| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Woo Jae Kim, Miguel N Rivera, Erik J Coffman, Daniel A Habe. The WTX tumor suppressor enhances p53 acetylation by CBP/p300. Molecular cell. vol 45. issue 5. 2012-05-07. PMID:22285752. |
in p53-reconstitution experiments, cell-cycle arrest, apoptosis, and p53 target-gene expression are suppressed by depletion of wtx. |
2012-05-07 |
2023-08-12 |
Not clear |
| Kun-Hung Shen, En-Shyh Lin, Po-Lin Kuo, Chung-Yi Chen, Ya-Ling Hs. Isolinderanolide B, a butanolide extracted from the stems of Cinnamomum subavenium, inhibits proliferation of T24 human bladder cancer cells by blocking cell cycle progression and inducing apoptosis. Integrative cancer therapies. vol 10. issue 4. 2012-05-04. PMID:21196431. |
to identity the anticancer mechanism of iob, its effect on apoptosis, cell cycle distribution, and levels of p53, p21 waf1/cip1, fas/apo-1 receptor, and fas ligand was assayed. |
2012-05-04 |
2023-08-12 |
human |
| Ashley J Vargas, Sivanandane Sittadjody, Thilakavathy Thangasamy, Erin E Mendoza, Kirsten H Limesand, Randy Bur. Exploiting tyrosinase expression and activity in melanocytic tumors: quercetin and the central role of p53. Integrative cancer therapies. vol 10. issue 4. 2012-05-04. PMID:21196432. |
two pathways are proposed for exploiting tyrosinase expression: (a) a p53-dependent pathway leading to apoptosis or arrest and (b) a reactive oxygen species-mediated induction of endoplasmic reticulum stress in p53 mutant tumors. |
2012-05-04 |
2023-08-12 |
Not clear |
| Rosa Linda Messina, Mariangela Sanfilippo, Veronica Vella, Giuseppe Pandini, Paolo Vigneri, Maria Luisa Nicolosi, Fiorenza Gianì, Riccardo Vigneri, Francesco Frasc. Reactivation of p53 mutants by prima-1 [corrected] in thyroid cancer cells. International journal of cancer. vol 130. issue 10. 2012-05-04. PMID:21647879. |
p53 reactivation and induction of massive apoptosis (prima-1) is a compound restoring the tumor-suppressor activity of p53 mutants. |
2012-05-04 |
2023-08-12 |
Not clear |
| Wen-Tan Huang, Praveen K Vayalil, Toshio Miyata, James Hagood, Rui-Ming Li. Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis. American journal of respiratory cell and molecular biology. vol 46. issue 1. 2012-05-03. PMID:21852684. |
furthermore, we show that tm5275 induced apoptosis in both myofibroblasts (tgf-β1-treated) and naive (tgf-β1-untreated) human lung fibroblasts, and this apoptosis was associated with the activation of caspase-3/7, the induction of p53, and the inhibition of α-smooth muscle actin, fibronectin, and pai-1 expression. |
2012-05-03 |
2023-08-12 |
mouse |
| Tingzhe Sun, Weiwei Yang, Jing Liu, Pingping She. Modeling the basal dynamics of p53 system. PloS one. vol 6. issue 11. 2012-05-03. PMID:22114721. |
once activated by stress, p53 leads to cellular responses such as cell cycle arrest and apoptosis. |
2012-05-03 |
2023-08-12 |
Not clear |
| Youngsoo Lee, Erin R P Shull, Pierre-Olivier Frappart, Sachin Katyal, Vanessa Enriquez-Rios, Jingfeng Zhao, Helen R Russell, Eric J Brown, Peter J McKinno. ATR maintains select progenitors during nervous system development. The EMBO journal. vol 31. issue 5. 2012-05-03. PMID:22266795. |
whereas the atr-deficient embryonic cerebellar external germinal layer underwent p53- (and p16(ink4a/arf))-independent proliferation arrest, other brain regions suffered apoptosis that was partially p53 dependent. |
2012-05-03 |
2023-08-12 |
Not clear |
| Linda Vuong, Shannon M Conley, Muayyad R Al-Ubaid. Expression and role of p53 in the retina. Investigative ophthalmology & visual science. vol 53. issue 3. 2012-05-03. PMID:22427613. |
this activation leads to alterations in target gene expression, giving p53 a regulatory role in diverse cellular functions such as apoptosis, senescence, and cell cycle arrest. |
2012-05-03 |
2023-08-12 |
human |
| Jeong Eun Lee, Jin Sun Kang, In Chul Shin, Soo-Jin Lee, Dong-Hoon Hyun, Kyung Suk Lee, Hyun Chul Ko. Fluazinam-induced apoptosis of SH-SY5Y cells is mediated by p53 and Bcl-2 family proteins. Neurotoxicology. vol 32. issue 6. 2012-05-02. PMID:21907236. |
fluazinam-induced apoptosis of sh-sy5y cells is mediated by p53 and bcl-2 family proteins. |
2012-05-02 |
2023-08-12 |
human |
| Jeong Eun Lee, Jin Sun Kang, In Chul Shin, Soo-Jin Lee, Dong-Hoon Hyun, Kyung Suk Lee, Hyun Chul Ko. Fluazinam-induced apoptosis of SH-SY5Y cells is mediated by p53 and Bcl-2 family proteins. Neurotoxicology. vol 32. issue 6. 2012-05-02. PMID:21907236. |
we showed that neuronal cell death in response to fzn was due to apoptosis because fzn increased cytochrome c release into the cytosol and activated caspase-3 through the accumulation of p53. |
2012-05-02 |
2023-08-12 |
human |
