| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhu Yuan, Kang Cao, Chao Lin, Lei Li, Huan-yi Liu, Xin-yu Zhao, Lei Liu, Hong-xin Deng, Jiong Li, Chun-lai Nie, Yu-quan We. The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1. Molecular medicine (Cambridge, Mass.). vol 17. issue 11-12. 2012-08-03. PMID:21863213. |
the p53 upregulated modulator of apoptosis (puma) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by bcl-x(l) and mcl-1. |
2012-08-03 |
2023-08-12 |
Not clear |
| Zhu Yuan, Kang Cao, Chao Lin, Lei Li, Huan-yi Liu, Xin-yu Zhao, Lei Liu, Hong-xin Deng, Jiong Li, Chun-lai Nie, Yu-quan We. The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1. Molecular medicine (Cambridge, Mass.). vol 17. issue 11-12. 2012-08-03. PMID:21863213. |
puma (p53 upregulated modulator of apoptosis), a bh3-only bcl-2 family protein, was recently identified as a transcriptional target of p53 and a potent apoptosis inducer in various cancer cells. |
2012-08-03 |
2023-08-12 |
Not clear |
| Marie Lue Antony, Su-Hyeong Kim, Shivendra V Sing. Critical role of p53 upregulated modulator of apoptosis in benzyl isothiocyanate-induced apoptotic cell death. PloS one. vol 7. issue 2. 2012-08-03. PMID:22359675. |
critical role of p53 upregulated modulator of apoptosis in benzyl isothiocyanate-induced apoptotic cell death. |
2012-08-03 |
2023-08-12 |
human |
| Marie Lue Antony, Su-Hyeong Kim, Shivendra V Sing. Critical role of p53 upregulated modulator of apoptosis in benzyl isothiocyanate-induced apoptotic cell death. PloS one. vol 7. issue 2. 2012-08-03. PMID:22359675. |
instead, the bitc-treated mcf-7 and mda-mb-231 cells exhibited upregulation of p53 upregulated modulator of apoptosis (puma) protein. |
2012-08-03 |
2023-08-12 |
human |
| Manuel Luedeke, Irina Coinac, Carmen M Linnert, Natalia Bogdanova, Antje E Rinckleb, Mark Schrader, Walther Vogel, Josef Hoegel, Andreas Meyer, Thilo Dörk, Christiane Maie. Prostate cancer risk is not altered by TP53AIP1 germline mutations in a German case-control series. PloS one. vol 7. issue 3. 2012-08-03. PMID:22457820. |
prostate cancer susceptibility has previously been associated with truncating germline variants in the gene tp53aip1 (tumor protein p53 regulated apoptosis inducing protein 1). |
2012-08-03 |
2023-08-12 |
Not clear |
| K A McAllister, S A Lorimore, E G Wright, P J Coate. In vivo interactions between ionizing radiation, inflammation and chemical carcinogens identified by increased DNA damage responses. Radiation research. vol 177. issue 5. 2012-08-03. PMID:22463680. |
short-term measurements of p53 stabilization, induction of p21/cdkn1a and of apoptosis also identify these interactive effects. |
2012-08-03 |
2023-08-12 |
mouse |
| Zhongqiu Wang, Erich M Sturgis, Wei Guo, Xicheng Song, Fenghua Zhang, Li Xu, Qingyi Wei, Guojun L. Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer. PloS one. vol 7. issue 4. 2012-08-03. PMID:22523600. |
the interplay between p53 and p73 and hpv16 may lead to deregulation of cell cycle and apoptosis, through which inflammation/immune responses control the hpv clearance and escape of immune surveillance, and subsequently contribute to tumor hpv16 status. |
2012-08-03 |
2023-08-12 |
human |
| Carole Brosseau, Kay Colston, Angus George Dalgleish, Christine Galustia. The immunomodulatory drug lenalidomide restores a vitamin D sensitive phenotype to the vitamin D resistant breast cancer cell line MDA-MB-231 through inhibition of BCL-2: potential for breast cancer therapeutics. Apoptosis : an international journal on programmed cell death. vol 17. issue 2. 2012-08-01. PMID:22109882. |
an apoptosis protein array showed that the 1,25-d3 and lenalidomide combination increased pro-apoptotic proteins (phosphorylated p53) and decreased bcl-2 expression. |
2012-08-01 |
2023-08-12 |
Not clear |
| Jian-Min Yuan, Xue-Dong Li, Zhao-Yong Liu, Guo-Qing Hou, Jian-Hui Kang, Dong-Yang Huang, Shi-Xin D. Cisplatin induces apoptosis via upregulating Wrap53 in U-2OS osteosarcoma cells. Asian Pacific journal of cancer prevention : APJCP. vol 12. issue 12. 2012-08-01. PMID:22471498. |
we sought to investigate changes in wrap53 and p53 levels in an osteosarcoma cell line (u-2os) exposed to cisplatin and to study apoptosis before and after knockdown of wrap53. |
2012-08-01 |
2023-08-12 |
Not clear |
| D Muthna, J Vavrova, E Lukasova, A Tichy, J Knizek, R Kohlerova, N Mazankova, M Rezacov. Valproic acid decreases the reparation capacity of irradiated MOLT-4 cells. Molekuliarnaia biologiia. vol 46. issue 1. 2012-07-31. PMID:22642109. |
two-millimolar va increased apoptosis induction after irradiation as well as phosphorylation of h2ax and provokes an increase in the level of p53 and its phosphorylation at ser392 in 4 h post-irradiation. |
2012-07-31 |
2023-08-12 |
Not clear |
