| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Kenzelmann Broz, Stephano Spano Mello, Kathryn T Bieging, Dadi Jiang, Rachel L Dusek, Colleen A Brady, Arend Sidow, Laura D Attard. Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. Genes & development. vol 27. issue 9. 2013-07-02. PMID:23651856. |
together, our data highlight an intimate connection between p53 and autophagy through a vast transcriptional network and indicate that autophagy contributes to p53-dependent apoptosis and cancer suppression. |
2013-07-02 |
2023-08-12 |
mouse |
| Yuanxiang Jin, Xiuhong Pan, Limin Cao, Bufang Ma, Zhengwei F. Embryonic exposure to cis-bifenthrin enantioselectively induces the transcription of genes related to oxidative stress, apoptosis and immunotoxicity in zebrafish (Danio rerio). Fish & shellfish immunology. vol 34. issue 2. 2013-07-01. PMID:23261506. |
we observed that the mrna levels of the most genes related to oxidative stress, apoptosis and immunotoxicity including cu/zn-superoxide dismutase (cu/zn-sod), catalase (cat), p53, murine double minute 2 (mdm2), b-cell lymphoma/leukaemia-2 gene (bcl2), bcl2 associated x protein (bax), apoptotic protease activating factor-1 (apaf1), caspase 9 (cas9), caspase 3 (cas3), interleukin-1 beta (il-1β) and interleukin-8(il-8) were much higher in 1s-cis-bf treated group than those in cis-bf or 1r-cis-bf treated ones, suggesting that 1s-cis-bf has higher risk to induced oxidative stress, apoptosis and immunotoxicity than 1r-cis-bf in zebrafish. |
2013-07-01 |
2023-08-12 |
cat |
| Ayesha Elias, Jing Wu, Taosheng Che. Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity. Molecular pharmacology. vol 83. issue 6. 2013-07-01. PMID:23536728. |
the loss of p53 function in tumor cells leads to aberrant cell proliferation, apoptosis, carcinogenesis, and altered sensitivity to chemotherapeutic drugs, whereas pxr contributes to chemoresistance in many cancer cells. |
2013-07-01 |
2023-08-12 |
human |
| Chunning Zheng, Wei Jia, Yong Tang, HuiLiang Zhao, Yingsheng Jiang, Shaochuan Su. Mesothelin regulates growth and apoptosis in pancreatic cancer cells through p53-dependent and -independent signal pathway. Journal of experimental & clinical cancer research : CR. vol 31. 2013-06-28. PMID:23034174. |
the aim of the present study was to evaluate the effects of mesothelin on proliferation and apoptosis in pancreatic cancer cells with different p53 status and to explore its signal pathway. |
2013-06-28 |
2023-08-12 |
human |
| Chunning Zheng, Wei Jia, Yong Tang, HuiLiang Zhao, Yingsheng Jiang, Shaochuan Su. Mesothelin regulates growth and apoptosis in pancreatic cancer cells through p53-dependent and -independent signal pathway. Journal of experimental & clinical cancer research : CR. vol 31. 2013-06-28. PMID:23034174. |
when p53 was blocked by sirna in the stable mesothelin shrna transfected capan-2 cells, puma was inhibited, followed by increased proliferative capability and decreased cell apoptosis. |
2013-06-28 |
2023-08-12 |
human |
| Maria Zingariello, Fabrizio Martelli, Fiorella Ciaffoni, Francesca Masiello, Barbara Ghinassi, Emanuela D'Amore, Margherita Massa, Giovanni Barosi, Laura Sancillo, Xiaochun Li, Judith D Goldberg, Rosa Alba Rana, Anna Rita Migliacci. Characterization of the TGF-β1 signaling abnormalities in the Gata1low mouse model of myelofibrosis. Blood. vol 121. issue 17. 2013-06-27. PMID:23462118. |
david-pathway analyses identified alterations of tgf-β1, hedgehog, and p53 signaling in marrow and spleen and of mammalian target of rapamycin (mtor) in spleen only and predicted that these alterations would induce consequences consistent with the gata1(low) phenotype (increased apoptosis and g1 arrest both in marrow and spleen and increased osteoblast differentiation and reduced ubiquitin-mediated proteolysis in marrow only). |