| Meenakshi Umar, Rohit Upadhyay, Rohini Khurana, Shaleen Kumar, Uday Chand Ghoshal, Balraj Mitta. Role of p53 and p73 genes polymorphisms in susceptibility to esophageal cancer: a case control study in a northern Indian population. Molecular biology reports. vol 39. issue 2. 2012-05-01. PMID:21573788. |
genetic variants in p53 and in its homologue p73 may modulate esophageal cancer (ec) risk because they are supposed to influence cell cycle progression, apoptosis and dna repair. |
2012-05-01 |
2023-08-12 |
human |
| b' Ahmet Taner S\\xc3\\xbcmb\\xc3\\xbcl, Hikmet Akk\\xc4\\xb1z, S\\xc3\\xbcleyman Bayram, Aynur Bekar, Ersin Akg\\xc3\\xb6ll\\xc3\\xbc, Macit Sand\\xc4\\xb1k\\xc3\\xa7\\xc4\\xb. p53 codon 72 polymorphism is associated with susceptibility to hepatocellular carcinoma in the Turkish population: a case-control study. Molecular biology reports. vol 39. issue 2. 2012-05-01. PMID:21607615.' |
the tumor suppressor p53 gene plays a crucial role in preventing carcinogenesis through its ability to induce cell cycle arrest and apoptosis following dna damage and oncogene activation. |
2012-05-01 |
2023-08-12 |
human |
| Lan Wang, Rui Gao, Long Y. Combined analysis of the association between p73 G4C14-to-A4T14 polymorphisms and cancer risk. Molecular biology reports. vol 39. issue 2. 2012-05-01. PMID:21617940. |
p73 is a structural and functional homologue of p53, and plays an important role in regulating cell cycle and apoptosis. |
2012-05-01 |
2023-08-12 |
Not clear |
| Walter Hanel, Ute M Mol. Links between mutant p53 and genomic instability. Journal of cellular biochemistry. vol 113. issue 2. 2012-05-01. PMID:22006292. |
the tumor suppressor p53 has long been known to play a central role in maintaining a stable genome in the face of toxic insults through its role in promoting cell-cycle checkpoints, dna repair, and apoptosis. |
2012-05-01 |
2023-08-12 |
Not clear |
| Salma Abdelmoula-Souissi, Imed Mabrouk, Ali Gargouri, Raja Mokdad-Gargour. Expression of the human tumor suppressor p53 induces cell death in Pichia pastoris. FEMS yeast research. vol 12. issue 1. 2012-04-30. PMID:22093905. |
interestingly, human p53 induces cell death in recombinant strains mut(s) with characteristic markers of apoptosis such as dna fragmentation, exposure of phosphatidylserine, and reactive oxygen species generation. |
2012-04-30 |
2023-08-12 |
human |
| Aaron K Holley, Sanjit Kumar Dhar, Yong Xu, Daret K St Clai. Manganese superoxide dismutase: beyond life and death. Amino acids. vol 42. issue 1. 2012-04-27. PMID:20454814. |
apoptosis is associated with an increase in mitochondrial levels of p53 suggesting a link between mnsod deficiency and mitochondrial-mediated apoptosis. |
2012-04-27 |
2023-08-12 |
mouse |
| Aaron K Holley, Sanjit Kumar Dhar, Yong Xu, Daret K St Clai. Manganese superoxide dismutase: beyond life and death. Amino acids. vol 42. issue 1. 2012-04-27. PMID:20454814. |
thus, p53 translocation to mitochondria and subsequent inactivation of mnsod explain the observed mitochondrial dysfunction that leads to transcription-dependent mechanisms of p53-induced apoptosis. |
2012-04-27 |
2023-08-12 |
mouse |
| Aaron K Holley, Sanjit Kumar Dhar, Yong Xu, Daret K St Clai. Manganese superoxide dismutase: beyond life and death. Amino acids. vol 42. issue 1. 2012-04-27. PMID:20454814. |
administration of mnte-2-pyp(5+) following apoptosis but prior to proliferation leads to suppression of protein carbonyls and reduces the activity of ap-1 and the level of the proliferating cellular nuclear antigen, without reducing the activity of p53 or dna fragmentation following tpa treatment. |
2012-04-27 |
2023-08-12 |
mouse |
| Hankui Chen, Emily Hays, Jay Liboon, Chris Neely, Kevin Kolman, Nalini Chanda. Osteocalcin gene expression is regulated by wild-type p53. Calcified tissue international. vol 89. issue 5. 2012-04-27. PMID:21964930. |
the tumor-suppressor p53 is a transcription factor that regulates a number of genes in the process of cell-cycle inhibition, apoptosis, and dna damage. |
2012-04-27 |
2023-08-12 |
human |
| Yun Hee Kang, Mi-Young Park, Do-Young Yoon, Seung Ro Han, Chung Il Lee, Na Young Ji, Pyung-Keun Myung, Hee Gu Lee, Jae Wha Kim, Young Il Yeom, Ye Jin Jang, Dong Kuk Ahn, Jong Wan Kim, Eun Young Son. Dysregulation of overexpressed IL-32α in hepatocellular carcinoma suppresses cell growth and induces apoptosis through inactivation of NF-κB and Bcl-2. Cancer letters. vol 318. issue 2. 2012-04-27. PMID:22198481. |
furthermore, il-32α suppression in hepatocellular carcinoma decreased expression of phospho-p38 mapk, nf-κb, and antiapoptotic protein bcl-2 and induced expression of proapoptotic proteins as well as p53 and puma resulting in the suppression of cell growth and induction of intrinsic apoptosis. |
2012-04-27 |
2023-08-12 |
Not clear |