| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Zheng, Huifang Dai, Mian Zhou, Xiaojin Li, Changwei Liu, Zhigang Guo, Xiwei Wu, Jun Wu, Charles Wang, John Zhong, Qin Huang, Julio Garcia-Aguilar, Gerd P Pfeifer, Binghui She. Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression. Nature communications. vol 3. 2012-07-26. PMID:22569363. |
meanwhile, dna methylation silences p53 target genes to bypass the p53-mediated senescence and apoptosis. |
2012-07-26 |
2023-08-12 |
human |
| Xin Yu, Alexei Vazquez, Arnold J Levine, Darren R Carpiz. Allele-specific p53 mutant reactivation. Cancer cell. vol 21. issue 5. 2012-07-26. PMID:22624712. |
this compound kills p53(r172h) knockin mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner. |
2012-07-26 |
2023-08-12 |
mouse |
| Young Joo Choi, Yang Jee Kim, Joong Won Lee, Younghyun Lee, Yong-Beom Lim, Hai Won Chun. Cyto-/genotoxic effect of CdSe/ZnS quantum dots in human lung adenocarcinoma cells for potential photodynamic UV therapy applications. Journal of nanoscience and nanotechnology. vol 12. issue 3. 2012-07-26. PMID:22755033. |
qd-induced cell death was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt), apoptosis, and lactate dehydrogenase (ldh) assays, as well as by real-time pcr analysis of differential mrna levels of genes, such as ataxia telangiectasia mutated (atm), p53, and caspase-9, involved in apoptosis. |
2012-07-26 |
2023-08-12 |
human |
| D Dixit, V Sharma, S Ghosh, V S Mehta, E Se. Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition. Cell death & disease. vol 3. 2012-07-24. PMID:22318540. |
activation of p53 function involved its increased transcriptional activation, dna-binding ability, increased expression of p53 target genes associated with cell cycle progression and apoptosis. |
2012-07-24 |
2023-08-12 |
Not clear |
| D Dixit, V Sharma, S Ghosh, V S Mehta, E Se. Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition. Cell death & disease. vol 3. 2012-07-24. PMID:22318540. |
interestingly, ck2-is downregulated sirt1 activity and over-expression of sirt1 decreased p53 transcriptional activity and rescued cells from ck2-i-induced apoptosis. |
2012-07-24 |
2023-08-12 |
Not clear |
| R Gogna, E Madan, P Kuppusamy, U Pat. Re-oxygenation causes hypoxic tumor regression through restoration of p53 wild-type conformation and post-translational modifications. Cell death & disease. vol 3. 2012-07-24. PMID:22419115. |
we have thus concluded that oxygen therapy without pressure, as opposed to hbo therapy, may be ideal for hypoxic tumor regression, which functions through oxygen-mediated rescue of mutant p53 followed by induction of apoptosis. |
2012-07-24 |
2023-08-12 |
Not clear |
| Zhengli Xu, Laisheng Chou, Jiao Su. Effects of SiO2 nanoparticles on HFL-I activating ROS-mediated apoptosis via p53 pathway. Journal of applied toxicology : JAT. vol 32. issue 5. 2012-07-23. PMID:21766316. |
effects of sio2 nanoparticles on hfl-i activating ros-mediated apoptosis via p53 pathway. |
2012-07-23 |
2023-08-12 |
human |
| Zhengli Xu, Laisheng Chou, Jiao Su. Effects of SiO2 nanoparticles on HFL-I activating ROS-mediated apoptosis via p53 pathway. Journal of applied toxicology : JAT. vol 32. issue 5. 2012-07-23. PMID:21766316. |
these findings implied that sio(2) nps might induce apoptosis of hfl-is by stimulating reactive oxygen species release and subsequently causing the activation of p53 pathway in vitro. |
2012-07-23 |
2023-08-12 |
human |
| Ali A Alshatwi, Gowhar Shafi, Tarique N Hasan, Amal A Al-Hazzani, Mohammed A Alsaif, Mohammed A Alfawaz, K Y Lei, Anjana Munsh. Apoptosis-mediated inhibition of human breast cancer cell proliferation by lemon citrus extract. Asian Pacific journal of cancer prevention : APJCP. vol 12. issue 6. 2012-07-23. PMID:22126498. |
in addition, the apoptosis mediated by le extract in the mcf-7 cells was associated with the increased expression of the tumor suppressor p53 and caspase-3. |
2012-07-23 |
2023-08-12 |
human |
| James D Orth, Alexander Loewer, Galit Lahav, Timothy J Mitchiso. Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Molecular biology of the cell. vol 23. issue 4. 2012-07-23. PMID:22171325. |
prolonged mitotic arrest triggers partial activation of apoptosis, resulting in dna damage and p53 induction. |
2012-07-23 |
2023-08-12 |
human |
| Annika Müer, Tim Overkamp, Bernd Gillissen, Antje Richter, Thomas Pretzsch, Ana Milojkovic, Bernd Dörken, Peter T Daniel, Philipp Hemmat. p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins. The Journal of biological chemistry. vol 287. issue 21. 2012-07-23. PMID:22354970. |
