| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laia Llovera, Sylvia Mansilla, José Portuga. Apoptotic-like death occurs through a caspase-independent route in colon carcinoma cells undergoing mitotic catastrophe. Cancer letters. vol 326. issue 1. 2012-12-03. PMID:22885806. |
we have examined the relationship between chemotherapy-induced mitotic catastrophe and cell death by apoptosis in both wild-type and p53(-/-) hct116 human colon carcinoma cells treated with nanomolar concentrations of paclitaxel (ptx), a drug that acts on tubulin altering the normal development of mitosis. |
2012-12-03 |
2023-08-12 |
human |
| H Zhu, C Liu, J Sun, M Li, J Hu. Effect of GSK-3 inhibitor on the proliferation of multipotent male germ line stem cells (mGSCs) derived from goat testis. Theriogenology. vol 77. issue 9. 2012-11-30. PMID:22444555. |
in contrast, there was no significant change in expression of apoptosis markers, p53, p21 and cyclin-related genes (cyclin a, cdk2, cyclin d1), as determined by rt-pcr analysis. |
2012-11-30 |
2023-08-12 |
mouse |
| Ying Wang, Wen-Ling Zheng, Wen-Li M. Lobaplatin inhibits the proliferation of hepatollular carcinoma through p53 apoptosis axis. Hepatitis monthly. vol 12. issue 10 HCC. 2012-11-30. PMID:23193415. |
lobaplatin inhibits the proliferation of hepatollular carcinoma through p53 apoptosis axis. |
2012-11-30 |
2023-08-12 |
Not clear |
| Aymeric Bailly, Anton Gartne. Germ cell apoptosis and DNA damage responses. Advances in experimental medicine and biology. vol 757. 2012-11-29. PMID:22872480. |
this apoptosis appears to be regulated similar to dna damage-induced apoptosis in the mouse germ line and converges on p53 family transcription factors. |
2012-11-29 |
2023-08-12 |
mouse |
| Zhen Gu, Yahong Liu, Yongjie Zhang, Shulei Jin, Qi Chen, David Goltzman, Andrew Karaplis, Dengshun Mia. Absence of PTHrP nuclear localization and carboxyl terminus sequences leads to abnormal brain development and function. PloS one. vol 7. issue 7. 2012-11-28. PMID:22844494. |
results showed that pthrp knock-in mice display abnormal brain shape and structures; decreased neural cell proliferative capacity and increased apoptosis associated with up-regulation of cyclin dependent kinase inhibitors p16, p21, p27 and p53 and down-regulation of the bmi-1 oncogene; delayed neural cell differentiation; and impaired hippocampal synaptic transmission and plasticity. |
2012-11-28 |
2023-08-12 |
mouse |
| Neetu Singh, Deeba Zaidi, Hari Shyam, Ramesh Sharma, Anil Kumar Balapur. Polyphenols sensitization potentiates susceptibility of MCF-7 and MDA MB-231 cells to Centchroman. PloS one. vol 7. issue 6. 2012-11-27. PMID:22768036. |
however, res/cur sensitization enhanced apoptosis in p53 mutant mda mb-231 cells without/with involvement of ros mediated jnk/p38 adjunct to caspase-9. |
2012-11-27 |
2023-08-12 |
human |
| Shinya Abe, Morito Kurata, Shiho Suzuki, Kouhei Yamamoto, Ken-ichi Aisaki, Jun Kanno, Masanobu Kitagaw. Minichromosome maintenance 2 bound with retroviral Gp70 is localized to cytoplasm and enhances DNA-damage-induced apoptosis. PloS one. vol 7. issue 6. 2012-11-27. PMID:22768239. |
phosphorylated dna-pk exhibited elevated kinase activity to phosphorylate p53, thereby up-regulating p53-dependent apoptosis. |
2012-11-27 |
2023-08-12 |
mouse |
| Hee-Jin Ahn, Young Cha, Seok-Ho Moon, Jee-Eun Jung, Kyung-Soon Par. Ell3 enhances differentiation of mouse embryonic stem cells by regulating epithelial-mesenchymal transition and apoptosis. PloS one. vol 7. issue 6. 2012-11-27. PMID:22768269. |
in addition, apoptosis of differentiating ell3-knock out mescs was associated with enhanced expression of p53. |
2012-11-27 |
2023-08-12 |
mouse |
| Emil Rudolf, Stanislav John, Miroslav Cervink. Irinotecan induces senescence and apoptosis in colonic cells in vitro. Toxicology letters. vol 214. issue 1. 2012-11-27. PMID:22898888. |
epithelial cells upregulated the expression of p53, which was subsequently specifically phosphorylated, massively activated p38 and initiated mitochondrial, caspase-dependent apoptosis. |
2012-11-27 |
2023-08-12 |
Not clear |
| Yi Guo, Xiao-guang Zhang, Nan Zhao, Tian-ren Li, Hui L. [Gemin3 inhibits cell apoptosis through suppression of p53 expression]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. vol 33. issue 11. 2012-11-26. PMID:22335944. |
[gemin3 inhibits cell apoptosis through suppression of p53 expression]. |
2012-11-26 |
2023-08-12 |
Not clear |
