| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Cárdeno, Marina Sánchez-Hidalgo, M Angeles Rosillo, Catalina Alarcón de la Lastr. Oleuropein, a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1α. Nutrition and cancer. vol 65. issue 1. 2013-07-22. PMID:23368925. |
our novel findings demonstrate that ol limits the growth and induces apoptosis in ht-29 cells via p53 pathway activation adapting the hif-1α response to hypoxia. |
2013-07-22 |
2023-08-12 |
human |
| Xiuxiu Lv, Xiaohui Yu, Yiyang Wang, Faqiang Wang, Hongmei Li, Yanping Wang, Daxiang Lu, Renbin Qi, Huadong Wan. Berberine inhibits doxorubicin-triggered cardiomyocyte apoptosis via attenuating mitochondrial dysfunction and increasing Bcl-2 expression. PloS one. vol 7. issue 10. 2013-07-19. PMID:23077597. |
pretreatment with compound c, an ampk inhibitor, also suppressed p53 phosphorylation and apoptosis in dox-treated cardiomyocytes. |
2013-07-19 |
2023-08-12 |
rat |
| Xiuxiu Lv, Xiaohui Yu, Yiyang Wang, Faqiang Wang, Hongmei Li, Yanping Wang, Daxiang Lu, Renbin Qi, Huadong Wan. Berberine inhibits doxorubicin-triggered cardiomyocyte apoptosis via attenuating mitochondrial dysfunction and increasing Bcl-2 expression. PloS one. vol 7. issue 10. 2013-07-19. PMID:23077597. |
tunel and western blot assays showed that ber not only decreased myocardial apoptosis, caspase-3 activation, ampkα and p53 phosphorylation, but also increased bcl-2 expression in myocardium of rats exposed to dox for 84 h. these findings indicate that ber attenuates dox-induced cardiomyocyte apoptosis via protecting mitochondria, inhibiting an increase in the amp/atp ratio and ampkα phosphorylation as well as elevating bcl-2 expression, which offer a novel mechanism responsible for protection of ber against dox-induced cardiomyopathy. |
2013-07-19 |
2023-08-12 |
rat |
| Pieter Voskamp, Carolien A Bodmann, Gudrun E Koehl, Heggert G Rebel, Marjolein G E Van Olderen, Andreas Gaumann, Abdoel El Ghalbzouri, Cornelis P Tensen, Jan N Bouwes Bavinck, Rein Willemze, Edward K Geissler, Frank R De Gruij. Dietary immunosuppressants do not enhance UV-induced skin carcinogenesis, and reveal discordance between p53-mutant early clones and carcinomas. Cancer prevention research (Philadelphia, Pa.). vol 6. issue 2. 2013-07-19. PMID:23233735. |
immunosuppressants (azathioprine, cyclosporine, tacrolimus, mycophenolate mofetil, and rapamycin) were assessed on altering the uv induction of apoptosis in human skin models and of p53 mutant cell clones (putative tumor precursors) and ensuing skin carcinomas (with mutant p53) in the skin of hairless mice. |
2013-07-19 |
2023-08-12 |
mouse |
| Hai-Bin Zhu, Kai Yang, Yan-Qi Xie, Yi-Wei Lin, Qi-Qi Mao, Li-Ping Xi. Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells. World journal of surgical oncology. vol 11. 2013-07-18. PMID:23356234. |
silencing of mutant p53 by sirna induces cell cycle arrest and apoptosis in human bladder cancer cells. |
2013-07-18 |
2023-08-12 |
human |
| V Lisiansky, I Naumov, S Shapira, D Kazanov, A Starr, N Arber, S Krau. Gene therapy of pancreatic cancer targeting the K-Ras oncogene. Cancer gene therapy. vol 19. issue 12. 2013-07-17. PMID:23099885. |
the aim of this study is to selectively kill ras-transformed cells by overexpressing the pro-apoptotic protein, p53 upregulated modulator of apoptosis (puma) under a ras-responsive promoter. |
2013-07-17 |
2023-08-12 |
mouse |
| Yoshimi Shionome, Li Yan, Song Liu, Toshiaki Saeki, Toru Ouch. Integrity of p53 associated pathways determines induction of apoptosis of tumor cells resistant to Aurora-A kinase inhibitors. PloS one. vol 8. issue 1. 2013-07-17. PMID:23383195. |
integrity of p53 associated pathways determines induction of apoptosis of tumor cells resistant to aurora-a kinase inhibitors. |
2013-07-17 |
2023-08-12 |
mouse |
| Yoshimi Shionome, Li Yan, Song Liu, Toshiaki Saeki, Toru Ouch. Integrity of p53 associated pathways determines induction of apoptosis of tumor cells resistant to Aurora-A kinase inhibitors. PloS one. vol 8. issue 1. 2013-07-17. PMID:23383195. |
in this study, we investigated the roles of genes involved in p53 pathway (p53, puma, p21, bax, and chk2) in response to aurora-a inhibitors, vx680 and mk-8745, and explored whether chemoresistant tumor cells would further undergo apoptosis with other therapeutic agents. |
2013-07-17 |
2023-08-12 |
mouse |
| Victor C Wong, Jessica L Morse, Anatoly Zhitkovic. p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells. Toxicology and applied pharmacology. vol 269. issue 3. 2013-07-17. PMID:23566959. |
p53 activation by ni(ii) is a hif-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells. |
2013-07-17 |
2023-08-12 |
human |