p14(arf)-induced apoptosis in p53 protein-deficient cells is mediated by bh3-only protein-independent derepression of bak protein through down-regulation of mcl-1 and bcl-xl proteins. |
2012-07-23 |
2023-08-12 |
Not clear |
| Annika Müer, Tim Overkamp, Bernd Gillissen, Antje Richter, Thomas Pretzsch, Ana Milojkovic, Bernd Dörken, Peter T Daniel, Philipp Hemmat. p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins. The Journal of biological chemistry. vol 287. issue 21. 2012-07-23. PMID:22354970. |
taken together, these data indicate that in the absence of functional p53 and bax, p14(arf) triggers mitochondrial apoptosis signaling by activating bak, which is facilitated by down-regulating anti-apoptotic mcl-1 and bcl-x(l). |
2012-07-23 |
2023-08-12 |
Not clear |
| Lin Guo, Na Zhu, Zhen Guo, Guang-ke Li, Chu Chen, Nan Sang, Qing-chen Ya. Particulate matter (PM10) exposure induces endothelial dysfunction and inflammation in rat brain. Journal of hazardous materials. vol 213-214. 2012-07-23. PMID:22365138. |
also, the sample up-regulated bax/bcl-2 ratio and p53 expression, and induced neuronal apoptosis. |
2012-07-23 |
2023-08-12 |
rat |
| J-Y Chang, M-F Chiang, S-R Lin, M-H Lee, H He, P-Y Chou, S-J Chen, Y-A Chen, L-Y Yang, F-J Lai, C-C Hsieh, T-H Hsieh, H-M Sheu, C-I Sze, N-S Chan. TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death. Cell death & disease. vol 3. 2012-07-23. PMID:22534828. |
tiaf1, p53 and wox1 acted synergistically in suppressing anchorage-independent growth, blocking cell migration and causing apoptosis. |
2012-07-23 |
2023-08-12 |
human |
| Nishant Mohan, Naren L Banik, Swapan K Ra. Synergistic efficacy of a novel combination therapy controls growth of Bcl-x(L) bountiful neuroblastoma cells by increasing differentiation and apoptosis. Cancer biology & therapy. vol 12. issue 9. 2012-07-20. PMID:21878749. |
protein gel blotting manifested that combination therapy increased apoptosis with downregulation of the anti-apoptotic proteins bcl-x(l), bcl-2 and mcl-1 and upregulation of the pro-apoptotic proteins bax, p53, puma (p53 upregulated modulator of apoptosis), and noxa, ultimately causing activation of caspase-3. |
2012-07-20 |
2023-08-12 |
human |
| Lei Zhang, Junshan Ruan, Linggeng Yan, Weidong Li, Yu Wu, Li Tao, Feng Zhang, Shizhong Zheng, Aiyun Wang, Yin L. Xanthatin induces cell cycle arrest at G2/M checkpoint and apoptosis via disrupting NF-κB pathway in A549 non-small-cell lung cancer cells. Molecules (Basel, Switzerland). vol 17. issue 4. 2012-07-19. PMID:22450683. |
xathatin also increased total p53 protein levels, decreased bcl-2/bax ratio and expression of the downstream factors procaspase-9 and procaspase-3, which triggered the intrinsic apoptosis pathway. |
2012-07-19 |
2023-08-12 |
human |
| Hye Jin Wang, Eun Young Lee, Seung Jin Han, Soo Hyun Kim, Byung-Wan Lee, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Le. Dual pathways of p53 mediated glucolipotoxicity-induced apoptosis of rat cardiomyoblast cell: activation of p53 proapoptosis and inhibition of Nrf2-NQO1 antiapoptosis. Metabolism: clinical and experimental. vol 61. issue 4. 2012-07-18. PMID:22154326. |
dual pathways of p53 mediated glucolipotoxicity-induced apoptosis of rat cardiomyoblast cell: activation of p53 proapoptosis and inhibition of nrf2-nqo1 antiapoptosis. |
2012-07-18 |
2023-08-12 |
rat |
| Hye Jin Wang, Eun Young Lee, Seung Jin Han, Soo Hyun Kim, Byung-Wan Lee, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Le. Dual pathways of p53 mediated glucolipotoxicity-induced apoptosis of rat cardiomyoblast cell: activation of p53 proapoptosis and inhibition of Nrf2-NQO1 antiapoptosis. Metabolism: clinical and experimental. vol 61. issue 4. 2012-07-18. PMID:22154326. |
we demonstrated that the elevated p53 mediated glucolipotoxicity-induced apoptosis of rat cardiomyoblast cell through dual pathways: stimulating pro-apoptosis signaling as well as suppressing anti-apoptosis pathway of nrf2-nqo1 signaling. |
2012-07-18 |
2023-08-12 |
rat |
| A Keim, O G Rössler, T L Rothhaar, G Thie. Arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-Jun. Neuroscience. vol 206. 2012-07-18. PMID:22260869. |
arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-jun. |
2012-07-18 |
2023-08-12 |
human |
| Julia Donauer, Ilona Schreck, Urban Liebel, Carsten Weis. Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells. Archives of toxicology. vol 86. issue 2. 2012-07-16. PMID:21983885. |
role and interaction of p53, bax and the stress-activated protein kinases p38 and jnk in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells. |
2012-07-16 |
2023-08-12 |
human |