| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Zhang, Li Tao, Junshan Ruan, Weidong Li, Yu Wu, Linggeng Yan, Feng Zhang, Fangtian Fan, Shizhong Zheng, Aiyun Wang, Yin L. Xanthatin induces G2/M cell cycle arrest and apoptosis in human gastric carcinoma MKN-45 cells. Planta medica. vol 78. issue 9. 2012-10-26. PMID:22532019. |
western blot analysis elucidated that: a) xanthatin downregulated expression of chk1 and chk2 and phosphorylation of cdc2, which are known as key g2/m transition regulators; b) xanthatin increased p53 activation, decreased the bcl-2/bax ratio and the levels of downstream procaspase-9 and procaspase-3, which are key regulators in the intrinsic apoptosis pathway; c) xanthatin blocked phosphorylation of nf-κb (p65 subunit) and of iκbα, which might contribute to its proapoptotic effects on mkn-45 cells. |
2012-10-26 |
2023-08-12 |
human |
| Min-Jin Lim, Ji-Yeon Ahn, Youngsoo Han, Chi-Ho Yu, Mi-Hyoung Kim, Sae-Lo-Oom Lee, Dae-Seog Lim, Jie-Young Son. Acriflavine enhances radiosensitivity of colon cancer cells through endoplasmic reticulum stress-mediated apoptosis. The international journal of biochemistry & cell biology. vol 44. issue 8. 2012-10-26. PMID:22564437. |
because the tumor suppressor p53 plays a central role in radiation-mediated responses, including cell cycle-arrest and apoptosis, a number of studies have suggested that p53 could be a useful therapeutic target of anti-cancer agents. |
2012-10-26 |
2023-08-12 |
mouse |
| Anke Hertrampf, Carsten Gründemann, Sebastian Jäger, Melanie Laszczyk, Torsten Giesemann, Roman Hube. In vitro cytotoxicity of cyclodextrin-bonded birch bark extract. Planta medica. vol 78. issue 9. 2012-10-26. PMID:22573365. |
the pathway of cytotoxic effects was further investigated by immunoblotting of apoptosis inducing factor (aif) and p53. |
2012-10-26 |
2023-08-12 |
mouse |
| Juhura G Almazi, Swetlana Mactier, O Giles Best, Ben Crossett, Stephen P Mulligan, Richard I Christopherso. Fludarabine nucleoside induces accumulations of p53, p63 and p73 in the nuclei of human B-lymphoid cell lines, with cytosolic and mitochondrial increases in p53. Proteomics. Clinical applications. vol 6. issue 5-6. 2012-10-25. PMID:22641291. |
human raji cells treated with fludarabine nucleoside (2-faraa, 3 μm) undergo apoptosis with accumulation of p53 in the nuclei as multiple phosphorylated isoforms and c-terminal truncated derivatives. |
2012-10-25 |
2023-08-12 |
human |
| José Cisneros, James Hagood, Marco Checa, Blanca Ortiz-Quintero, Miguel Negreros, Iliana Herrera, Carlos Ramos, Annie Pardo, Moisés Selma. Hypermethylation-mediated silencing of p14(ARF) in fibroblasts from idiopathic pulmonary fibrosis. American journal of physiology. Lung cellular and molecular physiology. vol 303. issue 4. 2012-10-24. PMID:22707614. |
p14(arf)-hypermethylated ipf fibroblasts were significantly more resistant to staurosporine-and s-nitrosoglutathione-induced apoptosis compared with normal and nonmethylated ipf fibroblasts (p < 0.01) and showed reduced levels of p53. |
2012-10-24 |
2023-08-12 |
Not clear |
| Dong Won Ryu, Chung Han Le. Outcome of triple-negative breast cancer in patients with or without markers regulating cell cycle and cell death. Journal of the Korean Surgical Society. vol 83. issue 4. 2012-10-24. PMID:23091790. |
the genes p53 and b-cell lymphoma (bcl)-2 play an important role in regulating the mechanisms of apoptosis. |
