| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pani A Apostolidis, Stephan Lindsey, William M Miller, Eleftherios T Papoutsaki. Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation. Physiological genomics. vol 44. issue 12. 2012-10-01. PMID:22548738. |
our data support a model whereby p53 expression during megakaryopoiesis serves to control polyploidization and the transition from endomitosis to apoptosis by impeding cell cycling and promoting apoptosis. |
2012-10-01 |
2023-08-12 |
Not clear |
| Haowei Yan, Nan Liu, Zhenghong Zhao, Xinmin Zhang, Hao Xu, Bing Shao, Weiqun Ya. Expression and purification of human TAT-p53 fusion protein in Pichia pastoris and its influence on HepG2 cell apoptosis. Biotechnology letters. vol 34. issue 7. 2012-09-28. PMID:22426841. |
p53 is an attractive target in molecular cancer therapeutics because of its critical role in regulating cell cycle arrest and apoptosis. |
2012-09-28 |
2023-08-12 |
human |
| Haitao Ji, Zhiyong Ding, David Hawke, Dongming Xing, Bing-Hua Jiang, Gordon B Mills, Zhimin L. AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. EMBO reports. vol 13. issue 6. 2012-09-28. PMID:22510990. |
akt-dependent phosphorylation of niban regulates nucleophosmin- and mdm2-mediated p53 stability and cell apoptosis. |
2012-09-28 |
2023-08-12 |
human |
| Haitao Ji, Zhiyong Ding, David Hawke, Dongming Xing, Bing-Hua Jiang, Gordon B Mills, Zhimin L. AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. EMBO reports. vol 13. issue 6. 2012-09-28. PMID:22510990. |
conversely, depletion of or deficiency in niban expression promotes stabilization of p53 with increased cell apoptosis. |
2012-09-28 |
2023-08-12 |
human |
| Ajay Kumar, Shiva Kant, Sukh Mahendra Sing. Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation. Chemico-biological interactions. vol 199. issue 1. 2012-09-28. PMID:22705712. |
moreover, we also observed an alteration in the expression of other apoptosis and cell survival regulatory molecules: puma, glut1, bcl2, p53, cad, caspase-3 and hsp70. |
2012-09-28 |
2023-08-12 |
Not clear |
| Hsiang-Ping Lee, Te-Mao Li, Jung-Ying Tsao, Yi-Chin Fong, Chih-Hsin Tan. Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death receptor pathway. International immunopharmacology. vol 13. issue 2. 2012-09-26. PMID:22522053. |
in addition, p53 involved in curcumin-mediated fas, fasl, and dr5 expression and cell apoptosis in chondrosarcoma cells. |
2012-09-26 |
2023-08-12 |
human |
| Hiroyuki Mochizuki, Yuko Goto-Koshino, Masahiko Sato, Yasuhito Fujino, Koichi Ohno, Hajime Tsujimot. Comparison of the antitumor effects of an MDM2 inhibitor, nutlin-3, in feline lymphoma cell lines with or without p53 mutation. Veterinary immunology and immunopathology. vol 147. issue 3-4. 2012-09-26. PMID:22578852. |
from these results, we concluded that nutlin-3 has an antitumor effect on feline lymphoma cell lines harboring the wt-p53 gene through accumulation and activation of p53 leading to cell cycle arrest and apoptosis. |
2012-09-26 |
2023-08-12 |
human |
| Sayani Banerjee, Pratip Chakraborty, Piyali Saha, Soma Aditya Bandyopadhyay, Sutapa Banerjee, Syed N Kabi. Ovotoxic effects of galactose involve attenuation of follicle-stimulating hormone bioactivity and up-regulation of granulosa cell p53 expression. PloS one. vol 7. issue 2. 2012-09-24. PMID:22319579. |
the in vitro effects of galactose were studied in isolated whole follicles in respect of generation of reactive oxygen species (ros) and expression of caspase 3, and in isolated granulosa cells in respect of mitochondrial membrane potential, expression of p53, and apoptosis. |
2012-09-24 |
2023-08-12 |
human |
| Sayani Banerjee, Pratip Chakraborty, Piyali Saha, Soma Aditya Bandyopadhyay, Sutapa Banerjee, Syed N Kabi. Ovotoxic effects of galactose involve attenuation of follicle-stimulating hormone bioactivity and up-regulation of granulosa cell p53 expression. PloS one. vol 7. issue 2. 2012-09-24. PMID:22319579. |
in isolated granulosa cells, galactose disrupted mitochondrial membrane potential, stimulated p53 expression, and induced apoptosis in vitro; however co-treatment with either fsh or estradiol significantly prevented galactose-induced granulosa cell p53 expression. |
2012-09-24 |
2023-08-12 |
human |
| Weiguo Liang, Dongping Ye, Libing Dai, Yan Shen, Jiake X. Overexpression of hTERT extends replicative capacity of human nucleus pulposus cells, and protects against serum starvation-induced apoptosis and cell cycle arrest. Journal of cellular biochemistry. vol 113. issue 6. 2012-09-21. PMID:22298321. |
in addition, they showed resistance to serum starvation-induced apoptosis, g1 cell cycle arrest, and gene expression of p53, ccne1, fas, and caspase 3. |
