| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shabana Din, Matthew Mason, Mirko Völkers, Bevan Johnson, Christopher T Cottage, Zeping Wang, Anya Y Joyo, Pearl Quijada, Peter Erhardt, Nancy S Magnuson, Mathias H Konstandin, Mark A Sussma. Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 15. 2013-07-12. PMID:23530233. |
interestingly, adenovirus pim-dominant negative nrcms show increased expression of bcl-2 homology 3 (bh3)-only protein p53 up-regulated modulator of apoptosis (puma), which has been previously shown to induce drp1 accumulation at mitochondria and increase sensitivity to apoptotic stimuli. |
2013-07-12 |
2023-08-12 |
rat |
| Mianen Sun, Tong Zhou, Eric Jonasch, Richard S Jop. DDX3 regulates DNA damage-induced apoptosis and p53 stabilization. Biochimica et biophysica acta. vol 1833. issue 6. 2013-07-11. PMID:23470959. |
ddx3 regulates dna damage-induced apoptosis and p53 stabilization. |
2013-07-11 |
2023-08-12 |
Not clear |
| Dana Thomasova, Shrikant R Mulay, Hauke Bruns, Hans-Joachim Ander. p53-independent roles of MDM2 in NF-κB signaling: implications for cancer therapy, wound healing, and autoimmune diseases. Neoplasia (New York, N.Y.). vol 14. issue 12. 2013-07-10. PMID:23308042. |
it serves as a negative regulator of p53 and thereby limits cell cycle arrest and apoptosis. |
2013-07-10 |
2023-08-12 |
Not clear |
| Yevgeny Tendler, Russell Pokroy, Alex Panshin, Gary Weisinge. p53 protein subcellular localization and apoptosis in rodent corneal epithelium cell culture following ultraviolet irradiation. International journal of molecular medicine. vol 31. issue 3. 2013-07-10. PMID:23338225. |
p53 protein subcellular localization and apoptosis in rodent corneal epithelium cell culture following ultraviolet irradiation. |
2013-07-10 |
2023-08-12 |
Not clear |
| Yevgeny Tendler, Russell Pokroy, Alex Panshin, Gary Weisinge. p53 protein subcellular localization and apoptosis in rodent corneal epithelium cell culture following ultraviolet irradiation. International journal of molecular medicine. vol 31. issue 3. 2013-07-10. PMID:23338225. |
p53 expression and function have been documented in malignancy, apoptosis and the aging processes. |
2013-07-10 |
2023-08-12 |
Not clear |
| Yevgeny Tendler, Russell Pokroy, Alex Panshin, Gary Weisinge. p53 protein subcellular localization and apoptosis in rodent corneal epithelium cell culture following ultraviolet irradiation. International journal of molecular medicine. vol 31. issue 3. 2013-07-10. PMID:23338225. |
we also observed that the apoptotic index increased following uv irradiation in the same time frame as the p53 nuclear transfer and was partially suppressed by pifithrin-α, which is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription. |
2013-07-10 |
2023-08-12 |
Not clear |
| Lu Zhang, HongJuan Jing, LiuQing Cui, HuanQing Li, Bo Zhou, GuangZhou Zhou, Fang Da. 3,4-Dimethoxystilbene, a resveratrol derivative with anti-angiogenic effect, induces both macroautophagy and apoptosis in endothelial cells. Journal of cellular biochemistry. vol 114. issue 3. 2013-07-09. PMID:23059970. |
our results showed that 3,4-dms exerted its anti-angiogenic effect likely through induction of endothelial cell apoptosis via a pathway involving p53, bax, cytochrome c, and caspase proteases. |
2013-07-09 |
2023-08-12 |
Not clear |
| Aysegul Yildiz-Unal, Sirin Korulu, Arzu Karaba. SpeedyRINGO inhibits calpain-directed apoptosis in neurons. Journal of Alzheimer's disease : JAD. vol 31. issue 4. 2013-07-08. PMID:22751172. |
speedyringo is an atypical cell cycle regulator that has been shown to have protective effects in mitotic cells against apoptosis by inhibiting caspase-3 activation when p53 is present. |
2013-07-08 |
2023-08-12 |
rat |
| Richard J Jones, Chad C Bjorklund, Veerabhadran Baladandayuthapani, Deborah J Kuhn, Robert Z Orlowsk. Drug resistance to inhibitors of the human double minute-2 E3 ligase is mediated by point mutations of p53, but can be overcome with the p53 targeting agent RITA. Molecular cancer therapeutics. vol 11. issue 10. 2013-07-08. PMID:22933706. |
these cells also showed cross-resistance to bortezomib, doxorubicin, cisplatin, and melphalan, but remained sensitive to the small molecule inhibitor rita (reactivation of p53 and induction of tumor cell apoptosis). |
2013-07-08 |
2023-08-12 |
human |
| Michael Tam, Pei Lin, Peter Hu, Patrick A Lenno. Examining Hedgehog pathway genes GLI3, SHH, and PTCH1 and the p53 target GLIPR1/GLIPR1L1/GLIPR1L2 gene cluster using fluorescence in situ hybridization uncovers GLIPR1/GLIPR1L1/GLIPR1L2 deletion in 9% of patients with multiple myeloma. Journal of the Association of Genetic Technologists. vol 36. issue 3. 2013-07-04. PMID:20978342. |
mutations resulting in defective components of the p53 pathway, which serves a critical role in mediating cellular stress response by triggering dna repair, cell cycle arrest, senescence and apoptosis, have also been identified. |
2013-07-04 |
2023-08-12 |
Not clear |
