| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Mundle, V Kotelnikov, N Wood, J Coon, E Horvath, S Taylor, S Lafollette, D Caldarelli, J Hutchinson, W Panje, H Preisler, A Raz. Assessment of apoptosis in relation to proliferation and mutational status of p53 gene in head and neck cancers. International journal of oncology. vol 8. issue 6. 2012-10-02. PMID:21544492. |
the spontaneous apoptosis in hn tumors seems unrelated to mutations in the p53 gene. |
2012-10-02 |
2023-08-12 |
Not clear |
| V Damiano, G Diisernia, F Ciardiello, S Pepe, A Bianco, C Bianco, A Ruggiero, G Baldassarre, G Merlo, G Tortor. Overexpression of wild-type p53 overrides the mitogenic effect of ri-alpha subunit of protein-kinase-a in human breast cells. International journal of oncology. vol 7. issue 2. 2012-10-02. PMID:21552843. |
retroviral vector-mediated overexpression of wild-type p53 in the mcf-10a neo and mcf-10a ri alpha cells determined a marked inhibition of ri alpha protein expression in mcf-10a-p53 cells and induced g0/g1 accumulation, cell gowth arrest and changes in cell morphology not due to apoptosis in both mcf-10a-p53 and mcf-10a ri alpha-p53 cells. |
2012-10-02 |
2023-08-12 |
human |
| Y Sun, Z Dong, J Jackman, G Hegamyer, H Kim, N Colbur. Status of the mdm-2 and waf-1 genes in mouse epidermal jb6 variants harboring wild-type p53 - a p53-independent induction of waf-1. International journal of oncology. vol 6. issue 2. 2012-10-02. PMID:21556561. |
we conclude from this study that a) there is no evidence for mutational inactivation of waf-1 that might mimic p53 inactivation in the jb6 model; b) elevated expression of mdm-2 and/or waf-1 might be involved in neoplastic progression; and c) there is a p53-independent pathway controlling waf-1 expression which may mediate p53-independent apoptosis. |
2012-10-02 |
2023-08-12 |
mouse |
| C Gotz, M Montenar. P53 and its implication in apoptosis (review). International journal of oncology. vol 6. issue 5. 2012-10-02. PMID:21556650. |
p53 and its implication in apoptosis (review). |
2012-10-02 |
2023-08-12 |
Not clear |
| C Gotz, M Montenar. P53 and its implication in apoptosis (review). International journal of oncology. vol 6. issue 5. 2012-10-02. PMID:21556650. |
this controlled process called apoptosis is composed of a cascade of events which are dominantly influenced by p53. |
2012-10-02 |
2023-08-12 |
Not clear |
| C Gotz, M Montenar. P53 and its implication in apoptosis (review). International journal of oncology. vol 6. issue 5. 2012-10-02. PMID:21556650. |
a possible clinical implication of apoptosis and the implication of p53 in this process will be discussed. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Schulzelutum, J Siegel, R Schmidt, B Plaumann, C Braun, C Haessler, G Brandner, R Hes. Filtered, tar-free and aerosol-free cigarette-smoke causes accumulation of the tumor-suppressor protein p53 in rodent cells. International journal of oncology. vol 5. issue 6. 2012-10-02. PMID:21559728. |
after 1 min exposure to 1:5 air-diluted filtered cigarette smoke maximal p53 accumulation occured about 20 h later, whereas maximal dna fragmentation and apoptosis and maximal roi levels were found after 10 min of exposure. |
2012-10-02 |
2023-08-12 |
Not clear |
| Y Gazitt, G Erdo. Fluctuations and nuclear translocation of p53, C-myc, cdc-2 and pcna proteins during growth and commitment to differentiation of agf cells. International journal of oncology. vol 4. issue 1. 2012-10-02. PMID:21566891. |
transcription regulatory proteins such as c-myc and p53 play an important role in the regulation of cell growth, differentiation and apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Y Gazitt, M Lavia, G Erdo. Regulation of cell-growth and apoptosis in synchronized agf cells - involvement of oncogenes and cell-cycle regulatory proteins. International journal of oncology. vol 3. issue 3. 2012-10-02. PMID:21573390. |
the fluctuations in the levels of the proliferation cell nuclear antigen (pcna), cyclin a, cdc-2, c-myc and p53 proteins were monitored in synchronized cultures and in cells undergoing apoptosis by immunofluorescence staining and flow cytometry. |
2012-10-02 |
2023-08-12 |
Not clear |
