| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valentina Zuco, Michelandrea De Cesare, Raffaella Cincinelli, Raffaella Nannei, Claudio Pisano, Nadia Zaffaroni, Franco Zunin. Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo. PloS one. vol 6. issue 12. 2012-08-27. PMID:22194993. |
in contrast to saha, which was substantially less effective in sensitizing cells to paclitaxel-induced apoptosis, st2782 prevented up-regulation of p21(waf1/cip1) by paclitaxel, which has a protective role in response to taxanes, and caused p53 down-regulation, acetylation and mitochondrial localization of acetylated p53. |
2012-08-27 |
2023-08-12 |
human |
| Fiona M Guerra, Jennifer L Gommerman, Steven A Corfe, Christopher J Paige, Robert Rottape. Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response. PloS one. vol 7. issue 4. 2012-08-27. PMID:22545114. |
the hipks have been shown to be involved in growth regulation and apoptosis, with numerous studies highlighting hipk regulation of the tumor suppressor p53. |
2012-08-27 |
2023-08-12 |
mouse |
| Bassam Lajin, Amal Alachkar, Amir Alhaj Saku. A quadruplex tetra-primer ARMS-PCR method for the simultaneous detection of TP53 Arg72Pro, IVS3 16bp Del/Ins and IVS6+62A>G, and NQO1 C609T polymorphisms. Gene. vol 504. issue 2. 2012-08-27. PMID:22633876. |
the nad(p)h:quinone oxidoreductase 1, which is encoded by the nqo1 gene and, plays a direct role in apoptosis in addition to its recently discovered role as a regulator for p53. |
2012-08-27 |
2023-08-12 |
Not clear |
| Hong-Shui Lv, Xiang-Qian Kong, Qian-Qian Ming, Xing Jin, Jun-Ying Miao, Bao-Xiang Zha. Synthesis of 5-benzyl-2-phenylpyrazolo[1,5-a]pyrazin-4,6(5H,7H)-dione derivatives and discovery of an apoptosis inducer for H322 lung cancer cells. Bioorganic & medicinal chemistry letters. vol 22. issue 2. 2012-08-24. PMID:22209459. |
the compound 5j could selectively inhibit the growth of h322 lung cancer cells which contain a mutated p53 gene in a dose-dependent manner through inducing apoptosis of cells. |
2012-08-24 |
2023-08-12 |
Not clear |
| Hyun-A Seong, Hyunjung H. Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation. The Journal of biological chemistry. vol 287. issue 25. 2012-08-24. PMID:22532570. |
mpk38 functionally enhances p53-mediated apoptosis and cell cycle arrest in a kinase-dependent manner by stimulating p53 nuclear translocation. |
2012-08-24 |
2023-08-12 |
Not clear |
| Po-Yuan Chen, Kai-Chun Lin, Jing-Pin Lin, Nou-Ying Tang, Jai-Sing Yang, Kung-Wen Lu, Jing-Gung Chun. Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G(0)/G(1) Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-08-24. PMID:22919418. |
peitc induced g(0)/g(1) phase arrest through the effects of associated protein such as p53, p21, p17, cdk2 and cyclin e, and it triggered apoptosis through promotion of bax and bid expression and reduction of bcl-2, leading to decrease the levels of mitochondrial membrane potential (ΔΨ(m)), and followed the releases of cytochrome c, aif and endo g then for causing apoptosis in hsc-3 cells. |
2012-08-24 |
2023-08-12 |
human |
| Hong-yun Wang, Gao-fei Xiong, Ji-xiang Zhang, Hong Xu, Wu-hua Guo, Jiang-jing Xu, Xiang-yang Xion. The role of XPD in cell apoptosis and viability and its relationship with p53 and cdk2 in hepatoma cells. Medical oncology (Northwood, London, England). vol 29. issue 1. 2012-08-23. PMID:21264535. |
the role of xpd in cell apoptosis and viability and its relationship with p53 and cdk2 in hepatoma cells. |
2012-08-23 |
2023-08-12 |
Not clear |
| Hong-yun Wang, Gao-fei Xiong, Ji-xiang Zhang, Hong Xu, Wu-hua Guo, Jiang-jing Xu, Xiang-yang Xion. The role of XPD in cell apoptosis and viability and its relationship with p53 and cdk2 in hepatoma cells. Medical oncology (Northwood, London, England). vol 29. issue 1. 2012-08-23. PMID:21264535. |
we investigated the role of xpd in cell apoptosis of hepatoma and its relationship with p53 during the regulation of hepatoma bio-behavior. |
2012-08-23 |
2023-08-12 |
Not clear |
| Hong-yun Wang, Gao-fei Xiong, Ji-xiang Zhang, Hong Xu, Wu-hua Guo, Jiang-jing Xu, Xiang-yang Xion. The role of XPD in cell apoptosis and viability and its relationship with p53 and cdk2 in hepatoma cells. Medical oncology (Northwood, London, England). vol 29. issue 1. 2012-08-23. PMID:21264535. |
our results indicate that xpd may play an important role in cell apoptosis of hepatoma by inducing an over-expression of p53, but suppressing expressions of c-myc and cdk2. |
2012-08-23 |
2023-08-12 |
Not clear |
| Muhammad Khan, Bo Yu, Azhar Rasul, Ali Al Shawi, Fei Yi, Hong Yang, Tonghui M. Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-08-23. PMID:22216058. |