| D Muthna, J Vavrova, E Lukasova, A Tichy, J Knizek, R Kohlerova, N Mazankova, M Rezacov. Valproic acid decreases the reparation capacity of irradiated MOLT-4 cells. Molekuliarnaia biologiia. vol 46. issue 1. 2012-07-31. PMID:22642109. |
the 24-hour treatment of molt-4 leukemia cells with 2 mm va results in radiosensitizing, increases apoptosis induction, h2ax phosphorylation, and also p53 and p21 activation. |
2012-07-31 |
2023-08-12 |
Not clear |
| Ajaikumar B Kunnumakkara, Bokyung Sung, Jayaraj Ravindran, Parmeswaran Diagaradjane, Amit Deorukhkar, Sanjit Dey, Cemile Koca, Zhimin Tong, Juri G Gelovani, Sushovan Guha, Sunil Krishnan, Bharat B Aggarwa. Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets. International journal of cancer. vol 131. issue 3. 2012-07-30. PMID:21935918. |
in vitro, zyflamend inhibited the proliferation of pancreatic cancer cell lines regardless of p53 status and also enhanced gemcitabine-induced apoptosis. |
2012-07-30 |
2023-08-12 |
mouse |
| Kristina Heyne, Judith Huwer, Vincent Zimmer, Michael Pfreundschuh, Jasmin Teresa Ney, Gunter Assman. Different apoptotic responses of RA synoviocytes depending on different genotypes of the mdm2 SNP T309G. Apoptosis : an international journal on programmed cell death. vol 17. issue 4. 2012-07-30. PMID:22187011. |
mdm2 is an ubiquitin ligase, which binds p53 and blocks its function as a transcription factor in the pathway of apoptosis. |
2012-07-30 |
2023-08-12 |
Not clear |
| Qi Zhang, Shelya X Zeng, Yu Zhang, Yiwei Zhang, Derong Ding, Qizhuang Ye, Samy O Meroueh, Hua L. A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. EMBO molecular medicine. vol 4. issue 4. 2012-07-30. PMID:22331558. |
here, we report a novel small molecule inauhzin (inz) that effectively reactivates p53 by inhibiting sirt1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. |
2012-07-30 |
2023-08-12 |
mouse |
| Qianhong Liu, Wenyu Han, Changjiang Sun, Liang Zhou, Limin Ma, Liancheng Lei, Shouqing Yan, Shanshan Liu, Chongtao Du, Xin Fen. Deep sequencing-based expression transcriptional profiling changes during Brucella infection. Microbial pathogenesis. vol 52. issue 5. 2012-07-30. PMID:22342430. |
pathway enrichment analysis indicated that the genes in the apoptosis pathway, nod-like receptor signaling pathway, fc gamma r-mediated phagocytosis, lysosome pathway, p53 signaling pathway, and protein processing in the endoplasmic reticulum significantly changed during the first 24 h post-infection. |
2012-07-30 |
2023-08-12 |
human |
| Chong-Zhi Wang, Guang-Jian Du, Zhiyu Zhang, Xiao-Dong Wen, Tyler Calway, Zhong Zhen, Mark W Musch, Marc Bissonnette, Eugene B Chang, Chun-Su Yua. Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer. International journal of oncology. vol 40. issue 6. 2012-07-30. PMID:22426808. |
compared to hct-116 (p53 wild-type), the p53 mutant cell line sw-480 was more sensitive to c-k as assessed by cell cycle regulation and apoptosis induction. |
2012-07-30 |
2023-08-12 |
human |
| Mariangela Pucci, Nicoletta Pasquariello, Natalia Battista, Monia Di Tommaso, Cinzia Rapino, Filomena Fezza, Michela Zuccolo, Roland Jourdain, Alessandro Finazzi Agrò, Lionel Breton, Mauro Maccarron. Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor. The Journal of biological chemistry. vol 287. issue 19. 2012-07-30. PMID:22431736. |
we also show that at higher concentrations aea induces normal human epidermal melanocyte apoptosis (∼3-fold over controls at 5 μm) through a trpv1-mediated pathway that increases dna fragmentation and p53 expression. |
2012-07-30 |
2023-08-12 |
human |
| Zhenghong Lin, Heeyoung Yang, Qingfei Kong, Jinping Li, Sang-Myeong Lee, Beixue Gao, Hongxin Dong, Jianjun Wei, Jianxun Song, Donna D Zhang, Deyu Fan. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Molecular cell. vol 46. issue 4. 2012-07-27. PMID:22542455. |
usp22 antagonizes p53 transcriptional activation by deubiquitinating sirt1 to suppress cell apoptosis and is required for mouse embryonic development. |
2012-07-27 |
2023-08-12 |
mouse |
| Zhenghong Lin, Heeyoung Yang, Qingfei Kong, Jinping Li, Sang-Myeong Lee, Beixue Gao, Hongxin Dong, Jianjun Wei, Jianxun Song, Donna D Zhang, Deyu Fan. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Molecular cell. vol 46. issue 4. 2012-07-27. PMID:22542455. |
the nad-dependent histone deacetylase sirt1 antagonizes p53 transcriptional activity to regulate cell-cycle progression and apoptosis. |
2012-07-27 |
2023-08-12 |
mouse |
| Zhenghong Lin, Heeyoung Yang, Qingfei Kong, Jinping Li, Sang-Myeong Lee, Beixue Gao, Hongxin Dong, Jianjun Wei, Jianxun Song, Donna D Zhang, Deyu Fan. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Molecular cell. vol 46. issue 4. 2012-07-27. PMID:22542455. |
in contrast, depletion of endogenous usp22 by rna interference destabilizes sirt1, inhibits sirt1-mediated deacetylation of p53 and elevates p53-dependent apoptosis. |
2012-07-27 |
2023-08-12 |
mouse |