| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mahmood S Choudhery, Mohsin Khan, Ruhma Mahmood, Sadia Mohsin, Shoaib Akhtar, Fatima Ali, Shaheen N Khan, Sheikh Riazuddi. Mesenchymal stem cells conditioned with glucose depletion augments their ability to repair-infarcted myocardium. Journal of cellular and molecular medicine. vol 16. issue 10. 2013-03-26. PMID:22435530. |
in this study, mscs from young (2 months) and aged (24 months) c57bl/6 mice were characterized for gene expression of igf-1, fgf-2, vegf, sirt-1, akt, p16(ink4a) , p21 and p53 along with measurements of population doubling (pd), superoxide dismutase (sod) activity and apoptosis. |
2013-03-26 |
2023-08-12 |
mouse |
| Sushil Devkota, Young Hoon Sung, Jung-Min Choi, Jaehoon Lee, Na Young Ha, Hyunki Kim, Byoung Chul Cho, Jaewhan Song, Han-Woong Le. Ei24-deficiency attenuates protein kinase Cα signaling and skin carcinogenesis in mice. The international journal of biochemistry & cell biology. vol 44. issue 11. 2013-03-26. PMID:22771957. |
etoposide-induced gene 24 (ei24) is a p53 target gene that inhibits growth, induces apoptosis and autophagy, as well as suppresses breast cancer. |
2013-03-26 |
2023-08-12 |
mouse |
| Dan Wu, Toshinori Ozaki, Yukari Yoshihara, Natsumi Kubo, Akira Nakagawar. Runt-related transcription factor 1 (RUNX1) stimulates tumor suppressor p53 protein in response to DNA damage through complex formation and acetylation. The Journal of biological chemistry. vol 288. issue 2. 2013-03-26. PMID:23148227. |
consistent with these observations, knockdown of runx1 attenuated adr-mediated induction of p53 target genes and suppressed adr-dependent apoptosis. |
2013-03-26 |
2023-08-12 |
Not clear |
| Jin Hyup Lee, Shobhan Gaddameedhi, Nuri Ozturk, Rui Ye, Aziz Sanca. DNA damage-specific control of cell death by cryptochrome in p53-mutant ras-transformed cells. Cancer research. vol 73. issue 2. 2013-03-26. PMID:23149912. |
furthermore, ras-transformed p53- and cry-null mouse skin fibroblasts are more sensitive than p53 mutants to apoptotic cell death initiated by agents that activate either the intrinsic or the extrinsic apoptosis pathways. |
2013-03-26 |
2023-08-12 |
mouse |
| Laura Bongiovanni, Francesca Mazzocchetti, Daniela Malatesta, Mariarita Romanucci, Andrea Ciccarelli, Paolo Buracco, Raffaella De Maria, Chiara Palmieri, Marina Martano, Emanuela Morello, Lorella Maniscalco, Leonardo Della Sald. Immunohistochemical investigation of cell cycle and apoptosis regulators (survivin, β-catenin, p53, caspase 3) in canine appendicular osteosarcoma. BMC veterinary research. vol 8. 2013-03-25. PMID:22686277. |
immunohistochemical investigation of cell cycle and apoptosis regulators (survivin, β-catenin, p53, caspase 3) in canine appendicular osteosarcoma. |
2013-03-25 |
2023-08-12 |
human |
| Laura Bongiovanni, Francesca Mazzocchetti, Daniela Malatesta, Mariarita Romanucci, Andrea Ciccarelli, Paolo Buracco, Raffaella De Maria, Chiara Palmieri, Marina Martano, Emanuela Morello, Lorella Maniscalco, Leonardo Della Sald. Immunohistochemical investigation of cell cycle and apoptosis regulators (survivin, β-catenin, p53, caspase 3) in canine appendicular osteosarcoma. BMC veterinary research. vol 8. 2013-03-25. PMID:22686277. |
despite several pathways have been investigated so far, few molecules have been identified as prognostic tools or potential therapeutic targets, and there is still the need to find out molecular pathways with specific influence over osa progression to facilitate earlier prognosis and treatment.aims of the present study were to evaluate the immunohistochemical pattern and levels of expression of a panel of molecules (survivin, β-catenin, caspase 3 -inactive and active forms- and p53) involved in cell cycle and apoptosis regulation in canine osa samples, known to be of interest in the study also of human osa, and to detect specific relations among them and with histological tumour grade, disease free interval (dfi) and overall survival (os). |
