| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Shao, Po Zhao, Xianghong L. [Expression and significance of bcl-2, bax, P53 in neuroendocrine carcinomas of the lung]. Zhongguo fei ai za zhi = Chinese journal of lung cancer. vol 9. issue 1. 2012-10-02. PMID:21144283. |
bcl-2 and bax are main regulators of cell apoptosis, both are downstream genes of wild-type p53 gene. |
2012-10-02 |
2023-08-12 |
Not clear |
| K J Pienta, J F William. Detection of apoptosis in renal cell carcinoma. Methods in molecular medicine. vol 53. 2012-10-02. PMID:21318790. |
the expression of bcl-2 and p53 has been implicated in the control of apoptosis in tumorigenesis, and as a possible pathway to which cancer treatments could be directed. |
2012-10-02 |
2023-08-12 |
Not clear |
| K J Pienta, J F William. Detection of apoptosis in renal cell carcinoma. Methods in molecular medicine. vol 53. 2012-10-02. PMID:21318790. |
a reciprocal correlation was found between apoptosis and p53 positivity in rcc suggesting that the presence of mutant p53 is a negative regulator of apoptosis (3). |
2012-10-02 |
2023-08-12 |
Not clear |
| J L Carroll, J Michael Mathis, M C Bell, J T Santos. p53 Adenovirus as Gene Therapy for Ovarian Cancer. Methods in molecular medicine. vol 39. 2012-10-02. PMID:21340840. |
the p53 gene product plays a role in normal cellular proliferation by regulating gene transcription, cell cycle control, and apoptosis (2). |
2012-10-02 |
2023-08-12 |
human |
| b' A Tullo, E Sbis\\xc3\\xa. Mutation of p53 Tumor Suppressor Gene in Hepatocellular Carcinoma. Methods in molecular medicine. vol 45. 2012-10-02. PMID:21341051.' |
p53 product is a 53-kda phosphoprotein involved in the regulation of cell cycle, in dna synthesis and repair, and in cell differentiation and apoptosis (see refs. |
2012-10-02 |
2023-08-12 |
Not clear |
| J Berg. Analysis of the p53 Status of Tumors : An Overview of Methods. Methods in molecular medicine. vol 28. 2012-10-02. PMID:21374038. |
p53 has been denoted "guardian of the genome" (3) owing to its essential cellular functions in apoptosis control, cell-cycle control, chromosomal segregation, gene transcription, and genomic stability (4). |
2012-10-02 |
2023-08-12 |
mouse |
| P D Allen, A C Newlan. Apoptosis detection by DNA analysis. Methods in molecular medicine. vol 6. 2012-10-02. PMID:21380708. |
the discovery that certain proto-oncogenes (3), e.g., c-myc and bcl-2 and the tumor suppressor gene p53 are implicated in the control of apoptosis has focused attention on both the role of apoptosis in tumorogenesis and as a possible pathway to which cancer therapeutic regimens could be directed (4). |
2012-10-02 |
2023-08-12 |
Not clear |
| K Brand, V Sandig, M Straus. Combined adenoviral transfer of tumor suppressor and cell-cycle genes for tumor-cell apoptosis. Methods in molecular medicine. vol 35. 2012-10-02. PMID:21390805. |
we have recently reported that the cotransfer of p53 and p16 leads to a better induction of apoptosis and reduction of tumor growth than the transfer of either gene alone (2). |
2012-10-02 |
2023-08-12 |
Not clear |
| U Herrlinger, A Jacobs, M Aghi, D E Schuback, X O Breakefiel. HSV-1 Vectors for Gene Therapy of Experimental CNS Tumors. Methods in molecular medicine. vol 35. 2012-10-02. PMID:21390812. |
other approaches use the transfer of genes that modulate angiogenesis (12,13) or are involved in apoptosis like p53 (14). |
2012-10-02 |
2023-08-12 |
Not clear |
| G L Clayman, D K Frank, P A Brus. Adenovirus-Mediated Wild-Type p53 Gene Transfer into Head and Neck Cancers. Methods in molecular medicine. vol 35. 2012-10-02. PMID:21390829. |
this strategy is based on the role that wild-type p53 plays as a tumor-suppressor gene and inducer of cell-cycle arrest and apoptosis (1 ,8-11). |
2012-10-02 |
2023-08-12 |
human |
| Eun Jeong Choi, Taehee Ki. Equol induced apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 but not MCF-7 cells. Molecular medicine reports. vol 1. issue 2. 2012-10-02. PMID:21479403. |
