| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rahul Bhowmick, Umesh Chandra Halder, Shiladitya Chattopadhyay, Mukti Kant Nayak, Mamta Chawla-Sarka. Rotavirus-encoded nonstructural protein 1 modulates cellular apoptotic machinery by targeting tumor suppressor protein p53. Journal of virology. vol 87. issue 12. 2013-07-29. PMID:23576507. |
p53, a member of the innate immune system, is triggered under stress to induce cell growth arrest and apoptosis. |
2013-07-29 |
2023-08-12 |
Not clear |
| Rahul Bhowmick, Umesh Chandra Halder, Shiladitya Chattopadhyay, Mukti Kant Nayak, Mamta Chawla-Sarka. Rotavirus-encoded nonstructural protein 1 modulates cellular apoptotic machinery by targeting tumor suppressor protein p53. Journal of virology. vol 87. issue 12. 2013-07-29. PMID:23576507. |
degradation of p53 during initial stages of infection inhibited apoptosis, as the proapoptotic genes puma and bax were downregulated. |
2013-07-29 |
2023-08-12 |
Not clear |
| Linyan Chen, Jing Chen, Hanhong X. Sasanquasaponin from Camellia oleifera Abel. induces cell cycle arrest and apoptosis in human breast cancer MCF-7 cells. Fitoterapia. vol 84. 2013-07-26. PMID:23164604. |
stimulation also induced activation of e2f1 and downregulation of p53, indicating that sqs induces cell cycle arrest and apoptosis via a p53-independent pathway; p53-independent apoptosis may be mediated by e2f1 activation. |
2013-07-26 |
2023-08-12 |
human |
| Jyh-Chang Jean, Elizabeth George, Klaus H Kaestner, Lou Ann Scism Brown, Avrum Spira, Martin Joyce-Brad. Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation. PloS one. vol 8. issue 1. 2013-07-26. PMID:23372771. |
klf4 mrna was induced in lung fibroblasts exposed to hyperoxia and constitutive expression of klf4 mrna in klf4-null fibroblasts induced mrnas for p21(cip1/waf1), smooth muscle actin, type 1 collagen, fibronectin and tenascin c. in klf4 perinatal null lung, p21(cip1/waf1)mrna expression was deficient prior to birth and associated with ongoing cell proliferation after birth; connective tissue gene expression was deficient around birth and smooth muscle actin protein expression was absent from myofibroblasts at tips of developing alveoli; p53, p21(cip1/waf1) and caspase-3 protein expression were widespread at birth suggesting excess apoptosis compared to normal lung. |
2013-07-26 |
2023-08-12 |
mouse |
| b' G\\xc3\\xbcl\\xc3\\xa7in Alp Avc\\xc4\\xb. [Genomic organization and proteins of human papillomavirus]. Mikrobiyoloji bulteni. vol 46. issue 3. 2013-07-25. PMID:22951665.' |
the binding of e6 protein to p53 leads its rapid degradation, and the eclipse in the g1 phase, dna repair mechanisms and apoptosis are terminated. |
2013-07-25 |
2023-08-12 |
human |
| Hirokazu Ohata, Makoto Miyazaki, Ryo Otomo, Yuko Matsushima-Hibiya, Chihiro Otsubo, Takahiro Nagase, Hirofumi Arakawa, Jun Yokota, Hitoshi Nakagama, Yoichi Taya, Masato Enar. NuMA is required for the selective induction of p53 target genes. Molecular and cellular biology. vol 33. issue 12. 2013-07-25. PMID:23589328. |
the p53 tumor suppressor protein is a transcription factor controlling various outcomes, such as growth arrest and apoptosis, through the regulation of different sets of target genes. |
2013-07-25 |
2023-08-12 |
Not clear |
| Anni I Nieminen, Vilja M Eskelinen, Heidi M Haikala, Topi A Tervonen, Yan Yan, Johanna I Partanen, Juha Klefströ. Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 20. 2013-07-25. PMID:23589839. |
