| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dan Dominissini, Sharon Moshitch-Moshkovitz, Schraga Schwartz, Mali Salmon-Divon, Lior Ungar, Sivan Osenberg, Karen Cesarkas, Jasmine Jacob-Hirsch, Ninette Amariglio, Martin Kupiec, Rotem Sorek, Gideon Rechav. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. vol 485. issue 7397. 2012-06-25. PMID:22575960. |
silencing the m(6)a methyltransferase significantly affects gene expression and alternative splicing patterns, resulting in modulation of the p53 (also known as tp53) signalling pathway and apoptosis. |
2012-06-25 |
2023-08-12 |
mouse |
| Stian Knappskog, Per E Lønnin. Effects of the MDM2 promoter SNP285 and SNP309 on Sp1 transcription factor binding and cancer risk. Transcription. vol 2. issue 5. 2012-06-22. PMID:22231115. |
the proto-oncogene mdm2 inhibits p53 and plays a key role in cell growth control and apoptosis. |
2012-06-22 |
2023-08-12 |
Not clear |
| Yan Li, Xu Li, Guangyu Fan, Jun-Ichi Fukushi, Yoshihiro Matsumoto, Yukihide Iwamoto, Yue Zh. Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing family tumors. Cancer letters. vol 320. issue 1. 2012-06-22. PMID:22266186. |
pharmacologic inhibitor of hdac, trichostatin a (tsa) promoted p53-p300 interaction and recruitment of p53 lys-382 to promoter regions of its target genes p21 and puma, consequently inducing apoptosis and stabilizing the acetylation of p53 at lys-382 together with the upregulation of p21 and puma, which were impaired in efts cells after the knockdown of p53 expression. |
2012-06-22 |
2023-08-12 |
Not clear |
| Ahmed Kamal, Ameruddin Azhar Mohammed, Thokhir B Shai. p53-Mdm2 inhibitors: patent review (2009 - 2010). Expert opinion on therapeutic patents. vol 22. issue 2. 2012-06-22. PMID:22316395. |
activated p53 is known to induce cell cycle arrest thereby leading to apoptosis and has been the subject of intensive research in the area of medicinal chemistry. |
2012-06-22 |
2023-08-12 |
human |
| Hong Wu, Rami Abou Zeinab, Elsa R Flores, Roger P Len. Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination. Molecular cancer research : MCR. vol 9. issue 12. 2012-06-21. PMID:21994467. |
p73, a homolog of the tumor suppressor p53, transactivates many p53 target genes, leading to apoptosis or cell-cycle arrest. |
2012-06-21 |
2023-08-12 |
mouse |
| Qian Qi, Weishan Huang, Yuting Bai, Gabriel Balmus, Robert S Weiss, Avery Augus. A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 8. 2012-06-21. PMID:22403441. |
in contrast, the increased apoptosis observed in itk(-/-) splenic inkt cells is not affected by txk overexpression, likely due to the lack of effect on the elevated expression of p53 regulated proapoptotic pathways fas, bax, and bad in those cells. |
2012-06-21 |
2023-08-12 |
mouse |
| Shu-Ting Liu, Yung-Lung Chang, Wei-Ming Wang, Min-Huey Chung, Wei-Shiang Lin, Wei-Yuan Chou, Shih-Ming Huan. A non-covalent interaction between small ubiquitin-like modifier-1 and Zac1 regulates Zac1 cellular functions. The international journal of biochemistry & cell biology. vol 44. issue 3. 2012-06-20. PMID:22227369. |
zac1, a zinc-finger protein that regulates apoptosis and cell cycle arrest 1, such as p53, can induce cell-cycle arrest and apoptosis. |
2012-06-20 |
2023-08-12 |
Not clear |
| Jinwook Shin, Hongjie Pan, Xiao-Ping Zhon. Regulation of mast cell survival and function by tuberous sclerosis complex 1. Blood. vol 119. issue 14. 2012-06-19. PMID:22362037. |
furthermore, tsc1 is critical for mast cell survival through multiple pathways of apoptosis including the down-regulation of p53, mir-34a, reactive oxygen species, and the up-regulation of bcl-2. |
2012-06-19 |
2023-08-12 |
Not clear |
| Ruijie Liu, Qingzhe Jin, Jianhua Huang, Yuanfa Liu, Xingguo Wang, Xinglong Zhou, Wenyue Mao, Shanshan Wan. In vitro toxicity of aflatoxin B1 and its photodegradation products in HepG2 cells. Journal of applied toxicology : JAT. vol 32. issue 4. 2012-06-18. PMID:21416478. |
cytotoxicity, apoptosis and p53 expression were assessed after exposure to different concentrations of afb1 (0-100 μm) and its two types of degradation products, namely the mixtures of photodegradation products in water (pw) and the mixtures of photodegradation products in peanut oil (po) for different time periods (0, 24, and 48 h). |
2012-06-18 |
2023-08-12 |
Not clear |
| Numsen Hail, Ping Chen, Jadwiga J Kepa, Lane R Bushma. Evidence supporting a role for dihydroorotate dehydrogenase, bioenergetics, and p53 in selective teriflunomide-induced apoptosis in transformed versus normal human keratinocytes. Apoptosis : an international journal on programmed cell death. vol 17. issue 3. 2012-06-18. PMID:22012334. |
evidence supporting a role for dihydroorotate dehydrogenase, bioenergetics, and p53 in selective teriflunomide-induced apoptosis in transformed versus normal human keratinocytes. |
