| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rachel L Dusek, Jamie L Bascom, Hannes Vogel, Sylvain Baron, Alexander D Borowsky, Mina J Bissell, Laura D Attard. Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer. Breast cancer research : BCR. vol 14. issue 2. 2013-04-24. PMID:22515648. |
perp is a transcriptional target of both p53 during dna damage-induced apoptosis and p63 during stratified epithelial development. |
2013-04-24 |
2023-08-12 |
mouse |
| Emilia Bialopiotrowicz, Aleksandra Szybinska, Bozena Kuzniewska, Laura Buizza, Daniela Uberti, Jacek Kuznicki, Urszula Wojd. Highly pathogenic Alzheimer's disease presenilin 1 P117R mutation causes a specific increase in p53 and p21 protein levels and cell cycle dysregulation in human lymphocytes. Journal of Alzheimer's disease : JAD. vol 32. issue 2. 2013-04-23. PMID:22810102. |
in both cell types, only the p117r mutation increased levels of key g1/s phase regulatory proteins, p53, and its effector p21, causing g1 phase prolongation with simultaneous s phase shortening, and lowering basal apoptosis. |
2013-04-23 |
2023-08-12 |
human |
| Chin-Yu Lai, An-Chi Tsai, Mei-Chuan Chen, Li-Hsun Chang, Hui-Lung Sun, Ya-Ling Chang, Chien-Chih Chen, Che-Ming Teng, Shiow-Lin Pa. Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo. PloS one. vol 7. issue 8. 2013-04-23. PMID:22912688. |
the same result was achieved by knocking down p53 with sirna in p53 wild-type cells, indicating that p53 plays a crucial role in aciculatin-induced apoptosis. |
2013-04-23 |
2023-08-12 |
mouse |
| Chin-Yu Lai, An-Chi Tsai, Mei-Chuan Chen, Li-Hsun Chang, Hui-Lung Sun, Ya-Ling Chang, Chien-Chih Chen, Che-Ming Teng, Shiow-Lin Pa. Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo. PloS one. vol 7. issue 8. 2013-04-23. PMID:22912688. |
collectively, these results indicate that aciculatin treatment induces cell cycle arrest and apoptosis via inhibition of mdm2 expression, thereby inducing p53 accumulation without significant dna damage and genome toxicity. |
2013-04-23 |
2023-08-12 |
mouse |
| Garth Funston, Walter Goh, Siau Jia Wei, Quah Soo Tng, Christopher Brown, Loh Jiah Tong, Chandra Verma, David Lane, Farid Ghadess. Binding of Translationally Controlled Tumour Protein to the N-terminal domain of HDM2 is inhibited by nutlin-3. PloS one. vol 7. issue 8. 2013-04-23. PMID:22912717. |
furthermore, we discovered that nutlin-3, a small molecule known to promote apoptosis and cell cycle arrest by blocking binding between hdm2 and p53, has a similar inhibitory effect on the interaction of hdm2 and tctp. |
2013-04-23 |
2023-08-12 |
Not clear |
| Alla Polotskaia, Sandy Hoffman, Nancy L Krett, Mala Shanmugam, Steven T Rosen, Jill Bargonett. 8-Amino-adenosine activates p53-independent cell death of metastatic breast cancers. Molecular cancer therapeutics. vol 11. issue 11. 2013-04-23. PMID:22973058. |
8-nh(2)-ado induced apoptotic death of mcf-7 cells and apoptosis was not inhibited by knockdown of functional p53. |
2013-04-23 |
2023-08-12 |
Not clear |
| Jessica J Gierut, Priya S Mathur, Wenjun Bie, Jin Han, Angela L Tyne. Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage. Molecular cancer therapeutics. vol 11. issue 11. 2013-04-23. PMID:22989419. |
knockdown of ptk6 enhances apoptosis in hct116 cells with wild-type p53, following treatment of cells with γ-radiation, doxorubicin, or 5-fluorouracil. |
2013-04-23 |
2023-08-12 |
Not clear |
| Minsoo Choi, Jue Shi, Sung Hoon Jung, Xi Chen, Kwang-Hyun Ch. Attractor landscape analysis reveals feedback loops in the p53 network that control the cellular response to DNA damage. Science signaling. vol 5. issue 251. 2013-04-23. PMID:23169817. |
the protein p53 functions as a tumor suppressor and can trigger either cell cycle arrest or apoptosis in response to dna damage. |
2013-04-23 |
2023-08-12 |
Not clear |
| Hiromitsu Saito, Ken-ichi Yamamura, Noboru Suzuk. Reduced bone morphogenetic protein receptor type 1A signaling in neural-crest-derived cells causes facial dysmorphism. Disease models & mechanisms. vol 5. issue 6. 2013-04-19. PMID:22773757. |
analysis of the nc-derived craniofacial mesenchyme of mutant embryos revealed an activation of the p53 apoptosis pathway, downregulation of both c-myc and bcl-xl, a normal growth rate but an incomplete expansion of mesenchymal cells. |
2013-04-19 |
2023-08-12 |
mouse |
| Xingang Xu, Kuan Zhang, Yong Huang, Li Ding, Guangda Chen, Honglei Zhang, Dewen Ton. Bovine herpes virus type 1 induces apoptosis through Fas-dependent and mitochondria-controlled manner in Madin-Darby bovine kidney cells. Virology journal. vol 9. 2013-04-19. PMID:22978358. |
previous studies suggest that bhv-1 may induce apoptosis in madin-darby bovine kidney (mdbk) cells via a mechanism only involving caspases and p53. |
2013-04-19 |
2023-08-12 |
cattle |