myc-induced ampk-phospho p53 pathway activates bak to sensitize mitochondrial apoptosis. |
2013-07-25 |
2023-08-12 |
Not clear |
| Subhasree Nag, Jiangjiang Qin, Kalkunte S Srivenugopal, Minghai Wang, Ruiwen Zhan. The MDM2-p53 pathway revisited. Journal of biomedical research. vol 27. issue 4. 2013-07-25. PMID:23885265. |
the p53 tumor suppressor is a key transcription factor regulating cellular pathways such as dna repair, cell cycle, apoptosis, angiogenesis, and senescence. |
2013-07-25 |
2023-08-12 |
human |
| Yukinori Taniguchi, Masaru Kawakam. Variation in the mechanical unfolding pathway of p53DBD induced by interaction with p53 N-terminal region or DNA. PloS one. vol 7. issue 11. 2013-07-24. PMID:23145047. |
the tumor suppressor p53 plays a crucial role in the cell cycle checkpoints, dna repair, and apoptosis. |
2013-07-24 |
2023-08-12 |
Not clear |
| Giusy Di Conza, Marianna Buttarelli, Olimpia Monti, Marsha Pellegrino, Francesca Mancini, Alfredo Pontecorvi, Katia Scotlandi, Fabiola Morett. IGF-1R/MDM2 relationship confers enhanced sensitivity to RITA in Ewing sarcoma cells. Molecular cancer therapeutics. vol 11. issue 6. 2013-07-22. PMID:22461661. |
here, we show that the small molecule reactivation of p53 and induction of tumor cell apoptosis (rita, nsc652287) is highly effective in reducing growth and tumorigenic potential of ewing sarcoma cell lines. |
2013-07-22 |
2023-08-12 |
Not clear |
| Nader Hadife, Christophe Nemos, Jean-Pol Frippiat, Tala Hamadé, Aurore Perrot, Ali Dallou. Interleukin-24 mediates apoptosis in human B-cells through early activation of cell cycle arrest followed by late induction of the mitochondrial apoptosis pathway. Leukemia & lymphoma. vol 54. issue 3. 2013-07-22. PMID:22860893. |
il-24-mediated apoptosis was also antagonized by pifithrin-alpha, an inhibitor of p53 transactivation. |
2013-07-22 |
2023-08-12 |
human |
| Eun Jung Park, Kyeong Sook Choi, Young Hyun Yoo, Taeg Kyu Kwo. Nutlin-3, a small-molecule MDM2 inhibitor, sensitizes Caki cells to TRAIL-induced apoptosis through p53-mediated PUMA upregulation and ROS-mediated DR5 upregulation. Anti-cancer drugs. vol 24. issue 3. 2013-07-22. PMID:23187459. |
combined treatment with nutlin-3 and trail markedly induces apoptosis in hct116 cells (p53 wild type), but not in hct116 p53-/- cells, suggesting that p53 is critical for the sensitizing effect of nutlin-3 on trail-induced apoptosis. |
2013-07-22 |
2023-08-12 |
mouse |
| Eun Jung Park, Kyeong Sook Choi, Young Hyun Yoo, Taeg Kyu Kwo. Nutlin-3, a small-molecule MDM2 inhibitor, sensitizes Caki cells to TRAIL-induced apoptosis through p53-mediated PUMA upregulation and ROS-mediated DR5 upregulation. Anti-cancer drugs. vol 24. issue 3. 2013-07-22. PMID:23187459. |
however, the upregulation of the p53-mediated protein p53 upregulated modulator of apoptosis (puma) by nutlin-3 is likely to be ros independent because antioxidants failed to block puma upregulation. |
2013-07-22 |
2023-08-12 |
mouse |
| Ayako Suzuki, Masatoshi Kariya, Noriomi Matsumura, Tsukasa Baba, Haruhiko Yagi, Masaki Mandai, Ikuo Konishi, Shingo Fuji. Expression of p53 and p21(WAF-1), apoptosis, and proliferation of smooth muscle cells in normal myometrium during the menstrual cycle: implication of DNA damage and repair for leiomyoma development. Medical molecular morphology. vol 45. issue 4. 2013-07-22. PMID:23224600. |
expression of p53 and p21(waf-1), apoptosis, and proliferation of smooth muscle cells in normal myometrium during the menstrual cycle: implication of dna damage and repair for leiomyoma development. |