2012-06-18 |
2023-08-12 |
human |
| Numsen Hail, Ping Chen, Jadwiga J Kepa, Lane R Bushma. Evidence supporting a role for dihydroorotate dehydrogenase, bioenergetics, and p53 in selective teriflunomide-induced apoptosis in transformed versus normal human keratinocytes. Apoptosis : an international journal on programmed cell death. vol 17. issue 3. 2012-06-18. PMID:22012334. |
conversely, a long-term exposure to tfn caused g(0)/g(1) arrest in the nhek cells, which supported a cytoprotective role for p53 against tfn-induced apoptosis. |
2012-06-18 |
2023-08-12 |
human |
| Tracey S Hanks, Katherine A Gaus. Pleomorphic adenoma gene-like 2 regulates expression of the p53 family member, p73, and induces cell cycle block and apoptosis in human promonocytic U937 cells. Apoptosis : an international journal on programmed cell death. vol 17. issue 3. 2012-06-18. PMID:22076304. |
pleomorphic adenoma gene-like 2 regulates expression of the p53 family member, p73, and induces cell cycle block and apoptosis in human promonocytic u937 cells. |
2012-06-18 |
2023-08-12 |
human |
| Tracey S Hanks, Katherine A Gaus. Pleomorphic adenoma gene-like 2 regulates expression of the p53 family member, p73, and induces cell cycle block and apoptosis in human promonocytic U937 cells. Apoptosis : an international journal on programmed cell death. vol 17. issue 3. 2012-06-18. PMID:22076304. |
there was significant increase in the p53 homologue, p73, with plagl2 expression, and consistent with mechanisms of p73-regulated cell cycle control and apoptosis, there was increased expression of known p73 target genes p21, dr5, trail, and bax. |
2012-06-18 |
2023-08-12 |
human |
| Valentina Manfé, Edyta Biskup, Peter Johansen, Maria R Kamstrup, Thorbjørn F Krejsgaard, Niels Morling, Hans C Wulf, Robert Gniadeck. MDM2 inhibitor nutlin-3a induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53. The Journal of investigative dermatology. vol 132. issue 5. 2012-06-18. PMID:22377766. |
mdm2 inhibitor nutlin-3a induces apoptosis and senescence in cutaneous t-cell lymphoma: role of p53. |
2012-06-18 |
2023-08-12 |
human |
| Valentina Manfé, Edyta Biskup, Peter Johansen, Maria R Kamstrup, Thorbjørn F Krejsgaard, Niels Morling, Hans C Wulf, Robert Gniadeck. MDM2 inhibitor nutlin-3a induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53. The Journal of investigative dermatology. vol 132. issue 5. 2012-06-18. PMID:22377766. |
in myla2000, mac1, and mac2a carrying wild-type p53, nutlin-3a induced apoptosis and senescence demonstrated by permanent g0/g1 cell-cycle block and expression of the senescence-associated β-galactosidase. |
2012-06-18 |
2023-08-12 |
human |
| Valentina Manfé, Edyta Biskup, Peter Johansen, Maria R Kamstrup, Thorbjørn F Krejsgaard, Niels Morling, Hans C Wulf, Robert Gniadeck. MDM2 inhibitor nutlin-3a induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53. The Journal of investigative dermatology. vol 132. issue 5. 2012-06-18. PMID:22377766. |
thus, targeting p53 by nutlin-3a may constitute a therapeutic approach in ctcl because of increased apoptosis and senescence of tumor cells. |
2012-06-18 |
2023-08-12 |
human |
| N Taira, K Yoshid. Post-translational modifications of p53 tumor suppressor: determinants of its functional targets. Histology and histopathology. vol 27. issue 4. 2012-06-14. PMID:22374721. |
however, cellular stimuli enable p53 to escape from the negative regulation, and then stably expressed p53 transactivates its target genes to induce cell cycle arrest, dna repair, or apoptosis. |
2012-06-14 |
2023-08-12 |
Not clear |
| Marc J Rigatti, Rajeev Verma, Glenn S Belinsky, Daniel W Rosenberg, Charles Giardin. Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells. Molecular carcinogenesis. vol 51. issue 5. 2012-06-13. PMID:21557332. |
the p53 tumor suppressor protein performs a number of cellular functions, ranging from the induction of cell cycle arrest and apoptosis to effects on dna repair. |
2012-06-13 |
2023-08-12 |
mouse |
| Marc J Rigatti, Rajeev Verma, Glenn S Belinsky, Daniel W Rosenberg, Charles Giardin. Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells. Molecular carcinogenesis. vol 51. issue 5. 2012-06-13. PMID:21557332. |
using a cell line derived from an aom-induced tumor, we found that four daily exposures to nutlin-3 induced persistent p53 stabilization and cell cycle arrest without significant apoptosis. |
2012-06-13 |
2023-08-12 |
mouse |
| Bing Zou, Chor S Chim, Roberta Pang, Hui Zeng, Yun Dai, Rongxin Zhang, Colin S C Lam, Victoria P Y Tan, Ivan F N Hung, Hui Y Lan, Benjamin C Y Won. XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification. Molecular carcinogenesis. vol 51. issue 5. 2012-06-13. PMID:21678496. |
xiap-associated factor 1 (xaf1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification. |
2012-06-13 |
2023-08-12 |
human |