| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bing Zou, Chor S Chim, Roberta Pang, Hui Zeng, Yun Dai, Rongxin Zhang, Colin S C Lam, Victoria P Y Tan, Ivan F N Hung, Hui Y Lan, Benjamin C Y Won. XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification. Molecular carcinogenesis. vol 51. issue 5. 2012-06-13. PMID:21678496. |
the present study was designed to examine the putative interaction between xaf1 and p53 and the functional importance of this interaction in regulation of apoptosis in human gastric and colon cancer cells. |
2012-06-13 |
2023-08-12 |
human |
| Bing Zou, Chor S Chim, Roberta Pang, Hui Zeng, Yun Dai, Rongxin Zhang, Colin S C Lam, Victoria P Y Tan, Ivan F N Hung, Hui Y Lan, Benjamin C Y Won. XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification. Molecular carcinogenesis. vol 51. issue 5. 2012-06-13. PMID:21678496. |
we also found that the over-expression of xaf1 led to activation of wild-type p53 via post-translational modification in cells with or without dna damage, which resulting in p53 nuclear accumulation and its increased transcriptional activity and enhancing p53-dependent apoptosis. |
2012-06-13 |
2023-08-12 |
human |
| Eun-Ryeong Hahm, Shivendra V Sing. Bim contributes to phenethyl isothiocyanate-induced apoptosis in breast cancer cells. Molecular carcinogenesis. vol 51. issue 6. 2012-06-12. PMID:21739479. |
the present study demonstrates that p53 upregulated modulator of apoptosis (puma)-independent apoptosis by peitc is mediated by b-cell lymphoma 2 interacting mediator of cell death (bim). |
2012-06-12 |
2023-08-12 |
mouse |
| Joseph D Jebelli, Claudie Hooper, Gwenn A Garden, Jennifer M Pococ. Emerging roles of p53 in glial cell function in health and disease. Glia. vol 60. issue 4. 2012-06-12. PMID:22105777. |
as a crucial hub connecting many intracellular control pathways, including cell-cycle control and apoptosis, p53 is ideally placed to coordinate the cellular response to a range of stresses. |
2012-06-12 |
2023-08-12 |
Not clear |
| Joseph D Jebelli, Claudie Hooper, Gwenn A Garden, Jennifer M Pococ. Emerging roles of p53 in glial cell function in health and disease. Glia. vol 60. issue 4. 2012-06-12. PMID:22105777. |
although neurodegenerative diseases each display a distinct and diverse molecular pathology, apoptosis is a widespread hallmark feature and the multimodal capacity of the p53 system to orchestrate apoptosis and glial cell behavior highlights p53 as a potential unifying target for therapeutic intervention in neurodegeneration. |
2012-06-12 |
2023-08-12 |
Not clear |
| Zijun Y Xu-Monette, L Jeffrey Medeiros, Yong Li, Robert Z Orlowski, Michael Andreeff, Carlos E Bueso-Ramos, Timothy C Greiner, Timothy J McDonnell, Ken H Youn. Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies. Blood. vol 119. issue 16. 2012-06-12. PMID:22275381. |
tumor suppression by p53 occurs via both transcription-dependent activities in the nucleus by which p53 regulates transcription of genes involved in cell cycle, dna repair, apoptosis, signaling, transcription, and metabolism; and transcription-independent activities that induces apoptosis and autophagy in the cytoplasm. |
2012-06-12 |
2023-08-12 |
human |
| Thomas Aschacher, Sandra Sampl, Lisa Käser, David Bernhard, Andreas Spittler, Klaus Holzmann, Michael Bergman. The combined use of known antiviral reverse transcriptase inhibitors AZT and DDI induce anticancer effects at low concentrations. Neoplasia (New York, N.Y.). vol 14. issue 1. 2012-06-12. PMID:22355273. |