2012-09-21 |
2023-08-12 |
mouse |
| Kwang Hwa Jung, Ji Heon Noh, Jeong Kyu Kim, Jung Woo Eun, Hyun Jin Bae, Hong Jian Xie, Young Gyoon Chang, Min Gyu Kim, Hanna Park, Jung Young Lee, Suk Woo Na. HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins. Journal of cellular biochemistry. vol 113. issue 6. 2012-09-21. PMID:22492270. |
hdac2 inactivation resulted in regression of tumor cell growth and activation of cellular apoptosis via p53 and bax activation and bcl2 suppression. |
2012-09-21 |
2023-08-12 |
mouse |
| Dennis Ma, Phillip Tremblay, Kevinjeet Mahngar, Pardis Akbari-Asl, Jonathan Collins, Tomas Hudlicky, James McNulty, Siyaram Pande. A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen. Investigational new drugs. vol 30. issue 3. 2012-09-20. PMID:21494837. |
a novel synthetic c-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen. |
2012-09-20 |
2023-08-12 |
human |
| Dennis Ma, Phillip Tremblay, Kevinjeet Mahngar, Pardis Akbari-Asl, Jonathan Collins, Tomas Hudlicky, James McNulty, Siyaram Pande. A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen. Investigational new drugs. vol 30. issue 3. 2012-09-20. PMID:21494837. |
we found that a c-1 acetoxymethyl derivative of 7-deoxypancratistatin, jc-th-acetate-4 (jcth-4), was effective in inducing apoptosis in both p53 positive (hct 116) and p53 negative (ht-29) human crc cell lines, demonstrating similar efficacy to that of natural pst. |
2012-09-20 |
2023-08-12 |
human |
| Pierre-Jacques Hamard, Dana J Lukin, James J Manfred. p53 basic C terminus regulates p53 functions through DNA binding modulation of subset of target genes. The Journal of biological chemistry. vol 287. issue 26. 2012-09-20. PMID:22514277. |
moreover, p53-induced growth arrest and apoptosis both require an intact p53 ctd. |
2012-09-20 |
2023-08-12 |
human |
| David Cerna, Hongyun Li, Siobhan Flaherty, Naoko Takebe, C Norman Coleman, Stephen S Yo. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner. The Journal of biological chemistry. vol 287. issue 26. 2012-09-20. PMID:22570471. |
gmx1778-mediated ros induction is p53-dependent, suggesting that the status of both p53 and naprt1 might affect tumor apoptosis, as determined by annexin-v staining. |
2012-09-20 |
2023-08-12 |
Not clear |
| María Gabriela Thomas, Luciana Luchelli, Malena Pascual, Vanesa Gottifredi, Graciela Lidia Boccacci. A monoclonal antibody against p53 cross-reacts with processing bodies. PloS one. vol 7. issue 5. 2012-09-19. PMID:22590546. |
the p53 tumor suppressor protein is an important regulator of cell proliferation and apoptosis. |
2012-09-19 |
2023-08-12 |
human |
| Yang Wang, Yudan Wei, Haiying Zhang, Yanfen Shi, Yulin Li, Ronggui L. Arsenic trioxide induces apoptosis of p53 null osteosarcoma MG63 cells through the inhibition of catalase. Medical oncology (Northwood, London, England). vol 29. issue 2. 2012-09-18. PMID:21308489. |
arsenic trioxide induces apoptosis of p53 null osteosarcoma mg63 cells through the inhibition of catalase. |
2012-09-18 |
2023-08-12 |
human |
| Yang Wang, Yudan Wei, Haiying Zhang, Yanfen Shi, Yulin Li, Ronggui L. Arsenic trioxide induces apoptosis of p53 null osteosarcoma MG63 cells through the inhibition of catalase. Medical oncology (Northwood, London, England). vol 29. issue 2. 2012-09-18. PMID:21308489. |
the present study indicates that p53 null osteosarcoma mg63 cells are susceptible to the ato; the inhibition of catalase and the resulted intracellular ros accumulation are an important molecular mechanism under which ato induces apoptosis of p53-deficient osteosarcoma cells. |
2012-09-18 |
2023-08-12 |
human |
| Junya Wada, Rui Kamada, Toshiaki Imagawa, Yoshiro Chuman, Kazuyasu Sakaguch. Inhibition of tumor suppressor protein p53-dependent transcription by a tetramerization domain peptide via hetero-oligomerization. Bioorganic & medicinal chemistry letters. vol 22. issue 8. 2012-09-18. PMID:22429466. |
tumor suppressor protein p53 induces cell cycle arrest, apoptosis, and senescence in response to cellular stresses. |
2012-09-18 |
2023-08-12 |
Not clear |
| Malcolm A Smith, Richard Gorlick, E Anders Kolb, Richard Lock, Hernan Carol, John M Maris, Stephen T Keir, Christopher L Morton, C Patrick Reynolds, Min H Kang, Janine Arts, Tarig Bashir, Michel Janicot, Raushan T Kurmasheva, Peter J Houghto. Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program. Pediatric blood & cancer. vol 59. issue 2. 2012-09-17. PMID:21922647. |
jnj-26854165 was originally developed as an activator of p53 capable of inducing apoptosis in cancer cell lines. |
2012-09-17 |
2023-08-12 |
Not clear |