2013-06-27 |
2023-08-12 |
mouse |
| Yasushi Sasaki, Ryota Koyama, Reo Maruyama, Takehiro Hirano, Miyuki Tamura, Jun Sugisaka, Hiromu Suzuki, Masashi Idogawa, Yasuhisa Shinomura, Takashi Tokin. CLCA2, a target of the p53 family, negatively regulates cancer cell migration and invasion. Cancer biology & therapy. vol 13. issue 14. 2013-06-26. PMID:22990203. |
the tumor suppressor p53 transcriptionally regulates a number of genes that are involved in cell-cycle inhibition, apoptosis and the maintenance of genetic stability. |
2013-06-26 |
2023-08-12 |
human |
| Shunqin Zhu, Tai Li, Juan Tan, Xiaomin Yan, Dunke Zhang, Chunqin Zheng, Yibiao Chen, Zhonghuai Xiang, Hongjuan Cu. Bax is essential for death receptor-mediated apoptosis in human colon cancer cells. Cancer biotherapy & radiopharmaceuticals. vol 27. issue 9. 2013-06-25. PMID:23113596. |
we treated hct116 cells and hct116 with p53(-/-) (ko) by 0.1 μg/ml trail for 24 hours, which indicated that hct116 parental cells are sensitive to p53-independent death receptor-induced apoptosis. |
2013-06-25 |
2023-08-12 |
human |
| Shunqin Zhu, Tai Li, Juan Tan, Xiaomin Yan, Dunke Zhang, Chunqin Zheng, Yibiao Chen, Zhonghuai Xiang, Hongjuan Cu. Bax is essential for death receptor-mediated apoptosis in human colon cancer cells. Cancer biotherapy & radiopharmaceuticals. vol 27. issue 9. 2013-06-25. PMID:23113596. |
although the p53 signaling pathway is totally intact in this system, the down-regulation of bax in hct116 cells is dramatically resistant to trail and failed to undergo apoptosis. |
2013-06-25 |
2023-08-12 |
human |
| Zheng-Lin Chen, Ping-Qing Gu, Kangsheng Liu, Ya-Juan Su, Ling-Juan Ga. The globular heads of the C1q receptor regulate apoptosis in human cervical squamous carcinoma cells via a p53-dependent pathway. Journal of translational medicine. vol 10. 2013-06-25. PMID:23268996. |
the purpose of this study was to investigate the relationship between mitochondrial dysfunction, p53 status and gc1qr expression and the regulation of apoptosis in human cervical squamous carcinoma cells (c33a and siha). |
2013-06-25 |
2023-08-12 |
human |
| Xia Wang, Lin Yang, Ji-jia She, Hong-mei Fan, Fu-cheng Zhang, You-ming Chen, Qi-feng Xi. [Hepatitis B virus X protein suppresses adriamycin-induced apoptosis of hepatocellular carcinoma cells and expression of p53 and PTEN]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 30. issue 8. 2013-06-24. PMID:20813662. |
[hepatitis b virus x protein suppresses adriamycin-induced apoptosis of hepatocellular carcinoma cells and expression of p53 and pten]. |
2013-06-24 |
2023-08-12 |
Not clear |
| Xia Wang, Lin Yang, Ji-jia She, Hong-mei Fan, Fu-cheng Zhang, You-ming Chen, Qi-feng Xi. [Hepatitis B virus X protein suppresses adriamycin-induced apoptosis of hepatocellular carcinoma cells and expression of p53 and PTEN]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 30. issue 8. 2013-06-24. PMID:20813662. |
to investigate the effect of hepatitis b virus x protein (hbx) on adriamycin-induced apoptosis of hepatocellular carcinoma cells and the expressions of p53 and pten. |
2013-06-24 |
2023-08-12 |
Not clear |
| Günter Eisele, Michael Welle. Targeting apoptosis pathways in glioblastoma. Cancer letters. vol 332. issue 2. 2013-06-24. PMID:21269762. |
in this review we describe the alterations affecting the p53 pathway, the bcl-2 protein family, the inhibitor of apoptosis proteins and several growth factor pathways involved in the regulation of programmed cell death and define possible targets for new therapies within these apoptotic pathways in glioblastomas. |
