| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Věra Králová, Soňa Benešová, Miroslav Cervinka, Emil Rudol. Selenite-induced apoptosis and autophagy in colon cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 2. 2012-05-22. PMID:22200533. |
in our previous work we showed differences in se-dependent growth inhibition, cell cycle alterations and apoptosis in colon cancer cells with functional (hct-116) and deleted (hct-116-p53ko) p53. |
2012-05-22 |
2023-08-12 |
Not clear |
| Věra Králová, Soňa Benešová, Miroslav Cervinka, Emil Rudol. Selenite-induced apoptosis and autophagy in colon cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 2. 2012-05-22. PMID:22200533. |
thus the aim of this study was to investigate in detail mechanisms, relationship and crosstalk between apoptosis and autophagy in se-treated hct-116 cancer cells differing in p53 status since p53 has been shown to play a well-known role in apoptosis but dichotomous role in autophagy. |
2012-05-22 |
2023-08-12 |
Not clear |
| Věra Králová, Soňa Benešová, Miroslav Cervinka, Emil Rudol. Selenite-induced apoptosis and autophagy in colon cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 2. 2012-05-22. PMID:22200533. |
we report that the absence of p53 in malignant colonocytes changes patterns of response to se-induced stress which include differential activation of map kinases (p38 - hct-116 and jnk - hct-116 p53ko) including their respective roles in the process of apoptosis and autophagy as well as the involvement of mtor or pi3k signaling. |
2012-05-22 |
2023-08-12 |
Not clear |
| Věra Králová, Soňa Benešová, Miroslav Cervinka, Emil Rudol. Selenite-induced apoptosis and autophagy in colon cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 2. 2012-05-22. PMID:22200533. |
our results seem to suggest that deletion of p53 inevitably leads to a higher level of instability and delays in an individual cell decision in the face of stress whether to activate apoptosis or autophagy which may consequently occur simultaneously with mutual dichotomous relationship. |
2012-05-22 |
2023-08-12 |
Not clear |
| Xiao-Jia Chen, Fei-Die Duan, Hui-Hua Zhang, Yi Xiong, Jin Wan. Sodium selenite-induced apoptosis mediated by ROS attack in human osteosarcoma U2OS cells. Biological trace element research. vol 145. issue 1. 2012-05-21. PMID:21826611. |
sse-induced apoptosis correlated with the activation of casp 3, downregulation of bcl-2, and upregulation of p53 and pten in u2os cells. |
2012-05-21 |
2023-08-12 |
human |
| Jianjian Zhu, Minh-Thanh Nguyen, Eiichiro Nakamura, Junming Yang, Susan Macke. Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway. Genesis (New York, N.Y. : 2000). vol 50. issue 2. 2012-05-21. PMID:21913308. |
cre-mediated recombination can induce apoptosis in vivo by activating the p53 dna damage-induced pathway. |
2012-05-21 |
2023-08-12 |
mouse |
| Jianjian Zhu, Minh-Thanh Nguyen, Eiichiro Nakamura, Junming Yang, Susan Macke. Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway. Genesis (New York, N.Y. : 2000). vol 50. issue 2. 2012-05-21. PMID:21913308. |
cre-induced apoptosis in this context is completely p53-dependent, suggesting that the apoptosis is stimulated by p53 activation in response to dna damage incurred during the process of cre-mediated recombination. |
2012-05-21 |
2023-08-12 |
mouse |
| Chris Zhiyi Zhang, Haitao Zhang, Jingping Yun, George Gong Chen, Paul Bo San La. Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo. Biochemical pharmacology. vol 83. issue 9. 2012-05-21. PMID:22342732. |
furthermore, p53 facilitated apoptosis caused by dha. |
2012-05-21 |
2023-08-12 |
mouse |
| J Robert Chang, Mohammad Ghafouri, Ruma Mukerjee, Asen Bagashev, Tinatin Chabrashvili, Bassel E Saway. Role of p53 in neurodegenerative diseases. Neuro-degenerative diseases. vol 9. issue 2. 2012-05-18. PMID:22042001. |
p53 plays an important role in many areas of cellular physiology and biology, ranging from cellular development and differentiation to cell cycle arrest and apoptosis. |
2012-05-18 |
2023-08-12 |
Not clear |
| J Robert Chang, Mohammad Ghafouri, Ruma Mukerjee, Asen Bagashev, Tinatin Chabrashvili, Bassel E Saway. Role of p53 in neurodegenerative diseases. Neuro-degenerative diseases. vol 9. issue 2. 2012-05-18. PMID:22042001. |
however, since the establishment of its role in cell cycle arrest, damage repair, and apoptosis (thus also establishing its importance in cancer development), numerous reports have demonstrated additional functions of p53 in various cells. |
2012-05-18 |
2023-08-12 |
Not clear |
| Yuan Li, Yue Zhao, Rongrong Jiang, Yuan Xu, Min Ling, Ying Pang, Lu Shen, Yun Zhou, Jianping Zhang, Jianwei Zhou, Xinru Wang, Qizhan Li. DNA-PKcs-mediated stabilization of p53 by JNK2 is involved in arsenite-induced DNA damage and apoptosis in human embryo lung fibroblast cells. Toxicology letters. vol 210. issue 3. 2012-05-18. PMID:22366412. |
dna-pkcs-mediated stabilization of p53 by jnk2 is involved in arsenite-induced dna damage and apoptosis in human embryo lung fibroblast cells. |
