| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenbin Liu, Chengchao Sho. Mycoplasma hyorhinis and Mycoplasma fermentans induce cell apoptosis and changes in gene expression profiles of 32D cells. Biological research. vol 44. issue 4. 2013-06-06. PMID:22446603. |
apoptosis related proteins bcl-2, bid and p53 were down-regulated, fas was up-regulated and bax was dysregulated in mycoplasma-infected 32d cells. |
2013-06-06 |
2023-08-12 |
human |
| Alessandra di Pietro, Roelof Koster, Wytske Boersma-van Eck, Wendy A Dam, Nanno H Mulder, Jourik A Gietema, Elisabeth G E de Vries, Steven de Jon. Pro- and anti-apoptotic effects of p53 in cisplatin-treated human testicular cancer are cell context-dependent. Cell cycle (Georgetown, Tex.). vol 11. issue 24. 2013-06-05. PMID:23165211. |
downregulation of p53 with sirna lowered cisplatin-induced apoptosis in tera and tera-cp, which was associated with a diminished fas membrane expression. |
2013-06-05 |
2023-08-12 |
human |
| Alessandra di Pietro, Roelof Koster, Wytske Boersma-van Eck, Wendy A Dam, Nanno H Mulder, Jourik A Gietema, Elisabeth G E de Vries, Steven de Jon. Pro- and anti-apoptotic effects of p53 in cisplatin-treated human testicular cancer are cell context-dependent. Cell cycle (Georgetown, Tex.). vol 11. issue 24. 2013-06-05. PMID:23165211. |
in contrast, p53 suppression augmented cisplatin-induced apoptosis in scha and 2102ep and concomitantly strongly suppressed mdm2 and p21 mrna and protein expression. |
2013-06-05 |
2023-08-12 |
human |
| Alessandra di Pietro, Roelof Koster, Wytske Boersma-van Eck, Wendy A Dam, Nanno H Mulder, Jourik A Gietema, Elisabeth G E de Vries, Steven de Jon. Pro- and anti-apoptotic effects of p53 in cisplatin-treated human testicular cancer are cell context-dependent. Cell cycle (Georgetown, Tex.). vol 11. issue 24. 2013-06-05. PMID:23165211. |
the opposite role of p53 in cisplatin-induced apoptosis among tc cell lines demonstrates the importance of the cellular context for the p53 transactivation phenotype in tc cells. |
2013-06-05 |
2023-08-12 |
human |
| Xiao-Wu Chen, Yuan Ming Di, Jian Zhang, Zhi-Wei Zhou, Chun Guang Li, Shu-Feng Zho. Interaction of herbal compounds with biological targets: a case study with berberine. TheScientificWorldJournal. vol 2012. 2013-06-05. PMID:23213296. |
in addition, berberine was found to interact with a mixture of biological pathways, such as alzheimer's disease-presenilin and -secretase pathways, angiogenesis, apoptosis signalling pathway, fas signalling pathway, hungtington disease, inflammation mediated by chemokine and cytokine signalling pathways, interleukin signalling pathway, and p53 pathways. |
2013-06-05 |
2023-08-12 |
Not clear |
| Kira G Hartman, Laura E McKnight, Melissa A Liriano, David J Webe. The evolution of S100B inhibitors for the treatment of malignant melanoma. Future medicinal chemistry. vol 5. issue 1. 2013-06-05. PMID:23256816. |
however, the discovery of p53 as a s100b target and the consequent impact on cell apoptosis redirected research efforts towards the development of inhibitors of this s100b-p53 interaction. |
2013-06-05 |
2023-08-12 |
Not clear |
| Isoko Kuriyama, Anna Miyazaki, Yuko Tsuda, Hiromi Yoshida, Yoshiyuki Mizushin. Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymerase β. Bioorganic & medicinal chemistry. vol 21. issue 2. 2013-06-05. PMID:23266186. |
this compound also induced apoptosis in hct116 cells with or without p53. |
2013-06-05 |
2023-08-12 |
human |
| Pedro Henrique Gazzinelli-Guimarães, Elaine Maria Souza-Fagundes, Guilherme Grossi Lopes Cancado, Virgillio Gandra Martins, Lucas Carvalho Dhom-Lemos, Natasha Delaqua Ricci, Jacqueline Araujo Fiuza, Lilian Lacerda Bueno, Rodrigo Rodrigues Cambraia Miranda, Silvia Guatimosim, Andrea Gazzinelli, Rodrigo Correa-Oliveira, Daniella Castanheira Bartholomeu, Ricardo Toshio Fujiwar. Cell apoptosis induced by hookworm antigens: a strategy of immunomodulation. Frontiers in bioscience (Elite edition). vol 5. 2013-06-05. PMID:23277021. |
the downmodulation of tnf receptors, as well as the up-regulation of the pro-apoptotic genes belonging to the bcl-2 and p53 families, suggest that hookworm antigens induced apoptosis by an intrinsic mitochondrial pathway, acting as a sophisticated strategy to safeguard parasite long-term survival in their hosts. |
2013-06-05 |
2023-08-12 |
human |
| Sally A Lorimore, Shubhra Rastogi, Debayan Mukherjee, Philip J Coates, Eric G Wrigh. The influence of p53 functions on radiation-induced inflammatory bystander-type signaling in murine bone marrow. Radiation research. vol 179. issue 4. 2013-06-04. PMID:23578188. |
in this article, we show that the bone marrow of irradiated p53(+/+) mice, but not p53(-/-) mice, produces the inflammatory pro-apoptotic cytokines fasl and tnf-α able to induce p53-independent apoptosis in vitro in nonirradiated p53(-/-) bone marrow cells. |
2013-06-04 |
2023-08-12 |
mouse |
