| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suchismita Mohanty, Arghya Adhikary, Samik Chakrabarty, Gaurisankar Sa, Tanya Da. Operation 'p53 Hunt' to combat cancer: theaflavins in action. Frontiers in bioscience (Scholar edition). vol 4. 2013-08-05. PMID:22202062. |
it describes how theaflavins, by steering a single molecular target - p53, regulate multiple hallmarks of carcinogenesis i.e., tumor glycolysis, angiogenesis, metastasis, apoptosis and drug resistance. |
2013-08-05 |
2023-08-12 |
human |
| Kensuke Kojima, Steven M Kornblau, Vivian Ruvolo, Archana Dilip, Seshagiri Duvvuri, R Eric Davis, Min Zhang, Zhiqiang Wang, Kevin R Coombes, Nianxiang Zhang, Yi Hua Qiu, Jared K Burks, Hagop Kantarjian, Sharon Shacham, Michael Kauffman, Michael Andreef. Prognostic impact and targeting of CRM1 in acute myeloid leukemia. Blood. vol 121. issue 20. 2013-08-05. PMID:23564911. |
crm1 inhibitor kpt-185 induced mainly full-length p53 and apoptosis in a p53-dependent manner, whereas inhibition of proliferation was p53 independent. |
2013-08-05 |
2023-08-12 |
mouse |
| Kensuke Kojima, Steven M Kornblau, Vivian Ruvolo, Archana Dilip, Seshagiri Duvvuri, R Eric Davis, Min Zhang, Zhiqiang Wang, Kevin R Coombes, Nianxiang Zhang, Yi Hua Qiu, Jared K Burks, Hagop Kantarjian, Sharon Shacham, Michael Kauffman, Michael Andreef. Prognostic impact and targeting of CRM1 in acute myeloid leukemia. Blood. vol 121. issue 20. 2013-08-05. PMID:23564911. |
nuclear retention of p53 induced by crm1 inhibition synergized with increased levels of p53 induced by mdm2 inhibition in apoptosis induction. |
2013-08-05 |
2023-08-12 |
mouse |
| Panpan Ye, Kana Lin, Zhaochun Li, Jian Liu, Ke Yao, Wen X. [(-)-Epigallocatechin gallate regulates expression of apoptotic genes and protects cultured human lens epithelial cells under hyperglycemia]. Molekuliarnaia biologiia. vol 47. issue 2. 2013-08-05. PMID:23808158. |
these findings suggest that egcg protects hleb-3 cells from high glucose-induced apoptosis by regulating the gene expression of the bcl-2 family, c-fos, c-myc and p53. |
2013-08-05 |
2023-08-12 |
human |
| Shu-Ting Chan, Nae-Cherng Yang, Chin-Shiu Huang, Jiunn-Wang Liao, Shu-Lan Ye. Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. PloS one. vol 8. issue 1. 2013-08-02. PMID:23342112. |
we first showed that quercetin (5 µm) significantly increased the growth arrest and apoptosis in a549 cells (expressing wild-type p53) induced by 25 ng/ml of (82.5 nm) tsa at 48 h by about 25% and 101%, respectively. |
2013-08-02 |
2023-08-12 |
mouse |
| Shu-Ting Chan, Nae-Cherng Yang, Chin-Shiu Huang, Jiunn-Wang Liao, Shu-Lan Ye. Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. PloS one. vol 8. issue 1. 2013-08-02. PMID:23342112. |
transfection of p53 sirna into a549 cells significantly but not completely diminished the enhancing effects of quercetin on tsa-induced apoptosis. |
2013-08-02 |
2023-08-12 |
mouse |
| Shu-Ting Chan, Nae-Cherng Yang, Chin-Shiu Huang, Jiunn-Wang Liao, Shu-Lan Ye. Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. PloS one. vol 8. issue 1. 2013-08-02. PMID:23342112. |
tumors from mice treated with tsa in combination with quercetin had higher p53 and apoptosis levels than did those from control and tsa-treated mice. |
2013-08-02 |
2023-08-12 |
mouse |
| Shu-Ting Chan, Nae-Cherng Yang, Chin-Shiu Huang, Jiunn-Wang Liao, Shu-Lan Ye. Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. PloS one. vol 8. issue 1. 2013-08-02. PMID:23342112. |