treatment of cells with both rti, but not with single rti, led to a significant accumulation of γh2ax, to p53 phosphorylation, and to cell apoptosis in all cell lines. |
2012-06-12 |
2023-08-12 |
mouse |
| Luisa F Martinez de Haro, Angeles Ortiz, Pascual Parrilla, Vicente Munitiz, Carlos M Martinez, Beatriz Revilla, David Ruiz de Angulo, Juan Bermejo, Jose Yélamos, Joaquin Molin. Long-term follow-up of malignancy biomarkers in patients with Barrett's esophagus undergoing medical or surgical treatment. Annals of surgery. vol 255. issue 5. 2012-06-12. PMID:22415421. |
this study aims to compare some validated biomarkers of malignancy (ki-67, p53, and apoptosis) between 2 groups of patients with barrett's esophagus (be) undergoing randomly medical or surgical treatment. |
2012-06-12 |
2023-08-12 |
Not clear |
| Sandra W M van Kol, Peter J M Hendriksen, Henk van Loveren, Ad Peijnenbur. Transcriptomics analysis of primary mouse thymocytes exposed to bis(tri-n-butyltin)dioxide (TBTO). Toxicology. vol 296. issue 1-3. 2012-06-12. PMID:22434021. |
treatment with tbto resulted in upregulation of genes involved in endoplasmatic reticulum (er) stress, nfkb and tnfα pathways, and genes involved in dna damage, p53 signaling and apoptosis. |
2012-06-12 |
2023-08-12 |
mouse |
| b' V A Tronov, Iu V Vinogradova, M Iu Loginova, V A Poplinskaia, M A Ostrovski\\xc4\\xa. [Mechanisms of radioresistance in terminally differentiated cells of mature retina]. Tsitologiia. vol 54. issue 3. 2012-06-12. PMID:22645991.' |
we evaluated morphological changes, dna damage and repair in retina, and expression of 5 proteins participating in apoptosis: p53, atm, fasr, parp and caspase 3 active. |
2012-06-12 |
2023-08-12 |
mouse |
| b' V A Tronov, Iu V Vinogradova, M Iu Loginova, V A Poplinskaia, M A Ostrovski\\xc4\\xa. [Mechanisms of radioresistance in terminally differentiated cells of mature retina]. Tsitologiia. vol 54. issue 3. 2012-06-12. PMID:22645991.' |
a single systemic administration of mnu (70 mg/kg) increased intracellular levels of p53, parp, fasr, caspase 3 active, which was followed by destructive changes in retina with sings of apoptosis of photoreceptors. |
2012-06-12 |
2023-08-12 |
mouse |
| Eun-Taex Oh, Moon-Taek Park, Bo-Hwa Choi, Seonggu Ro, Eun-Kyung Choi, Seong-Yun Jeong, Heon Joo Par. Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells. Investigational new drugs. vol 30. issue 2. 2012-06-11. PMID:20978925. |
enhancement of p53 acetylation by hdac inhibitors induces cell cycle arrest, differentiation, and apoptosis in cancer cells. |
2012-06-11 |
2023-08-12 |
human |
| Sophie S Chen, Agnieszka Michael, Simon A Butler-Manue. Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals. Discovery medicine. vol 13. issue 68. 2012-06-11. PMID:22284780. |
additionally, most of these phytochemicals have been shown to stabilize p53 protein, sensitize trail (tnf receptor apoptosis-inducing ligand) induced apoptosis, and prevent or delay chemotherapy-resistance. |
2012-06-11 |
2023-08-12 |
Not clear |
| D K Thotala, D E Hallahan, E M Yazlovitskay. Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway. Cell death and differentiation. vol 19. issue 3. 2012-06-08. PMID:21738215. |
we found that this could be due to regulation of apoptosis by subcellular localization and interaction of gsk-3β, p53 and mdm2. |
2012-06-08 |
2023-08-12 |
Not clear |
| E Shlevkov, G Morat. A dp53/JNK-dependant feedback amplification loop is essential for the apoptotic response to stress in Drosophila. Cell death and differentiation. vol 19. issue 3. 2012-06-08. PMID:21886179. |
