| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen-Jun Yan, Kai-Bao Wu, Zhi-Yong M. [Function of tumor suppressor p53 and its role in antiviral immunity]. Bing du xue bao = Chinese journal of virology. vol 28. issue 4. 2012-10-12. PMID:22978174. |
furthermore, there was a new function for p53 in antiviral apoptosis mentioned in the research, integration of interferon-alpha/beta signaling to p53 responses in tumour suppression and antiviral defense. |
2012-10-12 |
2023-08-12 |
Not clear |
| Tae-Dong Kim, Sook Shin, William L Berry, Sangphil Oh, Ralf Janknech. The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells. Journal of cellular biochemistry. vol 113. issue 4. 2012-10-11. PMID:22134899. |
finally, jmjd2a depletion induced apoptosis in hct116 cells and this effect was less pronounced in the absence of p53. |
2012-10-11 |
2023-08-12 |
human |
| Franziska Busch, Ali Mobasheri, Parviz Shayan, Ralf Stahlmann, Mehdi Shakibae. Sirt-1 is required for the inhibition of apoptosis and inflammatory responses in human tenocytes. The Journal of biological chemistry. vol 287. issue 31. 2012-10-11. PMID:22689577. |
transient transfection of tenocytes with aso against sirt-1 induced expression of bax and other proteins involved in apoptosis (cleaved caspase-3 and poly(adp-ribose)polymerase), acetylation of tumor suppressor p53, and mitochondrial degradation. |
2012-10-11 |
2023-08-12 |
human |
| Bradford Graves, Thelma Thompson, Mingxuan Xia, Cheryl Janson, Christine Lukacs, Dayanand Deo, Paola Di Lello, David Fry, Colin Garvie, Kuo-Sen Huang, Lin Gao, Christian Tovar, Allen Lovey, Jutta Wanner, Lyubomir T Vassile. Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 29. 2012-10-11. PMID:22745160. |
this mode of action effectively stabilized p53 and activated p53 signaling in cancer cells, leading to cell cycle arrest and apoptosis. |
2012-10-11 |
2023-08-12 |
Not clear |
| You-Cheng Hseu, Hsiao-Tung Tsou, K J Senthil Kumar, Kai-Yuan Lin, Hsueh-Wei Chang, Hsin-Ling Yan. The Antitumor Activity of Antrodia camphorata in Melanoma Cells: Modulation of Wnt/β-Catenin Signaling Pathways. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-10-11. PMID:23049605. |
furthermore, treatment of melanoma cells with ac resulted in a significant increase in apoptosis, which was associated with dna fragmentation, cytochrome c release, caspase-9 and -3 activation, parp degradation, bcl-2/bax dysregulation, and p53 expression. |
2012-10-11 |
2023-08-12 |
Not clear |
| Simone Di Giovanni, Khizr Rathor. p53-Dependent pathways in neurite outgrowth and axonal regeneration. Cell and tissue research. vol 349. issue 1. 2012-10-10. PMID:22271139. |
the tumor suppressor p53 is a multifunctional sensor of a number of cellular signals and pathways essential for cell biology, including dna damage, cell cycle regulation, apoptosis, angiogenesis and cell metabolism. |
2012-10-10 |
2023-08-12 |
Not clear |
| D T Arioz, M Tosun, C Polat, A Saylan, M Yilmaze. The effects of ischaemic preconditioning on ovarian apoptosis and p53 expression during laparoscopy. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. vol 32. issue 5. 2012-10-10. PMID:22663321. |
the effects of ischaemic preconditioning on ovarian apoptosis and p53 expression during laparoscopy. |
2012-10-10 |
2023-08-12 |
rat |
| D T Arioz, M Tosun, C Polat, A Saylan, M Yilmaze. The effects of ischaemic preconditioning on ovarian apoptosis and p53 expression during laparoscopy. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. vol 32. issue 5. 2012-10-10. PMID:22663321. |
we aimed to explore the effects of ischaemic preconditioning (ip) used to reduce ischaemic injury during laparoscopy on ovarian apoptosis and p53 expression. |
2012-10-10 |
2023-08-12 |
rat |
| D T Arioz, M Tosun, C Polat, A Saylan, M Yilmaze. The effects of ischaemic preconditioning on ovarian apoptosis and p53 expression during laparoscopy. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. vol 32. issue 5. 2012-10-10. PMID:22663321. |
all the data revealed that ovarian apoptosis and p53 expression were highest in group iv. |
2012-10-10 |
2023-08-12 |
rat |
| D T Arioz, M Tosun, C Polat, A Saylan, M Yilmaze. The effects of ischaemic preconditioning on ovarian apoptosis and p53 expression during laparoscopy. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. vol 32. issue 5. 2012-10-10. PMID:22663321. |
pp induces higher amount of apoptosis and p53 expression in ovary but preconditioning may have protective effects during laparoscopy. |
2012-10-10 |
2023-08-12 |
rat |