2012-10-24 |
2023-08-12 |
Not clear |
| Victor Chia-Hsiang Lin, Ya-Chu Tsai, Jia-Ni Lin, Ling-Ling Fan, Min-Hsiung Pan, Chi-Tang Ho, Jiumn-Yih Wu, Tzong-Der Wa. Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancer cells. Journal of agricultural and food chemistry. vol 60. issue 25. 2012-10-22. PMID:22670709. |
interestingly, the resolution between apoptosis and growth arrest following ampk activation is greatly influenced by p53 status. |
2012-10-22 |
2023-08-12 |
human |
| Victor Chia-Hsiang Lin, Ya-Chu Tsai, Jia-Ni Lin, Ling-Ling Fan, Min-Hsiung Pan, Chi-Tang Ho, Jiumn-Yih Wu, Tzong-Der Wa. Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancer cells. Journal of agricultural and food chemistry. vol 60. issue 25. 2012-10-22. PMID:22670709. |
however, pterostilbene induced apoptosis in p53 negative pc3 cells. |
2012-10-22 |
2023-08-12 |
human |
| Yan-Qing Guan, Zhibin Li, Aini Yang, Zheng Huang, Zhe Zheng, Lin Zhang, Ling Li, Jun-Ming Li. Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-α plus IFN-γ on polystyrene and the role of p53 activation. Biomaterials. vol 33. issue 26. 2012-10-22. PMID:22682938. |
cell cycle arrest and apoptosis of ovcar-3 and mcf-7 cells induced by co-immobilized tnf-α plus ifn-γ on polystyrene and the role of p53 activation. |
2012-10-22 |
2023-08-12 |
Not clear |
| Yan-Qing Guan, Zhibin Li, Aini Yang, Zheng Huang, Zhe Zheng, Lin Zhang, Ling Li, Jun-Ming Li. Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-α plus IFN-γ on polystyrene and the role of p53 activation. Biomaterials. vol 33. issue 26. 2012-10-22. PMID:22682938. |
the phosphorylation sites of the p53 regulation and the apoptosis key protein expressions of caspase 3, 8 and 9 are detected by western blot assay. |
2012-10-22 |
2023-08-12 |
Not clear |
| Yan-Qing Guan, Zhibin Li, Aini Yang, Zheng Huang, Zhe Zheng, Lin Zhang, Ling Li, Jun-Ming Li. Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-α plus IFN-γ on polystyrene and the role of p53 activation. Biomaterials. vol 33. issue 26. 2012-10-22. PMID:22682938. |
it is revealed that the co-immobilized drug leads to significant cell arrest in the s phase or g(1) and g(2) phase and offer high efficiency in mediating a caspase-dependent apoptosis via p53 transcriptional regulation. |
2012-10-22 |
2023-08-12 |
Not clear |
| Yan-Qing Guan, Zhibin Li, Aini Yang, Zheng Huang, Zhe Zheng, Lin Zhang, Ling Li, Jun-Ming Li. Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-α plus IFN-γ on polystyrene and the role of p53 activation. Biomaterials. vol 33. issue 26. 2012-10-22. PMID:22682938. |
moreover, upon the treatment by the co-immobilized drug, the two gynecologic cancer cell lines show different phosphorylation sites of p53 and then different caspase-dependent apoptosis pathways. |
2012-10-22 |
2023-08-12 |
Not clear |
| Yosuke Nakagawa, Akihisa Takahashi, Atsuhisa Kajihara, Nobuhiro Yamakawa, Yuichiro Imai, Ichiro Ota, Noritomo Okamoto, Eiichiro Mori, Taichi Noda, Yoshiya Furusawa, Tadaaki Kirita, Takeo Ohnish. Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation. Biochemical and biophysical research communications. vol 423. issue 4. 2012-10-22. PMID:22695120. |
although mutations and deletions in the p53 tumor suppressor gene lead to resistance to low linear energy transfer (let) radiation, high-let radiation efficiently induces cell lethality and apoptosis regardless of the p53 gene status in cancer cells. |
