| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Satoshi Tanida, Tsutomu Mizoshita, Keiji Ozeki, Hironobu Tsukamoto, Takeshi Kamiya, Hiromi Kataoka, Daitoku Sakamuro, Takashi Jo. Mechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment. International journal of surgical oncology. vol 2012. 2012-08-23. PMID:22778941. |
cisplatin forms inter- and intrastrand crosslinked dna adducts and its cytotoxicity is mediated by propagation of dna damage recognition signals to downstream pathways involving atr, p53, p73, and mitogen-activated protein kinases, ultimately resulting in apoptosis. |
2012-08-23 |
2023-08-12 |
Not clear |
| Venkat R Katkoori, Catalina Suarez-Cuervo, Chandrakumar Shanmugam, Nirag C Jhala, Tom Callens, Ludwine Messiaen, James Posey, Harvey L Bumpers, Sreelatha Meleth, William E Grizzle, Upender Mann. Bax expression is a candidate prognostic and predictive marker of colorectal cancer. Journal of gastrointestinal oncology. vol 1. issue 2. 2012-08-23. PMID:22811811. |
since the anti-tumor activity of 5-fluorouracil (5-fu) is due to induction of apoptosis, we assessed the value of expression of key apoptotic molecules (bax, bcl-2 and p53) in predicting the efficacy of 5-fu therapy for colorectal adenocarcinomas (crcs). |
2012-08-23 |
2023-08-12 |
Not clear |
| Kuen-Daw Tsai, Jung-Chung Lin, Shu-Mei Yang, Min-Jen Tseng, Jeng-Dong Hsu, Yi-Ju Lee, Jaw-Ming Chern. Curcumin Protects against UVB-Induced Skin Cancers in SKH-1 Hairless Mouse: Analysis of Early Molecular Markers in Carcinogenesis. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-08-23. PMID:22888366. |
the results suggest that the protective effect of cur against photocarcinogenesis is accompanied by downregulation of cell proliferative controls, involving thymine dimer, pcna, apoptosis, transcription factors nf-κb, and of inflammatory responses involving cox-2, pge2, and no, while upregulation of p53 and p21/cip1 to prevent dna damage and facilitate dna repair. |
2012-08-23 |
2023-08-12 |
mouse |
| Kathryn N Phoenix, Charan V Devarakonda, Melissa M Fox, Laura E Stevens, Kevin P Claffe. AMPKα2 Suppresses Murine Embryonic Fibroblast Transformation and Tumorigenesis. Genes & cancer. vol 3. issue 1. 2012-08-23. PMID:22893790. |
in addition, ampk localizes to centrosomes during cell division, plays a role in cellular polarization, and directly targets p53, affecting apoptosis. |
2012-08-23 |
2023-08-12 |
mouse |
| HaiBin Zhu, Qiqi Mao, Yiwei Lin, Kai Yang, Liping Xi. RNA interference targeting mutant p53 inhibits growth and induces apoptosis in DU145 human prostate cancer cells. Medical oncology (Northwood, London, England). vol 28 Suppl 1. 2012-08-22. PMID:20857345. |
rna interference targeting mutant p53 inhibits growth and induces apoptosis in du145 human prostate cancer cells. |
2012-08-22 |
2023-08-12 |
human |
| HaiBin Zhu, Qiqi Mao, Yiwei Lin, Kai Yang, Liping Xi. RNA interference targeting mutant p53 inhibits growth and induces apoptosis in DU145 human prostate cancer cells. Medical oncology (Northwood, London, England). vol 28 Suppl 1. 2012-08-22. PMID:20857345. |
using the du145 human androgen-independent prostate cancer cell line, we show that silencing of mutant p53 gene by rna interference led to significant inhibition of cell viability and growth, which was associated with cell cycle arrest at g1 and g2/m phase, and ultimately induced massive apoptosis. |
2012-08-22 |
2023-08-12 |
human |