| Hiroaki Inaba, Masae Kuboniwa, Hideyuki Sugita, Richard J Lamont, Atsuo Aman. Identification of signaling pathways mediating cell cycle arrest and apoptosis induced by Porphyromonas gingivalis in human trophoblasts. Infection and immunity. vol 80. issue 8. 2012-10-10. PMID:22689813. |
in addition, small interfering rna (sirna) knockdown of p53 abrogated both g(1) arrest and apoptosis. |
2012-10-10 |
2023-08-12 |
human |
| Linda Vuong, Daniel E Brobst, Anisse Saadi, Ivana Ivanovic, Muayyad R Al-Ubaid. Pattern of expression of p53, its family members, and regulators during early ocular development and in the post-mitotic retina. Investigative ophthalmology & visual science. vol 53. issue 8. 2012-10-10. PMID:22714890. |
because of its role in cell cycle regulation and apoptosis, p53 may be involved in maintaining the post-mitotic state of the adult eye. |
2012-10-10 |
2023-08-12 |
mouse |
| Ingrit Hamann, Charlotte König, Constanze Richter, Gunnar Jahnke, Andrea Hartwi. Impact of cadmium on hOGG1 and APE1 as a function of the cellular p53 status. Mutation research. vol 736. issue 1-2. 2012-10-09. PMID:21605570. |
the tumor suppressor protein p53, often called the guardian of the genome, is involved in important cellular processes, such as cell cycle control, apoptosis and dna repair. |
2012-10-09 |
2023-08-12 |
Not clear |
| Hye-Sook Seo, Han-Seok Choi, Soon-Re Kim, Youn Kyung Choi, Sang-Mi Woo, Incheol Shin, Jong-Kyu Woo, Sang-Yoon Park, Yong Cheol Shin, Seong-Gyu Ko, Seong-Kyu K. Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells. Molecular and cellular biochemistry. vol 366. issue 1-2. 2012-10-09. PMID:22527937. |
apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting stat3 and nfκb signaling in her2-overexpressing breast cancer cells. |
2012-10-09 |
2023-08-12 |
Not clear |
| Charles R Myer. The effects of chromium(VI) on the thioredoxin system: implications for redox regulation. Free radical biology & medicine. vol 52. issue 10. 2012-10-09. PMID:22542445. |
some of the signaling events discussed include the activation of apoptosis signal regulating kinase and map kinases (p38 and jnk) and the modulation of a number of redox-sensitive transcription factors including ap-1, nf-κb, p53, and nrf2. |
2012-10-09 |
2023-08-12 |
Not clear |
| Xinrong Chen, Jian Yan, Tao Che. Expression level of miR-34a rather than P53 gene status correlates with mutability in related human lymphoblast cell lines. Molecular carcinogenesis. vol 51. issue 8. 2012-10-08. PMID:21809390. |
the p53 gene is a tumor suppressor gene and can prevent mutation and tumor induction though apoptosis and dna repair when it is activated by genotoxic stress. |
2012-10-08 |
2023-08-12 |
human |
| Yuan Li, Rongrong Jiang, Yue Zhao, Yuan Xu, Min Ling, Ying Pang, Lu Shen, Yun Zhou, Jianping Zhang, Jianwei Zhou, Xinru Wang, Qizhan Li. Opposed arsenite-mediated regulation of p53-survivin is involved in neoplastic transformation, DNA damage, or apoptosis in human keratinocytes. Toxicology. vol 300. issue 3. 2012-10-05. PMID:22706169. |
our present study shows that, for human keratinocytes (hacat) cells, a low concentration of arsenite activates extracellular signal-regulated kinases (erks), which leads to up-regulation of nuclear factor κb (nf-κb) binding to dna and to elevated, nf-κb-dependent expression of mot-2 (a p53 inhibitor) and survivin (an inhibitor of apoptosis). |
2012-10-05 |
2023-08-12 |
human |
| Yuan Li, Rongrong Jiang, Yue Zhao, Yuan Xu, Min Ling, Ying Pang, Lu Shen, Yun Zhou, Jianping Zhang, Jianwei Zhou, Xinru Wang, Qizhan Li. Opposed arsenite-mediated regulation of p53-survivin is involved in neoplastic transformation, DNA damage, or apoptosis in human keratinocytes. Toxicology. vol 300. issue 3. 2012-10-05. PMID:22706169. |
the elevated levels of p53 lead to repair of dna damage and apoptosis. |
2012-10-05 |
2023-08-12 |
human |
| Yingjuan Qian, Yong-Sam Jung, Xinbin Che. Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 28. 2012-10-05. PMID:22723347. |
activation of p53 upon dna damage induces an array of target genes, leading to cell cycle arrest and/or apoptosis. |
2012-10-05 |
2023-08-12 |
Not clear |
| Camelia M Saffarini, Nicholas E Heger, Hideki Yamasaki, Tao Liu, Susan J Hall, Kim Boekelheid. Induction and persistence of abnormal testicular germ cells following gestational exposure to di-(n-butyl) phthalate in p53-null mice. Journal of andrology. vol 33. issue 3. 2012-10-04. PMID:21868749. |
this unique model identified a role for p53 in the perinatal apoptosis of dbp-induced mngs and provided insight into the long-term effects of gestational dbp exposure within a p53-null environment. |
2012-10-04 |
2023-08-12 |
mouse |