during equol-induced apoptosis, equol increased the number of cells in the sub-g0 phase and enhanced the level of p53. |
2012-10-02 |
2023-08-12 |
human |
| A Wolff, A Technau, G Brandne. Epothilone A induces apoptosis in neuroblastoma cells with multiple mechanisms of drug resistance. International journal of oncology. vol 11. issue 1. 2012-10-02. PMID:21528189. |
like paclitaxel, epothilone a induced apoptosis in neuroblastoma cells which exhibit constitutive cytoplasmic sequestration of p53 and, hence, an impaired dna-damage-dependent apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Y Zeng, N Prabhu, R Meng, W Eldeir. Adenovirus-mediated p53 gene therapy in nasopharyngeal cancer. International journal of oncology. vol 11. issue 2. 2012-10-02. PMID:21528203. |
infection with p53-expressing adenovirus (ad-p53) induced apoptosis and inhibited cell growth in all three npc cell lines, regardless of the endogenous p53 status. |
2012-10-02 |
2023-08-12 |
mouse |
| M Bache, J Dunst, P Wurl, D Frode, M Dietzel, A Meye, H Schmidt, F Rath, W Wohlrab, H Dralle, H Tauber. Radiation induced G2/M block and apoptosis in two human sarcoma cell lines with different p53 gene status. International journal of oncology. vol 11. issue 5. 2012-10-02. PMID:21528295. |
radiation induced g2/m block and apoptosis in two human sarcoma cell lines with different p53 gene status. |
2012-10-02 |
2023-08-12 |
human |
| M Bache, J Dunst, P Wurl, D Frode, M Dietzel, A Meye, H Schmidt, F Rath, W Wohlrab, H Dralle, H Tauber. Radiation induced G2/M block and apoptosis in two human sarcoma cell lines with different p53 gene status. International journal of oncology. vol 11. issue 5. 2012-10-02. PMID:21528295. |
in agreement with this, in terms of viability as well as the rate of apoptosis, a-204 (wt p53) showed a stronger response to irradiation than us8-93 (mt p53). |
2012-10-02 |
2023-08-12 |
human |
| C Ahn, M Hwang, P Ramsamooj, S Lee, M Jun. Rapamycin-induced apoptosis is p53-independent in human prostate carcinoma PC-3 cells. International journal of oncology. vol 11. issue 5. 2012-10-02. PMID:21528311. |
rapamycin induced apoptosis as well as the expression of p21(waf1) mrna and protein, independent of p53. |
2012-10-02 |
2023-08-12 |
human |
| Z Madar, I Zusma. The role of dietary factors in prevention of chemically-induced cancers (review). International journal of oncology. vol 11. issue 5. 2012-10-02. PMID:21528316. |
apoptosis, proliferating cell nuclear antigen (pcna) and p53 protein synthesis. |
2012-10-02 |
2023-08-12 |
rat |
| M Blagosklonny, G Wu, K Somasundaram, W Eldeir. Wild-type p53 is not sufficient for serum starvation-induced apoptosis in cancer cells but accelerates apoptosis in sensitive cells. International journal of oncology. vol 11. issue 6. 2012-10-02. PMID:21528317. |
wild-type p53 is not sufficient for serum starvation-induced apoptosis in cancer cells but accelerates apoptosis in sensitive cells. |
2012-10-02 |
2023-08-12 |
human |
| M Blagosklonny, G Wu, K Somasundaram, W Eldeir. Wild-type p53 is not sufficient for serum starvation-induced apoptosis in cancer cells but accelerates apoptosis in sensitive cells. International journal of oncology. vol 11. issue 6. 2012-10-02. PMID:21528317. |
however, other cell lines did not undergo apoptosis despite their expression of wt p53. |
2012-10-02 |
2023-08-12 |
human |
| M Blagosklonny, G Wu, K Somasundaram, W Eldeir. Wild-type p53 is not sufficient for serum starvation-induced apoptosis in cancer cells but accelerates apoptosis in sensitive cells. International journal of oncology. vol 11. issue 6. 2012-10-02. PMID:21528317. |
these results suggest that although p53 contributes to starvation-induced apoptosis in sensitive (hct116 and e1a-expressing h460) cancer cell lines, most cancer cells survived despite the presence of wt p53. |
2012-10-02 |
2023-08-12 |
human |