| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Biyun Ching, Xiu L Chen, Jing H A Yong, Jonathan M Wilson, Kum C Hiong, Eugene W L Sim, Wai P Wong, Siew H Lam, Shit F Chew, Yuen K I. Increases in apoptosis, caspase activity and expression of p53 and bax, and the transition between two types of mitochondrion-rich cells, in the gills of the climbing perch, Anabas testudineus, during a progressive acclimation from freshwater to seawater. Frontiers in physiology. vol 4. 2013-06-14. PMID:23760020. |
increases in apoptosis, caspase activity and expression of p53 and bax, and the transition between two types of mitochondrion-rich cells, in the gills of the climbing perch, anabas testudineus, during a progressive acclimation from freshwater to seawater. |
2013-06-14 |
2023-08-12 |
Not clear |
| Biyun Ching, Xiu L Chen, Jing H A Yong, Jonathan M Wilson, Kum C Hiong, Eugene W L Sim, Wai P Wong, Siew H Lam, Shit F Chew, Yuen K I. Increases in apoptosis, caspase activity and expression of p53 and bax, and the transition between two types of mitochondrion-rich cells, in the gills of the climbing perch, Anabas testudineus, during a progressive acclimation from freshwater to seawater. Frontiers in physiology. vol 4. 2013-06-14. PMID:23760020. |
this was further supported by an up-regulation of branchial mrna expression of p53, a key regulator of cell cycle arrest and apoptosis, between day 2 (salinity 10) and day 6 (seawater), and an increase in branchial p53 protein abundance on day 6. |
2013-06-14 |
2023-08-12 |
Not clear |
| Lifeng Feng, Min Pan, Jie Sun, Haiqi Lu, Qi Shen, Shengjie Zhang, Tingting Jiang, Liangyi Liu, Wei Jin, Yan Chen, Xian Wang, Hongchuan Ji. Histone deacetylase 3 inhibits expression of PUMA in gastric cancer cells. Journal of molecular medicine (Berlin, Germany). vol 91. issue 1. 2013-06-13. PMID:22763818. |
gene profiling results showed puma (p53 upregulated modulator of apoptosis) as one of 122 genes upregulated in tsa-treated gastric cancer cells. |
2013-06-13 |
2023-08-12 |
Not clear |
| Yingjuan Qian, Xinbin Che. Senescence regulation by the p53 protein family. Methods in molecular biology (Clifton, N.J.). vol 965. 2013-06-13. PMID:23296650. |
p53, a guardian of the genome, exerts its tumor suppression activity by regulating a large number of downstream targets involved in cell cycle arrest, dna repair, apoptosis, and cellular senescence. |
2013-06-13 |
2023-08-12 |
mouse |
| Renee D Read, Tim R Fenton, German G Gomez, Jill Wykosky, Scott R Vandenberg, Ivan Babic, Akio Iwanami, Huijun Yang, Webster K Cavenee, Paul S Mischel, Frank B Furnari, John B Thoma. A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. PLoS genetics. vol 9. issue 2. 2013-06-13. PMID:23459592. |
conversely, reduced expression of riok1 or riok2 disrupted akt signaling and caused cell cycle exit, apoptosis, and chemosensitivity in glioblastoma cells by inducing p53 activity through the rpl11-dependent ribosomal stress checkpoint. |
2013-06-13 |
2023-08-12 |
human |
| Adrian C Monk, Helen E Abud, Gary R Him. Dmp53 is sequestered to nuclear bodies in spermatogonia of Drosophila melanogaster. Cell and tissue research. vol 350. issue 2. 2013-06-12. PMID:22961348. |
p53 family members have been implicated in regulation of genomic integrity and apoptosis in a variety of tissues. |
2013-06-12 |
2023-08-12 |
drosophila_melanogaster |
| Taehee Kim, An Keun Ki. Taurine enhances anticancer activity of cisplatin in human cervical cancer cells. Advances in experimental medicine and biology. vol 776. 2013-06-12. PMID:23392883. |
