| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michelle Badura, Steve Braunstein, Jiri Zavadil, Robert J Schneide. DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 46. 2013-02-01. PMID:23112151. |
increased expression of eif4g1, common in breast cancers, was found to selectively increase translation of mrnas involved in cell survival and the ddr, preventing autophagy and apoptosis [survivin, hypoxia inducible factor 1α (hif1α), x-linked inhibitor of apoptosis (xiap)], promoting cell cycle arrest [growth arrest and dna damage protein 45a (gadd45a), protein 53 (p53), atr-interacting protein (atrip), check point kinase 1 (chk1)] and dna repair [p53 binding protein 1 (53bp1), breast cancer associated proteins 1, 2 (brca1/2), poly-adp ribose polymerase (parp), replication factor c2-5 (rfc2-5), ataxia telangiectasia mutated gene 1 (atm), meiotic recombination protein 11 (mre-11), and others]. |
2013-02-01 |
2023-08-12 |
Not clear |
| E O Kutumova, I N Kiselev, R N Sharipov, I N Lavrik, Fedor A Kolpako. A modular model of the apoptosis machinery. Advances in experimental medicine and biology. vol 736. 2013-01-30. PMID:22161332. |
using this approach, we created the apoptosis model including 13 modules: death stimuli (trail, cd95l, and tnf-α)-induced activation of caspase-8; survival stimuli (p53, egf, and nf-κb) regulation; the mitochondria level; cytochrome c- and smac-induced activation of caspase-3; direct activation of effector caspases by caspase-8 and - 12; parp and apoptosis execution phase modules. |
2013-01-30 |
2023-08-12 |
Not clear |
| Ralph Knöll, Steve Marsto. On mechanosensation, acto/myosin interaction, and hypertrophy. Trends in cardiovascular medicine. vol 22. issue 1. 2013-01-30. PMID:22841838. |
one emerging example is telethonin and its ability to interfere with p53 metabolism and hence apoptosis (mechanoptosis). |
2013-01-30 |
2023-08-12 |
Not clear |
| Ming-Fu Chiang, Shu-Ting Yeh, Hui-Fen Liao, Nan-Shan Chang, Yu-Jen Che. Overexpression of WW domain-containing oxidoreductase WOX1 preferentially induces apoptosis in human glioblastoma cells harboring mutant p53. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 66. issue 6. 2013-01-30. PMID:22898080. |
overexpression of ww domain-containing oxidoreductase wox1 preferentially induces apoptosis in human glioblastoma cells harboring mutant p53. |
2013-01-30 |
2023-08-12 |
human |
| Krystal N Seibert, Karim Essani, Bruce E Bejce. The Tanapoxvirus 142R Protein is a Serine-Threonine Kinase that Phosphorylates the Tumor Suppressor p53. The open virology journal. vol 7. 2013-01-30. PMID:23359106. |
we demonstrate that like b1r, tpv142r encodes a serine threonine kinase that can phosphorylate the tumor suppressor p53 and therefore has the potential for inhibiting apoptosis of infected cells. |
2013-01-30 |
2023-08-12 |
Not clear |
| Jing Tan, Binghai Chen, Leye He, Yuxin Tang, Zhiqiang Jiang, Guangmin Yin, Jinrong Wang, Xianzhen Jian. Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling. Chinese journal of cancer research = Chung-kuo yen cheng yen chiu. vol 24. issue 4. 2013-01-30. PMID:23359208. |
anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling. |
2013-01-30 |
2023-08-12 |
Not clear |
| Gaurav Pathria, Christine Wagner, Stephan N Wagne. Inhibition of CRM1-mediated nucleocytoplasmic transport: triggering human melanoma cell apoptosis by perturbing multiple cellular pathways. The Journal of investigative dermatology. vol 132. issue 12. 2013-01-29. PMID:22832492. |
