| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Sorrentino, M Mioni, C Giorgi, N Ruggeri, P Pinton, U Moll, F Mantovani, G Del Sa. The prolyl-isomerase Pin1 activates the mitochondrial death program of p53. Cell death and differentiation. vol 20. issue 2. 2013-06-21. PMID:22935610. |
in response to intense stress, the tumor protein p53 (p53) tumor suppressor rapidly mounts a direct mitochondrial death program that precedes transcription-mediated apoptosis. |
2013-06-21 |
2023-08-12 |
Not clear |
| D-Y Kim, W Kim, K-H Lee, S-H Kim, H-R Lee, H-J Kim, Y Jung, J-H Choi, K-T Ki. hnRNP Q regulates translation of p53 in normal and stress conditions. Cell death and differentiation. vol 20. issue 2. 2013-06-21. PMID:22935615. |
the p53 tumor-suppressor protein is stabilized under stress conditions and induces transcription of several genes to regulate cell cycle and apoptosis. |
2013-06-21 |
2023-08-12 |
mouse |
| D-Y Kim, W Kim, K-H Lee, S-H Kim, H-R Lee, H-J Kim, Y Jung, J-H Choi, K-T Ki. hnRNP Q regulates translation of p53 in normal and stress conditions. Cell death and differentiation. vol 20. issue 2. 2013-06-21. PMID:22935615. |
furthermore, we report that heterogeneous nuclear ribonucleoprotein (hnrnp) q binds to the 5'-untranslated region (utr) of mouse p53 mrna and regulates translation efficiency of p53 and apoptosis progression. |
2013-06-21 |
2023-08-12 |
mouse |
| Keiko Tsuganezawa, Yukari Nakagawa, Miki Kato, Shigenao Taruya, Fumio Takahashi, Morio Endoh, Rei Utata, Masumi Mori, Naoko Ogawa, Teruki Honma, Shigeyuki Yokoyama, Yoshinobu Hashizume, Masaaki Aoki, Takuma Kasai, Takanori Kigawa, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Akiko Tanak. A fluorescent-based high-throughput screening assay for small molecules that inhibit the interaction of MdmX with p53. Journal of biomolecular screening. vol 18. issue 2. 2013-06-21. PMID:22989451. |
to indicate the efficacy of the hit compound as a candidate anticancer drug, we showed that the hit compound triggered apoptosis after p53 and p21 accumulation in cultured mv4;11 leukemia cells. |
2013-06-21 |
2023-08-12 |
Not clear |
| R Brosh, Y Assia-Alroy, A Molchadsky, C Bornstein, E Dekel, S Madar, Y Shetzer, N Rivlin, N Goldfinger, R Sarig, V Rotte. p53 counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition. Cell death and differentiation. vol 20. issue 2. 2013-06-21. PMID:22996684. |
recent studies reported that inhibition of the p53 tumor suppressor profoundly facilitates reprogramming and attributed this effect to the ability of p53 to restrict proliferation and induce apoptosis. |
2013-06-21 |
2023-08-12 |
Not clear |
| Annika Hau, Paolo Ceppi, Marcus E Pete. CD95 is part of a let-7/p53/miR-34 regulatory network. PloS one. vol 7. issue 11. 2013-06-20. PMID:23166734. |
both cd95 and mir-34a are p53 target genes, and consequently, both the sensitivity of cancer cells to cd95-mediated apoptosis and the ability to respond to p53 mediated dna genotoxic stress are linked. |
2013-06-20 |
2023-08-12 |
human |
| Li-Na Xu, Bi-Nan Lu, Ming-Ming Hu, You-Wei Xu, Xu Han, Yan Qi, Jin-Yong Pen. Mechanisms involved in the cytotoxic effects of berberine on human colon cancer HCT-8 cells. Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al. vol 36. issue 3. 2013-06-20. PMID:23682426. |
we also found that berberine-induced apoptosis was associated with an upregulated expressions of p53 and prohibitin (phb), and decreased vimentin expression. |
2013-06-20 |
2023-08-12 |
human |
| Evguenia M Alexandrova, Ute M Mol. Role of p53 family members p73 and p63 in human hematological malignancies. Leukemia & lymphoma. vol 53. issue 11. 2013-06-19. PMID:22497596. |
p53, mutated in over half of human cancers and about 13% of all hematological malignancies, maintains genomic integrity and triggers cellular senescence and apoptosis of damaged cells. |
2013-06-19 |
2023-08-12 |
mouse |
| H Bernard, B Garmy-Susini, N Ainaoui, L Van Den Berghe, A Peurichard, S Javerzat, A Bikfalvi, D P Lane, J C Bourdon, A-C Prat. The p53 isoform, Δ133p53α, stimulates angiogenesis and tumour progression. Oncogene. vol 32. issue 17. 2013-06-19. PMID:22733133. |
the tumour suppressor p53, involved in dna repair, cell cycle arrest and apoptosis, also inhibits blood vessel formation, that is, angiogenesis, a process strongly contributing to tumour development. |
2013-06-19 |
2023-08-12 |
mouse |
| Ezz M El-Gamal, Mona S O Gouid. Quantitative changes in p53, Bcl-2 and apoptosis in blood and urine of bladder cancer patients. Clinical laboratory. vol 59. issue 3-4. 2013-06-19. PMID:23724625. |
