| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Hu, Hongjie Yao, Fei Gan, Anthony Tokarski, Yanming Wan. Interaction of OKL38 and p53 in regulating mitochondrial structure and function. PloS one. vol 7. issue 8. 2013-03-06. PMID:22912861. |
the tumor suppressor p53 is a well-known transcription factor controlling the expression of its target genes involved in cell cycle and apoptosis. |
2013-03-06 |
2023-08-12 |
Not clear |
| Jing Hu, Hongjie Yao, Fei Gan, Anthony Tokarski, Yanming Wan. Interaction of OKL38 and p53 in regulating mitochondrial structure and function. PloS one. vol 7. issue 8. 2013-03-06. PMID:22912861. |
recently, we identified a novel downstream target of p53, okl38, which relocalizes from nucleus to mitochondria upon forced expression to induce apoptosis. |
2013-03-06 |
2023-08-12 |
Not clear |
| Jing Hu, Hongjie Yao, Fei Gan, Anthony Tokarski, Yanming Wan. Interaction of OKL38 and p53 in regulating mitochondrial structure and function. PloS one. vol 7. issue 8. 2013-03-06. PMID:22912861. |
taken together, our studies suggest that okl38 regulates mitochondria morphology and functions during apoptosis together with p53. |
2013-03-06 |
2023-08-12 |
Not clear |
| Ming-Fu Chiang, Pei-Yi Chou, Wan-Jen Wang, Chun-I Sze, Nan-Shan Chan. Tumor Suppressor WWOX and p53 Alterations and Drug Resistance in Glioblastomas. Frontiers in oncology. vol 3. 2013-03-06. PMID:23459853. |
intriguingly, ectopic expression of wild type wwox preferentially induces apoptosis in human glioblastoma cells harboring mutant p53. |
2013-03-06 |
2023-08-12 |
human |
| Arwa S Kathiria, William L Neumann, Jennifer Rhees, Erin Hotchkiss, Yulan Cheng, Robert M Genta, Stephen J Meltzer, Rhonda F Souza, Arianne L Theis. Prohibitin attenuates colitis-associated tumorigenesis in mice by modulating p53 and STAT3 apoptotic responses. Cancer research. vol 72. issue 22. 2013-03-05. PMID:22869582. |
tg mice exhibited decreased susceptibility in a manner associated with increased apoptosis, p53, bax, and bad expression plus decreased bcl-xl and bcl-2 expression. |
2013-03-05 |
2023-08-12 |
mouse |
| Juan Jiao, Lin Dou, Miao Li, Yonggang Lu, Han-Bang Guo, Yong Man, Shu Wang, Jian L. NADPH oxidase 2 plays a critical role in dysfunction and apoptosis of pancreatic β-cells induced by very low-density lipoprotein. Molecular and cellular biochemistry. vol 370. issue 1-2. 2013-03-05. PMID:22911512. |
furthermore, we found that vldl induced dysfunction and apoptosis of pancreatic β-cells through jnk and p53 pathways, which were rescued by sirna-mediated nox2 reduction. |
2013-03-05 |
2023-08-12 |
mouse |
| Juan Jiao, Lin Dou, Miao Li, Yonggang Lu, Han-Bang Guo, Yong Man, Shu Wang, Jian L. NADPH oxidase 2 plays a critical role in dysfunction and apoptosis of pancreatic β-cells induced by very low-density lipoprotein. Molecular and cellular biochemistry. vol 370. issue 1-2. 2013-03-05. PMID:22911512. |
in conclusion, our data demonstrate a critical role of nox2-derived ros in dysfunction and apoptosis through jnk and p53 pathways in pancreatic β-cells induced by vldl. |
2013-03-05 |
2023-08-12 |
mouse |
| Hong Sug Kim, Kevin Woolard, Chen Lai, Peter O Bauer, Dragan Maric, Hua Song, Aiguo Li, Svetlana Kotliarova, Wei Zhang, Howard A Fin. Gliomagenesis arising from Pten- and Ink4a/Arf-deficient neural progenitor cells is mediated by the p53-Fbxw7/Cdc4 pathway, which controls c-Myc. Cancer research. vol 72. issue 22. 2013-03-05. PMID:22986743. |
we propose that p53 mutations contribute to gliomagenesis by both allowing the overexpression of c-myc through downregulation of fbxw7 and by protecting against c-myc-induced apoptosis. |
2013-03-05 |
2023-08-12 |
mouse |
| Tomoya Fukawa, Masaya Ono, Taisuke Matsuo, Hisanori Uehara, Tsuneharu Miki, Yusuke Nakamura, Hiro-omi Kanayama, Toyomasa Katagir. DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription through its interaction with NPM1 in renal cell carcinomas. Cancer research. vol 72. issue 22. 2013-03-05. PMID:23019224. |
as a result, hdm2 binding to p53 was reduced, causing p53 stablization with concomitant g(1) phase cell-cycle arrest and apoptosis. |
2013-03-05 |
2023-08-12 |
human |
| Rouba Hage-Sleiman, Maria O Esmerian, Hadile Kobeissy, Ghassan Dbaib. p53 and Ceramide as Collaborators in the Stress Response. International journal of molecular sciences. vol 14. issue 3. 2013-03-05. PMID:23455468. |
however, in other cases, in the absence of the tumor suppressor protein p53, apoptosis proceeds partly due to the activity of this "tumor suppressor lipid", ceramide. |
2013-03-05 |
2023-08-12 |
Not clear |