apoptosis was preceded by a g1 cell-cycle arrest, and even though crm1 inhibition mediated marked p53 and p21 induction in wild-type p53 melanoma cells, the latter's silencing or inactivation failed to alleviate apoptosis. |
2013-01-29 |
2023-08-12 |
human |
| M A El-Missiry, A I Othman, M A Amer, E Mohame. Ottelione A inhibited proliferation of Ehrlich ascites carcinoma cells in mice. Chemico-biological interactions. vol 200. issue 2-3. 2013-01-29. PMID:23131608. |
in conclusion, the differential expression of p53, cyclin d1, and rrna in eac cells as well as the infiltration of cd8+ after otte treatment may play critical roles in the g(0)/g(1) cell cycle arrest that blocks cell proliferation and induce apoptosis of cancer cells. |
2013-01-29 |
2023-08-12 |
mouse |
| S S Edranov, P A Motavki. Apoptosis as a mechanism of maxillary sinus mucosa injury in rats after experimental transection of the maxillary nerve. Bulletin of experimental biology and medicine. vol 153. issue 4. 2013-01-28. PMID:22977862. |
significant activation of apoptosis and proapoptotic factor p53 was found in the epithelium during week 1 after nerve transection. |
2013-01-28 |
2023-08-12 |
rat |
| N I Chalisova, N G Lopatina, N G Kamishev, N S Linkova, E A Koncevaya, A V Dudkov, L S Kozina, V Kh Khavinson, Yu S Titko. Effect of tripeptide Lys-Glu-Asp on physiological activity of neuroimmunoendocrine system cells. Bulletin of experimental biology and medicine. vol 153. issue 4. 2013-01-28. PMID:22977872. |
lys-glu-asp accelerates cell renewal processes (decrease of apoptosis marker p53 and increase of proliferation marker ki-67) in the pineal gland; this effect is more pronounced in cultures derived from old animals than in young cultures. |
2013-01-28 |
2023-08-12 |
bee |
| Manuel Rieber, Mary Strasberg-Riebe. Hypoxia, Mn-SOD and H(2)O(2) regulate p53 reactivation and PRIMA-1 toxicity irrespective of p53 status in human breast cancer cells. Biochemical pharmacology. vol 84. issue 12. 2013-01-25. PMID:22982566. |
since it is important to suppress tumor adaptation to hypoxia, irrespective of p53 status, we compared the efficacy of nutlin-3 which prevents mdm2-wt p53 interactions and prima-1 which promotes mutant p53 reactivation and induction of massive apoptosis, under normoxia and hypoxia, against (a) skbr3 breast carcinoma harboring a mutant p53r175h and over-expressing erbb2; and (b) genetically matched breast cancer erα positive mcf-7 cells harboring either wt p53 or mutant p53 r175h. |
2013-01-25 |
2023-08-12 |
human |
| Manuel Rieber, Mary Strasberg-Riebe. Hypoxia, Mn-SOD and H(2)O(2) regulate p53 reactivation and PRIMA-1 toxicity irrespective of p53 status in human breast cancer cells. Biochemical pharmacology. vol 84. issue 12. 2013-01-25. PMID:22982566. |
when using mcf-7 cells over-expressing mutant p53, prima-1 synergized with exogenous peroxidase to increase apoptosis concomitantly with induction of puma and mn-sod, under normoxia. |
2013-01-25 |
2023-08-12 |
human |
| Sujan Piya, Ji Young Kim, Jeehyeon Bae, Dai-Wu Seol, Ae Ran Moon, Tae-Hyoung Ki. DUSP6 is a novel transcriptional target of p53 and regulates p53-mediated apoptosis by modulating expression levels of Bcl-2 family proteins. FEBS letters. vol 586. issue 23. 2013-01-25. PMID:23108049. |