2013-06-24 |
2023-08-12 |
Not clear |
| Yang Liu, Rebecca J Whelan, Bikash R Pattnaik, Kai Ludwig, Enkateswar Subudhi, Helen Rowland, Nick Claussen, Noah Zucker, Shitanshu Uppal, David M Kushner, Mildred Felder, Manish S Patankar, Arvinder Kapu. Terpenoids from Zingiber officinale (Ginger) induce apoptosis in endometrial cancer cells through the activation of p53. PloS one. vol 7. issue 12. 2013-06-24. PMID:23300887. |
terpenoids from zingiber officinale (ginger) induce apoptosis in endometrial cancer cells through the activation of p53. |
2013-06-24 |
2023-08-12 |
Not clear |
| Yang Liu, Rebecca J Whelan, Bikash R Pattnaik, Kai Ludwig, Enkateswar Subudhi, Helen Rowland, Nick Claussen, Noah Zucker, Shitanshu Uppal, David M Kushner, Mildred Felder, Manish S Patankar, Arvinder Kapu. Terpenoids from Zingiber officinale (Ginger) induce apoptosis in endometrial cancer cells through the activation of p53. PloS one. vol 7. issue 12. 2013-06-24. PMID:23300887. |
inhibitor of p53, pifithrin-α, attenuated the anti-cancer effects of sdge and apoptosis was also not observed in the p53(neg) skov-3 cells. |
2013-06-24 |
2023-08-12 |
Not clear |
| Yang Liu, Rebecca J Whelan, Bikash R Pattnaik, Kai Ludwig, Enkateswar Subudhi, Helen Rowland, Nick Claussen, Noah Zucker, Shitanshu Uppal, David M Kushner, Mildred Felder, Manish S Patankar, Arvinder Kapu. Terpenoids from Zingiber officinale (Ginger) induce apoptosis in endometrial cancer cells through the activation of p53. PloS one. vol 7. issue 12. 2013-06-24. PMID:23300887. |
our studies demonstrate that terpenoids from sdge mediate apoptosis by activating p53 and should be therefore be investigated as agents for the treatment of endometrial cancer. |
2013-06-24 |
2023-08-12 |
Not clear |
| André Brandl, Tobias Wagner, Katharina M Uhlig, Shirley K Knauer, Roland H Stauber, Frauke Melchior, Günter Schneider, Thorsten Heinzel, Oliver H Kräme. Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress. Journal of molecular cell biology. vol 4. issue 5. 2013-06-21. PMID:22493095. |
dynamically regulated sumoylation of hdac2 controls p53 deacetylation and restricts apoptosis following genotoxic stress. |
2013-06-21 |
2023-08-12 |
Not clear |
| André Brandl, Tobias Wagner, Katharina M Uhlig, Shirley K Knauer, Roland H Stauber, Frauke Melchior, Günter Schneider, Thorsten Heinzel, Oliver H Kräme. Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress. Journal of molecular cell biology. vol 4. issue 5. 2013-06-21. PMID:22493095. |
deacetylation of p53 at lysine 320 by sumoylated hdac2 blocks recruitment of p53 into promoter-associated complexes and p53-dependent expression of genes for cell cycle control and apoptosis. |
2013-06-21 |
2023-08-12 |
Not clear |
| André Brandl, Tobias Wagner, Katharina M Uhlig, Shirley K Knauer, Roland H Stauber, Frauke Melchior, Günter Schneider, Thorsten Heinzel, Oliver H Kräme. Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress. Journal of molecular cell biology. vol 4. issue 5. 2013-06-21. PMID:22493095. |
thereby, catalytically active sumoylated hdac2 restricts p53 functions and attenuates dna damage-induced apoptosis. |
2013-06-21 |
2023-08-12 |
Not clear |
| Laura Zannini, Giacomo Buscemi, Ja-Eun Kim, Enrico Fontanella, Domenico Deli. DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage. Journal of molecular cell biology. vol 4. issue 5. 2013-06-21. PMID:22735644. |
dbc1 depletion in human cells increases sirt1 activity, resulting in the deacetylation of p53 and protection from apoptosis. |
2013-06-21 |
2023-08-12 |
human |