| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takenobu Nii, Tomotoshi Marumoto, Kenzaburo Tan. Roles of p53 in various biological aspects of hematopoietic stem cells. Journal of biomedicine & biotechnology. vol 2012. 2013-01-07. PMID:22778557. |
the tumor suppressor protein, p53, has been shown to play critical roles in maintenance of "cell integrity" under stress conditions by controlling its target genes that regulate cell cycle arrest, apoptosis, senescence, dna repair, or changes in metabolism. |
2013-01-07 |
2023-08-12 |
Not clear |
| Matthew D Neal, Chhinder P Sodhi, Hongpeng Jia, Mitchell Dyer, Charlotte E Egan, Ibrahim Yazji, Misty Good, Amin Afrazi, Ryan Marino, Dennis Slagle, Congrong Ma, Maria F Branca, Thomas Prindle, Zachary Grant, John Ozolek, David J Hacka. Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. The Journal of biological chemistry. vol 287. issue 44. 2013-01-07. PMID:22955282. |
toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. |
2013-01-07 |
2023-08-12 |
mouse |
| Hanaa A Hassan, Hani S Hafez, Mona S God. Mentha piperita as a pivotal neuro-protective agent against gamma irradiation induced DNA fragmentation and apoptosis : Mentha extract as a neuroprotective against gamma irradiation. Cytotechnology. vol 65. issue 1. 2013-01-07. PMID:23011739. |
significant increase in % of apoptosis and p53 protein expression as apoptotic biomarkers were coincided with significant decrease in bcl(2) as an anti-apoptotic marker. |
2013-01-07 |
2023-08-12 |
mouse |
| Fengchun Ye, Ali Abdul Lattif, Jianping Xie, Aaron Weinberg, Shoujiang Ga. Nutlin-3 induces apoptosis, disrupts viral latency and inhibits expression of angiopoietin-2 in Kaposi sarcoma tumor cells. Cell cycle (Georgetown, Tex.). vol 11. issue 7. 2013-01-04. PMID:22421142. |
reactivation of p53 results in a g 1 cell cycle arrest, leading to inhibition of proliferation and apoptosis. |
2013-01-04 |
2023-08-12 |
mouse |
| Fatma Bensassi, Cindy Gallerne, Ossama Sharaf El Dein, Mohamed Rabeh Hajlaoui, Hassen Bacha, Christophe Lemair. Cell death induced by the Alternaria mycotoxin Alternariol. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 6. 2013-01-04. PMID:22542754. |
aoh-induced apoptosis was mediated through a mitochondria-dependent pathway, characterized by a p53 activation, an opening of the mitochondrial permeability transition pore (ptp), a loss of mitochondrial transmembrane potential (ΔΨm), a downstream generation of o(2)(*-) and caspase 9 and 3 activation. |
2013-01-04 |
2023-08-12 |
human |
| Shuqiang Liu, Dan Wang, Junwen Zhang, Dongzhi Zhang, Meng Gong, Chao Wang, Ning Wei, Wenhua Liu, Yongqi Wang, Chongxue Zhao, Yaxiong Cui, Defu H. Citrinin reduces testosterone secretion by inducing apoptosis in rat Leydig cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 6. 2013-01-04. PMID:22564900. |
taken together, these results suggested that ctn reduced testosterone secretion by inducing apoptosis in rat leydig cells, a mechanism that might account for ctn stimulation of p53 expression followed by activation of multiple caspases. |
2013-01-04 |
2023-08-12 |
mouse |
| Matt Lam, Amtul R Carmichael, Helen R Griffith. An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression. PloS one. vol 7. issue 6. 2013-01-04. PMID:22761954. |
an aqueous extract of fagonia cretica induces dna damage, cell cycle arrest and apoptosis in breast cancer cells via foxo3a and p53 expression. |
2013-01-04 |
2023-08-12 |
Not clear |
| Shelly Sorrells, Seth Carbonneau, Erik Harrington, Aye T Chen, Bridgid Hast, Brett Milash, Ujwal Pyati, Michael B Major, Yi Zhou, Leonard I Zon, Rodney A Stewart, A Thomas Look, Cicely Jett. Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53. PLoS genetics. vol 8. issue 8. 2013-01-04. PMID:22952453. |
we further show that ccdc94 and the prp19 complex protect cells from ir-induced apoptosis by repressing the expression of p53 mrna. |
2013-01-04 |
2023-08-12 |
human |
| K Kim, K W Jeong, H Kim, J Choi, W Lu, M R Stallcup, W A. Functional interplay between p53 acetylation and H1.2 phosphorylation in p53-regulated transcription. Oncogene. vol 31. issue 39. 2013-01-03. PMID:22249259. |
consistent with these findings, point mutations mimicking modification states of h1.2 and p53 lead to a significant increase in p53-induced apoptosis. |
2013-01-03 |
2023-08-12 |
Not clear |
| Jing Zhou, Shuai-Er Hu, Shi-Hao Tan, Ruoxi Cao, Yiyang Chen, Dajing Xia, Xinqiang Zhu, Xing-Fen Yang, Choon-Nam Ong, Han-Ming She. Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells. Autophagy. vol 8. issue 3. 2013-01-03. PMID:22302005. |
importantly, andro is capable of sensitizing cisplatin-induced cell killing determined with both short-term apoptosis assays and long-term clonogenic test, via suppression of autophagy, a process independent of p53. |
2013-01-03 |
2023-08-12 |
human |