these data indicate that regulation of the expression of p53 by quercetin plays an important role in enhancing tsa-induced apoptosis in a549 cells. |
2013-08-02 |
2023-08-12 |
mouse |
| Shulamit Sebban, Marganit Farago, Dan Gashai, Lena Ilan, Eli Pikarsky, Ittai Ben-Porath, Shulamit Katza. Vav1 fine tunes p53 control of apoptosis versus proliferation in breast cancer. PloS one. vol 8. issue 1. 2013-08-02. PMID:23342133. |
vav1 fine tunes p53 control of apoptosis versus proliferation in breast cancer. |
2013-08-02 |
2023-08-12 |
human |
| Shulamit Sebban, Marganit Farago, Dan Gashai, Lena Ilan, Eli Pikarsky, Ittai Ben-Porath, Shulamit Katza. Vav1 fine tunes p53 control of apoptosis versus proliferation in breast cancer. PloS one. vol 8. issue 1. 2013-08-02. PMID:23342133. |
tunel and γ-h2ax foci assays confirmed that expression of vav1 increased apoptosis in mcf-7 cells but not au565 cells and shrna experiments revealed that p53 is required for this pro-apoptotic effect of vav1 in these cells. |
2013-08-02 |
2023-08-12 |
human |
| Camille Brochier, Gretel Dennis, Mark A Rivieccio, Kathryn McLaughlin, Giovanni Coppola, Rajiv R Ratan, Brett Langle. Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 20. 2013-08-02. PMID:23678107. |
specific acetylation of p53 by hdac inhibition prevents dna damage-induced apoptosis in neurons. |
2013-08-02 |
2023-08-12 |
mouse |
| Camille Brochier, Gretel Dennis, Mark A Rivieccio, Kathryn McLaughlin, Giovanni Coppola, Rajiv R Ratan, Brett Langle. Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 20. 2013-08-02. PMID:23678107. |
specifically, we identify that acetylation at k382 and k381 prevents p53 from associating with the pro-apoptotic puma gene promoter, activating transcription, and inducing apoptosis in mouse primary cortical neurons. |
2013-08-02 |
2023-08-12 |
mouse |
| Xin Wang, Hua Bai, Xiaodi Zhang, Jiangzheng Liu, Peipei Cao, Nai Liao, Wei Zhang, Zhao Wang, Chunxu Ha. Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis. Carcinogenesis. vol 34. issue 6. 2013-08-01. PMID:23404993. |
cyclooxygenase-2 (cox-2) and p53 were involved in oa-exerted effect, and extracellular signal-regulated kinase-p53 signaling played a central role in oa-activated cascades responsible for apoptosis and cell cycle arrest. |
2013-08-01 |
2023-08-12 |
mouse |
| Haijun Yu, Yonglong Zou, Lei Jiang, Qi Yin, Xinyu He, Lingli Chen, Zhiwen Zhang, Wangwen Gu, Yaping L. Induction of apoptosis in non-small cell lung cancer by downregulation of MDM2 using pH-responsive PMPC-b-PDPA/siRNA complex nanoparticles. Biomaterials. vol 34. issue 11. 2013-07-31. PMID:23352573. |
mdm2 knockdown in p53 mutant nsclc h2009 cells induced significant cell cycle arrest, apoptosis and growth inhibition through upregulation of p21 and activation of caspase-3. |
2013-07-31 |
2023-08-12 |
mouse |
| Na Guo, Zhilan Pen. MG132, a proteasome inhibitor, induces apoptosis in tumor cells. Asia-Pacific journal of clinical oncology. vol 9. issue 1. 2013-07-30. PMID:22897979. |
there are many cancer-related molecules in which the protein levels present in cells are regulated by a proteasomal pathway; for example, tumor inhibitors (p53, e2a, c-myc, c-jun, c-fos), transcription factors (transcription factor nuclear factor-kappa b, iκbα, hifi, yyi, icer), cell cycle proteins (cyclin a and b, p27, p21, iap1/3), mg132 induces cell apoptosis through formation of reactive oxygen species or the upregulation and downregulation of these factors, which is ultimately dependent upon the activation of the caspase family of cysteine proteases. |