induction of apoptosis was related to p53 expression and activation of caspase-3, caspase-6, caspase-7, and caspase-9. |
2013-06-12 |
2023-08-12 |
human |
| Christian Tovar, Bradford Graves, Kathryn Packman, Zoran Filipovic, Brian Higgins, Mingxuan Xia, Christine Tardell, Rosario Garrido, Edmund Lee, Kenneth Kolinsky, Kwong-Him To, Michael Linn, Frank Podlaski, Peter Wovkulich, Binh Vu, Lyubomir T Vassile. MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models. Cancer research. vol 73. issue 8. 2013-06-12. PMID:23400593. |
treatment of cancer cells expressing wild-type p53 with rg7112 activated the p53 pathway, leading to cell-cycle arrest and apoptosis. |
2013-06-12 |
2023-08-12 |
mouse |
| Ada Fiorini, Rukhsana Sultana, Eugenio Barone, Giovanna Cenini, Marzia Perluigi, Cesare Mancuso, Jian Cai, Jon B Klein, Daret St Clair, D Allan Butterfiel. Lack of p53 affects the expression of several brain mitochondrial proteins: insights from proteomics into important pathways regulated by p53. PloS one. vol 7. issue 11. 2013-06-11. PMID:23209608. |
the tumor suppressor protein p53 has been described "as the guardian of the genome" for its crucial role in regulating the transcription of numerous genes responsible for cells cycle arrest, senescence, or apoptosis in response to various stress signals. |
2013-06-11 |
2023-08-12 |
mouse |
| Ada Fiorini, Rukhsana Sultana, Eugenio Barone, Giovanna Cenini, Marzia Perluigi, Cesare Mancuso, Jian Cai, Jon B Klein, Daret St Clair, D Allan Butterfiel. Lack of p53 affects the expression of several brain mitochondrial proteins: insights from proteomics into important pathways regulated by p53. PloS one. vol 7. issue 11. 2013-06-11. PMID:23209608. |
although p53 promotes longevity by decreasing the risk of cancer through activation of apoptosis or cellular senescence, several findings suggest that an increase of its activity may have deleterious effects leading to selected aspects of the aging phenotype and neurodegenerative diseases. |
2013-06-11 |
2023-08-12 |
mouse |
| Karishma Gupta, Vijay S Thakur, Natarajan Bhaskaran, Akbar Nawab, Melissa A Babcook, Mark W Jackson, Sanjay Gupt. Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. PloS one. vol 7. issue 12. 2013-06-11. PMID:23285096. |
we have previously demonstrated that green tea polyphenols (gtp) induce apoptosis in prostate cancer cells irrespective of p53 status. |
2013-06-11 |
2023-08-12 |
human |
| Karishma Gupta, Vijay S Thakur, Natarajan Bhaskaran, Akbar Nawab, Melissa A Babcook, Mark W Jackson, Sanjay Gupt. Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. PloS one. vol 7. issue 12. 2013-06-11. PMID:23285096. |
here we investigated the mechanisms of gtp-induced apoptosis in human prostate cancer lncap cells stably-transfected with short hairpin-rna against p53 (lncapshp53) and control vector (lncapshv). |
2013-06-11 |
2023-08-12 |
human |
| Yunyi Liu, Wei Wang, Bin Fang, Fengyun Ma, Qian Zheng, Pengyi Deng, Shasha Zhao, Mingjie Chen, Guangxiao Yang, Guangyuan H. Anti-tumor effect of germacrone on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis. European journal of pharmacology. vol 698. issue 1-3. 2013-06-10. PMID:23117090. |
in the meantime, the up-regulation of p53 and reactive oxygen species increase were observed, which suggested that germacrone might be a new potent chemopreventive drug candidate for liver cancer via regulating the expression of proteins related to g2/m cell cycle and apoptosis, and p53 and oxidative damage may play important roles in the inhibition of human hepatoma cells growth by germacrone. |
