| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linlin Li, Wenqiang Cao, Wenjie Zheng, Cundong Fan, Tianfeng Che. Ruthenium complexes containing 2,6-bis(benzimidazolyl)pyridine derivatives induce cancer cell apoptosis by triggering DNA damage-mediated p53 phosphorylation. Dalton transactions (Cambridge, England : 2003). vol 41. issue 41. 2013-02-26. PMID:22968364. |
ruthenium complexes containing 2,6-bis(benzimidazolyl)pyridine derivatives induce cancer cell apoptosis by triggering dna damage-mediated p53 phosphorylation. |
2013-02-26 |
2023-08-12 |
Not clear |
| Linlin Li, Wenqiang Cao, Wenjie Zheng, Cundong Fan, Tianfeng Che. Ruthenium complexes containing 2,6-bis(benzimidazolyl)pyridine derivatives induce cancer cell apoptosis by triggering DNA damage-mediated p53 phosphorylation. Dalton transactions (Cambridge, England : 2003). vol 41. issue 41. 2013-02-26. PMID:22968364. |
taken together, these results suggest that rubmp, as a promising anticancer agent, induces cancer cell apoptosis by triggering dna damage-mediated p53 phosphorylation. |
2013-02-26 |
2023-08-12 |
Not clear |
| Camilla Sampaoli, Lidia Cerquetti, Randa El Gawhary, Barbara Bucci, Donatella Amendola, Rodolfo Marchese, Silvia Misiti, Giuseppe Novelli, Vincenzo Toscano, Antonio Stiglian. p53 Stabilization induces cell growth inhibition and affects IGF2 pathway in response to radiotherapy in adrenocortical cancer cells. PloS one. vol 7. issue 9. 2013-02-26. PMID:23028800. |
(wt)p53 over-expression also increased cell death by apoptosis following radiation in both cell lines. |
2013-02-26 |
2023-08-12 |
Not clear |
| Panagiota A Sotiropoulou, Andrea E Karambelas, Maud Debaugnies, Aurelie Candi, Peter Bouwman, Virginie Moers, Tatiana Revenco, Ana Sofia Rocha, Kiyotoshi Sekiguchi, Jos Jonkers, Cedric Blanpai. BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes & development. vol 27. issue 1. 2013-02-26. PMID:23271346. |
interestingly, hf matrix transient amplifying progenitors present increased dna damage, p53 stabilization, and caspase-dependent apoptosis compared with the interfollicular and sebaceous progenitors, leading to hyperproliferation, apoptosis, and subsequent depletion of the prospective adult hf scs. |
2013-02-26 |
2023-08-12 |
mouse |
| Éder Maiquel Simão, Marialva Sinigaglia, Cristhian Augusto Bugs, Mauro Antonio Alves Castro, Giovani Rubert Librelotto, Ronnie Alves, José Carlos Merino Mombac. Induced genome maintenance pathways in pre-cancer tissues describe an anti-cancer barrier in tumor development. Molecular bioSystems. vol 8. issue 11. 2013-02-25. PMID:22955060. |
we find that the main alterations in pre-cancer samples comprising the barrier are: (1) dna double strand-breaks signaling and repair pathways induction, (2) upregulation of cyclin-dependent kinases, (3) p53 dependent (and independent) repair and apoptosis pathways induction and (4) replicative senescence induction early in tissue transformation. |
2013-02-25 |
2023-08-12 |
Not clear |
| Éder Maiquel Simão, Marialva Sinigaglia, Cristhian Augusto Bugs, Mauro Antonio Alves Castro, Giovani Rubert Librelotto, Ronnie Alves, José Carlos Merino Mombac. Induced genome maintenance pathways in pre-cancer tissues describe an anti-cancer barrier in tumor development. Molecular bioSystems. vol 8. issue 11. 2013-02-25. PMID:22955060. |
the results give support to the model, furthermore they reveal the involvement of additional mechanisms in pre-cancer, including the early induction of replicative senescence and of p53 independent apoptosis. |
2013-02-25 |
2023-08-12 |
Not clear |
