| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asghar Ghorbani, Maryam Nazari, Mahmood Jeddi-Tehrani, Hamid Zan. The citrus flavonoid hesperidin induces p53 and inhibits NF-κB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARγ-dependent mechanism. European journal of nutrition. vol 51. issue 1. 2012-06-04. PMID:21445621. |
the citrus flavonoid hesperidin induces p53 and inhibits nf-κb activation in order to trigger apoptosis in nalm-6 cells: involvement of pparγ-dependent mechanism. |
2012-06-04 |
2023-08-12 |
Not clear |
| J W Tyner, A M Jemal, M Thayer, B J Druker, B H Chan. Targeting survivin and p53 in pediatric acute lymphoblastic leukemia. Leukemia. vol 26. issue 4. 2012-06-04. PMID:21960246. |
furthermore, inhibition of survivin increases p53-dependent apoptosis that can be rescued by inhibition of p53. |
2012-06-04 |
2023-08-12 |
Not clear |
| Karam Aboudehen, Sylvia Hilliard, Zubaida Saifudeen, Samir S El-Dah. Mechanisms of p53 activation and physiological relevance in the developing kidney. American journal of physiology. Renal physiology. vol 302. issue 8. 2012-06-04. PMID:22237799. |
p53 activation results in cell cycle arrest and apoptosis. |
2012-06-04 |
2023-08-12 |
Not clear |
| Manujendra N Saha, Hua Jiang, Yijun Yang, Xiaoyun Zhu, Xiaoming Wang, Aaron D Schimmer, Lugui Qiu, Hong Chan. Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma. PloS one. vol 7. issue 1. 2012-06-04. PMID:22276160. |
rita is a small molecule which can induce apoptosis in tumor cells by activating the p53 pathway. |
2012-06-04 |
2023-08-12 |
Not clear |
| Manujendra N Saha, Hua Jiang, Yijun Yang, Xiaoyun Zhu, Xiaoming Wang, Aaron D Schimmer, Lugui Qiu, Hong Chan. Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma. PloS one. vol 7. issue 1. 2012-06-04. PMID:22276160. |
disruption of the jnk signal pathway by small interfering rna (sirna) against jnk or jnk specific inhibitor, sp-600125 inhibited the activation of p53 and attenuated apoptosis induced by rita in myeloma cells carrying wild type p53. |
2012-06-04 |
2023-08-12 |
Not clear |
| Manujendra N Saha, Hua Jiang, Yijun Yang, Xiaoyun Zhu, Xiaoming Wang, Aaron D Schimmer, Lugui Qiu, Hong Chan. Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma. PloS one. vol 7. issue 1. 2012-06-04. PMID:22276160. |
our study unveils a previously undescribed mechanism of rita-induced p53-mediated apoptosis through jnk signaling pathway and provides the rationale for combination of p53 activating drugs with jnk activators in the treatment of mm. |
2012-06-04 |
2023-08-12 |
Not clear |
| Lifeng Zhang, Eric Pang, Rachel R Ogorzalek Loo, Jianyu Rao, Vay-Liang W Go, Joseph A Loo, Qing-Yi L. Concomitant inhibition of HSP90, its mitochondrial localized homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-II cells. Proteomics. vol 11. issue 24. 2012-06-01. PMID:22116673. |
furthermore, we showed that gte inhibited akt activation and the levels of mutant p53 protein, and induced apoptosis and growth suppression of the cells. |
2012-06-01 |
2023-08-12 |
human |
| Yuan-Yuan Hua, Xiao-Shu Wang, Yu Zhang, Chen-Guo Yao, Xi-Ming Zhang, Zheng-Ai Xion. Intense picosecond pulsed electric fields induce apoptosis through a mitochondrial-mediated pathway in HeLa cells. Molecular medicine reports. vol 5. issue 4. 2012-06-01. PMID:22307872. |