| Kejun Zhang, Bingyuan Zhang, Yun Lu, Chuandong Sun, Wei Zhao, Xuelong Jiao, Jilin Hu, Peng Mu, Hai Lu, Changyong Zho. Slug inhibition upregulates radiation-induced PUMA activity leading to apoptosis in cholangiocarcinomas. Medical oncology (Northwood, London, England). vol 28 Suppl 1. 2012-08-22. PMID:21120639. |
slug, a snail family transcription factor, is a suppressor of puma (p53 upregulated modulator of apoptosis), which has been shown to be involved in the control of apoptosis. |
2012-08-22 |
2023-08-12 |
Not clear |
| Makiko Ono, Hitoshi Tsuda, Chikako Shimizu, Sohei Yamamoto, Tatsuhiro Shibata, Harukaze Yamamoto, Taizo Hirata, Kan Yonemori, Masashi Ando, Kenji Tamura, Noriyuki Katsumata, Takayuki Kinoshita, Yuichi Takiguchi, Hideki Tanzawa, Yasuhiro Fujiwar. Tumor-infiltrating lymphocytes are correlated with response to neoadjuvant chemotherapy in triple-negative breast cancer. Breast cancer research and treatment. vol 132. issue 3. 2012-08-22. PMID:21562709. |
expression of basal markers and p53, histological grade 3, high til scores, and apoptosis were more frequent in tnbc and the hr-/her2+ subtype than in the hr+/her2- subtype (p = 0.002 for til and p < 0.001 for others). |
2012-08-22 |
2023-08-12 |
Not clear |
| E Sugihara, T Shimizu, K Kojima, N Onishi, K Kai, J Ishizawa, K Nagata, N Hashimoto, H Honda, M Kanno, M Miwa, S Okada, M Andreeff, H Say. Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor. Oncogene. vol 31. issue 23. 2012-08-21. PMID:21986948. |
furthermore, the mdm2 inhibitor nutlin-3 restored p53 and induced massive apoptosis in mouse pre-b all/lbl cells derived from ink4a/arf(-/-) cells and human b-all cell lines lacking ink4a and arf expression, suggesting that mdm2 inhibition may be a novel therapeutic approach to the treatment of ink4a/arf(-/-) b-all/lbl, such as is frequently found in ph(+) all and relapsed all. |
2012-08-21 |
2023-08-12 |
mouse |
| E Diaz-Rodriguez, M García-Lavandeira, S Perez-Romero, A Senra, C Cañibano, I Palmero, M G Borrello, C Dieguez, C V Alvare. Direct promoter induction of p19Arf by Pit-1 explains the dependence receptor RET/Pit-1/p53-induced apoptosis in the pituitary somatotroph cells. Oncogene. vol 31. issue 23. 2012-08-21. PMID:22020338. |
in the absence of gdnf, ret behaves as a dependence receptor, becomes intracellularly processed and induces strong pit-1 expression leading to p53 accumulation and apoptosis. |
2012-08-21 |
2023-08-12 |
Not clear |
| E Diaz-Rodriguez, M García-Lavandeira, S Perez-Romero, A Senra, C Cañibano, I Palmero, M G Borrello, C Dieguez, C V Alvare. Direct promoter induction of p19Arf by Pit-1 explains the dependence receptor RET/Pit-1/p53-induced apoptosis in the pituitary somatotroph cells. Oncogene. vol 31. issue 23. 2012-08-21. PMID:22020338. |
ret/pit-1 induces p19arf/p53 and apoptosis not only in a somatotroph cell line but also in primary cultures of pituitary somatotrophs, where arf sirna interference also blocks p53 and apoptosis. |
2012-08-21 |
2023-08-12 |
Not clear |
| Maria Chomova, Zuzana Tatarkova, Dusan Dobrota, Peter Raca. Ischemia-induced inhibition of mitochondrial complex I in rat brain: effect of permeabilization method and electron acceptor. Neurochemical research. vol 37. issue 5. 2012-08-20. PMID:22219133. |
add to this, initialization of p53 mitochondrial apoptosis through p53, bax, bcl-x(l) proteins and a possible involvement of grim-19, the ci structural subunit, in apoptotic processes were also studied. |
2012-08-20 |
2023-08-12 |
rat |
