| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Zhan, Robert Korngold, Cecilia Lezcano, Frank McKeon, George F Murph. Graft-versus-host disease-related cytokine-driven apoptosis depends on p73 in cytokeratin 15-positive target cells. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 18. issue 6. 2013-05-03. PMID:22469882. |
we hypothesized that gvhd-induced target cell injury may be related to pathways involving the p53 family that are constitutively expressed by epithelial stem cells and designed to trigger physiological apoptosis as a result of environmental danger signals. |
2013-05-03 |
2023-08-12 |
mouse |
| Wen-jing Su, Jun-shun Fang, Feng Cheng, Chao Liu, Fang Zhou, Jian Zhan. RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 5. 2013-05-03. PMID:23319651. |
the knockdown of rnf2 induces apoptosis, which can be rescued through the reduction of p53 expression. |
2013-05-03 |
2023-08-12 |
human |
| Hee-Yeon Jeon, Hyunsook Le. Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death. The FEBS journal. vol 280. issue 6. 2013-05-02. PMID:23351126. |
cell death in the absence of aurora-a was partially rescued by co-injection of the p53 morpholino, suggesting that apoptosis after aurora-a depletion is p53-dependent. |
2013-05-02 |
2023-08-12 |
zebrafish |
| Alessandra Insinga, Angelo Cicalese, Mario Faretta, Barbara Gallo, Luisa Albano, Simona Ronzoni, Laura Furia, Andrea Viale, Pier Giuseppe Pelicc. DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 10. 2013-05-02. PMID:23417300. |
we show that irradiation of hematopoietic and mammary stem cells up-regulates the cell cycle inhibitor p21, a known target of p53, which prevents p53 activation and inhibits p53 basal activity, impeding apoptosis and leading to cell cycle entry and symmetric self-renewing divisions. |
2013-05-02 |
2023-08-12 |
Not clear |
| Danielly Cristiny Ferraz da Costa, Fabiana Alves Casanova, Julia Quarti, Maitê Santos Malheiros, Daniel Sanches, Patricia Souza Dos Santos, Eliane Fialho, Jerson L Silv. Transient transfection of a wild-type p53 gene triggers resveratrol-induced apoptosis in cancer cells. PloS one. vol 7. issue 11. 2013-05-01. PMID:23152798. |
transient transfection of a wild-type p53 gene triggers resveratrol-induced apoptosis in cancer cells. |
2013-05-01 |
2023-08-12 |
Not clear |
| Guang-quan Li, Xing-gui Chen, Xing-ping Wu, Jing-dun Xie, Yong-ju Liang, Xiao-qin Zhao, Wei-qiang Chen, Li-wu F. Effect of dicycloplatin, a novel platinum chemotherapeutical drug, on inhibiting cell growth and inducing cell apoptosis. PloS one. vol 7. issue 11. 2013-05-01. PMID:23152837. |
besides, some apoptosis related events were observed after treatment with dicycloplatin, including increase of reactive oxygen species (ros), collapse of mitochondrial membrane potential (Δψm), release of cytochrome c from the mitochondria to the cytosol, upregulation of p53, which were accompanied by activation of caspase-9, caspase-3, caspase-8, and poly (adp-ribose) polymerase cleavage in a concentration-dependent manner. |
2013-05-01 |
2023-08-12 |
Not clear |
| M Brune, M Müller, G Melino, A Bierhaus, T Schilling, P P Nawrot. Depletion of the receptor for advanced glycation end products (RAGE) sensitizes towards apoptosis via p53 and p73 posttranslational regulation. Oncogene. vol 32. issue 11. 2013-04-30. PMID:22543586. |
depletion of the receptor for advanced glycation end products (rage) sensitizes towards apoptosis via p53 and p73 posttranslational regulation. |
2013-04-30 |
2023-08-12 |
Not clear |
| M Brune, M Müller, G Melino, A Bierhaus, T Schilling, P P Nawrot. Depletion of the receptor for advanced glycation end products (RAGE) sensitizes towards apoptosis via p53 and p73 posttranslational regulation. Oncogene. vol 32. issue 11. 2013-04-30. PMID:22543586. |
the increase of p53 and p73 transactivational activity was essential for the rage-dependent regulation of apoptosis, because knockdown of p53 and p73 significantly decreased apoptosis in rage-deficient but not in rage-expressing cells. |
2013-04-30 |
2023-08-12 |
Not clear |
| M Brune, M Müller, G Melino, A Bierhaus, T Schilling, P P Nawrot. Depletion of the receptor for advanced glycation end products (RAGE) sensitizes towards apoptosis via p53 and p73 posttranslational regulation. Oncogene. vol 32. issue 11. 2013-04-30. PMID:22543586. |
thus, the rage-mediated posttranslational regulation of p53 and p73 orchestrates a sequence of events culminating in control of intrinsic and extrinsic apoptosis signaling pathways. |
2013-04-30 |
2023-08-12 |
Not clear |
| Shao-Bin Cheng, Li-Chen Wu, Yun-Chih Hsieh, Chi-Hao Wu, Yu-Ju Chan, Li-Hsun Chang, Chieh-Ming J Chang, Shih-Lan Hsu, Chieh-Lin Teng, Chun-Chi W. Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human hepatocellular carcinoma HepG2 cells. Journal of agricultural and food chemistry. vol 60. issue 38. 2013-04-30. PMID:22946656. |
