| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazutoshi Iijima, Hiroyuki Yamada, Masashi Miharu, Ken-Ichi Imadome, Yoshitaka Miyagawa, Shingo Akimoto, Kenichiro Kobayashi, Hajime Okita, Atsuko Nakazawa, Shigeyoshi Fujiwara, Junichiro Fujimoto, Nobutaka Kiyokaw. ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis. European journal of immunology. vol 42. issue 12. 2013-02-12. PMID:22945289. |
the direct binding of znf385b with p53 has suggested the involvement of znf385b in b-cell apoptosis via modulation of p53 transactivation; our data indicate that znf385b characteristically expressed in gc b cells has both proapoptotic and antiapoptotic activities depending on the type of isoform and should be a novel player in gc b-cell selection. |
2013-02-12 |
2023-08-12 |
Not clear |
| Xin Wu, Li Sun, Li Zhang, Zheng-Quan Liu, Qiang Luo, Lin-Xi Zhan. [Impact of Toxoplasma gondii on the proliferation and apoptosis of tumor cell lines]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases. vol 30. issue 2. 2013-02-11. PMID:22908820. |
t. gondii induced cell apoptosis in a549 tumor cells, p53 and bcl-2 gene expression was respectively up-regulated and down-regulated. |
2013-02-11 |
2023-08-12 |
Not clear |
| Paweł Hikisz, Zofia M Kiliańsk. PUMA, a critical mediator of cell death--one decade on from its discovery. Cellular & molecular biology letters. vol 17. issue 4. 2013-02-11. PMID:23001513. |
puma (p53 upregulated modulator of apoptosis) is a pro-apoptotic member of the bh3-only subgroup of the bcl-2 family. |
2013-02-11 |
2023-08-12 |
human |
| Ana S Leal, Rui Wang, Jorge A R Salvador, Yongkui Jin. Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells. Bioorganic & medicinal chemistry. vol 20. issue 19. 2013-02-08. PMID:22959527. |
compound 32 arrests cell cycle in g1 phase and induces apoptosis in aspc-1 cells with upregulation of p53, p21(waf1) and noxa protein levels. |
2013-02-08 |
2023-08-12 |
Not clear |
| Yanlin Li, Lin Zhao, Haigang Sun, Jiankun Yu, Na Li, Jingwei Liang, Yan Wang, Miao He, Xuefeng Bai, Zhaojin Yu, Zhihong Zheng, Xiaoyi Mi, Enhua Wang, Minjie We. Gene silencing of FANCF potentiates the sensitivity to mitoxantrone through activation of JNK and p38 signal pathways in breast cancer cells. PloS one. vol 7. issue 8. 2013-02-07. PMID:22952942. |
fancf silencing increased jnk and p38 mediated activation of p53 in mx-treated breast cancer cells, activated the mitochondrial apoptosis pathway. |
2013-02-07 |
2023-08-12 |
Not clear |
| Ankit Rai, Avadhesha Surolia, Dulal Pand. An antitubulin agent BCFMT inhibits proliferation of cancer cells and induces cell death by inhibiting microtubule dynamics. PloS one. vol 7. issue 8. 2013-02-07. PMID:22952952. |
bcfmt-treated mcf-7 cells showed enhanced nuclear accumulation of p53 and its downstream p21, which consequently activated apoptosis in these cells. |
2013-02-07 |
2023-08-12 |
mouse |
| Paola Tucc. Caloric restriction: is mammalian life extension linked to p53? Aging. vol 4. issue 8. 2013-02-07. PMID:22983298. |
this novel, lifespan regulating function of p53 may be evolutionarily more ancient than its relatively recent role in apoptosis and tumour suppression, and is likely to provide many new insights into lifespan modulation. |
2013-02-07 |
2023-08-12 |
Not clear |
| Subhasis Das, Kaushik Kumar Dey, Rashmi Bharti, Sujata MaitiChoudhury, Sukumar Maiti, Mahitosh Manda. PKI 166 induced redox signalling and apoptosis through activation of p53, MAP kinase and caspase pathway in epidermoid carcinoma. Journal of experimental therapeutics & oncology. vol 10. issue 2. 2013-02-07. PMID:23350354. |
pki 166 induced redox signalling and apoptosis through activation of p53, map kinase and caspase pathway in epidermoid carcinoma. |
2013-02-07 |
2023-08-12 |
Not clear |
| George C Bobustuc, Joshua S Smith, Sreeram Maddipatla, Sheila Jeudy, Arati Limaye, Beth Isley, Maria-Lourdes M Caparas, Susan M Constantino, Nikita Shah, Cheryl H Baker, Kalkunte S Srivenugopal, Said Baidas, Santhi D Kondur. MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy. Molecular medicine (Cambridge, Mass.). vol 18. 2013-02-06. PMID:22549111. |
in tamoxifen-resistant breast cancer cells, bg alone or in combination with antiestrogen (tamoxifen [tam]/ici 182,780 [fulvestrant, faslodex]) therapy enhances p53 upregulated modulator of apoptosis (puma) expression, cytochrome c release and poly (adp-ribose) polymerase (parp) cleavage, all indicative of apoptosis. |
2013-02-06 |
2023-08-12 |
Not clear |
| Tatiana Goretsky, Ramanarao Dirisina, Preetika Sinh, Navdha Mittal, Elizabeth Managlia, David B Williams, Daniela Posca, Hyunji Ryu, Rebecca B Katzman, Terrence A Barret. p53 mediates TNF-induced epithelial cell apoptosis in IBD. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22863952. |
p53 mediates tnf-induced epithelial cell apoptosis in ibd. |
2013-02-06 |
2023-08-12 |
mouse |