2013-07-30 |
2023-08-12 |
Not clear |
| Hongqin Zhuang, Weiwei Jiang, Xiangyu Zhang, Fan Qiu, Ziyi Gan, Wei Cheng, Jing Zhang, Shengwen Guan, Bo Tang, Qilai Huang, Xinhua Wu, Xiaofeng Huang, Wenhui Jiang, Qingang Hu, Min Lu, Zi-Chun Hu. Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions. Journal of molecular medicine (Berlin, Germany). vol 91. issue 2. 2013-07-30. PMID:22948392. |
we demonstrated that hsp70 suppression by sirna sensitized nsclc cells to trail-induced apoptosis by upregulating the expressions of death receptor 4 (dr4) and death receptor 5 (dr5) through activating nf-κb, jnk, and, subsequently, p53, consequently significantly amplifying trail-mediated caspase-8 processing and activity, cytosolic translocation of cytochrome c, and cell death. |
2013-07-30 |
2023-08-12 |
mouse |
| Suganya Sekaran, Selvakumar Kandaswamy, Krishnamoorthy Gunasekaran, Elumalai Perumal, Fariya Yasmine Afsar Basha, Balasakthi Janani Madhan Mohan, Arunakaran Jagadeesa. Protective role of quercetin on polychlorinated biphenyls (Aroclor-1254) induced oxidative stress and apoptosis in liver of adult male rats. Journal of biochemical and molecular toxicology. vol 26. issue 12. 2013-07-30. PMID:23281070. |
whereas simultaneous treatment with quercetin normalized all the biochemical parameters, consequently it inhibited apoptosis mediated by aroclor-1254 by downregulating aryl hydrocarbon receptor, p53 and apoptotic protein (bax, caspase-9, caspase-3) and upregulating the antiapoptotic protein (bcl-2) expression patterns; thereby, quercetin reduces alteration in hepatocellular morphology. |
2013-07-30 |
2023-08-12 |
rat |
| Esha Madan, Rajan Gogna, Periannan Kuppusamy, Madan Bhatt, Abbas Ali Mahdi, Uttam Pat. SCO2 induces p53-mediated apoptosis by Thr845 phosphorylation of ASK-1 and dissociation of the ASK-1-Trx complex. Molecular and cellular biology. vol 33. issue 7. 2013-07-30. PMID:23319048. |
p53 prevents cancer via cell cycle arrest, apoptosis, and the maintenance of genome stability. |
2013-07-30 |
2023-08-12 |
Not clear |
| YuZhen Li, ZhenRong Lv, XiuHua Liu, WenTing Su, Chen Wang, Nana Li, Dandan Song, Tianqi Ta. Hypoxic postconditioning inhibits endoplasmic reticulum stress-mediated cardiomyocyte apoptosis by targeting PUMA. Shock (Augusta, Ga.). vol 39. issue 3. 2013-07-30. PMID:23364433. |
here, we hypothesized that postconditioning targeted p53 upregulated modulator of apoptosis (puma) to protect cardiomyocytes against endoplasmic reticulum stress-mediated apoptosis. |
2013-07-30 |
2023-08-12 |
Not clear |
| Yong Li, Michael W Gordon, Zijun Y Xu-Monette, Carlo Visco, Alexander Tzankov, Dehui Zou, Lugui Qiu, Santiago Montes-Moreno, Karen Dybkaer, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L Richards, Eric D Hsi, William W L Choi, J Han van Krieken, Qin Huang, Weiyun Ai, Maurilio Ponzoni, Andrés J M Ferreri, Jane N Winter, Ronald S Go, Miguel A Piris, Michael B Møller, Lin Wu, Michael Wang, Kenneth S Ramos, L Jeffrey Medeiros, Ken H Youn. Single nucleotide variation in the TP53 3' untranslated region in diffuse large B-cell lymphoma treated with rituximab-CHOP: a report from the International DLBCL Rituximab-CHOP Consortium Program. Blood. vol 121. issue 22. 2013-07-30. PMID:23515929. |
in addition, a germline snv (rs78378222) located in the tp53 polyadenylation signal resulted in downregulation of both p53 messenger rna and protein levels and reduction of cellular apoptosis. |
2013-07-30 |
2023-08-12 |
Not clear |