| Y Gazitt, M Lavia, G Erdo. Regulation of cell-growth and apoptosis in synchronized agf cells - involvement of oncogenes and cell-cycle regulatory proteins. International journal of oncology. vol 3. issue 3. 2012-10-02. PMID:21573390. |
most importantly, however, the level of staining for c-myc, p53, cyclin a, cdc-2 and pcna increased markedly during apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| J Lee, S Kim, T Yoon, K Cho, M Yang, S Lee, J R. Bcl-2 and p53 expressions in large-cell lymphoma. Oncology reports. vol 4. issue 2. 2012-10-02. PMID:21590070. |
bcl-2 and p53 regulate apoptosis in a see-saw fashion and are expressed abnormally in a variety of malignant tumors. |
2012-10-02 |
2023-08-12 |
Not clear |
| U Consoli, H Li, P Huang, T Kobayashi, M Andreeff, V Levin, W Zhan. Enhancement of apoptosis in irradiated glioblastoma cells by pentoxifylline. Oncology reports. vol 4. issue 4. 2012-10-02. PMID:21590120. |
pentoxifylline has recently been shown to sensitize breast cancer cells in which the wild-type p53 function was abrogated to cisplatin-induced apoptosis. |
2012-10-02 |
2023-08-12 |
human |
| G Srinivas, P Kusumakumari, M Nair, K Panicker, M Pilla. Tumor proliferative compartment, multidrug resistance gene product and apoptosis regulatory p53 and bcl-2 proteins in pediatric acute lymphoblastic leukemia. Oncology reports. vol 4. issue 5. 2012-10-02. PMID:21590201. |
tumor proliferative compartment, multidrug resistance gene product and apoptosis regulatory p53 and bcl-2 proteins in pediatric acute lymphoblastic leukemia. |
2012-10-02 |
2023-08-12 |
Not clear |
| M Makino, H Shirai, K Sugamura, O Kimura, M Maeta, H Itoh, N Kaibar. Increased induction of apoptosis of human colorectal cancer cells after preoperative treatment with 5-fluorouracil. Oncology reports. vol 3. issue 2. 2012-10-02. PMID:21594360. |
we examined whether the administration of 5-fluorouracil (5-fu) could enhance apoptosis of colorectal cancer cells, and we investigated the relationship between apoptosis and the expression of ki-67, p53, and c-myc. |
2012-10-02 |
2023-08-12 |
human |
| M Makino, H Shirai, K Sugamura, O Kimura, M Maeta, H Itoh, N Kaibar. Increased induction of apoptosis of human colorectal cancer cells after preoperative treatment with 5-fluorouracil. Oncology reports. vol 3. issue 2. 2012-10-02. PMID:21594360. |
there was no clear correlation between expression of apoptosis and the expression of p53 or c-myc. |
2012-10-02 |
2023-08-12 |
human |
| L Zhang, E Mao, R Priddy, M Rosi. p53 overexpression in oral lichen planus. Oncology reports. vol 3. issue 6. 2012-10-02. PMID:21594527. |
since the pathogenesis of olps involves cell-mediated cytotoxicity (cmc) which causes marked apoptosis, it is possible that the p53 expression represents wild-type p53 that may be regulating the apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Y Murayama, Y Mishim. New cancer strategy - apoptosis based therapy by growth-factors (review). Oncology reports. vol 2. issue 1. 2012-10-02. PMID:21597680. |
p53 and rb gene is emphasized as a key gene in induction of cell cycle progression and apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Y Murayam. High-concentration of epidermal growth-factor induces apoptosis in breast and esophageal cancer-cells transplanted into nude-mice. Oncology reports. vol 1. issue 6. 2012-10-02. PMID:21607490. |
two mu g of egf induced apoptosis in es-4 esophageal cancer cells and mx-1 breast cancer cells after increased accumulation of p53 induced by 2 mu g of egf. |
2012-10-02 |
2023-08-12 |
mouse |
| Y Murayam. High-concentration of epidermal growth-factor induces apoptosis in breast and esophageal cancer-cells transplanted into nude-mice. Oncology reports. vol 1. issue 6. 2012-10-02. PMID:21607490. |
on the other hand, using um-1 breast cancer cells, we inhibited p53 expression by 2 mu g of tgf-beta 1 and detected apoptosis and pcna immunostaining. |
2012-10-02 |
2023-08-12 |
mouse |
| W Wörner, D Schren. 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses apoptosis and leads to hyperphosphorylation of p53 in rat hepatocytes. Environmental toxicology and pharmacology. vol 6. issue 4. 2012-10-02. PMID:21781900. |
2,3,7,8-tetrachlorodibenzo-p-dioxin suppresses apoptosis and leads to hyperphosphorylation of p53 in rat hepatocytes. |
2012-10-02 |
2023-08-12 |
rat |