| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin Meng, Hai-Hua Zhang, Chun-Xiang Zhou, Chen Li, Feng Zhang, Qi-Bing Me. The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. Oncology reports. vol 28. issue 1. 2012-09-04. PMID:22552631. |
here, we report that, trichostatin a (tsa), a pan-hdac inhibitor, could induce g2/m cell cycle arrest and apoptosis in both colorectal cancer cell lines with wild-type p53 (ht116 cells) and mutant p53 (ht29 cells), although hct116 cells had more apoptotic cells than ht29 cells. |
2012-09-04 |
2023-08-12 |
human |
| Jin Meng, Hai-Hua Zhang, Chun-Xiang Zhou, Chen Li, Feng Zhang, Qi-Bing Me. The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. Oncology reports. vol 28. issue 1. 2012-09-04. PMID:22552631. |
however, cells with normal p53 function are more sensitive to tsa-induced apoptosis. |
2012-09-04 |
2023-08-12 |
human |
| Shijun Li, Guangxia Shi, Hong Yuan, Tao Zhou, Qiuping Zhang, Hong Zhu, Xiaoyan Wan. Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP. Oncology reports. vol 28. issue 1. 2012-09-04. PMID:22552744. |
abnormal expression pattern of the aspp family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iaspp. |
2012-09-04 |
2023-08-12 |
human |
| Shijun Li, Guangxia Shi, Hong Yuan, Tao Zhou, Qiuping Zhang, Hong Zhu, Xiaoyan Wan. Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP. Oncology reports. vol 28. issue 1. 2012-09-04. PMID:22552744. |
downregulation of iaspp by sirna stimulated apoptosis through p53 in two nsclc cell lines. |
2012-09-04 |
2023-08-12 |
human |
| Othman A Al-Shabanah, Abdulaziz M Aleisa, Mohamed M Hafez, Salim S Al-Rejaie, Abdulaziz A Al-Yahya, Saleh A Bakheet, Mohamed M Al-Harbi, Mohamed M Sayed-Ahme. Desferrioxamine attenuates doxorubicin-induced acute cardiotoxicity through TFG-β/Smad p53 pathway in rat model. Oxidative medicine and cellular longevity. vol 2012. 2012-09-04. PMID:22619697. |
(2) dox increases apoptosis through upregulation of cdkn2a and p53 and downregulation of mdm2 gene expression. |
2012-09-04 |
2023-08-12 |
rat |
| Rui Li, Yun-Gui Yang, Yunzhou Gao, Zhao-Qi Wang, Wei-Min Ton. A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons. Cell research. vol 22. issue 5. 2012-08-31. PMID:22212482. |
notably, in contrast to massive apoptotic cell death in nbs1-deficient cerebella, activation of p53 leads to a defective neuroprogenitor proliferation in neocortex, likely via specific persistent induction of hematopoietic zinc finger (hzf) that preferentially promotes p53-mediated cell cycle arrest whilst inhibiting apoptosis. |
2012-08-31 |
2023-08-12 |
mouse |
| Mariana A Callero, Guadalupe V Suárez, Gabriela Luzzani, Boris Itkin, Binh Nguyen, Andrea I Loaiza-Pere. Aryl hydrocarbon receptor activation by aminoflavone: new molecular target for renal cancer treatment. International journal of oncology. vol 41. issue 1. 2012-08-31. PMID:22485252. |
apoptosis induced by the drug was evaluated by 4,6-diamidino-2-phenylindole and acridine orange/ethidium bromide staining and by measuring phosphorylated p53 (p-p53) and p21 levels, caspase 3 activation and poly(adp-ribose) polymerase cleavage. |
2012-08-31 |
2023-08-12 |
human |
| Vijay S Thakur, Karishma Gupta, Sanjay Gupt. Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases. International journal of oncology. vol 41. issue 1. 2012-08-31. PMID:22552582. |
acetylation of the tumor suppressor gene p53 at the carboxy-terminal lysine (lys) residues enhances its transcriptional activity associated with cell cycle arrest and apoptosis. |
2012-08-31 |
2023-08-12 |
human |
| Vijay S Thakur, Karishma Gupta, Sanjay Gupt. Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases. International journal of oncology. vol 41. issue 1. 2012-08-31. PMID:22552582. |
the increased gtp/egcg-mediated p53 acetylation enhanced its binding on the promoters of p21/waf1 and bax, which was associated with increased accumulation of cells in the g0/g1 phase of the cell cycle and induction of apoptosis. |
2012-08-31 |
2023-08-12 |
human |
| Rita Paro, Gian Mario Tiboni, Roberto Buccione, Gianna Rossi, Valerio Cellini, Rita Canipari, Sandra Ceccon. The fungicide mancozeb induces toxic effects on mammalian granulosa cells. Toxicology and applied pharmacology. vol 260. issue 2. 2012-08-30. PMID:22369882. |
we examined parameters such as cell morphology, induction of apoptosis, and p53 expression levels. |
2012-08-30 |
2023-08-12 |
mouse |