| Tatiana Goretsky, Ramanarao Dirisina, Preetika Sinh, Navdha Mittal, Elizabeth Managlia, David B Williams, Daniela Posca, Hyunji Ryu, Rebecca B Katzman, Terrence A Barret. p53 mediates TNF-induced epithelial cell apoptosis in IBD. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22863952. |
chronic ulcerative colitis (cuc) is characterized by increased intestinal epithelial cell (iec) apoptosis associated with elevated tumor necrosis factor (tnf), inducible nitric oxide synthase (inos), and p53. |
2013-02-06 |
2023-08-12 |
mouse |
| Tatiana Goretsky, Ramanarao Dirisina, Preetika Sinh, Navdha Mittal, Elizabeth Managlia, David B Williams, Daniela Posca, Hyunji Ryu, Rebecca B Katzman, Terrence A Barret. p53 mediates TNF-induced epithelial cell apoptosis in IBD. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22863952. |
we previously showed that p53 is increased in crypt iecs in human colitis and is needed for iec apoptosis in chronic dextran sulfate sodium-colitis. |
2013-02-06 |
2023-08-12 |
mouse |
| Tatiana Goretsky, Ramanarao Dirisina, Preetika Sinh, Navdha Mittal, Elizabeth Managlia, David B Williams, Daniela Posca, Hyunji Ryu, Rebecca B Katzman, Terrence A Barret. p53 mediates TNF-induced epithelial cell apoptosis in IBD. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22863952. |
induction of iec apoptosis correlated with increased p53, which was attenuated in inos(-/-) mice. |
2013-02-06 |
2023-08-12 |
mouse |
| Tatiana Goretsky, Ramanarao Dirisina, Preetika Sinh, Navdha Mittal, Elizabeth Managlia, David B Williams, Daniela Posca, Hyunji Ryu, Rebecca B Katzman, Terrence A Barret. p53 mediates TNF-induced epithelial cell apoptosis in IBD. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22863952. |
iec p53 levels and apoptosis were reduced in il-10(-/-) colitic mice treated with neutralizing tnf mab and the inos inhibitor, aminoguanidine, further suggesting that tnf and inos are upstream of p53 during colitis-induced iec apoptosis. |
2013-02-06 |
2023-08-12 |
mouse |
| Tatiana Goretsky, Ramanarao Dirisina, Preetika Sinh, Navdha Mittal, Elizabeth Managlia, David B Williams, Daniela Posca, Hyunji Ryu, Rebecca B Katzman, Terrence A Barret. p53 mediates TNF-induced epithelial cell apoptosis in IBD. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22863952. |
iec apoptosis and p53 levels were assessed in control versus untreated or anti-tnf-treated cuc patients with equivalent levels of inflammation. |
2013-02-06 |
2023-08-12 |
mouse |
| Tatiana Goretsky, Ramanarao Dirisina, Preetika Sinh, Navdha Mittal, Elizabeth Managlia, David B Williams, Daniela Posca, Hyunji Ryu, Rebecca B Katzman, Terrence A Barret. p53 mediates TNF-induced epithelial cell apoptosis in IBD. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22863952. |
data indicated that iec apoptosis and p53 levels were clearly higher in untreated cuc but markedly reduced in patients treated with anti-tnf mab. |
2013-02-06 |
2023-08-12 |
mouse |
| Young Min Chung, See-Hyoung Park, Wen-Bin Tsai, Shih-Ya Wang, Masa-Aki Ikeda, Jonathan S Berek, David J Chen, Mickey C-T H. FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage. Nature communications. vol 3. 2013-02-05. PMID:22893124. |
the protein ataxia-telangiectasia mutated (atm) is activated by dna double-strand breaks and regulates apoptosis via p53. |
2013-02-05 |
2023-08-12 |
Not clear |
| Young Min Chung, See-Hyoung Park, Wen-Bin Tsai, Shih-Ya Wang, Masa-Aki Ikeda, Jonathan S Berek, David J Chen, Mickey C-T H. FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage. Nature communications. vol 3. 2013-02-05. PMID:22893124. |
foxo3 is essential for dna damage-induced apoptosis and conversely foxo3 requires atm, chk2 and phosphorylated p53 isoforms to trigger apoptosis as a result of dna damage. |
2013-02-05 |
2023-08-12 |
Not clear |
| Dariush Honardoust, Jie Ding, Mathew Varkey, Heather A Shankowsky, Edward E Tredge. Deep dermal fibroblasts refractory to migration and decorin-induced apoptosis contribute to hypertrophic scarring. Journal of burn care & research : official publication of the American Burn Association. vol 33. issue 5. 2013-02-04. PMID:22210076. |
decorin resulted in a significant increase in the expression of apoptosis markers, histone-1, caspase-1, caspase-8, and p53 in superficial fibroblasts when compared with deep dermal fibroblasts. |
2013-02-04 |
2023-08-12 |
Not clear |
| Khanapur Manjulatha, S Srinivas, Naveen Mulakayala, D Rambabu, M Prabhakar, Kalle M Arunasree, Mallika Alvala, M V Basaveswara Rao, Manojit Pa. Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: their evaluation as inhibitors of SIRT1. Bioorganic & medicinal chemistry letters. vol 22. issue 19. 2013-02-04. PMID:22929231. |
compound 3a [(z)-2-(5-bromo-2-hydroxybenzylidene) benzofuran-3(2h)-one] was identified as a potent inhibitor of sirt1 (ic(50)=1μm) which showed a dose dependent increase in the acetylation of p53 resulting in induction of apoptosis. |
2013-02-04 |
2023-08-12 |
Not clear |