2012-10-22 |
2023-08-12 |
human |
| Yoshitaka Nogi, Takeshi Kanno, Takashi Nakano, Yumiko Fujita, Chiharu Tabata, Kazuya Fukuoka, Akinobu Gotoh, Tomoyuki Nishizak. AMP converted from intracellularly transported adenosine upregulates p53 expression to induce malignant pleural mesothelioma cell apoptosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 30. issue 1. 2012-10-22. PMID:22759956. |
amp converted from intracellularly transported adenosine upregulates p53 expression to induce malignant pleural mesothelioma cell apoptosis. |
2012-10-22 |
2023-08-12 |
human |
| M Gryko, A Pryczynicz, K Guzińska-Ustymowicz, Z Kamocki, K Zaręba, A Kemona, B Kędr. Immunohistochemical assessment of apoptosis-associated proteins: p53, Bcl-xL, Bax and Bak in gastric cancer cells in correlation with clinical and pathomorphological factors. Advances in medical sciences. vol 57. issue 1. 2012-10-19. PMID:22440942. |
the p53 protein as well as bcl-2 family proteins such as bax, bak and bcl-xl regulate apoptosis. |
2012-10-19 |
2023-08-12 |
Not clear |
| Annette Künkele, Katleen De Preter, Lukas Heukamp, Theresa Thor, Kristian W Pajtler, Wolfgang Hartmann, Michel Mittelbronn, Michael A Grotzer, Hedwig E Deubzer, Frank Speleman, Alexander Schramm, Angelika Eggert, Johannes H Schult. Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas. Neuro-oncology. vol 14. issue 7. 2012-10-18. PMID:22591662. |
targeting the p53-mdm2 axis using nutlin-3 significantly reduced cell viability and induced either cell cycle arrest or apoptosis and expression of the p53 target gene p21 in these 4 cell lines. |
2012-10-18 |
2023-08-12 |
mouse |
| R Kibe, S Zhang, D Guo, L Marrero, F Tsien, P Rodriguez, S Khan, A Zieske, J Huang, W Li, S K Durum, T Iwakuma, Y Cu. IL-7Rα deficiency in p53null mice exacerbates thymocyte telomere erosion and lymphomagenesis. Cell death and differentiation. vol 19. issue 7. 2012-10-17. PMID:22281704. |
we hypothesized that il-7rα(null)-induced apoptosis is partially contributed by an elevated p53 activity. |
2012-10-17 |
2023-08-12 |
mouse |
| P Taebunpakul, B S Sayan, M Flinterman, P Klanrit, J Gäken, E W Odell, G Melino, M Tavassol. Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and ΔNp73 isoforms through ubiquitin ligase PIR2. Apoptosis : an international journal on programmed cell death. vol 17. issue 8. 2012-10-17. PMID:22484480. |
the mechanism of apoptin-induced cell death is currently unknown but it appears to induce apoptosis independent of p53 status. |
2012-10-17 |
2023-08-12 |
chicken |
| P Taebunpakul, B S Sayan, M Flinterman, P Klanrit, J Gäken, E W Odell, G Melino, M Tavassol. Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and ΔNp73 isoforms through ubiquitin ligase PIR2. Apoptosis : an international journal on programmed cell death. vol 17. issue 8. 2012-10-17. PMID:22484480. |
here we show that p73, a p53 family member, is important in apoptin-induced apoptosis. |
2012-10-17 |
2023-08-12 |
chicken |
| P Taebunpakul, B S Sayan, M Flinterman, P Klanrit, J Gäken, E W Odell, G Melino, M Tavassol. Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and ΔNp73 isoforms through ubiquitin ligase PIR2. Apoptosis : an international journal on programmed cell death. vol 17. issue 8. 2012-10-17. PMID:22484480. |
in p53 deficient and/or mutated cells, apoptin induced the expression of tap73 leading to the induction of apoptosis. |
2012-10-17 |
2023-08-12 |
chicken |