| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prema S Rao, Arun Satelli, Majid Moridani, Marjorie Jenkins, U Subrahmanyeswara Ra. Luteolin induces apoptosis in multidrug resistant cancer cells without affecting the drug transporter function: involvement of cell line-specific apoptotic mechanisms. International journal of cancer. vol 130. issue 11. 2012-05-11. PMID:21792893. |
analysis of various proliferative signaling pathways indicated that luteolin-induced apoptosis involves reactive oxygen species generation, dna damage, activation of atr → chk2 → p53 signaling pathway, inhibition of nf-kb signaling pathway, activation of p38 pathway and depletion of antiapoptotic proteins. |
2012-05-11 |
2023-08-12 |
human |
| Sung Ho Park, Jeong Heon Lee, Gwang-Beom Lee, Hyun-Jung Byun, Boh-Ram Kim, Chan-Yong Park, Hong-Bae Kim, Seung Bae Rh. PDCD6 additively cooperates with anti-cancer drugs through activation of NF-κB pathways. Cellular signalling. vol 24. issue 3. 2012-05-10. PMID:22142513. |
pdcd6 promotes tnfα-dependent apoptosis through the activation of nf-κb signaling pathways, increasing bax, p53, and p21 expression, while also down-regulating bcl-2 and bcl-xl expression. |
2012-05-10 |
2023-08-12 |
Not clear |
| Jonathan C King, Qing-Yi Lu, Gang Li, Aune Moro, Hiroki Takahashi, Monica Chen, Vay Liang W Go, Howard A Reber, Guido Eibl, O Joe Hine. Evidence for activation of mutated p53 by apigenin in human pancreatic cancer. Biochimica et biophysica acta. vol 1823. issue 2. 2012-05-10. PMID:22227579. |
transcription-dependent p53 activity was reversed by pifithrin-α, a specific dna binding inhibitor of p53, but not growth inhibition or apoptosis suggesting transcription-independent p53 activity. |
2012-05-10 |
2023-08-12 |
human |
| Jonathan C King, Qing-Yi Lu, Gang Li, Aune Moro, Hiroki Takahashi, Monica Chen, Vay Liang W Go, Howard A Reber, Guido Eibl, O Joe Hine. Evidence for activation of mutated p53 by apigenin in human pancreatic cancer. Biochimica et biophysica acta. vol 1823. issue 2. 2012-05-10. PMID:22227579. |
cell cycle arrest and apoptosis induction may be mediated by transcription-independent p53 function via interactions with bclxl and puma. |
2012-05-10 |
2023-08-12 |
human |
| D Fouad, F S Ataya, J Muntan. Expression of p53 during apoptosis induced by D-galactosamine and the protective role of PGE1 in cultured rat hepatocytes. Pakistan journal of biological sciences : PJBS. vol 14. issue 21. 2012-05-10. PMID:22514887. |
expression of p53 during apoptosis induced by d-galactosamine and the protective role of pge1 in cultured rat hepatocytes. |
2012-05-10 |
2023-08-12 |
rat |
| D Fouad, F S Ataya, J Muntan. Expression of p53 during apoptosis induced by D-galactosamine and the protective role of PGE1 in cultured rat hepatocytes. Pakistan journal of biological sciences : PJBS. vol 14. issue 21. 2012-05-10. PMID:22514887. |
we examined the change in the expression level of p53 by western blotting in hepatocytes and its effect on apoptosis as a response of treatment with d-galactosamine, prostaglandin e1 and/or the proteosome inhibitor (psi). |
2012-05-10 |
2023-08-12 |
rat |
| J Di, Y Zhang, J Zhen. Reactivation of p53 by inhibiting Mdm2 E3 ligase: a novel antitumor approach. Current cancer drug targets. vol 11. issue 8. 2012-05-09. PMID:21762075. |
the p53 tumor suppressor has been pursued as a cancer therapeutic target based on its ability to induce cell cycle arrest and apoptosis. |
2012-05-09 |
2023-08-12 |
Not clear |
| Raffaella Bosco, Marco Rabusin, Rebecca Voltan, Claudio Celeghini, Federica Corallini, Silvano Capitani, Paola Secchier. Anti-leukemic activity of dasatinib in both p53(wild-type) and p53(mutated) B malignant cells. Investigational new drugs. vol 30. issue 1. 2012-05-08. PMID:20953816. |
the multi-kinase inhibitor dasatinib induced a variable but significant decrease of viability in both p53(wild-type) (eheb, jvm-2, jvm-3) and p53(mutated) (mec-1, mec-2, bjab) prolymphocytic b leukemic cells, due to a combination of cell cycle block in g1 and apoptosis. |
2012-05-08 |
2023-08-12 |
Not clear |
| Srirupa Roy, Gagan Deep, Chapla Agarwal, Rajesh Agarwa. Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45α-dependent manner. Carcinogenesis. vol 33. issue 3. 2012-05-08. PMID:22166495. |
importantly, under p53 and gadd45α knockdown conditions, cells were more susceptible to uvb-induced apoptosis without any significant s phase arrest, and protective effects of silibinin were compromised. |
2012-05-08 |
2023-08-12 |
mouse |
| Kaustubh A Jinturkar, Chakkumkal Anish, Mukesh K Kumar, Tamishraha Bagchi, Amulya K Panda, Ambikanandan R Misr. Liposomal formulations of Etoposide and Docetaxel for p53 mediated enhanced cytotoxicity in lung cancer cell lines. Biomaterials. vol 33. issue 8. 2012-05-08. PMID:22200537. |
the p53 mediated enhanced cytotoxicity by increased apoptosis and necrosis was also confirmed using annexin v - fitc assay. |
2012-05-08 |
2023-08-12 |
Not clear |
