| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Na Li, Yangyan He, Ling Wang, Chunfen Mo, Jie Zhang, Wei Zhang, Junhong Li, Zhiyong Liao, Xiaoqiang Tang, Hengyi Xia. D-galactose induces necroptotic cell death in neuroblastoma cell lines. Journal of cellular biochemistry. vol 112. issue 12. 2012-04-06. PMID:21826710. |
d-gal treatment can transcriptionally up-regulate the genes relevant to necroptosis (bmf, bnip3) and autophagy (atg5, tigar) but not the genes related to apoptosis (caspase3, bax, and p53). |
2012-04-06 |
2023-08-12 |
Not clear |
| Pei-Ming Yang, Ho-Hsing Tseng, Chih-Wen Peng, Wen-Shu Chen, Shu-Jun Chi. Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy. International journal of oncology. vol 40. issue 2. 2012-04-06. PMID:21922137. |
although p53 was also activated by fisetin, the fisetin-induced apoptosis was not rescued by the p53 inhibitor pifithrin-α. |
2012-04-06 |
2023-08-12 |
human |
| Yuedan Zhou, Enming Zhang, Christine Berggreen, Xingjun Jing, Peter Osmark, Stefan Lang, Corrado M Cilio, Olga Göransson, Leif Groop, Erik Renström, Ola Hansso. Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway. Human molecular genetics. vol 21. issue 1. 2012-04-06. PMID:21965303. |
sirna-mediated reduction in tcf7l2 activity resulted in increased apoptosis and increased expression of tp53, which resulted in elevated p53 protein activity and an increased expression of the p53 target gene tp53inp1 (encoding p53-induced-nuclear-protein 1). |
2012-04-06 |
2023-08-12 |
rat |
| Qiliang Cai, Yi Guo, Bingyi Xiao, Shuvomoy Banerjee, Abhik Saha, Jie Lu, Tina Glisovic, Erle S Robertso. Epstein-Barr virus nuclear antigen 3C stabilizes Gemin3 to block p53-mediated apoptosis. PLoS pathogens. vol 7. issue 12. 2012-04-06. PMID:22174681. |
small hairpin rna based knockdown of gemin3 in b lymphoma or lcl cells remarkably attenuates the ability of ebna3c to inhibit the transcription activity of p53 on its downstream genes p21 and bax, as well as apoptosis. |
2012-04-06 |
2023-08-12 |
human |
| Karima Rjiba-Touati, Imen Ayed-Boussema, Chayma Bouaziz, Anis Belarbia, Awatef Azzabi, Abdelatif Achour, Wafa Hassen, Hassen Bach. Protective effect of erythropoietin against cisplatin-induced nephrotoxicity in rats: antigenotoxic and antiapoptotic effect. Drug and chemical toxicology. vol 35. issue 1. 2012-04-05. PMID:21834728. |
apoptosis was revealed by an enhancement of proapoptotic protein (e.g., p53 and bax) levels, decrease in antiapoptotic proteins (e.g., bcl2 and hsp27), and increase in caspase-3 activity. |
2012-04-05 |
2023-08-12 |
rat |
| Wan-li Wei, Hong-yan Hu, Li-juan Zhang, Yun Chen, En Ye, Xiao-fang Wan. [Promoter methylation of ASPP1 and ASPP2 genes in non-small cell lung cancers]. Zhonghua bing li xue za zhi = Chinese journal of pathology. vol 40. issue 8. 2012-04-05. PMID:22169642. |
to investigate the methylation status of cpg islands in the promoter region and the protein expression of aspp1 and aspp2 genes in non-small-cell lung cancer (nsclc) and their relationship with cellular apoptosis and p53 gene expression. |
2012-04-05 |
2023-08-12 |
Not clear |
| Young-Ah Suh, Sean M Post, Ana C Elizondo-Fraire, Daniela R Maccio, James G Jackson, Adel K El-Naggar, Carolyn Van Pelt, Tamara Terzian, Guillermina Lozan. Multiple stress signals activate mutant p53 in vivo. Cancer research. vol 71. issue 23. 2012-04-04. PMID:21983037. |
