| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Melarangi, J Zhuang, K Lin, N Rockliffe, A G Bosanquet, M Oates, J R Slupsky, A R Pettit. Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak. Cell death & disease. vol 3. 2012-11-08. PMID:22898870. |
dexamethasone-induced apoptosis was unaffected by p53 dysfunction and more pronounced in cases with unmutated ighv genes. |
2012-11-08 |
2023-08-12 |
Not clear |
| Christian Liedtke, Christian Trautwei. The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer. European journal of cell biology. vol 91. issue 6-7. 2012-11-07. PMID:22153863. |
targeted stimulation of the caspase-8 promoter by interferons alpha and gamma, cytotoxic drugs or p53 can substantially sensitize hepatoma cells for apoptosis, whereas hepatocellular carcinoma frequently present an inactive caspase-8 gene promoter. |
2012-11-07 |
2023-08-12 |
mouse |
| Dejuan Kong, Shumei Ma, Bing Liang, Heqing Yi, Yinlong Zhao, Rui Xin, Li Cui, Lili Jia, Xin Liu, Xiaodong Li. The different regulatory effects of p53 status on multidrug resistance are determined by autophagy in ovarian cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 66. issue 4. 2012-11-07. PMID:22564245. |
it has been verified that apoptosis is not the only mechanism for mdr regulation by p53, the roles of autophagy in mdr is less studied. |
2012-11-07 |
2023-08-12 |
Not clear |
| Bo Wang, Liming Fang, Hui Zhao, Tong Xiang, Dechun Wan. MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells. Acta biochimica et biophysica Sinica. vol 44. issue 8. 2012-11-07. PMID:22843172. |
targeted disruption of the p53-mdm2 interaction by nutlin-3a stabilizes p53 and selectively activates the p53 pathway only in os cells with wild-type p53, resulting in a pronounced anti-proliferative and cytotoxic effect due to g1 cell cycle arrest and apoptosis both in vitro and in vivo. |
2012-11-07 |
2023-08-12 |
mouse |
| Susmita Mondal, Kaushik Bhattacharya, Asish Mallick, Rajender Sangwan, Chitra Manda. Bak compensated for Bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during Withanolide D-induced apoptosis. PloS one. vol 7. issue 3. 2012-11-05. PMID:22479585. |
present study reports that withanolide d (withad), a steroidal lactone isolated from withania somnifera, induced cellular apoptosis in which mitochondria and p53 were intricately involved. |
2012-11-05 |
2023-08-12 |
Not clear |
| Susmita Mondal, Kaushik Bhattacharya, Asish Mallick, Rajender Sangwan, Chitra Manda. Bak compensated for Bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during Withanolide D-induced apoptosis. PloS one. vol 7. issue 3. 2012-11-05. PMID:22479585. |
moreover, lowered apoptogenic effect of hct116p53-/- over hct116p53+/+ established a strong correlation between withad-mediated apoptosis and p53. |
2012-11-05 |
2023-08-12 |
Not clear |
| Lara Grande, Gabriel Bretones, Manuel Rosa-Garrido, Eva M Garrido-Martin, Teresa Hernandez, Susana Fraile, Luisa Botella, Enrique de Alava, August Vidal, Xavier Garcia del Muro, Alberto Villanueva, M Dolores Delgado, Jose L Fernandez-Lun. Transcription factors Sp1 and p73 control the expression of the proapoptotic protein NOXA in the response of testicular embryonal carcinoma cells to cisplatin. The Journal of biological chemistry. vol 287. issue 32. 2012-11-05. PMID:22718761. |
we have studied the molecular mechanisms involved in the induction of apoptosis in response to cisplatin, and found that proapoptotic noxa is transcriptionally up-regulated following cisplatin exposure, even in the absence of p53, in ntera2 cisplatin-sensitive cells but not in 1411hp-resistant cells. |
2012-11-05 |
2023-08-12 |
Not clear |
| Yasumoto Yamasaki, Hiroshi Tazawa, Yuuri Hashimoto, Toru Kojima, Shinji Kuroda, Shuya Yano, Ryosuke Yoshida, Futoshi Uno, Hiroyuki Mizuguchi, Akira Ohtsuru, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwar. A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression. European journal of cancer (Oxford, England : 1990). vol 48. issue 14. 2012-11-02. PMID:22244827. |
obp-702 caused increased apoptosis compared to obp-301 or a replication-deficient adenovirus expressing the p53 gene (ad-p53) in h358 and t.tn cells. |
2012-11-02 |
2023-08-12 |
human |
| Tayebeh Hamzehloie, Majid Mojarrad, Mohammad Hasanzadeh Nazarabadi, Sahar Shekouh. The role of tumor protein 53 mutations in common human cancers and targeting the murine double minute 2-p53 interaction for cancer therapy. Iranian journal of medical sciences. vol 37. issue 1. 2012-11-02. PMID:23115424. |
p53 is a potent transcription factor that is activated in response to diverse stresses, leading to the induction of cell cycle arrest, apoptosis or senescence. |
2012-11-02 |
2023-08-12 |
human |