| Kaustubh A Jinturkar, Chakkumkal Anish, Mukesh K Kumar, Tamishraha Bagchi, Amulya K Panda, Ambikanandan R Misr. Liposomal formulations of Etoposide and Docetaxel for p53 mediated enhanced cytotoxicity in lung cancer cell lines. Biomaterials. vol 33. issue 8. 2012-05-08. PMID:22200537. |
the increased apoptosis suggested restored p53 function and reduced anti-apoptotic drug resistance theirby causing cell sensitization and synergism towards cytotoxicity. |
2012-05-08 |
2023-08-12 |
Not clear |
| H G Rebel, C A Bodmann, G C van de Glind, F R de Gruij. UV-induced ablation of the epidermal basal layer including p53-mutant clones resets UV carcinogenesis showing squamous cell carcinomas to originate from interfollicular epidermis. Carcinogenesis. vol 33. issue 3. 2012-05-08. PMID:22227037. |
mutated p53 may give cells growth advantage over neighbouring cells by impaired apoptosis. |
2012-05-08 |
2023-08-12 |
mouse |
| Adele Adamo, Alexander Woglar, Nicola Silva, Alexandra Penkner, Verena Jantsch, Adriana La Volp. Transgene-mediated cosuppression and RNA interference enhance germ-line apoptosis in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 9. 2012-05-08. PMID:22331911. |
"silencing-induced apoptosis" is dependent upon sir-2.1 and cep-1 (the worm p53 ortholog), and is accompanied by a rise in rad-51 foci, a marker for ongoing dna repair, indicating induction of dna double-strand breaks. |
2012-05-08 |
2023-08-12 |
caenorhabditis_elegans |
| L D Gamble, U R Kees, D A Tweddle, J Lune. MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63. Oncogene. vol 31. issue 6. 2012-05-07. PMID:21725357. |
we have recently shown that p53 is a direct transcriptional target of mycn in neuroblastoma and that p53-mediated apoptosis may be an important mechanism of mycn-induced apoptosis. |
2012-05-07 |
2023-08-12 |
Not clear |
| L D Gamble, U R Kees, D A Tweddle, J Lune. MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63. Oncogene. vol 31. issue 6. 2012-05-07. PMID:21725357. |
we hypothesized that reactivation of p53 by inhibition of its negative regulator mdm2, using the mdm2-p53 antagonists nutlin-3 and mi-63, will result in p53-mediated growth arrest and apoptosis especially in mycn-amplified cells. |
2012-05-07 |
2023-08-12 |
Not clear |
| L D Gamble, U R Kees, D A Tweddle, J Lune. MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63. Oncogene. vol 31. issue 6. 2012-05-07. PMID:21725357. |
using the shep tet21n mycn-regulatable system, mycn(-) cells were more resistant to both nutlin-3 and mi-63 mediated growth inhibition and apoptosis compared with mycn(+) cells and sirna-mediated knockdown of mycn in four mycn-amplified cell lines resulted in decreased p53 expression and activation, as well as decreased levels of apoptosis following treatment with mdm2-p53 antagonists. |
2012-05-07 |
2023-08-12 |
Not clear |
| Shashi Rajput, Mahitosh Manda. Antitumor promoting potential of selected phytochemicals derived from spices: a review. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). vol 21. issue 2. 2012-05-07. PMID:21876437. |
however, the in-vitro and in-vivo studies in the last few decades have demonstrated that some phytochemicals derived from 'natural products' such as fruits, vegetables and certain spices, referred to as chemopreventive agents, including capsaicin, trans-anethole, thymoquinone, diosgenin, allicin, can not only reduce the risk of acquiring specific cancer but also have been shown to suppress cancer cell proliferation, inhibit growth factor signaling pathways, induce apoptosis, inhibit nuclear factor-κb, ap-1, akt, mapk, wnt, notch, p53, ar, er, and jak-stat, etc., activation pathways, inhibit angiogenesis, suppress the expression of antiapoptotic proteins, and inhibit cyclooxygenase-2. |
2012-05-07 |
2023-08-12 |
Not clear |
| Giuseppina Bonizzi, Angelo Cicalese, Alessandra Insinga, Pier Giuseppe Pelicc. The emerging role of p53 in stem cells. Trends in molecular medicine. vol 18. issue 1. 2012-05-07. PMID:21907001. |
as a tumor suppressor, p53 regulates cellular responses to different stress stimuli by inducing reversible cell cycle arrest and dna repair, or triggering senescence or apoptosis. |
2012-05-07 |
2023-08-12 |
Not clear |
| Lu Zhang, Guangzhou Zhou, Wei Song, Xiaorong Tan, Yuqi Guo, Bo Zhou, Hongjuan Jing, Sujuan Zhao, Liangke Che. Pterostilbene protects vascular endothelial cells against oxidized low-density lipoprotein-induced apoptosis in vitro and in vivo. Apoptosis : an international journal on programmed cell death. vol 17. issue 1. 2012-05-07. PMID:21928089. |
pt may protect huvecs against oxldl-induced apoptosis by downregulating lox-1-mediated activation through a pathway involving oxidative stress, p53, mitochondria, cytochrome c and caspase protease. |
2012-05-07 |
2023-08-12 |
mouse |
| Cheng-Wu Zeng, Xing-Ju Zhang, Kang-Yu Lin, Hua Ye, Shu-Ying Feng, Hua Zhang, Yue-Qin Che. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Molecular pharmacology. vol 81. issue 4. 2012-05-07. PMID:22252650. |
in addition, we demonstrated that cpt induced apoptosis in cancer cells by mir-125b-mediated mitochondrial pathways via targeting to the 3'-untranslated (utr) regions of bak1, mcl1, and p53. |
2012-05-07 |
2023-08-12 |
Not clear |