in response to stress, p53 is released from its negative regulators, mainly murine double minute 2 (mdm2), allowing p53 to be stabilized to activate cell-cycle arrest, senescence, and apoptosis programs. |
2012-04-04 |
2023-08-12 |
mouse |
| Shanqin Xu, Bingbing Jiang, Xiuyun Hou, Chaomei Shi, Markus M Bachschmid, Mengwei Zang, Tony J Verbeuren, Richard A Cohe. High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice. Journal of cardiovascular pharmacology. vol 58. issue 3. 2012-04-03. PMID:21654327. |
our purpose was to determine if high-fat diet and treatment with a polyphenol regulate the acetylation of lysine-382 of p53, the site regulated by sirtuin-1, and apoptosis in the endothelium of the atherosclerotic lesion-prone mouse aortic arch. |
2012-04-03 |
2023-08-12 |
mouse |
| Shanqin Xu, Bingbing Jiang, Xiuyun Hou, Chaomei Shi, Markus M Bachschmid, Mengwei Zang, Tony J Verbeuren, Richard A Cohe. High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice. Journal of cardiovascular pharmacology. vol 58. issue 3. 2012-04-03. PMID:21654327. |
these results indicate that high-fat diet increases and s17834 decreases the acetylation of p53 in lesion-prone aortic endothelial cells of normal mice independently of blood lipids, suggesting that the polyphenol may regulate endothelial cell p53 acetylation and apoptosis via local actions. |
2012-04-03 |
2023-08-12 |
mouse |
| Bridget C O'Connor, Erica L Macke, Catherine E Keega. Additive effect of TAp63 deficiency on the adrenocortical dysplasia (acd) phenotype. Mammalian genome : official journal of the International Mammalian Genome Society. vol 22. issue 11-12. 2012-04-03. PMID:22038471. |
we previously showed that apoptosis is the primary mechanism causing the acd skeletal phenotype, and that p53 deficiency rescues the skeletal defects of the acd phenotype but has no effect on the perinatal lethality. |
2012-04-03 |
2023-08-12 |
mouse |
| Gerd Bungartz, Hannah Land, David T Scadden, Stephen G Emerso. NF-Y is necessary for hematopoietic stem cell proliferation and survival. Blood. vol 119. issue 6. 2012-04-03. PMID:22072554. |
these defects are accompanied by the dysregulation of multiple genes that influence cell cycle control (cyclin b1 and p21), apoptosis (bcl-2), and self-renewal (hoxb4, notch1, bmi-1) and are independent of p53. |
2012-04-03 |
2023-08-12 |
mouse |
| Raja Mokdad-Gargouri, Salma Abdelmoula-Soussi, Nadia Hadiji-Abbès, Ines Yacoubi-Hadj Amor, Istabrak Borchani-Chabchoub, Ali Gargour. Yeasts as a tool for heterologous gene expression. Methods in molecular biology (Clifton, N.J.). vol 824. 2012-04-03. PMID:22160908. |
besides the production as a goal of both expressions, we also report on an unexpected result that has occurred in s. cerevisiae: the overexpression of human p53 induces yeast cell death with characteristic markers of apoptosis, such as the externalization of phosphatidylserines and dna strand cleavage. |
2012-04-03 |
2023-08-12 |
human |
| Fanglin Zhang, Yaping Shi, Lily Wang, Subramaniam Srira. Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis. PloS one. vol 6. issue 2. 2012-04-02. PMID:21346816. |
role of hdac3 on p53 expression and apoptosis in t cells of patients with multiple sclerosis. |
2012-04-02 |
2023-08-12 |
Not clear |
| Tingting Zhang, Yanping Gao, Yu Mao, Quanbo Zhang, Caiyu Lin, Ping Lin, Jie Zhang, Xiujie Wan. Growth inhibition and apoptotic effect of alpha-eleostearic acid on human breast cancer cells. Journal of natural medicines. vol 66. issue 1. 2012-04-02. PMID:21691836. |