| Yen-Ying Ma, Hao Lin, Fang-Mei Chang, Ting-Chang Chang, Tiffany Trieu, Hannah I Pridgen, Yinghao Zhang, Jianjun Huang, Karina Patiño-Guzman, Nabih Diab, Angelica Cantu, Thomas J Slaga, Sung-Jen We. Identification of the deleted in split hand/split foot 1 protein as a novel biomarker for human cervical cancer. Carcinogenesis. vol 34. issue 1. 2013-02-25. PMID:23024267. |
when dss1 levels are reduced using shrna, the cells ultimately undergo apoptosis via activation of p53 and the p53 downstream targets, and cleavage of apoptosis-associated proteins including cpp32/caspase-3, poly(adp-ribose)polymerase and dna-pkcs. |
2013-02-25 |
2023-08-12 |
human |
| Ana Villegas-Méndez, Pascal Fender, Marina I Garin, Romy Rothe, Lavinia Liguori, Bruno Marques, Jean-Luc Lenorman. Functional characterisation of the WW minimal domain for delivering therapeutic proteins by adenovirus dodecahedron. PloS one. vol 7. issue 9. 2013-02-25. PMID:23028993. |
using these minimal ww domains fused to the tumor suppressor p53 protein, we show efficient cellular uptake and distribution into cancer cells, leading to specific induction of apoptosis in these cells. |
2013-02-25 |
2023-08-12 |
Not clear |
| Ye-Qin Yang, Chun-Yu Zhang, Yan Sun, Li-Ping Jing, Qian Tu, En Zhan. [Changes of iNOS, P53 and apoptosis in III degrees pressure ulcer]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 27. issue 1. 2013-02-21. PMID:21560340. |
[changes of inos, p53 and apoptosis in iii degrees pressure ulcer]. |
2013-02-21 |
2023-08-12 |
Not clear |
| Chindo Hicks, Ranjit Kumar, Antonio Pannuti, Kandis Backus, Alexandra Brown, Jesus Monico, Lucio Miel. An Integrative Genomics Approach for Associating GWAS Information with Triple-Negative Breast Cancer. Cancer informatics. vol 12. 2013-02-21. PMID:23423317. |
network modeling and pathway prediction revealed multi-gene pathways including p53, nfkb, brca, apoptosis, dna repair, dna mismatch, and excision repair pathways enriched for snps mapped to genes significantly associated with tnbc. |
2013-02-21 |
2023-08-12 |
Not clear |
| Basant Kumar Thakur, Tino Dittrich, Prakash Chandra, Annette Becker, Wolfgang Kuehnau, Jan-Henning Klusmann, Dirk Reinhardt, Karl Welt. Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells. International journal of cancer. vol 132. issue 4. 2013-02-20. PMID:22815158. |
further, knockdown of p53 attenuated the effects of fk866 on apoptosis and cell cycle arrest, which was partly associated with decreased expression of p21 and bax. |
2013-02-20 |
2023-08-12 |
Not clear |
| Shun X Ren, Alfred S L Cheng, Ka F To, Joanna H M Tong, May S Li, Jing Shen, Jin Shen, Clover C M Wong, Lin Zhang, Ruby L Y Chan, Xiao J Wang, Simon S M Ng, Lawrence C M Chiu, Victor E Marquez, Richard L Gallo, Francis K L Chan, Jun Yu, Joseph J Y Sung, William K K Wu, Chi H Ch. Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer research. vol 72. issue 24. 2013-02-20. PMID:23100468. |
correspondingly, colonic mucosa of cathelicidin-deficient mice exhibited reduced expression of p53, bax, and bak and increased expression of bcl-2 together with a lower basal level of apoptosis. |
2013-02-20 |
2023-08-12 |
mouse |
| Yingjian Liang, Juan Liu, Zhaohui Fen. The regulation of cellular metabolism by tumor suppressor p53. Cell & bioscience. vol 3. issue 1. 2013-02-18. PMID:23388203. |
cell cycle arrest, apoptosis and senescence are most well-understood functions of p53, and are traditionally accepted as the major mechanisms for p53 in tumor suppression. |
2013-02-18 |
2023-08-12 |
Not clear |
| Diego d'Avila Paskulin, Vanessa Rodrigues Paixão-Côrtes, Pierre Hainaut, Maria Cátira Bortolini, Patricia Ashton-Proll. The TP53 fertility network. Genetics and molecular biology. vol 35. issue 4 (suppl). 2013-02-18. PMID:23412905. |