| Rita Paro, Gian Mario Tiboni, Roberto Buccione, Gianna Rossi, Valerio Cellini, Rita Canipari, Sandra Ceccon. The fungicide mancozeb induces toxic effects on mammalian granulosa cells. Toxicology and applied pharmacology. vol 260. issue 2. 2012-08-30. PMID:22369882. |
the expression level of p53, in terms of mrna and protein content, decreased significantly in comparison with unexposed cells, but no change in apoptosis was recorded. |
2012-08-30 |
2023-08-12 |
mouse |
| Sojin Shin, Kyo Chul Moon, Keon Uk Park, Eunyoung H. MicroRNA-513a-5p mediates TNF-α and LPS induced apoptosis via downregulation of X-linked inhibitor of apoptotic protein in endothelial cells. Biochimie. vol 94. issue 6. 2012-08-30. PMID:22504158. |
treatment of huvecs with tnf-α and lps attenuated x-linked inhibitor of apoptosis (xiap) while increased caspase-3 expression, poly adp-ribose polymerase (parp) cleavage, and p53 expression. |
2012-08-30 |
2023-08-12 |
human |
| Tae-Dong Kim, Sangphil Oh, Sook Shin, Ralf Janknech. Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D. PloS one. vol 7. issue 4. 2012-08-30. PMID:22514644. |
jmjd2d depletion also induced more strongly apoptosis in p53(-/-) compared to wild-type hct116 cells. |
2012-08-30 |
2023-08-12 |
Not clear |
| Jack W Penn, Adriaan O Grobbelaar, Kerstin J Rolf. The role of the TGF-β family in wound healing, burns and scarring: a review. International journal of burns and trauma. vol 2. issue 1. 2012-08-30. PMID:22928164. |
other putative mechanisms which may underlie the pathogenesis of hypertrophic scars include excessive inflammation, excessive angiogenesis, altered levels of matrix metalloproteinases, growth factors, and delayed apoptosis of fibrotic myofibroblasts either due to p53 genetic alterations or tensile forces across the wound. |
2012-08-30 |
2023-08-12 |
human |
| Essam M Abdelalim, Ikuo Tooyam. NPR-C protects embryonic stem cells from apoptosis by regulating p53 levels. Stem cells and development. vol 21. issue 8. 2012-08-29. PMID:21846177. |
npr-c protects embryonic stem cells from apoptosis by regulating p53 levels. |
2012-08-29 |
2023-08-12 |
Not clear |
| Essam M Abdelalim, Ikuo Tooyam. NPR-C protects embryonic stem cells from apoptosis by regulating p53 levels. Stem cells and development. vol 21. issue 8. 2012-08-29. PMID:21846177. |
conversely, chemical inhibition of p53 by α-pifithrin significantly reduced apoptosis in npr-c-deficient cells. |
2012-08-29 |
2023-08-12 |
Not clear |
| Essam M Abdelalim, Ikuo Tooyam. NPR-C protects embryonic stem cells from apoptosis by regulating p53 levels. Stem cells and development. vol 21. issue 8. 2012-08-29. PMID:21846177. |
canf((4-23)), a selective npr-c agonist, protected es cells against oxidative stress-induced apoptosis, and blocked activation of p53 and nanog suppression in the presence of dna-damaging agents. |
2012-08-29 |
2023-08-12 |
Not clear |
| M-V Guillot-Sestier, F Checle. α-Secretase-derived cleavage of cellular prion yields biologically active catabolites with distinct functions. Neuro-degenerative diseases. vol 10. issue 1-4. 2012-08-29. PMID:22261541. |
thus, n1 inhibits sts-induced caspase-3 activation by downregulating p53 in various cell systems and protects rat retinal ganglion cells from hypoxia-induced apoptosis. |
2012-08-29 |
2023-08-12 |
rat |
| Cesar Muñoz-Fontela, Dolores González, Laura Marcos-Villar, Michela Campagna, Pedro Gallego, José González-Santamaría, Daniel Herranz, Wei Gu, Manuel Serrano, Stuart A Aaronson, Carmen Riva. Acetylation is indispensable for p53 antiviral activity. Cell cycle (Georgetown, Tex.). vol 10. issue 21. 2012-08-28. PMID:22033337. |
tumor suppressor p53 is known to be a direct transcriptional target of type i interferons (ifns), contributing to virus-induced apoptosis, and in turn activating itself the interferon pathway. |
2012-08-28 |
2023-08-12 |
Not clear |
| Chris P Gully, Guermarie Velazquez-Torres, Ji-Hyun Shin, Enrique Fuentes-Mattei, Edward Wang, Colin Carlock, Jian Chen, Daniel Rothenberg, Henry P Adams, Hyun Ho Choi, Sergei Guma, Liem Phan, Ping-Chieh Chou, Chun-Hui Su, Fanmao Zhang, Jiun-Sheng Chen, Tsung-Ying Yang, Sai-Ching J Yeung, Mong-Hong Le. Aurora B kinase phosphorylates and instigates degradation of p53. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 24. 2012-08-28. PMID:22611192. |
we show that aurora b phosphorylates p53 at s183, t211, and s215 to accelerate the degradation of p53 through the polyubiquitination-proteasome pathway, thus functionally suppressing the expression of p53 target genes involved in cell cycle inhibition and apoptosis (e.g., p21 and puma). |
2012-08-28 |
2023-08-12 |
human |