the mechanism for such effects might be associated with the inhibition of dna synthesis, induction of apoptosis, and cell cycle arrest of cancer cells through up-regulation of pparγ, p21, bax, p53, and caspase-3 expressions. |
2012-04-02 |
2023-08-12 |
human |
| Tobias Sperka, Zhangfa Song, Yohei Morita, Kodandaramireddy Nalapareddy, Luis Miguel Guachalla, André Lechel, Yvonne Begus-Nahrmann, Martin D Burkhalter, Monika Mach, Falk Schlaudraff, Birgit Liss, Zhenyu Ju, Michael R Speicher, K Lenhard Rudolp. Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction. Nature cell biology. vol 14. issue 1. 2012-04-02. PMID:22138576. |
the tumour suppressor p53 activates puma-dependent apoptosis and p21-dependent cell-cycle arrest in response to dna damage. |
2012-04-02 |
2023-08-12 |
mouse |
| Praphulla C Shukla, Krishna K Singh, Adrian Quan, Mohammed Al-Omran, Hwee Teoh, Fina Lovren, Liu Cao, Ilsa I Rovira, Yi Pan, Christine Brezden-Masley, Bobby Yanagawa, Aanika Gupta, Chu-Xia Deng, John G Coles, Howard Leong-Poi, William L Stanford, Thomas G Parker, Michael D Schneider, Toren Finkel, Subodh Verm. BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nature communications. vol 2. 2012-04-02. PMID:22186889. |
mechanistically, loss of cardiomyocyte brca1 results in impaired dna double-strand break repair and activated p53-mediated pro-apoptotic signalling culminating in increased cardiomyocyte apoptosis, whereas deletion of the p53 gene rescues brca1-deficient mice from cardiac failure. |
2012-04-02 |
2023-08-12 |
mouse |
| Fang Wang, Hongli Li, Haoying Shi, Baogui Su. Pro-apoptotic role of nuclear factor-κB in adriamycin-induced acute myocardial injury in rats. Molecular medicine reports. vol 5. issue 2. 2012-03-30. PMID:22011862. |
myocardial apoptosis was detected by tunel assay; myocardium p53 gene expression was examined by rt-pcr analysis; location and distribution of p53 was observed by immunohistochemical assay; myocardial expression of p53 protein was assessed by western blot analysis and activity of nf-κb was evaluated by electrophoretic mobility shift assay. |
2012-03-30 |
2023-08-12 |
rat |
| Petros C Papagiorgis, Adamantia E Zizi, Sophia Tseleni, Ioannis N Oikonomakis, Leonidas Sofras, Efstratios Patsouris, Nikolaos I Nikitea. Disparate clinicopathological correlations of p53 and Bcl-2 in colorectal cancer. Molecular medicine reports. vol 5. issue 2. 2012-03-30. PMID:22143931. |
p53 and bcl-2 (both regulators of cell apoptosis) have been considered to be involved in the initiation and progression of the colorectal tumorigenic process, respectively. |
2012-03-30 |
2023-08-12 |
Not clear |
| Teng Ma, Shumpei Yamada, Solachuddin J A Ichwan, Sachiko Iseki, Kiyoshi Ohtani, Megumi Otsu, Masa-Aki Iked. Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation. Biochemical and biophysical research communications. vol 417. issue 3. 2012-03-30. PMID:22166212. |
phosphorylation of p53 at ser46 (p53ser46) is considered to be a crucial modification regulating p53-mediated apoptosis. |
2012-03-30 |
2023-08-12 |
human |
| Teng Ma, Shumpei Yamada, Solachuddin J A Ichwan, Sachiko Iseki, Kiyoshi Ohtani, Megumi Otsu, Masa-Aki Iked. Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation. Biochemical and biophysical research communications. vol 417. issue 3. 2012-03-30. PMID:22166212. |
although controversial, nutlin-3 was shown to induce p53-mediated apoptosis in a manner independent of p53 phosphorylation. |
2012-03-30 |
2023-08-12 |
human |