| Song Chen, Hedeel Guy Evans, David R Evan. FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short. PloS one. vol 7. issue 3. 2012-08-20. PMID:22427918. |
flash knockdown in ht1080 mutant cells defective in p53 did not significantly accelerate fas mediated apoptosis indicating that the effect was dependent on functional p53. |
2012-08-20 |
2023-08-12 |
Not clear |
| Pierpaolo Aimola, Marco Carmignani, Anna Rita Volpe, Altomare Di Benedetto, Luigi Claudio, Michael P Waalkes, Adrie van Bokhoven, Erik J Tokar, Pier Paolo Claudi. Cadmium induces p53-dependent apoptosis in human prostate epithelial cells. PloS one. vol 7. issue 3. 2012-08-20. PMID:22448262. |
on the other hand, p53 silencing was able to suppress cadmium-induced apoptosis. |
2012-08-20 |
2023-08-12 |
human |
| Pierpaolo Aimola, Marco Carmignani, Anna Rita Volpe, Altomare Di Benedetto, Luigi Claudio, Michael P Waalkes, Adrie van Bokhoven, Erik J Tokar, Pier Paolo Claudi. Cadmium induces p53-dependent apoptosis in human prostate epithelial cells. PloS one. vol 7. issue 3. 2012-08-20. PMID:22448262. |
our results demonstrate that cadmium can induce p53-dependent apoptosis in human prostate epithelial cells and suggest p53 mutation as a possible contributing factor for the acquisition of apoptotic resistance in cadmium prostatic carcinogenesis. |
2012-08-20 |
2023-08-12 |
human |
| Meghali Goswami, Madeleine Duvic, Alexis Dougherty, Xiao N. Increased Twist expression in advanced stage of mycosis fungoides and Sézary syndrome. Journal of cutaneous pathology. vol 39. issue 5. 2012-08-20. PMID:22515221. |
twist, a transcription factor, is thought to promote solid tumor progression by blocking p53 and inhibiting c-myc-induced apoptosis. |
2012-08-20 |
2023-08-12 |
Not clear |
| Karen S Yee, Lukasz Grochola, Garth Hamilton, Anna Grawenda, Elisabeth E Bond, Helge Taubert, Peter Wurl, Gareth L Bond, Eric O'Neil. A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma. Cancer research. vol 72. issue 9. 2012-08-17. PMID:22389451. |
rassf1a-p.133ser failed to activate the mst2/lats pathway, which is required for yap/p73-mediated apoptosis, and negatively affected the activation of p53, culminating in a defective cellular response to dna damage. |
2012-08-17 |
2023-08-12 |
human |
| Lauren Brown-Endres, David Schoenfeld, Fang Tian, Hyung-Gu Kim, Takushi Namba, César Muñoz-Fontela, Anna Mandinova, Stuart A Aaronson, Sam W Le. Expression of the p53 target CDIP correlates with sensitivity to TNFα-induced apoptosis in cancer cells. Cancer research. vol 72. issue 9. 2012-08-17. PMID:22549949. |
expression of the p53 target cdip correlates with sensitivity to tnfα-induced apoptosis in cancer cells. |
2012-08-17 |
2023-08-12 |
Not clear |
| Yigen Li, Wenjin Huang, Shenyuan Huang, Jiulin Du, Cheng Huan. Screening of anti-cancer agent using zebrafish: comparison with the MTT assay. Biochemical and biophysical research communications. vol 422. issue 1. 2012-08-16. PMID:22560901. |
these compounds induced apoptosis and activated the p53 pathway in zebrafish within 3h treatment. |
2012-08-16 |
2023-08-12 |
zebrafish |
| Kiyoe Shimazaki, Takafumi Uchida, Akihiko Komine, Katsuhiko Takahash. p53 Retards cell-growth and suppresses etoposide-induced apoptosis in Pin1-deficient mouse embryonic fibroblasts. Biochemical and biophysical research communications. vol 422. issue 1. 2012-08-16. PMID:22564744. |
p53 retards cell-growth and suppresses etoposide-induced apoptosis in pin1-deficient mouse embryonic fibroblasts. |
2012-08-16 |
2023-08-12 |
mouse |