furthermore, our study revealed that induction of apoptosis was associated with cell cycle arrest at g2/m phase, upregulation of p53 and bax, decrease in mitochondrial membrane potential, release of cytochrome c, and activation of caspase 3. |
2012-08-23 |
2023-08-12 |
Not clear |
| Wen-Wen Huang, Jai-Sing Yang, Meng-Wei Lin, Po-Yuan Chen, Shang-Ming Chiou, Fu-Shin Chueh, Yu-Hsuan Lan, Shu-Jen Pai, Minoru Tsuzuki, Wai-Jane Ho, Jing-Gung Chun. Cucurbitacin E Induces G(2)/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes Apoptosis via Fas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-08-23. PMID:22272214. |
our results demonstrated that cucurbitacin e-induced g(2)/m arrest was associated with a marked increase in the levels of p53, p21 and a decrease in phospho-signal transducer and activator of transcription 3 (stat3), cyclin-dependent kinase 1 (cdk1) and cyclin b. cucurbitacin e-triggered apoptosis was accompanied with up-regulation of fas/cd95, truncated bid (t-bid) and a loss of ΔΨ(m), resulting in the releases of cytochrome c, apoptotic protease activating factor 1 (apaf-1) and apoptosis-inducing factor (aif), and sequential activation of caspase-8, caspase-9, and caspase-3. |
2012-08-23 |
2023-08-12 |
human |
| J L Schwartz, A N Shajahan, R Clark. The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer. International journal of breast cancer. vol 2011. 2012-08-23. PMID:22295238. |
irf1 is a tumor suppressor that mediates cell fate by facilitating apoptosis and can do so with or without functional p53. |
2012-08-23 |
2023-08-12 |
Not clear |
| Anjana Niga. Senescence (ageing) @ 2011. Indian journal of dermatology. vol 56. issue 6. 2012-08-23. PMID:22345758. |
besides this, the induction of apoptosis in stem and progenitor cells, increased p53 activity, and autophagy is also thought to trigger premature organismal ageing. |
2012-08-23 |
2023-08-12 |
mouse |
| Chindo Hicks, Ranjit Kumar, Antonio Pannuti, Lucio Miel. Integrative Analysis of Response to Tamoxifen Treatment in ER-Positive Breast Cancer Using GWAS Information and Transcription Profiling. Breast cancer : basic and clinical research. vol 6. 2012-08-23. PMID:22399860. |
key pathways identified included the apoptosis, p53, nfkb, dna repair and cell cycle pathways. |
2012-08-23 |
2023-08-12 |
Not clear |
| Songyan Zhang, Qiaojing Liu, Yanju Liu, Hong Qiao, Yu Li. Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-08-23. PMID:22454691. |
zerumbone, a southeast asian ginger sesquiterpene, induced apoptosis of pancreatic carcinoma cells through p53 signaling pathway. |
2012-08-23 |
2023-08-12 |
Not clear |
| Zhigang Kang, Shi-Yong Sun, Liang Ca. Activating Death Receptor DR5 as a Therapeutic Strategy for Rhabdomyosarcoma. ISRN oncology. vol 2012. 2012-08-23. PMID:22577581. |
like other types of cancers, rms develops by evading intrinsic apoptosis via mutations in the p53 tumor suppressor gene. |
2012-08-23 |
2023-08-12 |
Not clear |
| Zhigang Kang, Shi-Yong Sun, Liang Ca. Activating Death Receptor DR5 as a Therapeutic Strategy for Rhabdomyosarcoma. ISRN oncology. vol 2012. 2012-08-23. PMID:22577581. |
however, the ability to induce apoptosis via the death receptor-dependent extrinsic pathway remains largely intact in tumors with p53 mutations. |
2012-08-23 |
2023-08-12 |
Not clear |
| L Alexis Hoeferlin, Natalia V Oleinik, Natalia I Krupenko, Sergey A Krupenk. Activation of p21-Dependent G1/G2 Arrest in the Absence of DNA Damage as an Antiapoptotic Response to Metabolic Stress. Genes & cancer. vol 2. issue 9. 2012-08-23. PMID:22593801. |
in the present study, we have demonstrated that fdh-induced apoptosis is abrogated upon sirna knockdown of the p53 downstream target puma. |
2012-08-23 |
2023-08-12 |
Not clear |
| James Ming Phang, Wei Liu, Chad Hancock, Kyle J Christia. The proline regulatory axis and cancer. Frontiers in oncology. vol 2. 2012-08-23. PMID:22737668. |
the discovery that proline degradation is activated by p53 directed our attention to the initiation of apoptosis by proline oxidase/dehydrogenase. |
2012-08-23 |
2023-08-12 |
Not clear |
| Muhammad Khan, Bin Zheng, Fei Yi, Azhar Rasul, Zhuyi Gu, Ting Li, Hongwen Gao, Javed Iqbal Qazi, Hong Yang, Tonghui M. Pseudolaric Acid B induces caspase-dependent and caspase-independent apoptosis in u87 glioblastoma cells. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-08-23. PMID:22778780. |
further mechanistic study demonstrated that plab induced caspase-dependent apoptosis via upregulation of p53, increased level of proapoptotic protein bax, decreased level of antiapoptotic protein bcl-2, release of cytochrome c from mitochondria, activation of caspase-3 and proteolytic cleavage of poly (adp-ribose) polymerase (parp) and caspase-independent apoptosis through apoptosis inducing factor (aif). |
2012-08-23 |
2023-08-12 |
mouse |