2013-07-22 |
2023-08-12 |
Not clear |
| Natsumi Kubo, Dan Wu, Yukari Yoshihara, Meixiang Sang, Akira Nakagawara, Toshinori Ozak. Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2. Biochemical and biophysical research communications. vol 430. issue 3. 2013-07-22. PMID:23261415. |
upon severe dna damage, p53 promotes apoptosis to eliminate cells with seriously damaged dna to maintain genomic integrity. |
2013-07-22 |
2023-08-12 |
Not clear |
| Ana Cárdeno, Marina Sánchez-Hidalgo, M Angeles Rosillo, Catalina Alarcón de la Lastr. Oleuropein, a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1α. Nutrition and cancer. vol 65. issue 1. 2013-07-22. PMID:23368925. |
cell cycle and apoptosis were assessed by flow cytometry and changes in mapk cascade protein expression, hif-1α, p53, pparγ, and nfkβ signaling pathways by western blot. |
2013-07-22 |
2023-08-12 |
human |
| Ana Cárdeno, Marina Sánchez-Hidalgo, M Angeles Rosillo, Catalina Alarcón de la Lastr. Oleuropein, a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1α. Nutrition and cancer. vol 65. issue 1. 2013-07-22. PMID:23368925. |
our novel findings demonstrate that ol limits the growth and induces apoptosis in ht-29 cells via p53 pathway activation adapting the hif-1α response to hypoxia. |
2013-07-22 |
2023-08-12 |
human |
| Xiuxiu Lv, Xiaohui Yu, Yiyang Wang, Faqiang Wang, Hongmei Li, Yanping Wang, Daxiang Lu, Renbin Qi, Huadong Wan. Berberine inhibits doxorubicin-triggered cardiomyocyte apoptosis via attenuating mitochondrial dysfunction and increasing Bcl-2 expression. PloS one. vol 7. issue 10. 2013-07-19. PMID:23077597. |
pretreatment with compound c, an ampk inhibitor, also suppressed p53 phosphorylation and apoptosis in dox-treated cardiomyocytes. |
2013-07-19 |
2023-08-12 |
rat |
| Xiuxiu Lv, Xiaohui Yu, Yiyang Wang, Faqiang Wang, Hongmei Li, Yanping Wang, Daxiang Lu, Renbin Qi, Huadong Wan. Berberine inhibits doxorubicin-triggered cardiomyocyte apoptosis via attenuating mitochondrial dysfunction and increasing Bcl-2 expression. PloS one. vol 7. issue 10. 2013-07-19. PMID:23077597. |
tunel and western blot assays showed that ber not only decreased myocardial apoptosis, caspase-3 activation, ampkα and p53 phosphorylation, but also increased bcl-2 expression in myocardium of rats exposed to dox for 84 h. these findings indicate that ber attenuates dox-induced cardiomyocyte apoptosis via protecting mitochondria, inhibiting an increase in the amp/atp ratio and ampkα phosphorylation as well as elevating bcl-2 expression, which offer a novel mechanism responsible for protection of ber against dox-induced cardiomyopathy. |
2013-07-19 |
2023-08-12 |
rat |
| Pieter Voskamp, Carolien A Bodmann, Gudrun E Koehl, Heggert G Rebel, Marjolein G E Van Olderen, Andreas Gaumann, Abdoel El Ghalbzouri, Cornelis P Tensen, Jan N Bouwes Bavinck, Rein Willemze, Edward K Geissler, Frank R De Gruij. Dietary immunosuppressants do not enhance UV-induced skin carcinogenesis, and reveal discordance between p53-mutant early clones and carcinomas. Cancer prevention research (Philadelphia, Pa.). vol 6. issue 2. 2013-07-19. PMID:23233735. |
immunosuppressants (azathioprine, cyclosporine, tacrolimus, mycophenolate mofetil, and rapamycin) were assessed on altering the uv induction of apoptosis in human skin models and of p53 mutant cell clones (putative tumor precursors) and ensuing skin carcinomas (with mutant p53) in the skin of hairless mice. |
2013-07-19 |
2023-08-12 |
mouse |