2013-06-10 |
2023-08-12 |
human |
| Kausik Bishayee, Debrup Chakraborty, Samrat Ghosh, Naoual Boujedaini, Anisur Rahman Khuda-Bukhs. Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-DNA interaction. European journal of pharmacology. vol 698. issue 1-3. 2013-06-10. PMID:23142370. |
lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-dna interaction. |
2013-06-10 |
2023-08-12 |
Not clear |
| Kausik Bishayee, Debrup Chakraborty, Samrat Ghosh, Naoual Boujedaini, Anisur Rahman Khuda-Bukhs. Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-DNA interaction. European journal of pharmacology. vol 698. issue 1-3. 2013-06-10. PMID:23142370. |
administration of lycopodine down-regulated the expression of 5-lipoxygenase and the 5-oxo-ete receptor (oxe receptor1) and egf receptor, and caused up-regulation of cytochrome c with depolarization of mitochondrial inner membrane potential, without palpable change in p53 activity, resulting in apoptosis, cell arrest at g0/g1 stage and ultimately reduced proliferation of cancer cells; concomitantly, there was externalization of phosphotidyl serine residues. |
2013-06-10 |
2023-08-12 |
Not clear |
| Gamal T Ebid, Iman A Sedhom, Mosaad M El-Gammal, Manar M Monee. MDM2 T309G has a synergistic effect with P21 ser31arg single nucleotide polymorphisms on the risk of acute myeloid leukemia. Asian Pacific journal of cancer prevention : APJCP. vol 13. issue 9. 2013-06-10. PMID:23167335. |
p53 in its transcriptionally active form is capable of activating distinct target genes that contribute to either apoptosis or growth arrest, like p21. |
2013-06-10 |
2023-08-12 |
Not clear |
| V R Katkoori, K Manne, V S Vital-Reyes, C Rodríguez-Burford, C Shanmugam, M Sthanam, U Manne, C Chatla, S A Abdulkadir, W E Grizzl. Selective COX-2 inhibitor (celecoxib) decreases cellular growth in prostate cancer cell lines independent of p53. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 88. issue 1. 2013-06-10. PMID:23167625. |
earlier studies have shown that sensitivity of prostatic carcinoma (pca) to celecoxib is associated with apoptosis; however, these studies have not demonstrated adequately whether this effect is dependent on p53 status. |
2013-06-10 |
2023-08-12 |
Not clear |
| Yuan-Yuan Zhang, Li-Ming Zho. Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells. European journal of pharmacology. vol 698. issue 1-3. 2013-06-10. PMID:23178529. |
omentin-1, a new adipokine, promotes apoptosis through regulating sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells. |
2013-06-10 |
2023-08-12 |
human |
| Ritesh K Shukla, Ashutosh Kumar, Deepak Gurbani, Alok K Pandey, Shashi Singh, Alok Dhawa. TiO(2) nanoparticles induce oxidative DNA damage and apoptosis in human liver cells. Nanotoxicology. vol 7. issue 1. 2013-06-07. PMID:22047016. |
furthermore, immunoblot analysis revealed an increased expression of p53, bax, cyto-c, apaf-1, caspase-9 and caspase-3 and decreased the level of bcl-2 thereby indicating that apoptosis induced by tio(2) nps occurs via the caspase-dependent pathway. |
2013-06-07 |
2023-08-12 |
human |
| Sathish Kumar Natarajan, Weidong Zhu, Xinwen Liang, Lu Zhang, Andrew J Demers, Matthew C Zimmerman, Melanie A Simpson, Donald F Becke. Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death. Free radical biology & medicine. vol 53. issue 5. 2013-06-07. PMID:22796327. |
prodh expression is inducible by p53, leading to increased proline oxidation, reactive oxygen species formation, and induction of apoptosis. |
2013-06-07 |
2023-08-12 |
Not clear |