2013-03-25 |
2023-08-12 |
human |
| Shi-Wei Huang, Chun-Ying Wu, Yen-Ting Wang, Jun-Kai Kao, Chi-Chen Lin, Chia-Che Chang, Szu-Wei Mu, Yu-Yu Chen, Husan-Wen Chiu, Chuan-Hsun Chang, Shu-Mei Liang, Yi-Ju Chen, Jau-Ling Huang, Jeng-Jer Shie. p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells. Toxicology and applied pharmacology. vol 267. issue 1. 2013-03-25. PMID:23274516. |
p53 modulates the ampk inhibitor compound c induced apoptosis in human skin cancer cells. |
2013-03-25 |
2023-08-12 |
human |
| Shi-Wei Huang, Chun-Ying Wu, Yen-Ting Wang, Jun-Kai Kao, Chi-Chen Lin, Chia-Che Chang, Szu-Wei Mu, Yu-Yu Chen, Husan-Wen Chiu, Chuan-Hsun Chang, Shu-Mei Liang, Yi-Ju Chen, Jau-Ling Huang, Jeng-Jer Shie. p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells. Toxicology and applied pharmacology. vol 267. issue 1. 2013-03-25. PMID:23274516. |
in this study, we have demonstrated that compound c not only induced autophagy in all tested skin cancer cell lines but also caused more apoptosis in p53 wildtype skin cancer cells than in p53-mutant skin cancer cells. |
2013-03-25 |
2023-08-12 |
human |
| Shi-Wei Huang, Chun-Ying Wu, Yen-Ting Wang, Jun-Kai Kao, Chi-Chen Lin, Chia-Che Chang, Szu-Wei Mu, Yu-Yu Chen, Husan-Wen Chiu, Chuan-Hsun Chang, Shu-Mei Liang, Yi-Ju Chen, Jau-Ling Huang, Jeng-Jer Shie. p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells. Toxicology and applied pharmacology. vol 267. issue 1. 2013-03-25. PMID:23274516. |
overall, our results established that compound c-induced apoptosis in skin cancer cells was dependent on the cell's p53 status. |
2013-03-25 |
2023-08-12 |
human |
| Ying Ni, Charis En. Vitamin E protects against lipid peroxidation and rescues tumorigenic phenotypes in cowden/cowden-like patient-derived lymphoblast cells with germline SDHx variants. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 18. issue 18. 2013-03-22. PMID:22829200. |
we previously showed that sdhx variants result in elevated reactive oxygen species (ros), disruption of nicotinamide adenine dinucleotide (nad) equilibrium, and destabilization of p53 hence apoptosis resistance in cs/csl patient-derived lymphoblastoid cells. |
2013-03-22 |
2023-08-12 |
Not clear |
| Pingde Zhang, Stephanie Si Liu, Hextan Yuen Sheung Nga. TAp73-mediated the activation of c-Jun N-terminal kinase enhances cellular chemosensitivity to cisplatin in ovarian cancer cells. PloS one. vol 7. issue 8. 2013-03-22. PMID:22900074. |
here, we demonstrated a novel molecular mechanism for tap73-mediated apoptosis in response to cisplatin in ovarian cancer cells, and that was irrespective of p53 status. |
2013-03-22 |
2023-08-12 |
human |
| Arindam P Ghosh, Barbara J Klocke, Mary E Ballestas, Kevin A Rot. CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PloS one. vol 7. issue 6. 2013-03-21. PMID:22761832. |
puma (p53 upregulated modulator of apoptosis) and bim (bcl2 interacting mediator of cell death), pro-apoptotic bh3 domain-only, bcl2 family members, have previously been shown to regulate er stress-induced cell death, but the upstream signaling pathways that regulate this response in neuronal cells are incompletely defined. |
2013-03-21 |
2023-08-12 |
Not clear |
| Anup R Tilak, Sachin Kumar, Mohan C Pant, Neeraj Mathur, Ashwani Kuma. Polymorphism Arg72Pro of p53 confers susceptibility to squamous cell carcinoma of lungs in a North Indian population. DNA and cell biology. vol 32. issue 2. 2013-03-21. PMID:23317414. |
the tumor suppressor protein p53 functions to induce cell cycle arrest, dna repair, or apoptosis. |
2013-03-21 |
2023-08-12 |
Not clear |