ar-turmerone-induced apoptosis, confirmed by increased annexin v binding and dna fragmentation, was accompanied by reactive oxygen species (ros) production, mitochondrial membrane potential dissipation, increased bax and p53 up-regulated modulator of apoptosis (puma) levels, bax mitochondrial translocation, cytochrome c release, fas and death receptor 4 (dr4) augmentation, and caspase-3, -8, and -9 activation. |
2013-04-30 |
2023-08-12 |
human |
| Ji-Hyang Ha, Jae-Sun Shin, Mi-Kyung Yoon, Min-Sung Lee, Fahu He, Kwang-Hee Bae, Ho Sup Yoon, Chong-Kil Lee, Sung Goo Park, Yutaka Muto, Seung-Wook Ch. Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways. The Journal of biological chemistry. vol 288. issue 10. 2013-04-30. PMID:23316052. |
molecular interactions between the tumor suppressor p53 and the anti-apoptotic bcl-2 family proteins play an important role in the transcription-independent apoptosis of p53. |
2013-04-30 |
2023-08-12 |
Not clear |
| Ren-Kuo Lin, Chia-Wen Ho, Leroy F Liu, Yi Lisa Ly. Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis. The Journal of biological chemistry. vol 288. issue 10. 2013-04-30. PMID:23344961. |
altogether, our findings support a model in which top2β deficiency promotes cpt-induced apoptosis in quiescent non-s-phase cells, possibly due to rnap ls depletion and p53 accumulation. |
2013-04-30 |
2023-08-12 |
mouse |
| Rachel W Goehe, Molly L Bristol, Eden N Wilson, David A Gewirt. Autophagy, senescence, and apoptosis. Methods in molecular biology (Clifton, N.J.). vol 962. 2013-04-29. PMID:23150435. |
this chapter presents methods for interrogating the involvement of p53 in signaling to apoptosis, autophagy, and senescence. |
2013-04-29 |
2023-08-12 |
Not clear |
| Rachel W Goehe, Molly L Bristol, Eden N Wilson, David A Gewirt. Autophagy, senescence, and apoptosis. Methods in molecular biology (Clifton, N.J.). vol 962. 2013-04-29. PMID:23150435. |
this chapter provides up-to-date procedures relating to the molecular networks in which the p53 protein has been shown to play a central role that allows damaged cells either to adapt to stress (autophagy and/or senescence) or to progress towards programmed cell death (apoptosis). |
2013-04-29 |
2023-08-12 |
Not clear |
| Angelina V Vaseva, Ute M Mol. Identification of p53 in mitochondria. Methods in molecular biology (Clifton, N.J.). vol 962. 2013-04-29. PMID:23150438. |
our lab and others have discovered that a fraction of stress-induced wild-type p53 protein rapidly translocates to mitochondria upon various stress stimuli and exerts p53-dependent apoptosis. |
2013-04-29 |
2023-08-12 |
Not clear |
| Angelina V Vaseva, Ute M Mol. Identification of p53 in mitochondria. Methods in molecular biology (Clifton, N.J.). vol 962. 2013-04-29. PMID:23150438. |
direct targeting of p53 to mitochondria is sufficient to induce apoptosis in p53-null cells, without requiring further dna damage. |
2013-04-29 |
2023-08-12 |
Not clear |
| Emir Senturk, James J Manfred. Determine the effect of p53 on chemosensitivity. Methods in molecular biology (Clifton, N.J.). vol 962. 2013-04-29. PMID:23150441. |
activation of p53 signaling will trigger cell cycle arrest or apoptosis in normal cells, depending on such factors as cell type and genetic context. |
2013-04-29 |
2023-08-12 |
Not clear |
| Hiroshi I Suzuki, Kohei Miyazon. p53 actions on microRNA expression and maturation pathway. Methods in molecular biology (Clifton, N.J.). vol 962. 2013-04-29. PMID:23150446. |
in addition to the principal role as a transcription factor that transactivates many target genes involved in apoptosis and cell cycle control, p53 has been shown to exert various transactivation-independent effects both in the nucleus and in the cytoplasm. |
2013-04-29 |
2023-08-12 |
Not clear |
| Tarique N Hasan, Gowhar Shafi, Naveed A Syed, Muhammad A Alfawaz, Mohammed A Alsaif, Anjana Munshi, Kai Y Lei, Ali A Alshatw. Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis. Natural product communications. vol 8. issue 2. 2013-04-29. PMID:23513732. |
thus, ns was concluded to induce apoptosis in siha cell through both p53 and caspases activation. |
2013-04-29 |
2023-08-12 |
human |
| Matthias Gutekunst, Thomas Mueller, Andrea Weilbacher, Michael A Dengler, Jens Bedke, Stephan Kruck, Moshe Oren, Walter E Aulitzky, Heiko van der Kui. Cisplatin hypersensitivity of testicular germ cell tumors is determined by high constitutive Noxa levels mediated by Oct-4. Cancer research. vol 73. issue 5. 2013-04-26. PMID:23302226. |
oct-4-dependent high constitutive levels of this bh3-only protein prime embryonal carcinoma cells to undergo rapid and massive apoptosis in response to p53 activation. |
2013-04-26 |
2023-08-12 |
Not clear |