quantitative changes in p53, bcl-2 and apoptosis in blood and urine of bladder cancer patients. |
2013-06-19 |
2023-08-12 |
Not clear |
| Ezz M El-Gamal, Mona S O Gouid. Quantitative changes in p53, Bcl-2 and apoptosis in blood and urine of bladder cancer patients. Clinical laboratory. vol 59. issue 3-4. 2013-06-19. PMID:23724625. |
therefore, the present study was carried out to investigate the levels of anti-apoptotic proteins such as p53 and bcl-2, and of apoptosis itself as reflected by the increase in sub-g1 peak staining, in the blood and urine of bladder cancer patients, and to thus determine the usefulness of these parameters as tools for early and accurate prediction of tumor growth and development of metastases, in order to assess treatment benefit potential. |
2013-06-19 |
2023-08-12 |
Not clear |
| Qin Li, Guillermina Lozan. Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 19. issue 1. 2013-06-18. PMID:23262034. |
the p53 tumor suppressor is activated in response to cellular stresses to induce cell-cycle arrest, cellular senescence, and apoptosis. |
2013-06-18 |
2023-08-12 |
human |
| Cong-Cong Hou, Wan-Xi Yan. Characterization and expression pattern of p53 during spermatogenesis in the Chinese mitten crab Eriocheir sinensis. Molecular biology reports. vol 40. issue 2. 2013-06-17. PMID:23065235. |
p53, as a "guardian of the genome", plays an important role in cell cycle arrest, apoptosis, dna repair and inhibition of angiogenesis in different tissues including testis. |
2013-06-17 |
2023-08-12 |
Not clear |
| Bin Li, Liyan Wang, Baorong Ch. Upregulation of periostin prevents P53-mediated apoptosis in SGC-7901 gastric cancer cells. Molecular biology reports. vol 40. issue 2. 2013-06-17. PMID:23076534. |
restoration of p53 expression by delivering wild-type p53 gene resulted in a marked increase in drug-induced apoptosis in periostin-overexpressing sgc-7901 cells. |
2013-06-17 |
2023-08-12 |
human |
| Zaki A Sherif, Ahmed S Sulta. Divergent control of Cav-1 expression in non-cancerous Li-Fraumeni syndrome and human cancer cell lines. Cancer biology & therapy. vol 14. issue 1. 2013-06-17. PMID:23114650. |
cell lines developed from patients of a lfs family have decreased p53 activity as evidenced by the absence of apoptosis upon etoposide treatment. |
2013-06-17 |
2023-08-12 |
human |
| Qi Wang, Jun-Yu Wang, Xiao-Ping Zhang, Zhong-Wei Lv, Da Fu, Yi-Cheng Lu, Guo-Han Hu, Chun Luo, Ju-Xiang Che. RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis. Carcinogenesis. vol 34. issue 4. 2013-06-17. PMID:23276796. |
moreover, we demonstrate that knockdown of rlip76 increases apoptosis in different human gliomas independently of p53 status. |
2013-06-17 |
2023-08-12 |
mouse |
| Si Gao, Tianfeng Chen, Mei-Yuk Choi, Yuanwei Liang, Junyi Xue, Yum-Shing Won. Cyanidin reverses cisplatin-induced apoptosis in HK-2 proximal tubular cells through inhibition of ROS-mediated DNA damage and modulation of the ERK and AKT pathways. Cancer letters. vol 333. issue 1. 2013-06-17. PMID:23360684. |
the cleavage of caspases and parp, activation of p53 and mitochondrial-mediated apoptosis pathways induced by cisplatin were effectively blocked by cyanidin. |
2013-06-17 |
2023-08-12 |
Not clear |
| Amaia Lujambio, Leila Akkari, Janelle Simon, Danielle Grace, Darjus F Tschaharganeh, Jessica E Bolden, Zhen Zhao, Vishal Thapar, Johanna A Joyce, Valery Krizhanovsky, Scott W Low. Non-cell-autonomous tumor suppression by p53. Cell. vol 153. issue 2. 2013-06-17. PMID:23562644. |
the p53 tumor suppressor can restrict malignant transformation by triggering cell-autonomous programs of cell-cycle arrest or apoptosis. |
2013-06-17 |
2023-08-12 |
Not clear |
| Anuradha Sehrawat, Julie A Arlotti, Akira Murakami, Shivendra V Sing. Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo. Breast cancer research and treatment. vol 136. issue 2. 2013-06-14. PMID:23053663. |
even though zer treatment caused stabilization of p53 and induction of puma, these proteins were dispensable for zer-induced cell cycle arrest and/or apoptosis. |
2013-06-14 |
2023-08-12 |
mouse |
| Alison I Bernstein, Karen L O'Malle. MPP+-induces PUMA- and p53-dependent, but ATF3-independent cell death. Toxicology letters. vol 219. issue 2. 2013-06-14. PMID:23500530. |
the bh3-only protein, puma (p53 upregulated mediator of apoptosis), has been shown to be activated in response to many cellular stresses, including endoplasmic reticulum (er) stress and upr, and to induce cell death. |
2013-06-14 |
2023-08-12 |
mouse |