| Rouba Hage-Sleiman, Maria O Esmerian, Hadile Kobeissy, Ghassan Dbaib. p53 and Ceramide as Collaborators in the Stress Response. International journal of molecular sciences. vol 14. issue 3. 2013-03-05. PMID:23455468. |
furthermore, after highlighting the role and mechanism of action of p53 in apoptosis, we review the association of ceramide and p53 with respect to apoptosis. |
2013-03-05 |
2023-08-12 |
Not clear |
| Timothy A Sutton, Takashi Hato, Erik Mai, Momoko Yoshimoto, Sarah Kuehl, Melissa Anderson, Henry Mang, Zoya Plotkin, Rebecca J Chan, Pierre C Daghe. p53 is renoprotective after ischemic kidney injury by reducing inflammation. Journal of the American Society of Nephrology : JASN. vol 24. issue 1. 2013-03-04. PMID:23222126. |
in the rat, p53 promotes tubular apoptosis after ischemic aki. |
2013-03-04 |
2023-08-12 |
mouse |
| Oliver D K Maddocks, Celia R Berkers, Susan M Mason, Liang Zheng, Karen Blyth, Eyal Gottlieb, Karen H Vousde. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature. vol 493. issue 7433. 2013-03-04. PMID:23242140. |
in contrast to its role in promoting apoptosis during dna-damaging stress, p53 can promote cell survival during metabolic stress, a function that may contribute not only to tumour suppression but also to non-cancer-associated functions of p53. |
2013-03-04 |
2023-08-12 |
human |
| J Zhang, Q Sun, Z Zhang, S Ge, Z-G Han, W-T Che. Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop. Oncogene. vol 32. issue 1. 2013-02-28. PMID:22330136. |
re-expression of these mirnas suppresses cellular growth and triggers the apoptosis of epithelial cancer, in vitro and in vivo, by enhancing p53 activity via mdm2 turnover. |
2013-02-28 |
2023-08-12 |
human |
| Mika Kosaka, Moo Rim Kang, Glen Yang, Long-Cheng L. Targeted p21WAF1/CIP1 activation by RNAa inhibits hepatocellular carcinoma cells. Nucleic acid therapeutics. vol 22. issue 5. 2013-02-28. PMID:22909100. |
further analysis of dsp21-322 transfected cells revealed that dsp21-322 arrested the cell cycle at the g(0)/g(1) phase in hepg2 cells but at g(2)/m phase in hep3b cells which lack functional p53 and rb genes, and induced both early and late stage apoptosis by activating caspase 3 in both cell lines. |
2013-02-28 |
2023-08-12 |
Not clear |
| Liguo Zhang, Nai-Jia Huang, Chen Chen, Wanli Tang, Sally Kornblut. Ubiquitylation of p53 by the APC/C inhibitor Trim39. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 51. 2013-02-28. PMID:23213260. |
as such, trim39 may serve as a potential therapeutic target in tumors with wt p53 when mdm2 inhibition is insufficient to elevate p53 levels and apoptosis. |
2013-02-28 |
2023-08-12 |
Not clear |
| Gabriella D'Orazi, Cinzia Rinaldo, Silvia Sodd. Updates on HIPK2: a resourceful oncosuppressor for clearing cancer. Journal of experimental & clinical cancer research : CR. vol 31. 2013-02-27. PMID:22889244. |
recent findings demonstrated that hipk2 inhibitions do exist in tumors and depend by several mechanisms including hipk2 cytoplasmic localization, protein degradation, and loss of heterozygosity (loh), recapitulating the biological outcome obtained by rna interference studies in tumor cells, such as p53 inactivation, resistance to therapies, apoptosis inhibition, and tumor progression. |
2013-02-27 |
2023-08-12 |
mouse |
| Ruma Sarkar, Sutapa Mukherjee, Jaydip Biswas, Madhumita Ro. Sulphoraphane, a naturally occurring isothiocyanate induces apoptosis in breast cancer cells by targeting heat shock proteins. Biochemical and biophysical research communications. vol 427. issue 1. 2013-02-27. PMID:22975350. |
it was furthermore investigated whether modulation of hsps and hsf1 could induce apoptosis in these cells by altering the expressions of p53, p21 and some apoptotic proteins like bcl-2, bax, bid, bad, apaf-1 and aif. |
2013-02-27 |
2023-08-12 |
human |
| Zhiping Wang, Yuangang Liu, Maho Takahashi, Kathryn Van Hook, Kerstin M Kampa-Schittenhelm, Brett C Sheppard, Rosalie C Sears, Philip J S Stork, Charles D Lope. N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 1. 2013-02-27. PMID:23248303. |
the aspp2 (also known as 53bp2l) tumor suppressor is a proapoptotic member of a family of p53 binding proteins that functions in part by enhancing p53-dependent apoptosis via its c-terminal p53-binding domain. |
2013-02-27 |
2023-08-12 |
human |
| Yoshiaki Mizuguchi, Susan Specht, John G Lunz, Kumiko Isse, Natasha Corbitt, Toshihiro Takizawa, Anthony J Demetri. SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity. BMC molecular biology. vol 13. 2013-02-26. PMID:22731250. |
p53 is also widely recognized as the node in cellular stress responses that inhibits emt and triggers cell-cycle arrest, apoptosis, and cellular senescence. |
2013-02-26 |
2023-08-12 |
Not clear |