| Luis F M Barrezueta, Celina T F Oshima, Flávio O Lima, Henrique De Oliveira Costa, Thiago S Gomes, Ricardo A Neto, Marcello F De Franc. The intrinsic apoptotic signaling pathway in gastric adenocarcinomas of Brazilian patients: Immunoexpression of the Bcl-2 family (Bcl-2, Bcl-x, Bak, Bax, Bad) determined by tissue microarray analysis. Molecular medicine reports. vol 3. issue 2. 2013-07-04. PMID:21472231. |
the reduced expression of bak and bad and the increased expression of p53 and ki-67 in the adenocarcinomas demonstrate the imbalance between apoptosis and cellular proliferation, which results in uncontrolled tumor cell proliferation. |
2013-07-04 |
2023-08-12 |
Not clear |
| K Yanagihara, M Numoto, H Tauchi, Y Akama, H Yokozaki, E Tahara, K Kamiya, T Seit. Genetic status of p53 and induction of apoptosis by radiation or isoflavones in human gastric carcinoma cell lines. International journal of oncology. vol 9. issue 1. 2013-07-04. PMID:21541487. |
genetic status of p53 and induction of apoptosis by radiation or isoflavones in human gastric carcinoma cell lines. |
2013-07-04 |
2023-08-12 |
human |
| K Yanagihara, M Numoto, H Tauchi, Y Akama, H Yokozaki, E Tahara, K Kamiya, T Seit. Genetic status of p53 and induction of apoptosis by radiation or isoflavones in human gastric carcinoma cell lines. International journal of oncology. vol 9. issue 1. 2013-07-04. PMID:21541487. |
here, we assessed the role of p53 gene in cell cycle and apoptosis following treatment of 11 gastric carcinoma cell lines with gamma-rays, genistein, biochanin a, or daidzein. |
2013-07-04 |
2023-08-12 |
human |
| K Yanagihara, M Numoto, H Tauchi, Y Akama, H Yokozaki, E Tahara, K Kamiya, T Seit. Genetic status of p53 and induction of apoptosis by radiation or isoflavones in human gastric carcinoma cell lines. International journal of oncology. vol 9. issue 1. 2013-07-04. PMID:21541487. |
the rate of cell survival and apoptosis of the cells by gamma-irradiation or isoflavones did not correlate with p53 gene abnormalities. |
2013-07-04 |
2023-08-12 |
human |
| Wiem Chaabane, Sırma D User, Mohamed El-Gazzah, Roman Jaksik, Elaheh Sajjadi, Joanna Rzeszowska-Wolny, Marek J Lo. Autophagy, apoptosis, mitoptosis and necrosis: interdependence between those pathways and effects on cancer. Archivum immunologiae et therapiae experimentalis. vol 61. issue 1. 2013-07-04. PMID:23229678. |
here, what follows is a brief introduction on all three classical forms of cell death, followed by a more detailed insight into the role of p53, the master regulator of apoptosis, and other forms of cell death. |
2013-07-04 |
2023-08-12 |
Not clear |
| Wiem Chaabane, Sırma D User, Mohamed El-Gazzah, Roman Jaksik, Elaheh Sajjadi, Joanna Rzeszowska-Wolny, Marek J Lo. Autophagy, apoptosis, mitoptosis and necrosis: interdependence between those pathways and effects on cancer. Archivum immunologiae et therapiae experimentalis. vol 61. issue 1. 2013-07-04. PMID:23229678. |
while discussing p53 and also the role of caspases in cell death forms, we offer insight into the interplay between autophagy and apoptosis, or necrosis, where autophagy may initially serve pro-survival functions. |
2013-07-04 |
2023-08-12 |
Not clear |
| Chaoran Liu, Zhong Liu, Meng Li, Xiaoling Li, Yum-Shing Wong, Sai-Ming Ngai, Wenjie Zheng, Yibo Zhang, Tianfeng Che. Enhancement of auranofin-induced apoptosis in MCF-7 human breast cells by selenocystine, a synergistic inhibitor of thioredoxin reductase. PloS one. vol 8. issue 1. 2013-07-03. PMID:23342042. |
dna damage-mediated p53 phosphorylation and down-regulation of phosphorylated akt and erk also contributed to cell apoptosis. |
2013-07-03 |
2023-08-12 |
human |
| Da Pan, Paola Marcato, Dae-Gyun Ahn, Shashi Gujar, Lu-Zhe Pan, Maya Shmulevitz, Patrick W K Le. Activation of p53 by chemotherapeutic agents enhances reovirus oncolysis. PloS one. vol 8. issue 1. 2013-07-03. PMID:23342061. |
previously we showed that accumulation of the tumor suppressor protein p53 by nutlin-3a (a specific p53 stabilizer) enhanced reovirus-induced apoptosis, and resulted in significantly higher levels of reovirus dissemination. |
2013-07-03 |
2023-08-12 |
human |
| Valentina Basile, Silvia Belluti, Erika Ferrari, Chiara Gozzoli, Sonia Ganassi, Daniela Quaglino, Monica Saladini, Carol Imbrian. bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PloS one. vol 8. issue 1. 2013-07-02. PMID:23326480. |
a complex interplay between autophagy and apoptosis has come to light, taking into account that numerous genes, such as p53 and bcl-2 family members, are shared between these two pathways. |
2013-07-02 |
2023-08-12 |
human |
| Daniela Kenzelmann Broz, Stephano Spano Mello, Kathryn T Bieging, Dadi Jiang, Rachel L Dusek, Colleen A Brady, Arend Sidow, Laura D Attard. Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. Genes & development. vol 27. issue 9. 2013-07-02. PMID:23651856. |
while p53-induced autophagy does not affect cell cycle arrest in response to dna damage, it is important for both robust p53-dependent apoptosis triggered by dna damage and transformation suppression by p53. |
2013-07-02 |
2023-08-12 |
mouse |