dusp6 is a novel transcriptional target of p53 and regulates p53-mediated apoptosis by modulating expression levels of bcl-2 family proteins. |
2013-01-25 |
2023-08-12 |
human |
| Xiao-rong Yang, Yuan-yuan Wang, Kai-Kai La, Li Peng, Xiao-hong Song, Xiang-gang Shi, Xiao-feng Zhu, Ping-chung Leung, Chun-hay Ko, Chuang-xing Y. Inhibitory effects of cocoa tea (Camellia ptilophylla) in human hepatocellular carcinoma HepG2 in vitro and in vivo through apoptosis. The Journal of nutritional biochemistry. vol 23. issue 9. 2013-01-24. PMID:22018604. |
in addition, gcti increased the expression of cell cycle inhibitory proteins (p21, p27 and p53) and the bax-to-bcl-2 ratio to induce apoptosis. |
2013-01-24 |
2023-08-12 |
mouse |
| Dong Zhou, Yingjian Li, Lin Lin, Lili Zhou, Peter Igarashi, Youhua Li. Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice. Kidney international. vol 82. issue 5. 2013-01-24. PMID:22622501. |
consistently, apoptosis was more prevalent in kidneys of the knockout mice, which was accompanied by increased expression of p53 and bax, and decreased phosphorylated akt and survivin. |
2013-01-24 |
2023-08-12 |
mouse |
| Dong Zhou, Yingjian Li, Lin Lin, Lili Zhou, Peter Igarashi, Youhua Li. Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice. Kidney international. vol 82. issue 5. 2013-01-24. PMID:22622501. |
in vitro activation of β-catenin by wnt1 or stabilization of β-catenin protected tubular epithelial cells from apoptosis, activated akt, induced survivin, and repressed p53 and bax expression. |
2013-01-24 |
2023-08-12 |
mouse |
| Peter Canning, Frank von Delft, Alex N Bulloc. Structural basis for ASPP2 recognition by the tumor suppressor p73. Journal of molecular biology. vol 423. issue 4. 2013-01-24. PMID:22917970. |
most human cancers lose p53 function, yet all three proteins are capable of inducing apoptosis or cellular senescence. |
2013-01-24 |
2023-08-12 |
human |
| Hae-Yun Jung, Hyun-Jung Joo, Jong Kuk Park, Yeul Hong Ki. The Blocking of c-Met Signaling Induces Apoptosis through the Increase of p53 Protein in Lung Cancer. Cancer research and treatment. vol 44. issue 4. 2013-01-24. PMID:23341789. |
the blocking of c-met signaling induces apoptosis through the increase of p53 protein in lung cancer. |
2013-01-24 |
2023-08-12 |
human |
| He-Qi Bu, Jiang Luo, Hui Chen, Jian-Hong Zhang, Hong-Hai Li, Hong-Chun Guo, Zhao-Hong Wang, Sheng-Zhang Li. Oridonin enhances antitumor activity of gemcitabine in pancreatic cancer through MAPK-p38 signaling pathway. International journal of oncology. vol 41. issue 3. 2013-01-23. PMID:22710877. |
in vitro, oridonin inhibited the proliferation of the paca cell line, bxpc-3, potentiated the apoptosis induced by gemcitabine, induced g1 cell cycle arrest and activated p38 and p53; these results were significant when oridonin was combined with gemcitabine. |
2013-01-23 |
2023-08-12 |
mouse |
| Xiaofeng Zheng, Shuyan Yang, Yanchao Han, Xinyi Zhao, Long Zhao, Tian Tian, Jingyuan Tong, Pengfei Xu, Cong Xiong, Anming Men. Loss of zygotic NUP107 protein causes missing of pharyngeal skeleton and other tissue defects with impaired nuclear pore function in zebrafish embryos. The Journal of biological chemistry. vol 287. issue 45. 2013-01-23. PMID:22965233. |
extensive apoptosis occurs in the affected tissues, which is partially dependent on p53 apoptotic pathways. |
2013-01-23 |
2023-08-12 |
zebrafish |