| Victor C Wong, Jessica L Morse, Anatoly Zhitkovic. p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells. Toxicology and applied pharmacology. vol 269. issue 3. 2013-07-17. PMID:23566959. |
ni(ii)-treated h460 cells showed no evidence of necrosis and their apoptosis and clonogenic death were suppressed by p53 knockdown. |
2013-07-17 |
2023-08-12 |
human |
| Yong Wang, Chun Li, Yuli Ouyang, Tianjiao Shi, Xiaomin Yang, Junda Yu, Qi Qiu, Jing Han, Yan Wu, Binghua Tang, Wei Wan. QSYQ Attenuates Oxidative Stress and Apoptosis Induced Heart Remodeling Rats through Different Subtypes of NADPH-Oxidase. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-07-17. PMID:23861715. |
moreover, nox4 was another key targets to inhibit the p53 and caspase3, thus to reduce the hypertrophy and apoptosis, and eventually provide a synergetic cardiac protective effect. |
2013-07-17 |
2023-08-12 |
rat |
| Jacqueline L Y Chee, Suzan Saidin, David P Lane, Sai Mun Leong, Jacqueline E Noll, Paul M Neilsen, Yi Ting Phua, Hani Gabra, Tit Meng Li. Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9. Cell cycle (Georgetown, Tex.). vol 12. issue 2. 2013-07-16. PMID:23255126. |
these results suggest the inhibition of caspase-9 as a potential mechanism in evading apoptosis in tumors with high-level p53 expression that is cytoplasmically localized. |
2013-07-16 |
2023-08-12 |
Not clear |
| David F Calle. p53 continues to surprise: high levels of p53 can suppress apoptosis. Cell cycle (Georgetown, Tex.). vol 12. issue 2. 2013-07-16. PMID:23287473. |
p53 continues to surprise: high levels of p53 can suppress apoptosis. |
2013-07-16 |
2023-08-12 |
Not clear |
| Sun-Young Lee, Seok Joon Shin, Ho-Shik Ki. ERK1/2 activation mediated by the nutlin‑3‑induced mitochondrial translocation of p53. International journal of oncology. vol 42. issue 3. 2013-07-16. PMID:23314357. |
the tumor suppressor p53 induces growth arrest or apoptosis in response to genotoxic stress. |
2013-07-16 |
2023-08-12 |
human |
| Sun-Young Lee, Seok Joon Shin, Ho-Shik Ki. ERK1/2 activation mediated by the nutlin‑3‑induced mitochondrial translocation of p53. International journal of oncology. vol 42. issue 3. 2013-07-16. PMID:23314357. |
taking the above findings into account, it can be concluded that nutlin-3 activates erk1/2 prior to egfr phosphorylation via ros generation following the mitochondrial translocation of p53 and that nutlin-3-induced erk1/2 activation may play a role in protecting u2os cells from p53-dependent apoptosis, constituting a negative feedback loop for p53-induced apoptosis. |
2013-07-16 |
2023-08-12 |
human |
| Sang Kyu Lee, Young Sang Ki. Phosphorylation of eIF2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria. International journal of oncology. vol 42. issue 3. 2013-07-16. PMID:23354132. |
phosphorylation of eif2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria. |
2013-07-16 |
2023-08-12 |
Not clear |
| Sang Kyu Lee, Young Sang Ki. Phosphorylation of eIF2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria. International journal of oncology. vol 42. issue 3. 2013-07-16. PMID:23354132. |
furthermore, the eif2α knockdown sensitized cells to simvastatin-induced apoptosis and the overexpression of a non-phosphorylatable eif2α-mutant [serine 51(ser51)/alanine] enhanced the stabilization of p53 and its translocation to the mitochondria in response to simvastatin treatment. |
2013-07-16 |
2023-08-12 |
Not clear |
| Tolga Eichhorn, Corinna Hiller, Kerstin Hirschfelder, Martin Frank, R Luise Krauth-Siegel, Rolf Müller, Rolf Mertens, Thomas Effert. Identification by high-throughput in silico screening of radio-protecting compounds targeting the DNA-binding domain of the tumor suppressor p53. Cancer genomics & proteomics. vol 10. issue 1. 2013-07-16. PMID:23382585. |
therapies targeting p53 mostly concentrate on (re)activation of the p53 protein, to further induce apoptosis in cancer cells. |
2013-07-16 |
2023-08-12 |
Not clear |
| Iain Brown, Maria G Cascio, Dino Rotondo, Roger G Pertwee, Steven D Heys, Klaus W J Wahl. Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators. Progress in lipid research. vol 52. issue 1. 2013-07-12. PMID:23103355. |
they signal through p38, mapk, jun, pi3, akt, ceramide, caspases, mmps, ppars, vegf, nf-κb, p8, chop, trb3 and pro-apoptotic oncogenes (p53,p21 waf1/cip1) to induce cell cycle arrest, autophagy, apoptosis and tumour inhibition. |
2013-07-12 |
2023-08-12 |
Not clear |
| Filio Billia, Ludger Hauck, Daniela Grothe, Filip Konecny, Vivek Rao, Raymond H Kim, Tak W Ma. Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 15. 2013-07-12. PMID:23530187. |
this was accompanied by a trp53 (p53)-dependent decrease in capillary density, an excessive oxidation of dna, and increased cardiomyocyte apoptosis, key events in the development of hf. |
2013-07-12 |
2023-08-12 |
mouse |