the p53 protein has a key role as transcription factor in limiting oncogenesis through several growth suppressive functions, such as initiating apoptosis, senescence, or cell cycle arrest. |
2013-02-18 |
2023-08-12 |
human |
| W Zhang, J-X Qian, H-L Yi, Z-D Yang, C-F Wang, J-Y Chen, X-Z Wei, Q Fu, H M. The microRNA-29 plays a central role in osteosarcoma pathogenesis and progression. Molekuliarnaia biologiia. vol 46. issue 4. 2013-02-15. PMID:23113351. |
while mirna-29 members induced apoptosis through p53 gene activation, the effect of mirna-29a on osteoblastic cells was independent on p53 expression level. |
2013-02-15 |
2023-08-12 |
Not clear |
| Sarah Labib, Carole Yauk, Andrew Williams, Volker M Arlt, David H Phillips, Paul A White, Sabina Halappanava. Subchronic oral exposure to benzo(a)pyrene leads to distinct transcriptomic changes in the lungs that are related to carcinogenesis. Toxicological sciences : an official journal of the Society of Toxicology. vol 129. issue 1. 2013-02-14. PMID:22610609. |
at the transcriptomic level, a transition from activation of the dna damage response p53 pathway at the low dose to the induction of genes involved in angiogenesis, evasion of apoptosis and growth signals at the high doses was evident only in the lungs. |
2013-02-14 |
2023-08-12 |
mouse |
| Peng Jiang, Wenjing Du, Anthony Mancuso, Kathryn E Wellen, Xiaolu Yan. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. vol 493. issue 7434. 2013-02-13. PMID:23334421. |
downregulation of me1 and me2 also modulates the outcome of p53 activation, leading to strong induction of senescence, but not apoptosis, whereas enforced expression of either malic enzyme suppresses senescence. |
2013-02-13 |
2023-08-12 |
mouse |
| Rehan Khan, Abdul Quaiyoom Khan, Wajhul Qamar, Abdul Lateef, Farrah Ali, Muneeb U Rehman, Mir Tahir, Swati Sharma, Sarwat Sultan. Chrysin abrogates cisplatin-induced oxidative stress, p53 expression, goblet cell disintegration and apoptotic responses in the jejunum of Wistar rats. The British journal of nutrition. vol 108. issue 9. 2013-02-12. PMID:22309980. |
the plausible mechanism of cddp-induced jejunal toxicity includes oxidative stress, p53 and apoptosis via up-regulating the expression of caspase-6 and -3. |
2013-02-12 |
2023-08-12 |
rat |
| O Merkel, N Wacht, E Sifft, T Melchardt, F Hamacher, T Kocher, U Denk, J P Hofbauer, A Egle, M Scheideler, M Schlederer, M Steurer, L Kenner, R Grei. Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. Leukemia. vol 26. issue 12. 2013-02-12. PMID:22743622. |
in an extensive screen for p53-independent apoptosis inducers, actinomycin d was identified from 1496 substances and shown to induce apoptosis in primary cll cells derived from high-risk patients including those with aberrant p53, revealing a novel p53-independent mechanism of action. |
2013-02-12 |
2023-08-12 |
mouse |
| Kazutoshi Iijima, Hiroyuki Yamada, Masashi Miharu, Ken-Ichi Imadome, Yoshitaka Miyagawa, Shingo Akimoto, Kenichiro Kobayashi, Hajime Okita, Atsuko Nakazawa, Shigeyoshi Fujiwara, Junichiro Fujimoto, Nobutaka Kiyokaw. ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis. European journal of immunology. vol 42. issue 12. 2013-02-12. PMID:22945289. |
to elucidate the function of znf385b in healthy b cells, we established a tetracycline-controlled protein-inducible system in b-cell lines and observed that ectopic expression of the longest transcript variant of znf385b, possessing four zf domains, induced upregulation of perp and fas/cd95, a downstream target of p53, and activation of caspase, resulting in apoptosis induction. |
2013-02-12 |
2023-08-12 |
Not clear |