| Samisubbu R Naidu, Alexander J Lakhter, Elliot J Androph. PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy. Cell cycle (Georgetown, Tex.). vol 11. issue 14. 2012-11-26. PMID:22751435. |
we investigated the roles of lysine (k) acetylation and sumoylation on p53 and their relation to apoptosis and autophagy. |
2012-11-26 |
2023-08-12 |
Not clear |
| Samisubbu R Naidu, Alexander J Lakhter, Elliot J Androph. PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy. Cell cycle (Georgetown, Tex.). vol 11. issue 14. 2012-11-26. PMID:22751435. |
piasy-induced tip60 sumoylation augments p53 k120 acetylation and apoptosis. |
2012-11-26 |
2023-08-12 |
Not clear |
| Jun-Ming Liao, Xiang Zhou, Yu Zhang, Hua L. MiR-1246: a new link of the p53 family with cancer and Down syndrome. Cell cycle (Georgetown, Tex.). vol 11. issue 14. 2012-11-26. PMID:22751441. |
most of them are involved in regulation of the known p53 functions, such as cell cycle, apoptosis and senescence. |
2012-11-26 |
2023-08-12 |
Not clear |
| Ikhlass Hadj Salem, Fatma Kamoun, Nacim Louhichi, Moez Trigui, Chahnez Triki, Faiza Fakhfak. Impact of single-nucleotide polymorphisms at the TP53-binding and responsive promoter region of BCL2 gene in modulating the phenotypic variability of LGMD2C patients. Molecular biology reports. vol 39. issue 7. 2012-11-23. PMID:22367371. |
the result showed that muscle cells carrying the tp53-r72r and tp53-16 bp del/del genotypes displayed an increased p53 level which could be more effective in inducing apoptosis by activation of the pro-apoptotic gene expression. |
2012-11-23 |
2023-08-12 |
Not clear |
| Deepak Poudyal, Xiangli Cui, Phuong Mai Le, Tia Davis, Anne B Hofseth, Yu Jin, Alexander A Chumanevich, Michael J Wargovich, Mitzi Nagarkatti, Prakash S Nagarkatti, Anthony Windust, Lorne J Hofset. A limited role of p53 on the ability of a Hexane fraction of American ginseng to suppress mouse colitis. Journal of biomedicine & biotechnology. vol 2012. 2012-11-23. PMID:22899889. |
we found only a limited impact of p53 in the ability of hag to induce inflammatory cell apoptosis and suppress mouse colitis in vitro and in vivo. |
2012-11-23 |
2023-08-12 |
mouse |
| Deepak Poudyal, Xiangli Cui, Phuong Mai Le, Tia Davis, Anne B Hofseth, Yu Jin, Alexander A Chumanevich, Michael J Wargovich, Mitzi Nagarkatti, Prakash S Nagarkatti, Anthony Windust, Lorne J Hofset. A limited role of p53 on the ability of a Hexane fraction of American ginseng to suppress mouse colitis. Journal of biomedicine & biotechnology. vol 2012. 2012-11-23. PMID:22899889. |
therefore, hag might be very effective in targeting the inflammatory cells and cancer cells since it induces apoptosis of inflammatory cells and cell cycle arrest in both p53-/- and wt p53 colon cancer cells. |
2012-11-23 |
2023-08-12 |
mouse |
| Razmik Mirzayans, Bonnie Andrais, April Scott, David Murra. New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy. Journal of biomedicine & biotechnology. vol 2012. 2012-11-23. PMID:22911014. |
according to recent evidence, however, most p53 wild-type human cell types respond to ionizing radiation by undergoing stress-induced premature senescence (sips) and not apoptosis. |
2012-11-23 |
2023-08-12 |
human |
| Razmik Mirzayans, Bonnie Andrais, April Scott, David Murra. New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy. Journal of biomedicine & biotechnology. vol 2012. 2012-11-23. PMID:22911014. |
in addition to its well-studied role in cell cycle checkpoints, p21 regulates p53 and its upstream kinase (atm), controls gene expression, suppresses apoptosis, and induces sips. |
2012-11-23 |
2023-08-12 |
human |
| Chi-Wai Lee, Leo Lap-Yan Wong, Edith Yuk-Ting Tse, Heong-Fai Liu, Veronica Yee-Law Leong, Joyce Man-Fong Lee, D Grahame Hardie, Irene Oi-Lin Ng, Yick-Pang Chin. AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. Cancer research. vol 72. issue 17. 2012-11-19. PMID:22728651. |
the p53 deacetylase, sirt1, was phosphorylated and inactivated by ampk at thr344, promoting p53 acetylation and apoptosis of hcc cells. |
2012-11-19 |
2023-08-12 |
Not clear |
| Basant Kumar Thakur, Tino Dittrich, Prakash Chandra, Annette Becker, Yannick Lippka, Divakarvel Selvakumar, Jan-Henning Klusmann, Dirk Reinhardt, Karl Welt. Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells. Biochemical and biophysical research communications. vol 424. issue 3. 2012-11-19. PMID:22728882. |
a reduced rate of apoptosis and an increased number of cells in s-phase was accompanied after knockdown of p53 in these cells. |
2012-11-19 |
2023-08-12 |
human |