in stress-induced apoptosis, the dp53 (drosophila p53) gene and the jun n-terminal kinase (jnk) pathway function upstream in the activation of the proapoptotic genes. |
2012-06-08 |
2023-08-12 |
drosophila_melanogaster |
| Esha Madan, Rajan Gogna, Uttam Pat. p53 Ser15 phosphorylation disrupts the p53-RPA70 complex and induces RPA70-mediated DNA repair in hypoxia. The Biochemical journal. vol 443. issue 3. 2012-06-08. PMID:22288499. |
we have thus elucidated a novel pathway showing how dna-pk-mediated p53(ser15) phosphorylation dissociates the p53-rpa70 complex, thus enhancing ner/nhej repair, which causes resistance to apoptosis in hypoxic cancer cells. |
2012-06-08 |
2023-08-12 |
Not clear |
| You Song, Brit Salbu, Lene Sørlie Heier, Hans-Christian Teien, Ole-Christian Lind, Deborah Oughton, Karina Petersen, Bjørn Olav Rosseland, Lindis Skipperud, Knut Erik Tollefse. Early stress responses in Atlantic salmon (Salmo salar) exposed to environmentally relevant concentrations of uranium. Aquatic toxicology (Amsterdam, Netherlands). vol 112-113. 2012-06-08. PMID:22366426. |
the hepatic transcriptional level of 12 biomarker genes from four stress-response categories, including oxidative stress (γ-glutamyl cysteine synthetase (gcs), glutathione reductase (gr), glutathione peroxidase (gpx)), dna damage and repair (p53, cyclin-dependent kinase inhibitor 1 (p21), growth arrest and dna damage-inducible gene gamma (gadd45g), proliferating cell nuclear antigen (pcna), rad51), apoptosis (bcl2-associated x protein (bax), bcl-x, caspase 6a,) and protein degradation (ubiquitin) were evaluated by quantitative real-time polymerase chain reaction (q-rtpcr). |
2012-06-08 |
2023-08-12 |
Not clear |
| Shinta Tan, Brigitte M T Hougardy, Gert J Meersma, Bessel Schaap, Elisabeth G E de Vries, Ate G J van der Zee, Steven de Jon. Human papilloma virus 16 E6 RNA interference enhances cisplatin and death receptor-mediated apoptosis in human cervical carcinoma cells. Molecular pharmacology. vol 81. issue 5. 2012-06-07. PMID:22328720. |
we have investigated whether e6 suppression with small interfering rna (sirna) restores p53 functionality and sensitizes the hpv16-positive cervical cancer cell line siha to apoptosis by cisplatin, irradiation, recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhtrail), or agonistic anti-fas antibody. |
2012-06-07 |
2023-08-12 |
human |
| Shinta Tan, Brigitte M T Hougardy, Gert J Meersma, Bessel Schaap, Elisabeth G E de Vries, Ate G J van der Zee, Steven de Jon. Human papilloma virus 16 E6 RNA interference enhances cisplatin and death receptor-mediated apoptosis in human cervical carcinoma cells. Molecular pharmacology. vol 81. issue 5. 2012-06-07. PMID:22328720. |
e6 sirna resulted in decreased e6 mrna levels and enhanced p53 and p21 expression, demonstrating the restoration of p53 functionality in siha cells, without inducing high levels of apoptosis (<10%). |
2012-06-07 |
2023-08-12 |
human |
| Yuanmeng Jin, Krishna Ratnam, Peter Y Chuang, Ying Fan, Yifei Zhong, Yan Dai, Amin R Mazloom, Edward Y Chen, Vivette D'Agati, Huabao Xiong, Michael J Ross, Nan Chen, Avi Ma'ayan, John Cijiang H. A systems approach identifies HIPK2 as a key regulator of kidney fibrosis. Nature medicine. vol 18. issue 4. 2012-06-07. PMID:22406746. |
hipk2 induced apoptosis and the expression of epithelial-to-mesenchymal transition markers in kidney epithelial cells by activating the p53, transforming growth factor β (tgf-β)-smad family member 3 (smad3) and wnt-notch pathways. |
2012-06-07 |
2023-08-12 |
mouse |