in addition, activation of caspase-3, caspase-9, upregulation of bax, p53 and downregulation of bcl-2 were observed in hela cells also indicating apoptosis. |
2012-06-01 |
2023-08-12 |
Not clear |
| Kristen M Livesey, Rui Kang, Philip Vernon, William Buchser, Patricia Loughran, Simon C Watkins, Lin Zhang, James J Manfredi, Herbert J Zeh, Luyuan Li, Michael T Lotze, Daolin Tan. p53/HMGB1 complexes regulate autophagy and apoptosis. Cancer research. vol 72. issue 8. 2012-06-01. PMID:22345153. |
these insights provide a novel link between hmgb1 and p53 in the cross-regulation of apoptosis and autophagy in the setting of cell stress, providing insights into their reciprocal roles in carcinogenesis. |
2012-06-01 |
2023-08-12 |
mouse |
| Zhi-Gang Liu, Li Liu, Li-Hua Xu, Wei Yi, Ya-Lan Tao, Zi-Wei Tu, Man-Zhi Li, Mu-Sheng Zeng, Yun-Fei Xi. Bmi-1 induces radioresistance in MCF-7 mammary carcinoma cells. Oncology reports. vol 27. issue 4. 2012-05-30. PMID:22209830. |
furthermore, bmi-1 knockdown induced loss of mitochondrial membrane potential and enhanced apoptosis by up-regulating p53, p21, bax expression and down-regulating p-akt and bcl-2 expression. |
2012-05-30 |
2023-08-12 |
human |
| Ji-Young Bang, Eung-Yoon Kim, Dong-Ku Kang, Soo-Ik Chang, Moon-Hi Han, Kwang-Hyun Baek, In-Cheol Kan. Pharmacoproteomic analysis of a novel cell-permeable peptide inhibitor of tumor-induced angiogenesis. Molecular & cellular proteomics : MCP. vol 10. issue 8. 2012-05-29. PMID:21558493. |
proteomic analysis via antibody microarray showed up-regulation of p53 in p11-treated huvecs, resulting in induction of apoptosis via activation of caspases-3, -8, and -9. |
2012-05-29 |
2023-08-12 |
human |
| Lili Guo, Min Tang, Lifang Yang, Lanbo Xiao, Ann M Bode, Lili Li, Zigang Dong, Ya Ca. Epstein-Barr virus oncoprotein LMP1 mediates survivin upregulation by p53 contributing to G1/S cell cycle progression in nasopharyngeal carcinoma. International journal of molecular medicine. vol 29. issue 4. 2012-05-29. PMID:22266808. |
we further found that p53 promoted g1/s cell cycle progression, but did not induce apoptosis in lmp1-positive npc cells. |
2012-05-29 |
2023-08-12 |
Not clear |
| Lili Guo, Min Tang, Lifang Yang, Lanbo Xiao, Ann M Bode, Lili Li, Zigang Dong, Ya Ca. Epstein-Barr virus oncoprotein LMP1 mediates survivin upregulation by p53 contributing to G1/S cell cycle progression in nasopharyngeal carcinoma. International journal of molecular medicine. vol 29. issue 4. 2012-05-29. PMID:22266808. |
collectively, these findings suggest that p53 acting as a transcription factor promotes the transcriptional activity of survivin, and further increases its protein expression and phosphorylation in the regulation of lmp1, thus, leading to g1/s cell cycle progression with no effect on apoptosis in npc tumorigenesis. |
2012-05-29 |
2023-08-12 |
Not clear |
| Feng-Hou Gao, Feng Liu, Wei Wei, Li-Bin Liu, Mang-Hua Xu, Zhu-Ying Guo, Wei Li, Bin Jiang, Ying-Li W. Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells. International journal of molecular medicine. vol 29. issue 4. 2012-05-29. PMID:22294162. |
n-acetylcysteine, a reactive oxygen species scavenger, not only blocked the oridonin-induced increase in hydrogen peroxide and glutathione depletion, but also blocked apoptosis and senescence induced by oridonin, as evidenced by the decrease in annexin v and senescence-associated β-galactosidase- positive cells and the inhibition of oridonin-induced upregulation of p53 and p16 and downregulation of c-myc. |