| Ya-hong Zhang, Jing-gong Guo, Zi-hua Guo, Song-qiang Xi. [Involvement of p38-p53 signal pathway in resveratrol-induced apoptosis in MCF-7 cells]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 46. issue 11. 2013-06-03. PMID:22260024. |
resveratrol could induce apoptosis and activate p38 and p53 in a time dependent manner in mcf-7 cells. |
2013-06-03 |
2023-08-12 |
Not clear |
| Guang Yan, Kimmer Graham, Susan Lanza-Jacob. Curcumin enhances the anticancer effects of trichostatin a in breast cancer cells. Molecular carcinogenesis. vol 52. issue 5. 2013-06-03. PMID:22290509. |
we conclude that p53 independent apoptosis induced by combining curcumin and tsa involves jnk activation. |
2013-06-03 |
2023-08-12 |
Not clear |
| G Botta, L P De Santis, R Saladin. Current advances in the synthesis and antitumoral activity of SIRT1-2 inhibitors by modulation of p53 and pro-apoptotic proteins. Current medicinal chemistry. vol 19. issue 34. 2013-06-03. PMID:22998567. |
especially two sirtuin members, sirt1 and sirt2, have been found to antagonize p53-dependent transcriptional activation and apoptosis in response to dna damage by catalyzing p53 deacetylation. |
2013-06-03 |
2023-08-12 |
human |
| Patchara Ngok-Ngam, Piyajit Watcharasit, Apinya Thiantanawat, Jutamaad Satayaviva. Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y cells. Cellular & molecular biology letters. vol 18. issue 1. 2013-05-31. PMID:23161404. |
pharmacological inhibition of gsk3 attenuates dna damage-induced apoptosis via reduction of p53 mitochondrial translocation and bax oligomerization in neuroblastoma sh-sy5y cells. |
2013-05-31 |
2023-08-12 |
Not clear |
| Patchara Ngok-Ngam, Piyajit Watcharasit, Apinya Thiantanawat, Jutamaad Satayaviva. Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y cells. Cellular & molecular biology letters. vol 18. issue 1. 2013-05-31. PMID:23161404. |
furthermore, each of these agents induced translocation of p53 to the mitochondria and activated the mitochondrial pathway of apoptosis, as evidenced by the release of cytochrome c from the mitochondria. |
2013-05-31 |
2023-08-12 |
Not clear |
| Patchara Ngok-Ngam, Piyajit Watcharasit, Apinya Thiantanawat, Jutamaad Satayaviva. Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y cells. Cellular & molecular biology letters. vol 18. issue 1. 2013-05-31. PMID:23161404. |
both mitochondrial translocation of p53 and mitochondrial release of cytochrome c were attenuated by inhibition of gsk3, indicating that gsk3 promotes the dna damage-induced mitochondrial translocation of p53 and the mitochondrial apoptosis pathway. |
2013-05-31 |
2023-08-12 |
Not clear |
| B H Huang, J L Zhuo, C H W Leung, G D Lu, J J Liu, C T Yap, S C Hoo. PRAP1 is a novel executor of p53-dependent mechanisms in cell survival after DNA damage. Cell death & disease. vol 3. 2013-05-31. PMID:23235459. |
during dna damage, p53 can either promote cell survival by activating senescence or cell-cycle arrest and dna repair to maintain genomic integrity for cell survival or direct cells to undergo apoptosis to eliminate extensively damaged cells. |
2013-05-31 |
2023-08-12 |
Not clear |
| B H Huang, J L Zhuo, C H W Leung, G D Lu, J J Liu, C T Yap, S C Hoo. PRAP1 is a novel executor of p53-dependent mechanisms in cell survival after DNA damage. Cell death & disease. vol 3. 2013-05-31. PMID:23235459. |
the induction of prap1 expression by p53 may promote resistance of cancer cells to chemotherapeutic drugs such as 5-fluorouracil (5-fu), as knockdown of prap1 increases apoptosis in cancer cells after 5-fu treatment. |
2013-05-31 |
2023-08-12 |
Not clear |
| B H Huang, J L Zhuo, C H W Leung, G D Lu, J J Liu, C T Yap, S C Hoo. PRAP1 is a novel executor of p53-dependent mechanisms in cell survival after DNA damage. Cell death & disease. vol 3. 2013-05-31. PMID:23235459. |
prap1 appears to protect cells from apoptosis by inducing cell-cycle arrest, suggesting that the induction of prap1 expression by p53 in response to dna-damaging agents contributes to cancer cell survival. |
2013-05-31 |
2023-08-12 |
Not clear |
| Soumya Chatterjee, Gunjan Biswas, Swarnendu Chandra, Goutam Kumar Saha, Krishnendu Achary. Apoptogenic effects of Tricholoma giganteum on Ehrlich's ascites carcinoma cell. Bioprocess and biosystems engineering. vol 36. issue 1. 2013-05-30. PMID:22684905. |
our data also revealed an increase in the expression of pro-apoptotic protein p53 in eac and induced factors contributing to apoptosis. |
2013-05-30 |
2023-08-12 |
Not clear |
| Catarina M Henriques, Madalena C Carneiro, Inês M Tenente, António Jacinto, Miguel Godinho Ferreir. Telomerase is required for zebrafish lifespan. PLoS genetics. vol 9. issue 1. 2013-05-30. PMID:23349637. |
tert(-/-) mutants have impaired cell proliferation, accumulation of dna damage markers, and a p53 response leading to early apoptosis, followed by accumulation of senescent cells. |
2013-05-30 |
2023-08-12 |
mouse |