| Jifeng Wang, Baobing Zhao, Yuting Yi, Wei Zhang, Xuan Wu, Lianru Zhang, Yuemao She. Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-κB pathways. Biochemical pharmacology. vol 84. issue 7. 2012-11-01. PMID:22796259. |
therefore, we conclude that med inhibits mcf-7 cells by simultaneously activating p53 to induce apoptosis and suppressing nf-κb to disrupt cell proliferation. |
2012-11-01 |
2023-08-12 |
Not clear |
| A Iu Doroshevskaia, P M Kondratovskiĭ, A I Dubiko. [Small molecules--principal participants of pathogenesis of rheumatoid arthritis]. Klinicheskaia meditsina. vol 90. issue 6. 2012-11-01. PMID:22997714. |
poorly known pathogenetic mechanisms of rheumatoid arthritis (ra) including apoptosis and aging are considered with special reference to dysregulation of the p53 protein system. |
2012-11-01 |
2023-08-12 |
human |
| Zhaohai Wang, Xuelian Tang, Yilu Zhang, Ruizhao Qi, Zhiwei Li, Keming Zhang, Zhenwen Liu, Xinying Yan. Lobaplatin induces apoptosis and arrests cell cycle progression in human cholangiocarcinoma cell line RBE. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 66. issue 3. 2012-10-31. PMID:22425181. |
in addition, lobaplatin increased p53, bax expression, caspase-3 and poly (adp-ribose) polymerase (parp) cleavage, and reduced bcl-2 expression, which contributed to the apoptosis of cca cells. |
2012-10-31 |
2023-08-12 |
human |
| Guddadarangavvanahally K Jayaprakasha, Kotamballi N Chidambara Murthy, Rock Demarais, Bhimanagouda S Pati. Inhibition of prostate cancer (LNCaP) cell proliferation by volatile components from Nagami kumquats. Planta medica. vol 78. issue 10. 2012-10-31. PMID:22673830. |
significant increases in expression of bax/bcl2 and p53 proteins confirmed that volatile oil induces apoptosis. |
2012-10-31 |
2023-08-12 |
human |
| Zhiyong Cheng, Ning Yang, Wentong Liang, Xiaoyan Yan, Lin Li, Ling Pa. Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells. Leukemia & lymphoma. vol 53. issue 7. 2012-10-30. PMID:22185283. |
pten, nuclear factor-κb (nf-κb), i-κb, p53, multidrug resistance genes mdr1 and mrp, and apoptosis related genes bcl-2, bcl-xl and bax mrna levels were detected by real-time fluorescence relative-quantification reverse transcription polymerase chain reaction (fq-pcr). |
2012-10-30 |
2023-08-12 |
human |
| Jan Korbecki, Irena Baranowska-Bosiacka, Izabela Gutowska, Dariusz Chlube. Biochemical and medical importance of vanadium compounds. Acta biochimica Polonica. vol 59. issue 2. 2012-10-30. PMID:22693688. |
vanadium compounds inhibit p53-dependent apoptosis and promote entry into the s phase of cells containing functional p53 protein. |
2012-10-30 |
2023-08-12 |
human |
| Tobias Sperka, Jianwei Wang, K Lenhard Rudolp. DNA damage checkpoints in stem cells, ageing and cancer. Nature reviews. Molecular cell biology. vol 13. issue 9. 2012-10-30. PMID:22914294. |
dna damage induces cell-intrinsic checkpoints, including p53 and retinoblastoma (rb), as well as upstream regulators (exonuclease 1 (exo1), ataxia telangiectasia mutated (atm), atr, p16(ink4a) and p19(arf)) and downstream targets (p21, puma (p53 upregulated modulator of apoptosis) and sestrins). |
2012-10-30 |
2023-08-12 |
Not clear |
| Neeta Sing. Apoptosis in health and disease and modulation of apoptosis for therapy: An overview. Indian journal of clinical biochemistry : IJCB. vol 22. issue 2. 2012-10-30. PMID:23105676. |
consequently interest has emerged in employing various the rapeutic approaches such as gene therapy, antisense therapy, recombinant biologicals, organic and combinatorial chemistry, to specifically target apoptosis signaling pathways such as death receptors fas/trail, bcl-2, p53, iaps, smac and caspases, etc. |
2012-10-30 |
2023-08-12 |
Not clear |
| Ha Ryong Kim, Bo Hee Son, Soo Yeun Lee, Kyu Hyuck Chung, Seung Min O. The Role of p53 in Marijuana Smoke Condensates-induced Genotoxicity and Apoptosis. Environmental health and toxicology. vol 27. 2012-10-30. PMID:23106039. |
the role of p53 in marijuana smoke condensates-induced genotoxicity and apoptosis. |
2012-10-30 |
2023-08-12 |
Not clear |
| Ha Ryong Kim, Bo Hee Son, Soo Yeun Lee, Kyu Hyuck Chung, Seung Min O. The Role of p53 in Marijuana Smoke Condensates-induced Genotoxicity and Apoptosis. Environmental health and toxicology. vol 27. 2012-10-30. PMID:23106039. |
we evaluated a role of p53 on genotoxic effect and apoptosis in lung cancer cells exposed to marijuana smoke condensates (mscs). |
2012-10-30 |
2023-08-12 |
Not clear |
| Ho Tsoi, Terrence Chi-Kong Lau, Suk-Ying Tsang, Kwok-Fai Lau, Ho Yin Edwin Cha. CAG expansion induces nucleolar stress in polyglutamine diseases. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 33. 2012-10-29. PMID:22847428. |
our work provides in vivo evidence that expanded cag rnas trigger nucleolar stress and induce apoptosis via p53 and describes a polyq pathogenic mechanism that involves the nucleolus. |
2012-10-29 |
2023-08-12 |
Not clear |