| Ana Luzio, Sandra M Monteiro, António A Fontaínhas-Fernandes, Olinda Pinto-Carnide, Manuela Matos, Ana M Coimbr. Copper induced upregulation of apoptosis related genes in zebrafish (Danio rerio) gill. Aquatic toxicology (Amsterdam, Netherlands). vol 128-129. 2013-03-20. PMID:23314331. |
an approach to different apoptosis pathways was done selecting p53, caspase-8, caspase-9 and apoptosis inducing factor (aif) genes. |
2013-03-20 |
2023-08-12 |
zebrafish |
| Ana Luzio, Sandra M Monteiro, António A Fontaínhas-Fernandes, Olinda Pinto-Carnide, Manuela Matos, Ana M Coimbr. Copper induced upregulation of apoptosis related genes in zebrafish (Danio rerio) gill. Aquatic toxicology (Amsterdam, Netherlands). vol 128-129. 2013-03-20. PMID:23314331. |
apoptosis seems to be initiated via intrinsic pathway (caspase-9), through p53 activation; then followed by the extrinsic pathway (caspase-8) and finally by the caspase-independent pathway (aif). |
2013-03-20 |
2023-08-12 |
zebrafish |
| Wei-Ming Wang, Shu-Ting Liu, Shih-Ming Huang, Wei-Shiang Lin, Shyi-Gen Chen, Yung-Lung Chan. Zac1 functional interactions mediate AP-1 transcriptional activity. Biochimica et biophysica acta. vol 1813. issue 12. 2013-03-19. PMID:21864583. |
zac1 not only promotes cell cycle arrest and apoptosis but also acts as a transcriptional cofactor for nuclear receptors and p53. |
2013-03-19 |
2023-08-12 |
mouse |
| Isabel Zvibel, Adam Wagner, Metsada Pasmanik-Chor, Chen Varol, Varda Oron-Karni, Erwin M Santo, Zamir Halpern, Revital Kari. Transcriptional profiling identifies genes induced by hepatocyte-derived extracellular matrix in metastatic human colorectal cancer cell lines. Clinical & experimental metastasis. vol 30. issue 2. 2013-03-19. PMID:22930170. |
gene profiling analysis shows that after 2 days on hecm, 226 genes are up-regulated more than 2-fold in strongly metastatic sm cells, including genes involved in growth arrest and apoptosis, signal transduction, cell migration, proliferation, communication and angiogenesis, with activation of the erbb signaling network and p53 effectors. |
2013-03-19 |
2023-08-12 |
human |
| Maja T Tomicic, Bernd Kain. Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors. Biochimica et biophysica acta. vol 1835. issue 1. 2013-03-19. PMID:23006513. |
we discuss degradation of top1 as part of the repair pathway in the processing of top1 associated dna damage, give a summary of proteins involved in repair of cpt-induced replication mediated dsb, and highlight the role of p53 and inhibitors of apoptosis proteins (iaps), particularly xiap and survivin, in cancer cell resistance to cpt-like chemotherapeutics. |
2013-03-19 |
2023-08-12 |
Not clear |
| Sun Gwan Hwang, Jinah Park, Joo Young Park, Cheol Hyoung Park, Ki-Ho Lee, Jeong Woo Cho, Jong-Ik Hwang, Jae Young Seon. Anti-cancer activity of a novel small molecule compound that simultaneously activates p53 and inhibits NF-κB signaling. PloS one. vol 7. issue 9. 2013-03-19. PMID:23028510. |
the p53 and nf-κb pathways play important roles in diverse cellular functions, including cell growth, apoptosis, and tumorigenesis. |
2013-03-19 |
2023-08-12 |
human |
| Sara Cattelani, Giovanna Ferrari-Amorotti, Sara Galavotti, Raffaella Defferrari, Barbara Tanno, Samantha Cialfi, Jenny Vergalli, Valentina Fragliasso, Clara Guerzoni, Gloria Manzotti, Angela Rachele Soliera, Chiara Menin, Roberta Bertorelle, Heather P McDowell, Alessandro Inserra, Maria Luisa Belli, Luigi Varesio, Deborah Tweddle, Gian Paolo Tonini, Pierluigi Altavista, Carlo Dominici, Giuseppe Raschellà, Bruno Calabrett. The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform. Neoplasia (New York, N.Y.). vol 14. issue 7. 2013-03-18. PMID:22904680. |
the p53 codon 72 pro/pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72p isoform. |
2013-03-18 |
2023-08-12 |
human |