat |
| Rehan Khan, Abdul Quaiyoom Khan, Wajhul Qamar, Abdul Lateef, Mir Tahir, Muneeb U Rehman, Farrah Ali, Sarwat Sultan. Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. Toxicology and applied pharmacology. vol 258. issue 3. 2012-03-06. PMID:22155348. |
the plausible mechanism of cddp-induced colon toxicity and damage includes oxidative stress, activation of p38mapk and p53, and colonic epithelial cell apoptosis via upregulating the expression of bak and cleaved caspase-3. |
2012-03-06 |
2023-08-12 |
rat |
| C Lo Nigro, D Vivenza, M Monteverde, L Lattanzio, O Gojis, O Garrone, A Comino, M Merlano, P R Quinlan, N Syed, C A Purdie, A Thompson, C Palmieri, T Croo. High frequency of complex TP53 mutations in CNS metastases from breast cancer. British journal of cancer. vol 106. issue 2. 2012-03-02. PMID:22187033. |
alteration of p53 may contribute to malignant progression by abrogation of apoptosis induced by oncogene activation and by acquisition of gain-of-function properties, which promote tumour aggression. |
2012-03-02 |
2023-08-12 |
Not clear |
| James N Tsoporis, Forough Mohammadzadeh, Thomas G Parke. S100B: a multifunctional role in cardiovascular pathophysiology. Amino acids. vol 41. issue 4. 2012-03-01. PMID:20204434. |
s100b induces apoptosis by an extracellular mechanism by interacting with the receptor for advanced glycation end products and activating erk1/2 and p53 signaling. |
2012-03-01 |
2023-08-12 |
mouse |
| R Gatta, D Dolfini, R Mantovan. NF-Y joins E2Fs, p53 and other stress transcription factors at the apoptosis table. Cell death & disease. vol 2. 2012-03-01. PMID:21614092. |
nf-y joins e2fs, p53 and other stress transcription factors at the apoptosis table. |
2012-03-01 |
2023-08-12 |
Not clear |
| Aurélie Perraud, Hussein Akil, Michelle Nouaille, Daniel Petit, François Labrousse, Marie-Odile Jauberteau, Muriel Mathonne. Expression of p53 and DR5 in normal and malignant tissues of colorectal cancer: correlation with advanced stages. Oncology reports. vol 26. issue 5. 2012-03-01. PMID:21805040. |
tissues of 82 patients treated for colorectal cancer (crc) were analyzed using antibodies against aif, p53, dr4, dr5, cleaved caspase-3 and the tunel method to detect apoptosis; whereas staining of ki-67 was used as a proliferation marker. |
2012-03-01 |
2023-08-12 |
Not clear |
| Fieke Lamers, Ida van der Ploeg, Linda Schild, Marli E Ebus, Jan Koster, Bo R Hansen, Troels Koch, Rogier Versteeg, Huib N Caron, Jan J Molenaa. Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe. Endocrine-related cancer. vol 18. issue 6. 2012-03-01. PMID:21859926. |
immunofluorescence analysis of neuroblastoma cells after birc5 silencing showed formation of multinucleated cells indicating mitotic catastrophe, which leads to apoptosis via p53 and casp2. |
2012-03-01 |
2023-08-12 |
Not clear |
| Fieke Lamers, Ida van der Ploeg, Linda Schild, Marli E Ebus, Jan Koster, Bo R Hansen, Troels Koch, Rogier Versteeg, Huib N Caron, Jan J Molenaa. Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe. Endocrine-related cancer. vol 18. issue 6. 2012-03-01. PMID:21859926. |
we show that birc5 silencing indeed resulted in activation of p53 and we could rescue apoptosis by casp2 inhibition. |
2012-03-01 |
2023-08-12 |
Not clear |
| Deniz M Özata, Stefano Caramuta, David Velázquez-Fernández, Pinar Akçakaya, Hong Xie, Anders Höög, Jan Zedenius, Martin Bäckdahl, Catharina Larsson, Weng-Onn Lu. The role of microRNA deregulation in the pathogenesis of adrenocortical carcinoma. Endocrine-related cancer. vol 18. issue 6. 2012-03-01. PMID:21859927. |
protein expression of p53 upregulated modulator of apoptosis (puma), a potential target of mir-483-3p, was significantly decreased in acc, and inversely correlated with mir-483-3p expression. |
2012-03-01 |
2023-08-12 |
human |
| Anjani Kumar, Naveen Kumar Vishvakarma, Abhishek Tyagi, Alok Chandra Bharti, Sukh Mahendra Sing. Anti-neoplastic action of aspirin against a T-cell lymphoma involves an alteration in the tumour microenvironment and regulation of tumour cell survival. Bioscience reports. vol 32. issue 1. 2012-02-29. PMID:21692746. |
tumour cells obtained from aspirin-treated tumour-bearing mice demonstrated an altered expression of ph regulators monocarboxylate transporter-1 and v-atpase along with alteration in the level of cell survival regulatory molecules such as survivin, vascular endothelial growth factor, heat-shock protein 70, glucose transporter-1, socs-5 (suppressor of cytokine signalling-5), hif-1α (hypoxia-inducible factor-1α) and puma (p53 up-regulated modulator of apoptosis). |
2012-02-29 |
2023-08-12 |
mouse |