2012-05-29 |
2023-08-12 |
Not clear |
| Xiuzhen Han, Baoshan Xu, Christopher S Beevers, Yoshinobu Odaka, Long Chen, Lei Liu, Yan Luo, Hongyu Zhou, Wenxing Chen, Tao Shen, Shile Huan. Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells. Carcinogenesis. vol 33. issue 4. 2012-05-29. PMID:22298641. |
here, we show that curcumin-induced apoptosis in a panel of tumor cells with mutant p53. |
2012-05-29 |
2023-08-12 |
Not clear |
| Jérome Estaquier, François Vallette, Jean-Luc Vayssiere, Bernard Mignott. The mitochondrial pathways of apoptosis. Advances in experimental medicine and biology. vol 942. 2012-05-29. PMID:22399422. |
in this chapter, we present the current view on the mitochondrial pathway of apoptosis with a particular attention to new aspects of the regulation of the bcl-2 proteins family control of mitochondrial membrane permeabilization: the mechanisms implicated in their mitochondrial targeting and activation during apoptosis, the function(s) of the oncosuppressive protein p53 at the mitochondria and the role of the processes of mitochondrial fusion and fission. |
2012-05-29 |
2023-08-12 |
drosophila_melanogaster |
| So Young Park, Mi Suk Jeong, Se Bok Jan. In vitro binding properties of tumor suppressor p53 with PUMA and NOXA. Biochemical and biophysical research communications. vol 420. issue 2. 2012-05-25. PMID:22446329. |
tumor suppressor p53 induces apoptosis by transcriptional induction of puma and noxa, which encode proapoptotic bh3-only member bcl-1 family proteins. |
2012-05-25 |
2023-08-12 |
human |
| Laura Masuelli, Laura Marzocchella, Chiara Focaccetti, Ilaria Tresoldi, Camilla Palumbo, Valerio Izzi, Monica Benvenuto, Massimo Fantini, Florigio Lista, Umberto Tarantino, Andrea Modesti, Fabio Galvano, Roberto Be. Resveratrol and diallyl disulfide enhance curcumin-induced sarcoma cell apoptosis. Frontiers in bioscience (Landmark edition). vol 17. 2012-05-24. PMID:22201757. |
further, we explored the effects of the compounds, alone or in combination, on signal transduction pathways involved in apoptosis and growth of cancer cells and show that in rhabdomyosarcoma cells the apoptotic effect of cur, either alone or in combination, is independent of p53 activity. |
2012-05-24 |
2023-08-12 |
Not clear |
| Hongyan Zhu, Keyong Li, Jiren Liang, Jie Zhang, Qing W. Changes in the levels of DNA methylation in testis and liver of SD rats neonatally exposed to 5-aza-2'-deoxycytidine and cadmium. Journal of applied toxicology : JAT. vol 31. issue 5. 2012-05-22. PMID:21449042. |
we observed increased apoptosis and an increase in the p53 mrna level, accompanied by a decreased dna methylation level in the p53 gene promoter region, at day 8 pp in testis for the 5-aza-cdr-exposed groups but not in the cd-exposed group. |
2012-05-22 |
2023-08-12 |
rat |
| Duthika M Mallawaaratchy, Swetlana Mactier, Kimberley L Kaufman, Katherine Blomfield, Richard I Christopherso. The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells. Journal of proteomics. vol 75. issue 5. 2012-05-22. PMID:22172953. |
ly294002 increased cytosolic p53 with a concomitant decrease in nuclear p53, suggesting transfer of p53 to the cytosol where apoptosis might be initiated via the intrinsic mitochondrial pathway. |
2012-05-22 |
2023-08-12 |
human |