| Kleopatra Andreou, Ramkumar Rajendran, Marija Krstic-Demonacos, Constantinos Demonaco. Regulation of CXCR4 gene expression in breast cancer cells under diverse stress conditions. International journal of oncology. vol 41. issue 6. 2013-04-19. PMID:23023398. |
the expression of these genes is often modulated by the p53 tumor suppressor protein that induces apoptosis or cell cycle arrest in neoplastic cells. |
2013-04-19 |
2023-08-12 |
Not clear |
| Arijana Zorić, Andela Horvat, Neda Slad. Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis. Carcinogenesis. vol 34. issue 3. 2013-04-19. PMID:23188674. |
differential effects of diverse p53 isoforms on tap73 transcriptional activity and apoptosis. |
2013-04-19 |
2023-08-12 |
Not clear |
| Joana Dias Amaral, Federico Herrera, Pedro Miguel Rodrigues, Pedro Antunes Dionísio, Tiago Fleming Outeiro, Cecília Maria Pereira Rodrigue. Live-cell imaging of p53 interactions using a novel Venus-based bimolecular fluorescence complementation system. Biochemical pharmacology. vol 85. issue 6. 2013-04-19. PMID:23261524. |
p53 plays an important role in regulating a wide variety of cellular processes, such as cell cycle arrest and/or apoptosis. |
2013-04-19 |
2023-08-12 |
Not clear |
| Isolda Romero-Canelón, Luca Salassa, Peter J Sadle. The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes: control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway. Journal of medicinal chemistry. vol 56. issue 3. 2013-04-19. PMID:23368735. |
the contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes: control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway. |
2013-04-19 |
2023-08-12 |
Not clear |
| Jun Watanabe, Mai Nakagawa, Natsuko Watanabe, Morihiko Nakamur. Ubiquitin-like protein MNSFβ covalently binds to Bcl-G and enhances lipopolysaccharide/interferon γ-induced apoptosis in macrophages. The FEBS journal. vol 280. issue 5. 2013-04-18. PMID:23298187. |
conversely, co-transfection with mnsfβ and bcl-g greatly enhanced lps/ifnγ- induced apoptosis in raw264.7 cells, accompanied by increased expression of p53 and decreased cox-2 activity. |
2013-04-18 |
2023-08-12 |
mouse |
| Hernan Carol, C Patrick Reynolds, Min H Kang, Stephen T Keir, John M Maris, Richard Gorlick, E Anders Kolb, Catherine A Billups, Brian Geier, Raushan T Kurmasheva, Peter J Houghton, Malcolm A Smith, Richard B Loc. Initial testing of the MDM2 inhibitor RG7112 by the Pediatric Preclinical Testing Program. Pediatric blood & cancer. vol 60. issue 4. 2013-04-17. PMID:22753001. |
rg7112 is a selective inhibitor of p53-mdm2 binding that frees p53 from negative control, activating the p53 pathway in cancer cells leading to cell cycle arrest and apoptosis. |
2013-04-17 |
2023-08-12 |
Not clear |
| F Nikulenkov, C Spinnler, H Li, C Tonelli, Y Shi, M Turunen, T Kivioja, I Ignatiev, A Kel, J Taipale, G Selivanov. Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis. Cell death and differentiation. vol 19. issue 12. 2013-04-17. PMID:22790872. |
our analysis of genome-wide chromatin occupancy by p53 using chromatin immunoprecipitation (chip)-seq revealed 'p53 default program', that is, the pattern of major p53-bound sites that is similar upon p53 activation by nutlin3a, reactivation of p53 and induction of tumor cell apoptosis (rita) or 5-fluorouracil in breast cancer cells, despite different biological outcomes. |
2013-04-17 |
2023-08-12 |
Not clear |
| Podchanart Wanitchakool, Surawat Jariyawat, Kanoknetr Suksen, Darunee Soorukram, Patoomratana Tuchinda, Pawinee Piyachaturawa. Cleistanthoside A tetraacetate-induced DNA damage leading to cell cycle arrest and apoptosis with the involvement of p53 in lung cancer cells. European journal of pharmacology. vol 696. issue 1-3. 2013-04-17. PMID:23041153. |
cleistanthoside a tetraacetate-induced dna damage leading to cell cycle arrest and apoptosis with the involvement of p53 in lung cancer cells. |
2013-04-17 |
2023-08-12 |
human |
| Podchanart Wanitchakool, Surawat Jariyawat, Kanoknetr Suksen, Darunee Soorukram, Patoomratana Tuchinda, Pawinee Piyachaturawa. Cleistanthoside A tetraacetate-induced DNA damage leading to cell cycle arrest and apoptosis with the involvement of p53 in lung cancer cells. European journal of pharmacology. vol 696. issue 1-3. 2013-04-17. PMID:23041153. |
cat also inhibited dna topoisomerase iiα activity resulting in dna damage and increased the expression of the p53 protein with the subsequent induction of apoptosis. |
2013-04-17 |
2023-08-12 |
human |
| Yung Hyun Choi, Young Hyun Yo. Taxol-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. Oncology reports. vol 28. issue 6. 2013-04-16. PMID:23023313. |
in this study, we used mcf-7 and mda-mb-231 human breast carcinoma cells which have different estrogen receptor (er) and tumor suppressor p53 statuses to examine the mechanisms of taxol-induced growth inhibition and apoptosis. |
2013-04-16 |
2023-08-12 |
human |