2012-05-18 |
2023-08-12 |
human |
| Yuan Li, Yue Zhao, Rongrong Jiang, Yuan Xu, Min Ling, Ying Pang, Lu Shen, Yun Zhou, Jianping Zhang, Jianwei Zhou, Xinru Wang, Qizhan Li. DNA-PKcs-mediated stabilization of p53 by JNK2 is involved in arsenite-induced DNA damage and apoptosis in human embryo lung fibroblast cells. Toxicology letters. vol 210. issue 3. 2012-05-18. PMID:22366412. |
knockdown of dna-pkcs/jnk2 signal pathway or p53 reduces apoptosis but elevates the dna damage induced by a high level of arsenite. |
2012-05-18 |
2023-08-12 |
human |
| Yuan Li, Yue Zhao, Rongrong Jiang, Yuan Xu, Min Ling, Ying Pang, Lu Shen, Yun Zhou, Jianping Zhang, Jianwei Zhou, Xinru Wang, Qizhan Li. DNA-PKcs-mediated stabilization of p53 by JNK2 is involved in arsenite-induced DNA damage and apoptosis in human embryo lung fibroblast cells. Toxicology letters. vol 210. issue 3. 2012-05-18. PMID:22366412. |
these results suggest that dna-pkcs-mediated stabilization of p53 by jnk2 is involved in arsenite-induced dna damage and apoptosis. |
2012-05-18 |
2023-08-12 |
human |
| Junfeng Zhao, Congde Chen, Haochuan Zhang, Jinhui Shen, Hua Zhang, Xiaokun Lin, Le Qin, Xiaozhou Bao, Jie Lin, Wenqiang Lu, Xiangdong Wang, Xiaoming Che. Evaluation of cloned cells, animal model, and ATRA sensitivity of human testicular yolk sac tumor. Journal of translational medicine. vol 10. 2012-05-18. PMID:22410253. |
cisplatin induced apoptosis of tyst cells through the activation of p53 expression and down-regulation of bcl- expression. |
2012-05-18 |
2023-08-12 |
human |
| Peter Raca. Ischaemia-induced protein ubiquitinylation is differentially accompanied with heat-shock protein 70 expression after naïve and preconditioned ischaemia. Cellular and molecular neurobiology. vol 32. issue 1. 2012-05-17. PMID:21789629. |
the elevated level of hsp70 might represent plausible explanation of inhibition of both translocation of p53 to mitochondria and ischaemia-induced apoptosis observed after preconditioned ischaemia. |
2012-05-17 |
2023-08-12 |
rat |
| Reha Yildirimman, Gabriella Brolén, Mireia Vilardell, Gustav Eriksson, Jane Synnergren, Hans Gmuender, Atanas Kamburov, Magnus Ingelman-Sundberg, José Castell, Agustin Lahoz, Jos Kleinjans, Joost van Delft, Petter Björquist, Ralf Herwi. Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicological sciences : an official journal of the Society of Toxicology. vol 124. issue 2. 2012-05-16. PMID:21873647. |
in order to infer mechanistic information on the consequences of chemical exposure in hes-hep, we developed a computational method that measures the responses of biochemical pathways to the panel of treatments and showed that these responses were discriminative for the three toxicity classes and linked to carcinogenesis through p53, mitogen-activated protein kinases, and apoptosis pathway modules. |
2012-05-16 |
2023-08-12 |
human |
| Yuudai Kondo, Kentaro Nagai, Shingo Nakahata, Yusuke Saito, Tomonaga Ichikawa, Akira Suekane, Tomohiko Taki, Reika Iwakawa, Masato Enari, Masafumi Taniwaki, Jun Yokota, Sumio Sakoda, Kazuhiro Morishit. Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation. Cancer science. vol 103. issue 4. 2012-05-16. PMID:22320325. |
the expression of wild-type p53 suppressed cell growth and induced apoptosis via suppression of nuclear factor kappa-light-chain-enhancer of activated b cells activity. |
2012-05-16 |
2023-08-12 |
human |
| Akira Suzuki, Ryunosuke Kogo, Kohichi Kawahara, Masato Sasaki, Miki Nishio, Tomohiko Maehama, Takehiko Sasaki, Koshi Mimori, Masaki Mor. A new PICTure of nucleolar stress. Cancer science. vol 103. issue 4. 2012-05-16. PMID:22320853. |
mdm2-mediated ubiquitination and degradation of the tumor suppressor p53 is then blocked, resulting in p53 accumulation and the induction of p53-dependent cell cycle arrest and apoptosis. |
2012-05-16 |
2023-08-12 |
human |
| Manika P Bhadra, Nobuo Horikoshi, Sreerangam N C V L Pushpavallipvalli, Arpita Sarkar, Indira Bag, Anita Krishnan, John C Lucchesi, Rakesh Kumar, Qin Yang, Raj K Pandita, Mayank Singh, Utpal Bhadra, Joel C Eissenberg, Tej K Pandit. The role of MOF in the ionizing radiation response is conserved in Drosophila melanogaster. Chromosoma. vol 121. issue 1. 2012-05-14. PMID:22072291. |
mutation in drosophila mof also results in a defective mitotic checkpoint, enhanced apoptosis, and a defective p53 response post-irradiation. |
2012-05-14 |
2023-08-12 |
drosophila_melanogaster |
| Valentina Manfè, Edyta Biskup, Anne Rosbjerg, Maria Kamstrup, Anne Guldhammer Skov, Catharina Margrethe Lerche, Britt Thyssing Lauenborg, Niels Odum, Robert Gniadeck. miR-122 regulates p53/Akt signalling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma. PloS one. vol 7. issue 1. 2012-05-14. PMID:22235305. |
surprisingly, mir-122 overexpression decreased the sensitivity to the chemotherapy-induced apoptosis via a signaling circuit involving the activation of akt and inhibition of p53. |
2012-05-14 |
2023-08-12 |
Not clear |