| Kumiko Kato, Noboru Sasaki, Barkur S Shastr. Retinal ganglion cell (RGC) death in glaucomatous beagles is not associated with mutations in p53 and NTF4 genes. Veterinary ophthalmology. vol 15 Suppl 2. 2013-01-02. PMID:22524196. |
additionally, one previous study suggested that p53 codon 72 polymorphism (r72p) might have a greater susceptibility to apoptosis in some ethnic population. |
2013-01-02 |
2023-08-12 |
Not clear |
| Simon M Vogel, Matthias R Bauer, Andreas C Joerger, Rainer Wilcken, Tobias Brandt, Dmitry B Veprintsev, Trevor J Rutherford, Alan R Fersht, Frank M Boeckle. Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 42. 2012-12-31. PMID:23035244. |
the comparison of lca effects on apoptosis in hct116 p53(+/+) vs. p53(-/-) cells shows a predominantly p53-mediated induction of caspase-3/7. |
2012-12-31 |
2023-08-12 |
Not clear |
| Yu Ou, Zhijun Yuan, Kepeng Li, Xuegan Yan. Phycocyanin may suppress D-galactose-induced human lens epithelial cell apoptosis through mitochondrial and unfolded protein response pathways. Toxicology letters. vol 215. issue 1. 2012-12-31. PMID:23036742. |
the results demonstrated that phycocyanin suppressed sra01/04 cells' morphologic changes and apoptosis induced by d-galactose, inhibited the expression and activation of caspase 3, alternated the bax/bcl-2 ratio, and down-regulated the level of p53, grp78, and chop in d-galactose-treated sra01/04 cells. |
2012-12-31 |
2023-08-12 |
human |
| Yu Ou, Zhijun Yuan, Kepeng Li, Xuegan Yan. Phycocyanin may suppress D-galactose-induced human lens epithelial cell apoptosis through mitochondrial and unfolded protein response pathways. Toxicology letters. vol 215. issue 1. 2012-12-31. PMID:23036742. |
these results suggest that phycocyanin might suppress d-galactose-induced hlec apoptosis through two pathways: mitochondrial pathway, involving p53 and bcl-2 family protein expression, and unfolded protein response pathway, involving grp78 and chop expression. |
2012-12-31 |
2023-08-12 |
human |
| James J Asciolla, Thibaud T Renault, Jerry E Chipu. Examining BCL-2 family function with large unilamellar vesicles. Journal of visualized experiments : JoVE. issue 68. 2012-12-27. PMID:23070252. |
in addition, anti-apoptotic bcl-2 protein availability is also dictated by sensitizer/de-repressor bh3-only proteins, such as bad (bcl-2 antagonist of cell death) or puma (p53 upregulated modulator of apoptosis), which bind and inhibit anti-apoptotic members(7,9). |
2012-12-27 |
2023-08-12 |
xenopus_laevis |
| Azmi Yerlikaya, Emrah Okur, Engin Ulukay. The p53-independent induction of apoptosis in breast cancer cells in response to proteasome inhibitor bortezomib. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 5. 2012-12-26. PMID:22477712. |
the tumor suppressor protein p53 is a critical regulator of apoptosis in many cell types. |
2012-12-26 |
2023-08-12 |
Not clear |
| Azmi Yerlikaya, Emrah Okur, Engin Ulukay. The p53-independent induction of apoptosis in breast cancer cells in response to proteasome inhibitor bortezomib. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 5. 2012-12-26. PMID:22477712. |
p53 stimulates a wide network of signals that act through either extrinsic or intrinsic pathways of apoptosis. |
2012-12-26 |
2023-08-12 |
Not clear |
| Ting Zhou, Jingjing Duan, Yan Wang, Xin Chen, Ganping Zhou, Rongkan Wang, Liwu Fu, Feng X. Fluoxetine synergys with anticancer drugs to overcome multidrug resistance in breast cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 5. 2012-12-26. PMID:22549660. |
results of apoptosis proteins assay showed a upgrade of p53 and a downgrade of bcl-2 level by flx-adm or flx-ptx combinations in both cells. |
2012-12-26 |
2023-08-12 |
Not clear |
| Ting Zhou, Jingjing Duan, Yan Wang, Xin Chen, Ganping Zhou, Rongkan Wang, Liwu Fu, Feng X. Fluoxetine synergys with anticancer drugs to overcome multidrug resistance in breast cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 5. 2012-12-26. PMID:22549660. |
our findings indicated that by synergism with anticancer drugs, flx modulation of apoptosis via targeting p53 and bcl-2 expression, flx reverse the breast cancer cell's resistance and enhance the chemosensitivity to adm and ptx. |
2012-12-26 |
2023-08-12 |
Not clear |
| Eirini Thanopoulou, George Kotzamanis, Ioannis S Pateras, Nicholaos Ziras, Alexandros Papalambros, Theodoros Mariolis-Sapsakos, Fragiska Sigala, Elizabeth Johnson, Athanassios Kotsinas, Andreas Scorilas, Vassilis G Gorgouli. The single nucleotide polymorphism g.1548A >G (K469E) of the ICAM-1 gene is associated with worse prognosis in non-small cell lung cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 5. 2012-12-26. PMID:22562265. |
moreover, the expression of icam-1 is transcriptionally regulated by p53, and this snp has been shown to be related with apoptosis. |
2012-12-26 |
2023-08-12 |
Not clear |